On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat
Identifieur interne : 000B76 ( Istex/Corpus ); précédent : 000B75; suivant : 000B77On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat
Auteurs : S. P. Butcher ; I. Jacobson ; A. HambergerSource :
- Neuropharmacology [ 0028-3908 ] ; 1988.
Abstract
The in vivo effects of the acidic amino receptor agonist, kainic acid and the inhibitors of the uptake of glutamate, dihydrokainic acid and threo-3-hydroxyaspartate, on spontaneous activity and perforant path evoked field potentials were examined in the dentate gyrus of the rat. The effect of these compounds on extracellular levels of endogenous amino acids in the hippocampus was assessed simultaneously using in vivo microdialysis. Kainic acid (10–100 μM) and dihydrokainic acid (1–10 mM) both evoked epileptiform activity and an apparent loss of recurrent inhibition (as assessed using the paired-pulse technique). Extracellular increases in taurine, alanine and phosphoethanolamine were noted following administration of kainate (100 μM) and dihydrokainate (1–10 mM). An increase in extracellular glutamate and aspartate was also noted in rats treated with dihydrokainate (100μ-10μM). In contrast, threo-3-hydroxyaspartate did not induce epileptiform activity, suggesting that the epileptogenic effects of dihydrokainate and kainate are not mediated by inhibition of uptake. The effect of the N-methyl-d-aspartate receptor antagonist, d-2-amino-5-phosphonovalerate on these responses was studied. This compound attenuated the epileptiform activity and reversed the apparent loss of recurrent inhibition in response to both kainic acid and dihydrokainic acid. These data suggest that activation of N-methyl-d-aspartate receptors underlies the epileptogenic effects of both compounds, and the possible mechanisms which might be involved in this response are discussed.
Url:
DOI: 10.1016/0028-3908(88)90146-3
Links to Exploration step
ISTEX:0937B4C39C60EB3B70AAB175549A3B441D307655Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title><author><name sortKey="Butcher, S P" sort="Butcher, S P" uniqKey="Butcher S" first="S. P." last="Butcher">S. P. Butcher</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Jacobson, I" sort="Jacobson, I" uniqKey="Jacobson I" first="I." last="Jacobson">I. Jacobson</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Hamberger, A" sort="Hamberger, A" uniqKey="Hamberger A" first="A." last="Hamberger">A. Hamberger</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:0937B4C39C60EB3B70AAB175549A3B441D307655</idno><date when="1988" year="1988">1988</date><idno type="doi">10.1016/0028-3908(88)90146-3</idno><idno type="url">https://api.istex.fr/document/0937B4C39C60EB3B70AAB175549A3B441D307655/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B76</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B76</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title><author><name sortKey="Butcher, S P" sort="Butcher, S P" uniqKey="Butcher S" first="S. P." last="Butcher">S. P. Butcher</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Jacobson, I" sort="Jacobson, I" uniqKey="Jacobson I" first="I." last="Jacobson">I. Jacobson</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</mods:affiliation></affiliation></author><author><name sortKey="Hamberger, A" sort="Hamberger, A" uniqKey="Hamberger A" first="A." last="Hamberger">A. Hamberger</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Neuropharmacology</title><title level="j" type="abbrev">NP</title><idno type="ISSN">0028-3908</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988">1988</date><biblScope unit="volume">27</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="375">375</biblScope><biblScope unit="page" to="381">381</biblScope></imprint><idno type="ISSN">0028-3908</idno></series><idno type="istex">0937B4C39C60EB3B70AAB175549A3B441D307655</idno><idno type="DOI">10.1016/0028-3908(88)90146-3</idno><idno type="PII">0028-3908(88)90146-3</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0028-3908</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The in vivo effects of the acidic amino receptor agonist, kainic acid and the inhibitors of the uptake of glutamate, dihydrokainic acid and threo-3-hydroxyaspartate, on spontaneous activity and perforant path evoked field potentials were examined in the dentate gyrus of the rat. The effect of these compounds on extracellular levels of endogenous amino acids in the hippocampus was assessed simultaneously using in vivo microdialysis. Kainic acid (10–100 μM) and dihydrokainic acid (1–10 mM) both evoked epileptiform activity and an apparent loss of recurrent inhibition (as assessed using the paired-pulse technique). Extracellular increases in taurine, alanine and phosphoethanolamine were noted following administration of kainate (100 μM) and dihydrokainate (1–10 mM). An increase in extracellular glutamate and aspartate was also noted in rats treated with dihydrokainate (100μ-10μM). In contrast, threo-3-hydroxyaspartate did not induce epileptiform activity, suggesting that the epileptogenic effects of dihydrokainate and kainate are not mediated by inhibition of uptake. The effect of the N-methyl-d-aspartate receptor antagonist, d-2-amino-5-phosphonovalerate on these responses was studied. This compound attenuated the epileptiform activity and reversed the apparent loss of recurrent inhibition in response to both kainic acid and dihydrokainic acid. These data suggest that activation of N-methyl-d-aspartate receptors underlies the epileptogenic effects of both compounds, and the possible mechanisms which might be involved in this response are discussed.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>S.P. Butcher</name><affiliations><json:string>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</json:string></affiliations></json:item><json:item><name>I. Jacobson</name><affiliations><json:string>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</json:string></affiliations></json:item><json:item><name>A. Hamberger</name><affiliations><json:string>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>field potential</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>perforant path</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epilepsy</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>acidic amino acids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>2-amino-5-phosphonovalerate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>brain dialysis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampus</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>The in vivo effects of the acidic amino receptor agonist, kainic acid and the inhibitors of the uptake of glutamate, dihydrokainic acid and threo-3-hydroxyaspartate, on spontaneous activity and perforant path evoked field potentials were examined in the dentate gyrus of the rat. The effect of these compounds on extracellular levels of endogenous amino acids in the hippocampus was assessed simultaneously using in vivo microdialysis. Kainic acid (10–100 μM) and dihydrokainic acid (1–10 mM) both evoked epileptiform activity and an apparent loss of recurrent inhibition (as assessed using the paired-pulse technique). Extracellular increases in taurine, alanine and phosphoethanolamine were noted following administration of kainate (100 μM) and dihydrokainate (1–10 mM). An increase in extracellular glutamate and aspartate was also noted in rats treated with dihydrokainate (100μ-10μM). In contrast, threo-3-hydroxyaspartate did not induce epileptiform activity, suggesting that the epileptogenic effects of dihydrokainate and kainate are not mediated by inhibition of uptake. The effect of the N-methyl-d-aspartate receptor antagonist, d-2-amino-5-phosphonovalerate on these responses was studied. This compound attenuated the epileptiform activity and reversed the apparent loss of recurrent inhibition in response to both kainic acid and dihydrokainic acid. These data suggest that activation of N-methyl-d-aspartate receptors underlies the epileptogenic effects of both compounds, and the possible mechanisms which might be involved in this response are discussed.</abstract><qualityIndicators><score>6.9</score><pdfVersion>1.2</pdfVersion><pdfPageSize>504 x 756 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>7</keywordCount><abstractCharCount>1572</abstractCharCount><pdfWordCount>4344</pdfWordCount><pdfCharCount>27681</pdfCharCount><pdfPageCount>7</pdfPageCount><abstractWordCount>213</abstractWordCount></qualityIndicators><title>On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title><pii><json:string>0028-3908(88)90146-3</json:string></pii><genre><json:string>research-article</json:string></genre><host><volume>27</volume><pii><json:string>S0028-3908(00)X0166-9</json:string></pii><pages><last>381</last><first>375</first></pages><issn><json:string>0028-3908</json:string></issn><issue>4</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><title>Neuropharmacology</title><publicationDate>1988</publicationDate></host><categories><wos><json:string>PHARMACOLOGY & PHARMACY</json:string><json:string>NEUROSCIENCES</json:string></wos></categories><publicationDate>1988</publicationDate><copyrightDate>1988</copyrightDate><doi><json:string>10.1016/0028-3908(88)90146-3</json:string></doi><id>0937B4C39C60EB3B70AAB175549A3B441D307655</id><score>0.06554014</score><fulltext><json:item><original>true</original><mimetype>application/pdf</mimetype><extension>pdf</extension><uri>https://api.istex.fr/document/0937B4C39C60EB3B70AAB175549A3B441D307655/fulltext/pdf</uri></json:item><json:item><original>false</original><mimetype>application/zip</mimetype><extension>zip</extension><uri>https://api.istex.fr/document/0937B4C39C60EB3B70AAB175549A3B441D307655/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/0937B4C39C60EB3B70AAB175549A3B441D307655/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1988</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title><author xml:id="author-1"><persName><forename type="first">S.P.</forename><surname>Butcher</surname></persName><note type="biography">Present address: Department of Pharmacology, University of Edinburgh Medical School, 1 George Square, Edinburgh, U.K.</note><affiliation>To whom all correspondence and reprint requests should be sent.</affiliation><affiliation>Present address: Department of Pharmacology, University of Edinburgh Medical School, 1 George Square, Edinburgh, U.K.</affiliation><affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</affiliation></author><author xml:id="author-2"><persName><forename type="first">I.</forename><surname>Jacobson</surname></persName><affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</affiliation></author><author xml:id="author-3"><persName><forename type="first">A.</forename><surname>Hamberger</surname></persName><affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</affiliation></author></analytic><monogr><title level="j">Neuropharmacology</title><title level="j" type="abbrev">NP</title><idno type="pISSN">0028-3908</idno><idno type="PII">S0028-3908(00)X0166-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1988"></date><biblScope unit="volume">27</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="375">375</biblScope><biblScope unit="page" to="381">381</biblScope></imprint></monogr><idno type="istex">0937B4C39C60EB3B70AAB175549A3B441D307655</idno><idno type="DOI">10.1016/0028-3908(88)90146-3</idno><idno type="PII">0028-3908(88)90146-3</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1988</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>The in vivo effects of the acidic amino receptor agonist, kainic acid and the inhibitors of the uptake of glutamate, dihydrokainic acid and threo-3-hydroxyaspartate, on spontaneous activity and perforant path evoked field potentials were examined in the dentate gyrus of the rat. The effect of these compounds on extracellular levels of endogenous amino acids in the hippocampus was assessed simultaneously using in vivo microdialysis. Kainic acid (10–100 μM) and dihydrokainic acid (1–10 mM) both evoked epileptiform activity and an apparent loss of recurrent inhibition (as assessed using the paired-pulse technique). Extracellular increases in taurine, alanine and phosphoethanolamine were noted following administration of kainate (100 μM) and dihydrokainate (1–10 mM). An increase in extracellular glutamate and aspartate was also noted in rats treated with dihydrokainate (100μ-10μM). In contrast, threo-3-hydroxyaspartate did not induce epileptiform activity, suggesting that the epileptogenic effects of dihydrokainate and kainate are not mediated by inhibition of uptake. The effect of the N-methyl-d-aspartate receptor antagonist, d-2-amino-5-phosphonovalerate on these responses was studied. This compound attenuated the epileptiform activity and reversed the apparent loss of recurrent inhibition in response to both kainic acid and dihydrokainic acid. These data suggest that activation of N-methyl-d-aspartate receptors underlies the epileptogenic effects of both compounds, and the possible mechanisms which might be involved in this response are discussed.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>field potential</term></item><item><term>perforant path</term></item><item><term>epilepsy</term></item><item><term>acidic amino acids</term></item><item><term>2-amino-5-phosphonovalerate</term></item><item><term>brain dialysis</term></item><item><term>hippocampus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1988">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/0937B4C39C60EB3B70AAB175549A3B441D307655/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>NP</jid><aid>88901463</aid><ce:pii>0028-3908(88)90146-3</ce:pii><ce:doi>10.1016/0028-3908(88)90146-3</ce:doi><ce:copyright type="unknown" year="1988"></ce:copyright></item-info><head><ce:title>On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</ce:title><ce:author-group><ce:author><ce:given-name>S.P.</ce:given-name><ce:surname>Butcher</ce:surname><ce:cross-ref refid="FN1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>I.</ce:given-name><ce:surname>Jacobson</ce:surname></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Hamberger</ce:surname></ce:author><ce:affiliation><ce:textfn>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>To whom all correspondence and reprint requests should be sent.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>1</ce:label><ce:note-para>Present address: Department of Pharmacology, University of Edinburgh Medical School, 1 George Square, Edinburgh, U.K.</ce:note-para></ce:footnote></ce:author-group><ce:date-accepted day="1" month="10" year="1987"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The <ce:italic>in vivo</ce:italic> effects of the acidic amino receptor agonist, kainic acid and the inhibitors of the uptake of glutamate, dihydrokainic acid and threo-3-hydroxyaspartate, on spontaneous activity and perforant path evoked field potentials were examined in the dentate gyrus of the rat. The effect of these compounds on extracellular levels of endogenous amino acids in the hippocampus was assessed simultaneously using <ce:italic>in vivo</ce:italic> microdialysis. Kainic acid (10–100 μM) and dihydrokainic acid (1–10 mM) both evoked epileptiform activity and an apparent loss of recurrent inhibition (as assessed using the paired-pulse technique). Extracellular increases in taurine, alanine and phosphoethanolamine were noted following administration of kainate (100 μM) and dihydrokainate (1–10 mM). An increase in extracellular glutamate and aspartate was also noted in rats treated with dihydrokainate (100μ-10μM). In contrast, threo-3-hydroxyaspartate did not induce epileptiform activity, suggesting that the epileptogenic effects of dihydrokainate and kainate are not mediated by inhibition of uptake. The effect of the <math altimg="si1.gif">N-<rm>methyl-<scp>d</scp>-aspartate</rm></math> receptor antagonist, <ce:small-caps>d</ce:small-caps>-2-amino-5-phosphonovalerate on these responses was studied. This compound attenuated the epileptiform activity and reversed the apparent loss of recurrent inhibition in response to both kainic acid and dihydrokainic acid. These data suggest that activation of <math altimg="si2.gif">N-<rm>methyl-<scp>d</scp>-aspartate</rm></math> receptors underlies the epileptogenic effects of both compounds, and the possible mechanisms which might be involved in this response are discussed.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>field potential</ce:text></ce:keyword><ce:keyword><ce:text>perforant path</ce:text></ce:keyword><ce:keyword><ce:text>epilepsy</ce:text></ce:keyword><ce:keyword><ce:text>acidic amino acids</ce:text></ce:keyword><ce:keyword><ce:text>2-amino-5-phosphonovalerate</ce:text></ce:keyword><ce:keyword><ce:text>brain dialysis</ce:text></ce:keyword><ce:keyword><ce:text>hippocampus</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat</title></titleInfo><name type="personal"><namePart type="given">S.P.</namePart><namePart type="family">Butcher</namePart><affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</affiliation><description>To whom all correspondence and reprint requests should be sent.</description><description>Present address: Department of Pharmacology, University of Edinburgh Medical School, 1 George Square, Edinburgh, U.K.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Jacobson</namePart><affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hamberger</namePart><affiliation>Institute of Neurobiology, University of Goteborg, Goteborg, Sweden</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1988</dateIssued><copyrightDate encoding="w3cdtf">1988</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">The in vivo effects of the acidic amino receptor agonist, kainic acid and the inhibitors of the uptake of glutamate, dihydrokainic acid and threo-3-hydroxyaspartate, on spontaneous activity and perforant path evoked field potentials were examined in the dentate gyrus of the rat. The effect of these compounds on extracellular levels of endogenous amino acids in the hippocampus was assessed simultaneously using in vivo microdialysis. Kainic acid (10–100 μM) and dihydrokainic acid (1–10 mM) both evoked epileptiform activity and an apparent loss of recurrent inhibition (as assessed using the paired-pulse technique). Extracellular increases in taurine, alanine and phosphoethanolamine were noted following administration of kainate (100 μM) and dihydrokainate (1–10 mM). An increase in extracellular glutamate and aspartate was also noted in rats treated with dihydrokainate (100μ-10μM). In contrast, threo-3-hydroxyaspartate did not induce epileptiform activity, suggesting that the epileptogenic effects of dihydrokainate and kainate are not mediated by inhibition of uptake. The effect of the N-methyl-d-aspartate receptor antagonist, d-2-amino-5-phosphonovalerate on these responses was studied. This compound attenuated the epileptiform activity and reversed the apparent loss of recurrent inhibition in response to both kainic acid and dihydrokainic acid. These data suggest that activation of N-methyl-d-aspartate receptors underlies the epileptogenic effects of both compounds, and the possible mechanisms which might be involved in this response are discussed.</abstract><subject><genre>Keywords</genre><topic>field potential</topic><topic>perforant path</topic><topic>epilepsy</topic><topic>acidic amino acids</topic><topic>2-amino-5-phosphonovalerate</topic><topic>brain dialysis</topic><topic>hippocampus</topic></subject><relatedItem type="host"><titleInfo><title>Neuropharmacology</title></titleInfo><titleInfo type="abbreviated"><title>NP</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">198804</dateIssued></originInfo><identifier type="ISSN">0028-3908</identifier><identifier type="PII">S0028-3908(00)X0166-9</identifier><part><date>198804</date><detail type="volume"><number>27</number><caption>vol.</caption></detail><detail type="issue"><number>4</number><caption>no.</caption></detail><extent unit="issue pages"><start>337</start><end>450</end></extent><extent unit="pages"><start>375</start><end>381</end></extent></part></relatedItem><identifier type="istex">0937B4C39C60EB3B70AAB175549A3B441D307655</identifier><identifier type="DOI">10.1016/0028-3908(88)90146-3</identifier><identifier type="PII">0028-3908(88)90146-3</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Terre/explor/CobaltMaghrebV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B76 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000B76 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Terre
|area= CobaltMaghrebV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:0937B4C39C60EB3B70AAB175549A3B441D307655
|texte= On the epileptogenic effects of kainic acid and dihydrokainic acid in the dentate gyrus of the rat
}}
| This area was generated with Dilib version V0.6.32. |  |