Adipose triglycerides lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response.
Identifieur interne : 000015 ( PubMed/Corpus ); précédent : 000014; suivant : 000016Adipose triglycerides lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response.
Auteurs : Katia Aquilano ; Sara Baldelli ; Livia La Barbera ; Daniele Lettieri Barbato ; Giuseppe Tatulli ; Maria Rosa CirioloSource :
- Oncotarget [ 1949-2553 ] ; 2016.
Abstract
During aging skeletal muscle shows an accumulation of oxidative damage as well as intramyocellular lipid droplets (IMLDs). However, although the impact of these modifications on muscle tissue physiology is well established, the direct effectors critical for their occurrence are poorly understood. Here we show that during aging the main lipase of triacylglycerols, ATGL, significantly declines in gastrocnemius and its downregulation in C2C12 myoblast leads to the accumulation of lipid droplets. Indeed, we observed an increase of oxidative damage to proteins in terms of carbonylation, S-nitrosylation and ubiquitination that is dependent on a defective antioxidant cell response mediated by ATGL-PPARα-PGC-1α. Overall our findings describe a pivotal role for ATGL in the antioxidant/anti-inflammatory response of muscle cells highlighting this lipase as a therapeutic target for fighting the progressive decline in skeletal muscle mass and strength.
DOI: 10.18632/oncotarget.8552
PubMed: 27056902
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Adipose triglycerides lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response.</title><author><name sortKey="Aquilano, Katia" sort="Aquilano, Katia" uniqKey="Aquilano K" first="Katia" last="Aquilano">Katia Aquilano</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baldelli, Sara" sort="Baldelli, Sara" uniqKey="Baldelli S" first="Sara" last="Baldelli">Sara Baldelli</name><affiliation><nlm:affiliation>Università Telematica San Raffaele Roma, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="La Barbera, Livia" sort="La Barbera, Livia" uniqKey="La Barbera L" first="Livia" last="La Barbera">Livia La Barbera</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lettieri Barbato, Daniele" sort="Lettieri Barbato, Daniele" uniqKey="Lettieri Barbato D" first="Daniele" last="Lettieri Barbato">Daniele Lettieri Barbato</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tatulli, Giuseppe" sort="Tatulli, Giuseppe" uniqKey="Tatulli G" first="Giuseppe" last="Tatulli">Giuseppe Tatulli</name><affiliation><nlm:affiliation>IRCCS San Raffaele 'La Pisana', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ciriolo, Maria Rosa" sort="Ciriolo, Maria Rosa" uniqKey="Ciriolo M" first="Maria Rosa" last="Ciriolo">Maria Rosa Ciriolo</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27056902</idno><idno type="pmid">27056902</idno><idno type="doi">10.18632/oncotarget.8552</idno><idno type="wicri:Area/PubMed/Corpus">000015</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000015</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Adipose triglycerides lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response.</title><author><name sortKey="Aquilano, Katia" sort="Aquilano, Katia" uniqKey="Aquilano K" first="Katia" last="Aquilano">Katia Aquilano</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Baldelli, Sara" sort="Baldelli, Sara" uniqKey="Baldelli S" first="Sara" last="Baldelli">Sara Baldelli</name><affiliation><nlm:affiliation>Università Telematica San Raffaele Roma, Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="La Barbera, Livia" sort="La Barbera, Livia" uniqKey="La Barbera L" first="Livia" last="La Barbera">Livia La Barbera</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Lettieri Barbato, Daniele" sort="Lettieri Barbato, Daniele" uniqKey="Lettieri Barbato D" first="Daniele" last="Lettieri Barbato">Daniele Lettieri Barbato</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Tatulli, Giuseppe" sort="Tatulli, Giuseppe" uniqKey="Tatulli G" first="Giuseppe" last="Tatulli">Giuseppe Tatulli</name><affiliation><nlm:affiliation>IRCCS San Raffaele 'La Pisana', Rome, Italy.</nlm:affiliation></affiliation></author><author><name sortKey="Ciriolo, Maria Rosa" sort="Ciriolo, Maria Rosa" uniqKey="Ciriolo M" first="Maria Rosa" last="Ciriolo">Maria Rosa Ciriolo</name><affiliation><nlm:affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Oncotarget</title><idno type="eISSN">1949-2553</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">During aging skeletal muscle shows an accumulation of oxidative damage as well as intramyocellular lipid droplets (IMLDs). However, although the impact of these modifications on muscle tissue physiology is well established, the direct effectors critical for their occurrence are poorly understood. Here we show that during aging the main lipase of triacylglycerols, ATGL, significantly declines in gastrocnemius and its downregulation in C2C12 myoblast leads to the accumulation of lipid droplets. Indeed, we observed an increase of oxidative damage to proteins in terms of carbonylation, S-nitrosylation and ubiquitination that is dependent on a defective antioxidant cell response mediated by ATGL-PPARα-PGC-1α. Overall our findings describe a pivotal role for ATGL in the antioxidant/anti-inflammatory response of muscle cells highlighting this lipase as a therapeutic target for fighting the progressive decline in skeletal muscle mass and strength.</div></front></TEI><pubmed><MedlineCitation Status="Publisher" Owner="NLM"><PMID Version="1">27056902</PMID><DateCreated><Year>2016</Year><Month>4</Month><Day>13</Day></DateCreated><DateRevised><Year>2016</Year><Month>4</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1949-2553</ISSN><JournalIssue CitedMedium="Internet"><PubDate><Year>2016</Year><Month>Apr</Month><Day>1</Day></PubDate></JournalIssue><Title>Oncotarget</Title><ISOAbbreviation>Oncotarget</ISOAbbreviation></Journal><ArticleTitle>Adipose triglycerides lipase decrement affects skeletal muscle homeostasis during aging through FAs-PPARα-PGC-1α antioxidant response.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi">10.18632/oncotarget.8552</ELocationID><Abstract><AbstractText NlmCategory="UNASSIGNED">During aging skeletal muscle shows an accumulation of oxidative damage as well as intramyocellular lipid droplets (IMLDs). However, although the impact of these modifications on muscle tissue physiology is well established, the direct effectors critical for their occurrence are poorly understood. Here we show that during aging the main lipase of triacylglycerols, ATGL, significantly declines in gastrocnemius and its downregulation in C2C12 myoblast leads to the accumulation of lipid droplets. Indeed, we observed an increase of oxidative damage to proteins in terms of carbonylation, S-nitrosylation and ubiquitination that is dependent on a defective antioxidant cell response mediated by ATGL-PPARα-PGC-1α. Overall our findings describe a pivotal role for ATGL in the antioxidant/anti-inflammatory response of muscle cells highlighting this lipase as a therapeutic target for fighting the progressive decline in skeletal muscle mass and strength.</AbstractText></Abstract><AuthorList><Author><LastName>Aquilano</LastName><ForeName>Katia</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IRCCS San Raffaele 'La Pisana', Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Baldelli</LastName><ForeName>Sara</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Università Telematica San Raffaele Roma, Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>La Barbera</LastName><ForeName>Livia</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Lettieri Barbato</LastName><ForeName>Daniele</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Tatulli</LastName><ForeName>Giuseppe</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>IRCCS San Raffaele 'La Pisana', Rome, Italy.</Affiliation></AffiliationInfo></Author><Author><LastName>Ciriolo</LastName><ForeName>Maria Rosa</ForeName><Initials>MR</Initials><AffiliationInfo><Affiliation>Department of Biology, University of Rome 'Tor Vergata', Rome, Italy.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>IRCCS San Raffaele 'La Pisana', Rome, Italy.</Affiliation></AffiliationInfo></Author></AuthorList><Language>ENG</Language><PublicationTypeList><PublicationType UI="">JOURNAL ARTICLE</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>4</Month><Day>1</Day></ArticleDate></Article><MedlineJournalInfo><MedlineTA>Oncotarget</MedlineTA><NlmUniqueID>101532965</NlmUniqueID><ISSNLinking>1949-2553</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Gerotarget</Keyword><Keyword MajorTopicYN="N">antioxidants</Keyword><Keyword MajorTopicYN="N">inflammation</Keyword><Keyword MajorTopicYN="N">lipid metabolism</Keyword><Keyword MajorTopicYN="N">myoblasts</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2016</Year><Month>3</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>3</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>aheadofprint</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27056902</ArticleId><ArticleId IdType="pii">8552</ArticleId><ArticleId IdType="doi">10.18632/oncotarget.8552</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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