Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke
Identifieur interne : 000626 ( Istex/Corpus ); précédent : 000625; suivant : 000627Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke
Auteurs : J. De Reuck ; I. Claeys ; S. Martens ; Ph. Vanwalleghem ; G. Van Maele ; R. Phlypo ; H. HallezSource :
- European Journal of Neurology [ 1351-5101 ] ; 2006-04.
English descriptors
- KwdEn :
Abstract
It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy‐two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disability of the patients at 1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy. The size of the X‐ray hypoattenuation zone was compared on computed tomographic (CT) scans, performed in the weeks after the stroke and 1 week after single or repeated seizures. Lesion size was determined by superimposing the CT slices on digital cerebral vascular maps, on which the contours of the infarct area were delineated. The extent of the infarcts was expressed as the percentage fraction of the total surface area of the cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually compared. Infarcts predominated in the parieto‐temporal cortical regions. In the overall group the median Rankin score worsened significantly after seizures. The average size of the X‐ray hypoattenuation zone was also significantly increased on the CT scans after the seizures, compared with those after stroke, without clear evidence of recent infarction. Mutual comparison of patients with a single seizure episode and of those with epilepsy showed only a trend of more severe disability and of increase in lesion size in the post‐stroke epilepsy group. Delayed seizures and epilepsy after ischaemic stroke are accompanied by an increase in lesion size on CT and by worsening of the disability of the patients. This study does not allow to determine whether this is due to stroke recurrence or due to additional damage as a result of the seizures themselves.
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DOI: 10.1111/j.1468-1331.2006.01253.x
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ISTEX:3FAF7AC70B0B7DE8AF152509AAC0F7A40B2CDDFCLe document en format XML
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Martens</name><affiliation><mods:affiliation>Stroke Unit, Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Vanwalleghem, Ph" sort="Vanwalleghem, Ph" uniqKey="Vanwalleghem P" first="Ph." last="Vanwalleghem">Ph. Vanwalleghem</name><affiliation><mods:affiliation>Stroke Unit, Department of Neurology</mods:affiliation></affiliation></author><author><name sortKey="Van Maele, G" sort="Van Maele, G" uniqKey="Van Maele G" first="G." last="Van Maele">G. Van Maele</name><affiliation><mods:affiliation>Department of Medical Statistics, Ghent University Hospital, Ghent, Belgium</mods:affiliation></affiliation></author><author><name sortKey="Phlypo, R" sort="Phlypo, R" uniqKey="Phlypo R" first="R." last="Phlypo">R. 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Seventy‐two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disability of the patients at 1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy. The size of the X‐ray hypoattenuation zone was compared on computed tomographic (CT) scans, performed in the weeks after the stroke and 1 week after single or repeated seizures. Lesion size was determined by superimposing the CT slices on digital cerebral vascular maps, on which the contours of the infarct area were delineated. The extent of the infarcts was expressed as the percentage fraction of the total surface area of the cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually compared. Infarcts predominated in the parieto‐temporal cortical regions. In the overall group the median Rankin score worsened significantly after seizures. The average size of the X‐ray hypoattenuation zone was also significantly increased on the CT scans after the seizures, compared with those after stroke, without clear evidence of recent infarction. Mutual comparison of patients with a single seizure episode and of those with epilepsy showed only a trend of more severe disability and of increase in lesion size in the post‐stroke epilepsy group. Delayed seizures and epilepsy after ischaemic stroke are accompanied by an increase in lesion size on CT and by worsening of the disability of the patients. This study does not allow to determine whether this is due to stroke recurrence or due to additional damage as a result of the seizures themselves.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>J. De Reuck</name><affiliations><json:string>Stroke Unit, Department of Neurology</json:string></affiliations></json:item><json:item><name>I. 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Seventy‐two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disability of the patients at 1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy. The size of the X‐ray hypoattenuation zone was compared on computed tomographic (CT) scans, performed in the weeks after the stroke and 1 week after single or repeated seizures. Lesion size was determined by superimposing the CT slices on digital cerebral vascular maps, on which the contours of the infarct area were delineated. The extent of the infarcts was expressed as the percentage fraction of the total surface area of the cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually compared. Infarcts predominated in the parieto‐temporal cortical regions. In the overall group the median Rankin score worsened significantly after seizures. The average size of the X‐ray hypoattenuation zone was also significantly increased on the CT scans after the seizures, compared with those after stroke, without clear evidence of recent infarction. Mutual comparison of patients with a single seizure episode and of those with epilepsy showed only a trend of more severe disability and of increase in lesion size in the post‐stroke epilepsy group. Delayed seizures and epilepsy after ischaemic stroke are accompanied by an increase in lesion size on CT and by worsening of the disability of the patients. This study does not allow to determine whether this is due to stroke recurrence or due to additional damage as a result of the seizures themselves.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>computed tomography</term></item><item><term>disability</term></item><item><term>hemispheric infarct</term></item><item><term>lesion size</term></item><item><term>post‐stroke epilepsy</term></item><item><term>post‐stroke seizures</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2006-04">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><original>false</original><mimetype>text/plain</mimetype><extension>txt</extension><uri>https://api.istex.fr/document/3FAF7AC70B0B7DE8AF152509AAC0F7A40B2CDDFC/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-1331</doi><issn type="print">1351-5101</issn><issn type="electronic">1468-1331</issn><idGroup><id type="product" value="ENE"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="EUROPEAN JOURNAL OF NEUROLOGY">European Journal of Neurology</title></titleGroup></publicationMeta><publicationMeta level="part" position="04004"><doi origin="wiley">10.1111/ene.2006.13.issue-4</doi><numberingGroup><numbering type="journalVolume" number="13">13</numbering><numbering type="journalIssue" number="4">4</numbering></numberingGroup><coverDate startDate="2006-04">April 2006</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="13" status="forIssue"><doi origin="wiley">10.1111/j.1468-1331.2006.01253.x</doi><idGroup><id type="unit" value="ENE1253"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">Original Articles</title></titleGroup><eventGroup><event type="firstOnline" date="2006-04-21"></event><event type="publishedOnlineFinalForm" date="2006-04-21"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-03-06"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-24"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-16"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="402">402</numbering><numbering type="pageLast" number="407">407</numbering></numberingGroup><correspondenceTo>Jacques De Reuck, MD, PhD, Department of Neurology, Ghent University Hospital, De Pintelaan 185, BE‐9000 Ghent, Belgium (tel.: +32 9 240 45 41; fax: +32 9 240 49 71; e‐mail: <email>jacques.dereuck@gmail.com</email>).</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:ENE.ENE1253.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 21 December 2004 Accepted 11 May 2005</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="2"></count></countGroup><titleGroup><title type="main">Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke</title><title type="shortAuthors">J. De Ruck <i>et al.</i></title><title type="short">Post‐stroke seizures and epilepsy</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>J. De</givenNames><familyName>Reuck</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>I.</givenNames><familyName>Claeys</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>S.</givenNames><familyName>Martens</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Ph.</givenNames><familyName>Vanwalleghem</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a2"><personName><givenNames>G.</givenNames><familyName>Van Maele</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a3"><personName><givenNames>R.</givenNames><familyName>Phlypo</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a3"><personName><givenNames>H.</givenNames><familyName>Hallez</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Stroke Unit, Department of Neurology</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="BE"><unparsedAffiliation>Department of Medical Statistics, Ghent University Hospital, Ghent, Belgium</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="BE"><unparsedAffiliation>Department for Electronics and Information Systems, Ghent University, Ghent, Belgium</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">computed tomography</keyword><keyword xml:id="k2">disability</keyword><keyword xml:id="k3">hemispheric infarct</keyword><keyword xml:id="k4">lesion size</keyword><keyword xml:id="k5">post‐stroke epilepsy</keyword><keyword xml:id="k6">post‐stroke seizures</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p>It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy‐two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disability of the patients at 1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy. The size of the X‐ray hypoattenuation zone was compared on computed tomographic (CT) scans, performed in the weeks after the stroke and 1 week after single or repeated seizures. Lesion size was determined by superimposing the CT slices on digital cerebral vascular maps, on which the contours of the infarct area were delineated. The extent of the infarcts was expressed as the percentage fraction of the total surface area of the cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually compared. Infarcts predominated in the parieto‐temporal cortical regions. In the overall group the median Rankin score worsened significantly after seizures. The average size of the X‐ray hypoattenuation zone was also significantly increased on the CT scans after the seizures, compared with those after stroke, without clear evidence of recent infarction. Mutual comparison of patients with a single seizure episode and of those with epilepsy showed only a trend of more severe disability and of increase in lesion size in the post‐stroke epilepsy group. Delayed seizures and epilepsy after ischaemic stroke are accompanied by an increase in lesion size on CT and by worsening of the disability of the patients. This study does not allow to determine whether this is due to stroke recurrence or due to additional damage as a result of the seizures themselves.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Post‐stroke seizures and epilepsy</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Computed tomographic changes of the brain and clinical outcome of patients with seizures and epilepsy after an ischaemic hemispheric stroke</title></titleInfo><name type="personal"><namePart type="given">J. De</namePart><namePart type="family">Reuck</namePart><affiliation>Stroke Unit, Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">I.</namePart><namePart type="family">Claeys</namePart><affiliation>Stroke Unit, Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Martens</namePart><affiliation>Stroke Unit, Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ph.</namePart><namePart type="family">Vanwalleghem</namePart><affiliation>Stroke Unit, Department of Neurology</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Van Maele</namePart><affiliation>Department of Medical Statistics, Ghent University Hospital, Ghent, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Phlypo</namePart><affiliation>Department for Electronics and Information Systems, Ghent University, Ghent, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Hallez</namePart><affiliation>Department for Electronics and Information Systems, Ghent University, Ghent, Belgium</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2006-04</dateIssued><edition>Received 21 December 2004 Accepted 11 May 2005</edition><copyrightDate encoding="w3cdtf">2006</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="tables">2</extent></physicalDescription><abstract lang="en">It is not well established whether seizures and epilepsy after an ischaemic stroke increase the disability of patients. Seventy‐two patients with delayed seizures after a hemispheric infarct (37 with a single seizure and 35 with epilepsy) were included in the study. The modified Rankin scale was used to compare disability of the patients at 1 month after stroke and at 2 weeks after single or the last seizure, in case of epilepsy. The size of the X‐ray hypoattenuation zone was compared on computed tomographic (CT) scans, performed in the weeks after the stroke and 1 week after single or repeated seizures. Lesion size was determined by superimposing the CT slices on digital cerebral vascular maps, on which the contours of the infarct area were delineated. The extent of the infarcts was expressed as the percentage fraction of the total surface area of the cerebral hemisphere. Groups with a single seizure and with epilepsy were mutually compared. Infarcts predominated in the parieto‐temporal cortical regions. In the overall group the median Rankin score worsened significantly after seizures. The average size of the X‐ray hypoattenuation zone was also significantly increased on the CT scans after the seizures, compared with those after stroke, without clear evidence of recent infarction. Mutual comparison of patients with a single seizure episode and of those with epilepsy showed only a trend of more severe disability and of increase in lesion size in the post‐stroke epilepsy group. Delayed seizures and epilepsy after ischaemic stroke are accompanied by an increase in lesion size on CT and by worsening of the disability of the patients. This study does not allow to determine whether this is due to stroke recurrence or due to additional damage as a result of the seizures themselves.</abstract><subject lang="en"><genre>keywords</genre><topic>computed tomography</topic><topic>disability</topic><topic>hemispheric infarct</topic><topic>lesion size</topic><topic>post‐stroke epilepsy</topic><topic>post‐stroke seizures</topic></subject><relatedItem type="host"><titleInfo><title>European Journal of Neurology</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">1351-5101</identifier><identifier type="eISSN">1468-1331</identifier><identifier type="DOI">10.1111/(ISSN)1468-1331</identifier><identifier type="PublisherID">ENE</identifier><part><date>2006</date><detail type="volume"><caption>vol.</caption><number>13</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>402</start><end>407</end><total>6</total></extent></part></relatedItem><identifier type="istex">3FAF7AC70B0B7DE8AF152509AAC0F7A40B2CDDFC</identifier><identifier type="DOI">10.1111/j.1468-1331.2006.01253.x</identifier><identifier type="ArticleID">ENE1253</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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