Metal blood levels and hematological characteristics in wood mice (Apodemus sylvaticus L.) along a metal pollution gradient
Identifieur interne : 000834 ( Istex/Corpus ); précédent : 000833; suivant : 000835Metal blood levels and hematological characteristics in wood mice (Apodemus sylvaticus L.) along a metal pollution gradient
Auteurs : Damien Rogival ; Jan Scheirs ; Wim De Coen ; Ron Verhagen ; Ronny BlustSource :
- Environmental Toxicology and Chemistry [ 0730-7268 ] ; 2006-01.
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Abstract
The present study evaluated whether blood could be used as a nondestructive tool for monitoring metal exposure and related hematological effects in wood mice (Apodemus sylvaticus L.) living along a metal pollution gradient. Soil concentrations of arsenic, cadmium, copper, lead, silver, and zinc decreased with distance from the emission source. Blood levels of cadmium and lead differed significantly among sites, whereas those of the other metals did not. Blood levels of cadmium and lead correlated with soil concentrations of cadmium and lead, respectively. No such significant relationships were found for the other measured metals. Hematocrit levels decreased in wood mice from the most polluted site (45.96% ± 0.53% [mean ± standard error]) compared to the reference site (48.04% ± 0.47%). A negative correlation between hematocrit and blood levels of cadmium and lead was found. Erythrocyte count, leukocyte count, hemoglobin concentration, mean corpuscular hemoglobin (average wt of hemoglobin in a red blood cell in pg), and lysozyme activity did not differ among study sites. Mean corpuscular volume (average volume of a red blood cell in μm3) and mean corpuscular hemoglobin concentration (average proportion of hemoglobin in a red blood cell as a %) differed among study sites but showed no relationship with metal exposure. We conclude that whole blood from mice can be used for nondestructive monitoring of the exposure to nonessential metals under natural conditions. The present results indicate that decreased hematocrit levels may be an early warning signal for a negative impact of metal exposure on the oxygen‐transport capacity of blood in wood mice in their natural environment.
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DOI: 10.1897/04-659R1.1
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Soil concentrations of arsenic, cadmium, copper, lead, silver, and zinc decreased with distance from the emission source. Blood levels of cadmium and lead differed significantly among sites, whereas those of the other metals did not. Blood levels of cadmium and lead correlated with soil concentrations of cadmium and lead, respectively. No such significant relationships were found for the other measured metals. Hematocrit levels decreased in wood mice from the most polluted site (45.96% ± 0.53% [mean ± standard error]) compared to the reference site (48.04% ± 0.47%). A negative correlation between hematocrit and blood levels of cadmium and lead was found. Erythrocyte count, leukocyte count, hemoglobin concentration, mean corpuscular hemoglobin (average wt of hemoglobin in a red blood cell in pg), and lysozyme activity did not differ among study sites. Mean corpuscular volume (average volume of a red blood cell in μm3) and mean corpuscular hemoglobin concentration (average proportion of hemoglobin in a red blood cell as a %) differed among study sites but showed no relationship with metal exposure. We conclude that whole blood from mice can be used for nondestructive monitoring of the exposure to nonessential metals under natural conditions. The present results indicate that decreased hematocrit levels may be an early warning signal for a negative impact of metal exposure on the oxygen‐transport capacity of blood in wood mice in their natural environment.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>Damien Rogival</name><affiliations><json:string>Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Jan Scheirs</name><affiliations><json:string>Department of Biology Evolutionary Biology Group University of Antwerp, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Wim De Coen</name><affiliations><json:string>Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Ron Verhagen</name><affiliations><json:string>Department of Biology Evolutionary Biology Group University of Antwerp, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</json:string></affiliations></json:item><json:item><name>Ronny Blust</name><affiliations><json:string>Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Hematology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Heavy metals</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Blood</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Biomarker</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Mice</value></json:item></subject><articleId><json:string>ETC5620250119</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>The present study evaluated whether blood could be used as a nondestructive tool for monitoring metal exposure and related hematological effects in wood mice (Apodemus sylvaticus L.) living along a metal pollution gradient. Soil concentrations of arsenic, cadmium, copper, lead, silver, and zinc decreased with distance from the emission source. Blood levels of cadmium and lead differed significantly among sites, whereas those of the other metals did not. Blood levels of cadmium and lead correlated with soil concentrations of cadmium and lead, respectively. No such significant relationships were found for the other measured metals. Hematocrit levels decreased in wood mice from the most polluted site (45.96% ± 0.53% [mean ± standard error]) compared to the reference site (48.04% ± 0.47%). A negative correlation between hematocrit and blood levels of cadmium and lead was found. Erythrocyte count, leukocyte count, hemoglobin concentration, mean corpuscular hemoglobin (average wt of hemoglobin in a red blood cell in pg), and lysozyme activity did not differ among study sites. Mean corpuscular volume (average volume of a red blood cell in μm3) and mean corpuscular hemoglobin concentration (average proportion of hemoglobin in a red blood cell as a %) differed among study sites but showed no relationship with metal exposure. We conclude that whole blood from mice can be used for nondestructive monitoring of the exposure to nonessential metals under natural conditions. 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xml:lang="en"><p>The present study evaluated whether blood could be used as a nondestructive tool for monitoring metal exposure and related hematological effects in wood mice (Apodemus sylvaticus L.) living along a metal pollution gradient. Soil concentrations of arsenic, cadmium, copper, lead, silver, and zinc decreased with distance from the emission source. Blood levels of cadmium and lead differed significantly among sites, whereas those of the other metals did not. Blood levels of cadmium and lead correlated with soil concentrations of cadmium and lead, respectively. No such significant relationships were found for the other measured metals. Hematocrit levels decreased in wood mice from the most polluted site (45.96% ± 0.53% [mean ± standard error]) compared to the reference site (48.04% ± 0.47%). A negative correlation between hematocrit and blood levels of cadmium and lead was found. Erythrocyte count, leukocyte count, hemoglobin concentration, mean corpuscular hemoglobin (average wt of hemoglobin in a red blood cell in pg), and lysozyme activity did not differ among study sites. Mean corpuscular volume (average volume of a red blood cell in μm3) and mean corpuscular hemoglobin concentration (average proportion of hemoglobin in a red blood cell as a %) differed among study sites but showed no relationship with metal exposure. We conclude that whole blood from mice can be used for nondestructive monitoring of the exposure to nonessential metals under natural conditions. The present results indicate that decreased hematocrit levels may be an early warning signal for a negative impact of metal exposure on the oxygen‐transport capacity of blood in wood mice in their natural environment.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>Hematology</term></item><item><term>Heavy metals</term></item><item><term>Blood</term></item><item><term>Biomarker</term></item><item><term>Mice</term></item></list></keywords></textClass><textClass><keywords scheme="Journal Subject"><list><head>article-category</head><item><term>Environmental Toxicology</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-12-20">Received</change><change when="2005-06-28">Registration</change><change 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xml:lang="en" type="author"><keyword xml:id="kwd1">Hematology</keyword><keyword xml:id="kwd2">Heavy metals</keyword><keyword xml:id="kwd3">Blood</keyword><keyword xml:id="kwd4">Biomarker</keyword><keyword xml:id="kwd5">Mice</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>The present study evaluated whether blood could be used as a nondestructive tool for monitoring metal exposure and related hematological effects in wood mice (<i>Apodemus sylvaticus</i> L.) living along a metal pollution gradient. Soil concentrations of arsenic, cadmium, copper, lead, silver, and zinc decreased with distance from the emission source. Blood levels of cadmium and lead differed significantly among sites, whereas those of the other metals did not. Blood levels of cadmium and lead correlated with soil concentrations of cadmium and lead, respectively. No such significant relationships were found for the other measured metals. Hematocrit levels decreased in wood mice from the most polluted site (45.96% ± 0.53% [mean ± standard error]) compared to the reference site (48.04% ± 0.47%). A negative correlation between hematocrit and blood levels of cadmium and lead was found. Erythrocyte count, leukocyte count, hemoglobin concentration, mean corpuscular hemoglobin (average wt of hemoglobin in a red blood cell in pg), and lysozyme activity did not differ among study sites. Mean corpuscular volume (average volume of a red blood cell in μm<sup>3</sup>) and mean corpuscular hemoglobin concentration (average proportion of hemoglobin in a red blood cell as a %) differed among study sites but showed no relationship with metal exposure. We conclude that whole blood from mice can be used for nondestructive monitoring of the exposure to nonessential metals under natural conditions. The present results indicate that decreased hematocrit levels may be an early warning signal for a negative impact of metal exposure on the oxygen‐transport capacity of blood in wood mice in their natural environment.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Metal blood levels and hematological characteristics in wood mice (Apodemus sylvaticus L.) along a metal pollution gradient</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Effect of metal pollution on hematological characteristics</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Metal blood levels and hematological characteristics in wood mice (Apodemus sylvaticus L.) along a metal pollution gradient</title></titleInfo><name type="personal"><namePart type="given">Damien</namePart><namePart type="family">Rogival</namePart><affiliation>Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</affiliation><description>Correspondence: Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jan</namePart><namePart type="family">Scheirs</namePart><affiliation>Department of Biology Evolutionary Biology Group University of Antwerp, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wim</namePart><namePart type="family">De Coen</namePart><affiliation>Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ron</namePart><namePart type="family">Verhagen</namePart><affiliation>Department of Biology Evolutionary Biology Group University of Antwerp, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ronny</namePart><namePart type="family">Blust</namePart><affiliation>Department of Biology, Ecophysiology, Biochemistry and Toxicology Group, Groenenborgerlaan 171, B‐2020 Antwerp, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Wiley Periodicals, Inc.</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2006-01</dateIssued><dateCaptured encoding="w3cdtf">2004-12-20</dateCaptured><dateValid encoding="w3cdtf">2005-06-28</dateValid><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">3</extent><extent unit="tables">3</extent><extent unit="references">50</extent></physicalDescription><abstract lang="en">The present study evaluated whether blood could be used as a nondestructive tool for monitoring metal exposure and related hematological effects in wood mice (Apodemus sylvaticus L.) living along a metal pollution gradient. Soil concentrations of arsenic, cadmium, copper, lead, silver, and zinc decreased with distance from the emission source. Blood levels of cadmium and lead differed significantly among sites, whereas those of the other metals did not. Blood levels of cadmium and lead correlated with soil concentrations of cadmium and lead, respectively. No such significant relationships were found for the other measured metals. Hematocrit levels decreased in wood mice from the most polluted site (45.96% ± 0.53% [mean ± standard error]) compared to the reference site (48.04% ± 0.47%). A negative correlation between hematocrit and blood levels of cadmium and lead was found. Erythrocyte count, leukocyte count, hemoglobin concentration, mean corpuscular hemoglobin (average wt of hemoglobin in a red blood cell in pg), and lysozyme activity did not differ among study sites. Mean corpuscular volume (average volume of a red blood cell in μm3) and mean corpuscular hemoglobin concentration (average proportion of hemoglobin in a red blood cell as a %) differed among study sites but showed no relationship with metal exposure. We conclude that whole blood from mice can be used for nondestructive monitoring of the exposure to nonessential metals under natural conditions. The present results indicate that decreased hematocrit levels may be an early warning signal for a negative impact of metal exposure on the oxygen‐transport capacity of blood in wood mice in their natural environment.</abstract><subject lang="en"><genre>keywords</genre><topic>Hematology</topic><topic>Heavy metals</topic><topic>Blood</topic><topic>Biomarker</topic><topic>Mice</topic></subject><relatedItem type="host"><titleInfo><title>Environmental Toxicology and Chemistry</title><subTitle>An International Journal</subTitle></titleInfo><titleInfo type="abbreviated"><title>Environmental Toxicology and Chemistry</title></titleInfo><genre type="journal">journal</genre><subject><genre>article-category</genre><topic>Environmental Toxicology</topic></subject><identifier type="ISSN">0730-7268</identifier><identifier type="eISSN">1552-8618</identifier><identifier type="DOI">10.1002/(ISSN)1552-8618</identifier><identifier type="PublisherID">ETC</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>25</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>149</start><end>157</end><total>9</total></extent></part></relatedItem><identifier type="istex">0364936DBFF0289A528878F8229CD429A0BC48C3</identifier><identifier type="DOI">10.1897/04-659R1.1</identifier><identifier type="ArticleID">ETC5620250119</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 2006 SETAC</accessCondition><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Wiley Periodicals, Inc.</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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