Effects of status epilepticus on extracellular amino acids in the hippocampus
Identifieur interne : 000A09 ( Istex/Corpus ); précédent : 000A08; suivant : 000A10Effects of status epilepticus on extracellular amino acids in the hippocampus
Auteurs : Anders Lehmann ; Henrik Hagberg ; Ingemar Jacobson ; Anders HambergerSource :
- Brain Research [ 0006-8993 ] ; 1985.
English descriptors
Abstract
Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino acids were unaffected. BC seizures encompassed a slightly different pattern of alterations. In contrast to KA seizures, BC epilepsy had no effect on taurine. Significant increments were observed for PEA and alanine while elevations of ethanolamine were subtle. In both types of seizures, glutamate and GABA remained unaffected extracellularly, probably due to efficient recapture mechanisms.
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DOI: 10.1016/0006-8993(85)91422-2
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ISTEX:73AF65D77C3D6588B44D1B0F037A31256FD48C36Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effects of status epilepticus on extracellular amino acids in the hippocampus</title><author><name sortKey="Lehmann, Anders" sort="Lehmann, Anders" uniqKey="Lehmann A" first="Anders" last="Lehmann">Anders Lehmann</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence: A. Lehmann, Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Hagberg, Henrik" sort="Hagberg, Henrik" uniqKey="Hagberg H" first="Henrik" last="Hagberg">Henrik Hagberg</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation></author><author><name sortKey="Jacobson, Ingemar" sort="Jacobson, Ingemar" uniqKey="Jacobson I" first="Ingemar" last="Jacobson">Ingemar Jacobson</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</mods:affiliation></affiliation></author><author><name sortKey="Hamberger, Anders" sort="Hamberger, Anders" uniqKey="Hamberger A" first="Anders" last="Hamberger">Anders Hamberger</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:73AF65D77C3D6588B44D1B0F037A31256FD48C36</idno><date when="1985" year="1985">1985</date><idno type="doi">10.1016/0006-8993(85)91422-2</idno><idno type="url">https://api.istex.fr/document/73AF65D77C3D6588B44D1B0F037A31256FD48C36/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000A09</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000A09</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Effects of status epilepticus on extracellular amino acids in the hippocampus</title><author><name sortKey="Lehmann, Anders" sort="Lehmann, Anders" uniqKey="Lehmann A" first="Anders" last="Lehmann">Anders Lehmann</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence: A. Lehmann, Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg, Sweden.</mods:affiliation></affiliation></author><author><name sortKey="Hagberg, Henrik" sort="Hagberg, Henrik" uniqKey="Hagberg H" first="Henrik" last="Hagberg">Henrik Hagberg</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation></author><author><name sortKey="Jacobson, Ingemar" sort="Jacobson, Ingemar" uniqKey="Jacobson I" first="Ingemar" last="Jacobson">Ingemar Jacobson</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</mods:affiliation></affiliation></author><author><name sortKey="Hamberger, Anders" sort="Hamberger, Anders" uniqKey="Hamberger A" first="Anders" last="Hamberger">Anders Hamberger</name><affiliation><mods:affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="ISSN">0006-8993</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">359</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="147">147</biblScope><biblScope unit="page" to="151">151</biblScope></imprint><idno type="ISSN">0006-8993</idno></series><idno type="istex">73AF65D77C3D6588B44D1B0F037A31256FD48C36</idno><idno type="DOI">10.1016/0006-8993(85)91422-2</idno><idno type="PII">0006-8993(85)91422-2</idno><idno type="ArticleID">85914222</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>bicuculline</term><term>extracellular amino acid</term><term>hippocampus</term><term>kainic acid</term><term>status epilepticus</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino acids were unaffected. BC seizures encompassed a slightly different pattern of alterations. In contrast to KA seizures, BC epilepsy had no effect on taurine. Significant increments were observed for PEA and alanine while elevations of ethanolamine were subtle. In both types of seizures, glutamate and GABA remained unaffected extracellularly, probably due to efficient recapture mechanisms.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>Anders Lehmann</name><affiliations><json:string>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</json:string><json:string>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</json:string><json:string>Correspondence: A. Lehmann, Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg, Sweden.</json:string></affiliations></json:item><json:item><name>Henrik Hagberg</name><affiliations><json:string>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</json:string></affiliations></json:item><json:item><name>Ingemar Jacobson</name><affiliations><json:string>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</json:string><json:string>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</json:string></affiliations></json:item><json:item><name>Anders Hamberger</name><affiliations><json:string>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>status epilepticus</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>kainic acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bicuculline</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>extracellular amino acid</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hippocampus</value></json:item></subject><articleId><json:string>85914222</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino acids were unaffected. BC seizures encompassed a slightly different pattern of alterations. In contrast to KA seizures, BC epilepsy had no effect on taurine. Significant increments were observed for PEA and alanine while elevations of ethanolamine were subtle. 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(Biomedical Division)</p></availability><date>1985</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Effects of status epilepticus on extracellular amino acids in the hippocampus</title><author xml:id="author-1"><persName><forename type="first">Anders</forename><surname>Lehmann</surname></persName><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation><affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</affiliation><affiliation>Correspondence: A. Lehmann, Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg, Sweden.</affiliation></author><author xml:id="author-2"><persName><forename type="first">Henrik</forename><surname>Hagberg</surname></persName><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation></author><author xml:id="author-3"><persName><forename type="first">Ingemar</forename><surname>Jacobson</surname></persName><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation><affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</affiliation></author><author xml:id="author-4"><persName><forename type="first">Anders</forename><surname>Hamberger</surname></persName><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation></author></analytic><monogr><title level="j">Brain Research</title><title level="j" type="abbrev">BRES</title><idno type="pISSN">0006-8993</idno><idno type="PII">S0006-8993(00)X1530-2</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985"></date><biblScope unit="volume">359</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="147">147</biblScope><biblScope unit="page" to="151">151</biblScope></imprint></monogr><idno type="istex">73AF65D77C3D6588B44D1B0F037A31256FD48C36</idno><idno type="DOI">10.1016/0006-8993(85)91422-2</idno><idno type="PII">0006-8993(85)91422-2</idno><idno type="ArticleID">85914222</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino acids were unaffected. BC seizures encompassed a slightly different pattern of alterations. In contrast to KA seizures, BC epilepsy had no effect on taurine. Significant increments were observed for PEA and alanine while elevations of ethanolamine were subtle. In both types of seizures, glutamate and GABA remained unaffected extracellularly, probably due to efficient recapture mechanisms.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Key words</head><item><term>status epilepticus</term></item><item><term>kainic acid</term></item><item><term>bicuculline</term></item><item><term>extracellular amino acid</term></item><item><term>hippocampus</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/73AF65D77C3D6588B44D1B0F037A31256FD48C36/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier doc found" wicri:toSee="Elsevier, no converted or simple article"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 5.0.1//EN//XML" URI="art501.dtd" name="istex:docType"></istex:docType><istex:document><article version="5.0" xml:lang="en" docsubtype="fla"><item-info><jid>BRES</jid><aid>85914222</aid><ce:pii>0006-8993(85)91422-2</ce:pii><ce:doi>10.1016/0006-8993(85)91422-2</ce:doi><ce:copyright type="unknown" year="1985">Elsevier Science Publishers B.V. (Biomedical Division)</ce:copyright></item-info><head><ce:title>Effects of status epilepticus on extracellular amino acids in the hippocampus</ce:title><ce:author-group><ce:author><ce:given-name>Anders</ce:given-name><ce:surname>Lehmann</ce:surname><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup loc="post">2</ce:sup></ce:cross-ref><ce:cross-ref refid="cor1"><ce:sup loc="post">3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Henrik</ce:given-name><ce:surname>Hagberg</ce:surname><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Ingemar</ce:given-name><ce:surname>Jacobson</ce:surname><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref><ce:cross-ref refid="aff2"><ce:sup loc="post">2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Anders</ce:given-name><ce:surname>Hamberger</ce:surname><ce:cross-ref refid="aff1"><ce:sup loc="post">1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="aff1"><ce:label>1</ce:label><ce:textfn>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</ce:textfn></ce:affiliation><ce:affiliation id="aff2"><ce:label>2</ce:label><ce:textfn>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</ce:textfn></ce:affiliation><ce:correspondence id="cor1"><ce:label>3</ce:label><ce:text><ce:italic>Correspondence:</ce:italic> A. Lehmann, Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg, Sweden.</ce:text></ce:correspondence></ce:author-group><ce:date-accepted day="12" month="3" year="1985"></ce:date-accepted><ce:abstract id="ab1" class="author" xml:lang="en"><ce:abstract-sec><ce:simple-para view="all" id="simple-para.0010">Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino acids were unaffected. BC seizures encompassed a slightly different pattern of alterations. In contrast to KA seizures, BC epilepsy had no effect on taurine. Significant increments were observed for PEA and alanine while elevations of ethanolamine were subtle. In both types of seizures, glutamate and GABA remained unaffected extracellularly, probably due to efficient recapture mechanisms.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords class="keyword" xml:lang="en"><ce:section-title>Key words</ce:section-title><ce:keyword><ce:text>status epilepticus</ce:text></ce:keyword><ce:keyword><ce:text>kainic acid</ce:text></ce:keyword><ce:keyword><ce:text>bicuculline</ce:text></ce:keyword><ce:keyword><ce:text>extracellular amino acid</ce:text></ce:keyword><ce:keyword><ce:text>hippocampus</ce:text></ce:keyword></ce:keywords></head><tail view="all"><ce:bibliography view="all" id="bibliography.0010"><ce:section-title>References</ce:section-title><ce:bibliography-sec id="bibliography-sec.0010"><ce:bib-reference id="bib1"><ce:label>1</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Atillo</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Söderfeldt</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Kalimo</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Olsson</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Siesjö</ce:surname><ce:given-name>B.K.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Pathogenesis of brain lesions caused by experimental epilepsy</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Acta Neuropathol. (Berl.)</sb:maintitle></sb:title><sb:volume-nr>59</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>11</sb:first-page><sb:last-page>24</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib2"><ce:label>2</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Battistin</ce:surname><ce:given-name>L.</ce:given-name></sb:author><sb:author><ce:surname>Varotto</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Tezzon</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Pistollato</ce:surname><ce:given-name>L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Levels and uptake of taurine in various brain regions after drug induced generalized convulsions</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurochem. Res.</sb:maintitle></sb:title><sb:volume-nr>4</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>457</sb:first-page><sb:last-page>464</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib3"><ce:label>3</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Bazán</ce:surname><ce:given-name>N.G.</ce:given-name></sb:author><sb:author><ce:surname>Rodriguez de Turco</ce:surname><ce:given-name>E.B.</ce:given-name></sb:author><sb:author><ce:surname>Morelli de Liberti</ce:surname><ce:given-name>S.A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Free arachidonic acid and membrane lipids in the central nervous system during bicuculline-induced status epilepticus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Adv. Neurol.</sb:maintitle></sb:title><sb:volume-nr>34</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>305</sb:first-page><sb:last-page>310</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib4"><ce:label>4</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Ben-Ari</ce:surname><ce:given-name>Y.</ce:given-name></sb:author><sb:author><ce:surname>Tremblay</ce:surname><ce:given-name>E.</ce:given-name></sb:author><sb:author><ce:surname>Berger</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Nitecka</ce:surname><ce:given-name>L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Kainic acid seizure syndrome and binding sites in developing rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Dev. Brain Res.</sb:maintitle></sb:title><sb:volume-nr>316</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>284</sb:first-page><sb:last-page>288</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib5"><ce:label>5</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Chapman</ce:surname><ce:given-name>A.G.</ce:given-name></sb:author><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author><sb:author><ce:surname>Siesjö</ce:surname><ce:given-name>B.K.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Cerebral metabolic changes during prolonged epileptic seizures in rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>28</sb:volume-nr></sb:series><sb:date>1977</sb:date></sb:issue><sb:pages><sb:first-page>1025</sb:first-page><sb:last-page>1035</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib6"><ce:label>6</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Chapman</ce:surname><ce:given-name>A.G.</ce:given-name></sb:author><sb:author><ce:surname>Westerberg</ce:surname><ce:given-name>E.</ce:given-name></sb:author><sb:author><ce:surname>Premachandra</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Changes in regional neurotransmitter amino acid levels in rat brain during seizures induced by <ce:small-caps>l</ce:small-caps>-allylglycine, bicuculline and kainic acid</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>43</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>62</sb:first-page><sb:last-page>70</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib7"><ce:label>7</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Curtis</ce:surname><ce:given-name>D.R.</ce:given-name></sb:author><sb:author><ce:surname>Watkins</ce:surname><ce:given-name>J.C.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The excitation and depression of spinal neurons by structurally related amino acids</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>6</sb:volume-nr></sb:series><sb:date>1960</sb:date></sb:issue><sb:pages><sb:first-page>117</sb:first-page><sb:last-page>141</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib8"><ce:label>8</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dodd</ce:surname><ce:given-name>P.R.</ce:given-name></sb:author><sb:author><ce:surname>Bradford</ce:surname><ce:given-name>H.F.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Release of amino acids from the maturing cobalt-induced epileptic focus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Research</sb:maintitle></sb:title><sb:volume-nr>111</sb:volume-nr></sb:series><sb:date>1976</sb:date></sb:issue><sb:pages><sb:first-page>377</sb:first-page><sb:last-page>388</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib9"><ce:label>9</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Dodd</ce:surname><ce:given-name>P.R.</ce:given-name></sb:author><sb:author><ce:surname>Bradford</ce:surname><ce:given-name>H.F.</ce:given-name></sb:author><sb:author><ce:surname>Abdul-Ghani</ce:surname><ce:given-name>A.S.</ce:given-name></sb:author><sb:author><ce:surname>Cox</ce:surname><ce:given-name>D.W.G.</ce:given-name></sb:author><sb:author><ce:surname>Continho-Netto</ce:surname><ce:given-name>J.</ce:given-name></sb:author><sb:author><ce:surname>Regional</ce:surname><ce:given-name>alterations of synaptic O-phosphorylethanolamine in differentially housed mice</ce:given-name></sb:author></sb:authors></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pharmacol. Res. Commun.</sb:maintitle></sb:title><sb:volume-nr>6</sb:volume-nr></sb:series><sb:date>1974</sb:date></sb:issue><sb:pages><sb:first-page>377</sb:first-page><sb:last-page>395</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib10"><ce:label>10</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Essman</ce:surname><ce:given-name>W.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Regional alterations of synaptic O-phosphorylethanolamine in differentially housed mice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Pharmacol. Res. Commun.</sb:maintitle></sb:title><sb:volume-nr>6</sb:volume-nr></sb:series><sb:date>1974</sb:date></sb:issue><sb:pages><sb:first-page>377</sb:first-page><sb:last-page>395</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib11"><ce:label>11</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Evans</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Griffiths</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Early changes in the rat hippocampus following seizures induced by bicuculline or <ce:small-caps>l</ce:small-caps>-allylglycine: a light and electron microscope study</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuropathol. Appl. Neurobiol.</sb:maintitle></sb:title><sb:volume-nr>9</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>39</sb:first-page><sb:last-page>52</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib12"><ce:label>12</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Evans</ce:surname><ce:given-name>M.C.</ce:given-name></sb:author><sb:author><ce:surname>Griffiths</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Kainic acid seizures and the reversibility of calcium loading in vulnerable neurons in the hippocampus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neuropathol. Appl. Neurobiol.</sb:maintitle></sb:title><sb:volume-nr>10</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>285</sb:first-page><sb:last-page>302</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib13"><ce:label>13</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Fariello</ce:surname><ce:given-name>R.G.</ce:given-name></sb:author><sb:author><ce:surname>Golden</ce:surname><ce:given-name>G.T.</ce:given-name></sb:author><sb:author><ce:surname>Pisa</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Homoturine (3 aminopropanesulfonic acid; 3APS) protects from the convulsant and cytotoxic effect of systemically administered kainic acid</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurology</sb:maintitle></sb:title><sb:volume-nr>32</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>241</sb:first-page><sb:last-page>245</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib14"><ce:label>14</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Ferkany</ce:surname><ce:given-name>J.W.</ce:given-name></sb:author><sb:author><ce:surname>Coyle</ce:surname><ce:given-name>J.T.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Kainic acid selectively stimulates the release of endogenous excitaory acidic amino acids</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Pharmacol. Exp. Ther.</sb:maintitle></sb:title><sb:volume-nr>225</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>399</sb:first-page><sb:last-page>406</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib15"><ce:label>15</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Fischer</ce:surname><ce:given-name>R.S.</ce:given-name></sb:author><sb:author><ce:surname>Alger</ce:surname><ce:given-name>B.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Electrophysiological mechanisms of kainic acid induced epileptiform activity in the rat hippocampal slice</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurosci.</sb:maintitle></sb:title><sb:volume-nr>4</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>1312</sb:first-page><sb:last-page>1323</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib16"><ce:label>16</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Griffiths</ce:surname><ce:given-name>T.</ce:given-name></sb:author><sb:author><ce:surname>Evans</ce:surname><ce:given-name>M.C.</ce:given-name></sb:author><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Temporal lobe epilepsy, excitotoxins and the mechanism of selective neuronal loss</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:book-series><sb:series><sb:title><sb:maintitle>Wennergren Int. Symp. Ser.</sb:maintitle></sb:title><sb:volume-nr>39</sb:volume-nr></sb:series></sb:book-series><sb:date>1983</sb:date></sb:edited-book><sb:pages><sb:first-page>331</sb:first-page><sb:last-page>342</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib17"><ce:label>17</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Johnston</ce:surname><ce:given-name>G.A.R.</ce:given-name></sb:author><sb:author><ce:surname>Kennedy</ce:surname><ce:given-name>S.M.E.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>GABA receptors and phospholipids</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:given-name>F.</ce:given-name><ce:surname>Fonnum</ce:surname></sb:editor></sb:editors><sb:title><sb:maintitle>Amino Acids as Chemical Transmitters</sb:maintitle></sb:title><sb:date>1978</sb:date><sb:publisher><sb:name>Plenum Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>507</sb:first-page><sb:last-page>516</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib18"><ce:label>18</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Kiessling</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Hossman</ce:surname><ce:given-name>K.-A.</ce:given-name></sb:author><sb:author><ce:surname>Kleihues</ce:surname><ce:given-name>R.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Pulmonary edema during bicuculline-induced seizures in rats</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Exp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>74</sb:volume-nr></sb:series><sb:date>1981</sb:date></sb:issue><sb:pages><sb:first-page>430</sb:first-page><sb:last-page>438</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib19"><ce:label>19</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Koyama</ce:surname><ce:given-name>I.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Amino acids in the cobalt-induced epileptogenic and nonepileptogenic cat's cortex</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Can. J. Physiol. Pharmacol.</sb:maintitle></sb:title><sb:volume-nr>50</sb:volume-nr></sb:series><sb:date>1972</sb:date></sb:issue><sb:pages><sb:first-page>740</sb:first-page><sb:last-page>752</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib20"><ce:label>20</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lehmann</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Isacsson</ce:surname><ce:given-name>H.</ce:given-name></sb:author><sb:author><ce:surname>Hamberger</ce:surname><ce:given-name>A.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effects of in vivo administration of kainic acid on the extracellular amino acid pool in the rabbit hippocampus</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>40</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>1314</sb:first-page><sb:last-page>1320</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib21"><ce:label>21</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lindroth</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Mopper</ce:surname><ce:given-name>K.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>High-performance liquid chromatographic determination of subpicomole amounts of amino acids by precolumn fluorescence derivatization with <ce:italic>o</ce:italic>-phthaldialdehyde</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Anal. Chem.</sb:maintitle></sb:title><sb:volume-nr>51</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>1667</sb:first-page><sb:last-page>1674</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib22"><ce:label>22</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lindroth</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Hamberger</ce:surname><ce:given-name>A.</ce:given-name></sb:author><sb:author><ce:surname>Sandberg</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Liquid chromatographic determination of amino acids after precolumn fluorescence derivatization</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:given-name>A.</ce:given-name><ce:surname>Boulton</ce:surname></sb:editor><sb:editor><ce:surname>Baker</ce:surname></sb:editor><sb:editor><ce:surname>Wood</ce:surname></sb:editor></sb:editors><sb:title><sb:maintitle>Neurochemical Techniques and Analyses, Vol. 2, Amino Acids</sb:maintitle></sb:title><sb:date>1985</sb:date><sb:publisher><sb:name>Humana Press</sb:name><sb:location>New York</sb:location></sb:publisher></sb:edited-book></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib23"><ce:label>23</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Lloyd</ce:surname><ce:given-name>K.G.</ce:given-name></sb:author><sb:author><ce:surname>Davidson</ce:surname><ce:given-name>L.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>[<ce:sup loc="post">3</ce:sup>H]GABA binding in brains from Huntington's chorea patients: altered regulation by phospholipids?</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Science</sb:maintitle></sb:title><sb:volume-nr>205</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>1147</sb:first-page><sb:last-page>1149</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib24"><ce:label>24</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Löscher</ce:surname><ce:given-name>W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Effect of 2-aminoethanol on the synthesis, binding, uptake and metabolism of GABA</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>41</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>293</sb:first-page><sb:last-page>297</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib25"><ce:label>25</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Metabolic effects of prolonged epileptic seizures and the causation of epileptic brain damage</sb:maintitle></sb:title></sb:contribution><sb:host><sb:edited-book><sb:editors><sb:editor><ce:given-name>F.C.</ce:given-name><ce:surname>Rose</ce:surname></sb:editor></sb:editors><sb:title><sb:maintitle>Metabolic Disorders of the Nervous system</sb:maintitle></sb:title><sb:date>1981</sb:date><sb:publisher><sb:name>Pitman Press</sb:name><sb:location>Clifton, NJ, New York</sb:location></sb:publisher></sb:edited-book><sb:pages><sb:first-page>175</sb:first-page><sb:last-page>187</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib26"><ce:label>26</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Meldrum</ce:surname><ce:given-name>B.S.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Amino acid neurotransmitters and new approaches to anticonvulsant drug action</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Epilepsia</sb:maintitle></sb:title><sb:volume-nr>25</sb:volume-nr></sb:series><sb:issue-nr>Suppl. 2</sb:issue-nr><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>5140</sb:first-page><sb:last-page>5149</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib27"><ce:label>27</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Nicoletti</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>Perciavalle</ce:surname><ce:given-name>P.</ce:given-name></sb:author><sb:author><ce:surname>Berretta</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Speciale</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Polizzi</ce:surname><ce:given-name>M.C.</ce:given-name></sb:author><sb:author><ce:surname>Patti</ce:surname><ce:given-name>F.</ce:given-name></sb:author><sb:author><ce:surname>De Simone</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Sortino</ce:surname><ce:given-name>M.A.</ce:given-name></sb:author><sb:author><ce:surname>Di Giorgio</ce:surname><ce:given-name>R.M.</ce:given-name></sb:author><sb:author><ce:surname>Scapagnini</ce:surname><ce:given-name>V.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Altered time course of changes in the hippocampal concentration of excitatory and inhibitory amino acids during kainate-induced epilepsy</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Eur. J. Pharmacol.</sb:maintitle></sb:title><sb:volume-nr>103</sb:volume-nr></sb:series><sb:date>1984</sb:date></sb:issue><sb:pages><sb:first-page>133</sb:first-page><sb:last-page>137</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib28"><ce:label>28</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Nitsch</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Schmude</ce:surname><ce:given-name>B.</ce:given-name></sb:author><sb:author><ce:surname>Haug</ce:surname><ce:given-name>P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Alterations in the content of amino acid neurotrasmitters before the onset and during the course of methoxypyridoxine-induced seizures in individual brain regions</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>40</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>1571</sb:first-page><sb:last-page>1581</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib29"><ce:label>29</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Peterson</ce:surname><ce:given-name>D.W.</ce:given-name></sb:author><sb:author><ce:surname>Collins</ce:surname><ce:given-name>J.F.</ce:given-name></sb:author><sb:author><ce:surname>Bradford</ce:surname><ce:given-name>H.F.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The kindled amygdala model of epilepsy: anticonvulsant action of amino acid antagonists</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Research</sb:maintitle></sb:title><sb:volume-nr>275</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>169</sb:first-page><sb:last-page>172</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib30"><ce:label>30</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Sanberg</ce:surname><ce:given-name>P.R.</ce:given-name></sb:author><sb:author><ce:surname>Staines</ce:surname><ce:given-name>W.</ce:given-name></sb:author><sb:author><ce:surname>McGeer</ce:surname><ce:given-name>E.G.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Chronic taurine effects on various neurochemical indices in control and kainic acid-lesioned neostratum</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Brain Research</sb:maintitle></sb:title><sb:volume-nr>161</sb:volume-nr></sb:series><sb:date>1979</sb:date></sb:issue><sb:pages><sb:first-page>367</sb:first-page><sb:last-page>370</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib31"><ce:label>31</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Spanner</ce:surname><ce:given-name>S.</ce:given-name></sb:author><sb:author><ce:surname>Ansell</ce:surname><ce:given-name>G.B.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>The determination of free ethanolamine in brain tissue and its release on incubation</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>J. Neurochem.</sb:maintitle></sb:title><sb:volume-nr>30</sb:volume-nr></sb:series><sb:date>1978</sb:date></sb:issue><sb:pages><sb:first-page>497</sb:first-page><sb:last-page>498</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib32"><ce:label>32</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Van Gelder</ce:surname><ce:given-name>N.M.</ce:given-name></sb:author><sb:author><ce:surname>Siatisas</ce:surname><ce:given-name>I.</ce:given-name></sb:author><sb:author><ce:surname>Mébini</ce:surname><ce:given-name>C.</ce:given-name></sb:author><sb:author><ce:surname>Gloor</ce:surname><ce:given-name>P.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Feline generalized penicillin epilepsy: changes of glutamic acid and taurine parallel the progressive increase in excitability of the cortex</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Epilepsia</sb:maintitle></sb:title><sb:volume-nr>24</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>200</sb:first-page><sb:last-page>213</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib33"><ce:label>33</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Wolfensberger</ce:surname><ce:given-name>M.</ce:given-name></sb:author><sb:author><ce:surname>Felix</ce:surname><ce:given-name>D.</ce:given-name></sb:author><sb:author><ce:surname>Cuénod</ce:surname><ce:given-name>M.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>2-Aminoethanol as a possible neuromodulator in the pigeon optic tectum</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Neurosci. Lett.</sb:maintitle></sb:title><sb:volume-nr>32</sb:volume-nr></sb:series><sb:date>1982</sb:date></sb:issue><sb:pages><sb:first-page>53</sb:first-page><sb:last-page>58</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference><ce:bib-reference id="bib34"><ce:label>34</ce:label><sb:reference><sb:contribution langtype="en"><sb:authors><sb:author><ce:surname>Zucker</ce:surname><ce:given-name>D.K.</ce:given-name></sb:author><sb:author><ce:surname>Wooten</ce:surname><ce:given-name>G.F.</ce:given-name></sb:author><sb:author><ce:surname>Lothman</ce:surname><ce:given-name>E.W.</ce:given-name></sb:author></sb:authors><sb:title><sb:maintitle>Blood-brain barrier changes with kainic acid-induced limbic seizures</sb:maintitle></sb:title></sb:contribution><sb:host><sb:issue><sb:series><sb:title><sb:maintitle>Exp. Neurol.</sb:maintitle></sb:title><sb:volume-nr>79</sb:volume-nr></sb:series><sb:date>1983</sb:date></sb:issue><sb:pages><sb:first-page>422</sb:first-page><sb:last-page>433</sb:last-page></sb:pages></sb:host></sb:reference></ce:bib-reference></ce:bibliography-sec></ce:bibliography></tail></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Effects of status epilepticus on extracellular amino acids in the hippocampus</title></titleInfo><titleInfo type="alternative" lang="en" contentType="CDATA"><title>Effects of status epilepticus on extracellular amino acids in the hippocampus</title></titleInfo><name type="personal"><namePart type="given">Anders</namePart><namePart type="family">Lehmann</namePart><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation><affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</affiliation><affiliation>Correspondence: A. Lehmann, Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg, Sweden.</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Henrik</namePart><namePart type="family">Hagberg</namePart><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ingemar</namePart><namePart type="family">Jacobson</namePart><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation><affiliation>Department of Zoophysiology, University of Göteborg, P.O. Box 25059, S-400 31 Göteborg (Sweden)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Anders</namePart><namePart type="family">Hamberger</namePart><affiliation>Institute of Neurobiology, University of Göteborg, P.O. Box 33031, S-400 33 Göteborg (Sweden)</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Extracellular amino acids were followed in the hippocampus during sustained seizures induced by systemic administration of kainic acid (KA) or bicuculline (BC). KA epilepsy was associated with marked increases in phosphoethanolamine (PEA) and taurine. Alanine and ethanolamine were moderately raised while other amino acids were unaffected. BC seizures encompassed a slightly different pattern of alterations. In contrast to KA seizures, BC epilepsy had no effect on taurine. Significant increments were observed for PEA and alanine while elevations of ethanolamine were subtle. In both types of seizures, glutamate and GABA remained unaffected extracellularly, probably due to efficient recapture mechanisms.</abstract><subject lang="en"><genre>Key words</genre><topic>status epilepticus</topic><topic>kainic acid</topic><topic>bicuculline</topic><topic>extracellular amino acid</topic><topic>hippocampus</topic></subject><relatedItem type="host"><titleInfo><title>Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BRES</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19851216</dateIssued></originInfo><identifier type="ISSN">0006-8993</identifier><identifier type="PII">S0006-8993(00)X1530-2</identifier><part><date>19851216</date><detail type="volume"><number>359</number><caption>vol.</caption></detail><detail type="issue"><number>1–2</number><caption>no.</caption></detail><extent unit="issue pages"><start>1</start><end>412</end></extent><extent unit="pages"><start>147</start><end>151</end></extent></part></relatedItem><identifier type="istex">73AF65D77C3D6588B44D1B0F037A31256FD48C36</identifier><identifier type="DOI">10.1016/0006-8993(85)91422-2</identifier><identifier type="PII">0006-8993(85)91422-2</identifier><identifier type="ArticleID">85914222</identifier><accessCondition type="use and reproduction" contentType="copyright">©1985 Elsevier Science Publishers B.V. 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