Glutathione: new roles in redox signaling for an old antioxidant.
Identifieur interne : 000163 ( PubMed/Corpus ); précédent : 000162; suivant : 000164Glutathione: new roles in redox signaling for an old antioxidant.
Auteurs : Katia Aquilano ; Sara Baldelli ; Maria R. CirioloSource :
- Frontiers in pharmacology [ 1663-9812 ] ; 2014.
Abstract
The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. This review will be focused on the role of GSH in cell signaling by analysing the more recent advancements about its capability to modulate nitroxidative stress, autophagy, and viral infection.
DOI: 10.3389/fphar.2014.00196
PubMed: 25206336
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Ciriolo</name><affiliation><nlm:affiliation>Department of Biology, University of Rome Tor Vergata Rome, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.3389/fphar.2014.00196</idno><idno type="RBID">pubmed:25206336</idno><idno type="pmid">25206336</idno><idno type="wicri:Area/PubMed/Corpus">000163</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000163</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Glutathione: new roles in redox signaling for an old antioxidant.</title><author><name sortKey="Aquilano, Katia" sort="Aquilano, Katia" uniqKey="Aquilano K" first="Katia" last="Aquilano">Katia Aquilano</name><affiliation><nlm:affiliation>Department of Biology, University of Rome Tor Vergata Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baldelli, Sara" sort="Baldelli, Sara" uniqKey="Baldelli S" first="Sara" last="Baldelli">Sara Baldelli</name><affiliation><nlm:affiliation>Scientific Institute for Research, Hospitalization and Health Care, Università Telematica San Raffaele Roma Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ciriolo, Maria R" sort="Ciriolo, Maria R" uniqKey="Ciriolo M" first="Maria R" last="Ciriolo">Maria R. Ciriolo</name><affiliation><nlm:affiliation>Department of Biology, University of Rome Tor Vergata Rome, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Frontiers in pharmacology</title><idno type="eISSN">1663-9812</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The physiological roles played by the tripeptide glutathione have greatly advanced over the past decades superimposing the research on free radicals, oxidative stress and, more recently, redox signaling. In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. 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In particular, GSH is involved in nutrient metabolism, antioxidant defense, and regulation of cellular metabolic functions ranging from gene expression, DNA and protein synthesis to signal transduction, cell proliferation and apoptosis. 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