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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypertensive target organ damage predicts incident diabetes mellitus</title>
<author><name sortKey="Izzo, Raffaele" sort="Izzo, Raffaele" uniqKey="Izzo R" first="Raffaele" last="Izzo">Raffaele Izzo</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Simone, Giovanni" sort="De Simone, Giovanni" uniqKey="De Simone G" first="Giovanni" last="De Simone">Giovanni De Simone</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Trimarco, Valentina" sort="Trimarco, Valentina" uniqKey="Trimarco V" first="Valentina" last="Trimarco">Valentina Trimarco</name>
<affiliation><nlm:aff id="af2"><addr-line>Department of Neurosciences</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gerdts, Eva" sort="Gerdts, Eva" uniqKey="Gerdts E" first="Eva" last="Gerdts">Eva Gerdts</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Institute of Medicine</addr-line>
,<institution>University of Bergen</institution>
,<addr-line>Bergen</addr-line>
,<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4"><addr-line>Department of Heart Disease</addr-line>
,<institution>Haukeland University Hospital</institution>
,<addr-line>Bergen</addr-line>
,<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giudice, Renata" sort="Giudice, Renata" uniqKey="Giudice R" first="Renata" last="Giudice">Renata Giudice</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vaccaro, Olga" sort="Vaccaro, Olga" uniqKey="Vaccaro O" first="Olga" last="Vaccaro">Olga Vaccaro</name>
<affiliation><nlm:aff id="af5"><addr-line>Department of Clinical Medicine and Surgery</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Luca, Nicola" sort="De Luca, Nicola" uniqKey="De Luca N" first="Nicola" last="De Luca">Nicola De Luca</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Trimarco, Bruno" sort="Trimarco, Bruno" uniqKey="Trimarco B" first="Bruno" last="Trimarco">Bruno Trimarco</name>
<affiliation><nlm:aff id="af6"><addr-line>Department of Advanced Biomedical Sciences</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">23882068</idno>
<idno type="pmc">3836008</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3836008</idno>
<idno type="RBID">PMC:3836008</idno>
<idno type="doi">10.1093/eurheartj/eht281</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000445</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000445</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Hypertensive target organ damage predicts incident diabetes mellitus</title>
<author><name sortKey="Izzo, Raffaele" sort="Izzo, Raffaele" uniqKey="Izzo R" first="Raffaele" last="Izzo">Raffaele Izzo</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Simone, Giovanni" sort="De Simone, Giovanni" uniqKey="De Simone G" first="Giovanni" last="De Simone">Giovanni De Simone</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Trimarco, Valentina" sort="Trimarco, Valentina" uniqKey="Trimarco V" first="Valentina" last="Trimarco">Valentina Trimarco</name>
<affiliation><nlm:aff id="af2"><addr-line>Department of Neurosciences</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gerdts, Eva" sort="Gerdts, Eva" uniqKey="Gerdts E" first="Eva" last="Gerdts">Eva Gerdts</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af3"><addr-line>Institute of Medicine</addr-line>
,<institution>University of Bergen</institution>
,<addr-line>Bergen</addr-line>
,<country>Norway</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="af4"><addr-line>Department of Heart Disease</addr-line>
,<institution>Haukeland University Hospital</institution>
,<addr-line>Bergen</addr-line>
,<country>Norway</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Giudice, Renata" sort="Giudice, Renata" uniqKey="Giudice R" first="Renata" last="Giudice">Renata Giudice</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Vaccaro, Olga" sort="Vaccaro, Olga" uniqKey="Vaccaro O" first="Olga" last="Vaccaro">Olga Vaccaro</name>
<affiliation><nlm:aff id="af5"><addr-line>Department of Clinical Medicine and Surgery</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Luca, Nicola" sort="De Luca, Nicola" uniqKey="De Luca N" first="Nicola" last="De Luca">Nicola De Luca</name>
<affiliation><nlm:aff id="af1"><addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Trimarco, Bruno" sort="Trimarco, Bruno" uniqKey="Trimarco B" first="Bruno" last="Trimarco">Bruno Trimarco</name>
<affiliation><nlm:aff id="af6"><addr-line>Department of Advanced Biomedical Sciences</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">European Heart Journal</title>
<idno type="ISSN">0195-668X</idno>
<idno type="eISSN">1522-9645</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Aims</title>
<p>Whether patients with hypertensive preclinical cardiovascular disease (CVD) are at higher risk of incident diabetes has never been studied.</p>
</sec>
<sec><title>Methods and results</title>
<p>We assessed incident diabetes in 4176 hypertensive non-diabetic patients (age 58.7 ± 8.9 years, 58% male) with ≥1 year follow-up (median: 3.57 years; inter-quartile range: 2.04–7.25). Left ventricular (LV) hypertrophy (LVH) was defined as LV mass index (LVMi) ≥51 g/m<sup>2.7</sup>
. Carotid atherosclerosis (CA) was defined as intima-media thickness >1.5 mm. During follow-up, diabetes developed in 393 patients (9.4%), more frequently in those with than without initial LVH or CA (odds ratio = 1.97 and 1.67, respectively; both <italic>P</italic>
< 0.0001). In the Cox regression, the presence of either initial LVH or CA was associated with higher hazard of diabetes [hazards ratio (HR) = 1.30 and 1.38, respectively; both <italic>P</italic>
= 0.03], independently of the type and number of anti-hypertensive medications, initial systolic blood pressure (<italic>P</italic>
< 0.001), body mass index, fasting glucose, family history of diabetes (all <italic>P</italic>
< 0.0001), and therapy with β-blockers. The presence of one of the, or both, markers of preclinical CVD increased the chance of incident diabetes by 63 or 64%, respectively (both <italic>P</italic>
< 0.002), independently of significant confounders, a result that was confirmed (HR = 1.70 or 1.93, respectively; both <italic>P</italic>
< 0.0001) using ATPIII metabolic syndrome (HR = 2.73; <italic>P</italic>
< 0.0001) in the Cox model.</p>
</sec>
<sec><title>Conclusion</title>
<p>Initial LVH and CA are significant predictors of new onset diabetes in a large population of treated hypertensive patients, independently of initial metabolic profile, anti-hypertensive therapy, and other significant covariates. This sequence may be attributable to risk factors common to preclinical CVD and diabetes, but a vascular origin of diabetes cannot be excluded.</p>
</sec>
</div>
</front>
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<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Eur Heart J</journal-id>
<journal-id journal-id-type="iso-abbrev">Eur. Heart J</journal-id>
<journal-id journal-id-type="publisher-id">eurheartj</journal-id>
<journal-id journal-id-type="hwp">ehj</journal-id>
<journal-title-group><journal-title>European Heart Journal</journal-title>
</journal-title-group>
<issn pub-type="ppub">0195-668X</issn>
<issn pub-type="epub">1522-9645</issn>
<publisher><publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">23882068</article-id>
<article-id pub-id-type="pmc">3836008</article-id>
<article-id pub-id-type="doi">10.1093/eurheartj/eht281</article-id>
<article-id pub-id-type="publisher-id">eht281</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Clinical Research</subject>
<subj-group subj-group-type="heading"><subject>Prevention and Epidemiology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Hypertensive target organ damage predicts incident diabetes mellitus</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Izzo</surname>
<given-names>Raffaele</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>de Simone</surname>
<given-names>Giovanni</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Trimarco</surname>
<given-names>Valentina</given-names>
</name>
<xref ref-type="aff" rid="af2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gerdts</surname>
<given-names>Eva</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
<xref ref-type="aff" rid="af3">3</xref>
<xref ref-type="aff" rid="af4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Giudice</surname>
<given-names>Renata</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Vaccaro</surname>
<given-names>Olga</given-names>
</name>
<xref ref-type="aff" rid="af5">5</xref>
</contrib>
<contrib contrib-type="author"><name><surname>De Luca</surname>
<given-names>Nicola</given-names>
</name>
<xref ref-type="aff" rid="af1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Trimarco</surname>
<given-names>Bruno</given-names>
</name>
<xref ref-type="aff" rid="af6">6</xref>
</contrib>
</contrib-group>
<aff id="af1"><label>1</label>
<addr-line>Department of Translational Medical Sciences</addr-line>
,<institution>Federico II University Hospital</institution>
,<addr-line>via S. Pansini 5, 80131 Naples</addr-line>
,<country>Italy</country>
</aff>
<aff id="af2"><label>2</label>
<addr-line>Department of Neurosciences</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</aff>
<aff id="af3"><label>3</label>
<addr-line>Institute of Medicine</addr-line>
,<institution>University of Bergen</institution>
,<addr-line>Bergen</addr-line>
,<country>Norway</country>
</aff>
<aff id="af4"><label>4</label>
<addr-line>Department of Heart Disease</addr-line>
,<institution>Haukeland University Hospital</institution>
,<addr-line>Bergen</addr-line>
,<country>Norway</country>
</aff>
<aff id="af5"><label>5</label>
<addr-line>Department of Clinical Medicine and Surgery</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</aff>
<aff id="af6"><label>6</label>
<addr-line>Department of Advanced Biomedical Sciences</addr-line>
,<institution>Federico II University</institution>
,<addr-line>Naples</addr-line>
,<country>Italy</country>
</aff>
<author-notes><corresp id="cor1"><label>*</label>
Corresponding author. Tel: +39 081 746 2025, Fax: +39 081 546 6152, Email: <email>simogi@unina.it</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>21</day>
<month>11</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="epub"><day>23</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>23</day>
<month>7</month>
<year>2013</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>34</volume>
<issue>44</issue>
<fpage>3419</fpage>
<lpage>3426</lpage>
<history><date date-type="received"><day>3</day>
<month>1</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>20</day>
<month>6</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>27</day>
<month>6</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>© The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology.</copyright-statement>
<copyright-year>2013</copyright-year>
<license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/3.0/">http://creativecommons.org/licenses/by-nc/3.0/</ext-link>
), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p>
</license>
</permissions>
<self-uri content-type="pdf" xlink:type="simple" xlink:href="eht281.pdf"></self-uri>
<abstract><sec><title>Aims</title>
<p>Whether patients with hypertensive preclinical cardiovascular disease (CVD) are at higher risk of incident diabetes has never been studied.</p>
</sec>
<sec><title>Methods and results</title>
<p>We assessed incident diabetes in 4176 hypertensive non-diabetic patients (age 58.7 ± 8.9 years, 58% male) with ≥1 year follow-up (median: 3.57 years; inter-quartile range: 2.04–7.25). Left ventricular (LV) hypertrophy (LVH) was defined as LV mass index (LVMi) ≥51 g/m<sup>2.7</sup>
. Carotid atherosclerosis (CA) was defined as intima-media thickness >1.5 mm. During follow-up, diabetes developed in 393 patients (9.4%), more frequently in those with than without initial LVH or CA (odds ratio = 1.97 and 1.67, respectively; both <italic>P</italic>
< 0.0001). In the Cox regression, the presence of either initial LVH or CA was associated with higher hazard of diabetes [hazards ratio (HR) = 1.30 and 1.38, respectively; both <italic>P</italic>
= 0.03], independently of the type and number of anti-hypertensive medications, initial systolic blood pressure (<italic>P</italic>
< 0.001), body mass index, fasting glucose, family history of diabetes (all <italic>P</italic>
< 0.0001), and therapy with β-blockers. The presence of one of the, or both, markers of preclinical CVD increased the chance of incident diabetes by 63 or 64%, respectively (both <italic>P</italic>
< 0.002), independently of significant confounders, a result that was confirmed (HR = 1.70 or 1.93, respectively; both <italic>P</italic>
< 0.0001) using ATPIII metabolic syndrome (HR = 2.73; <italic>P</italic>
< 0.0001) in the Cox model.</p>
</sec>
<sec><title>Conclusion</title>
<p>Initial LVH and CA are significant predictors of new onset diabetes in a large population of treated hypertensive patients, independently of initial metabolic profile, anti-hypertensive therapy, and other significant covariates. This sequence may be attributable to risk factors common to preclinical CVD and diabetes, but a vascular origin of diabetes cannot be excluded.</p>
</sec>
</abstract>
<kwd-group><kwd>Diabetes</kwd>
<kwd>Hypertension</kwd>
<kwd>Target organ damage</kwd>
<kwd>Metabolic syndrome</kwd>
</kwd-group>
<counts><page-count count="8"></page-count>
</counts>
</article-meta>
</front>
<body><sec id="s1"><title>Introduction</title>
<p>A large body of epidemiological and pathological data indicates that type 2 diabetes mellitus (diabetes) is an independent risk factor for preclinical cardiovascular (CV) disease (CVD),<sup><xref ref-type="bibr" rid="EHT281C1">1</xref>
</sup>
including carotid atherosclerosis (CA) and left ventricular (LV) hypertrophy (LVH),<sup><xref ref-type="bibr" rid="EHT281C2">2</xref>
,<xref ref-type="bibr" rid="EHT281C3">3</xref>
</sup>
as well as for overt CVD in both men and women.<sup><xref ref-type="bibr" rid="EHT281C4">4</xref>
,<xref ref-type="bibr" rid="EHT281C5">5</xref>
</sup>
Diabetes also worsens survival in patients who develop clinical CVD.<sup><xref ref-type="bibr" rid="EHT281C6">6</xref>
</sup>
</p>
<p>We have previously demonstrated that uncontrolled blood pressure (BP) is associated with a two-fold increased risk of incident diabetes in treated hypertensive subjects,<sup><xref ref-type="bibr" rid="EHT281C7">7</xref>
</sup>
extending previous observations indicating that incident diabetes is more frequent in hypertensive than in normotensive subjects,<sup><xref ref-type="bibr" rid="EHT281C8">8</xref>
</sup>
and that combinations of hypertension, obesity, and abnormal lipid profile, which often coexist with diabetes, are associated with preclinical cardiovascular abnormalities.<sup><xref ref-type="bibr" rid="EHT281C1">1</xref>
,<xref ref-type="bibr" rid="EHT281C9">9</xref>
,<xref ref-type="bibr" rid="EHT281C10">10</xref>
</sup>
Interestingly, clusters of metabolic abnormalities and the presence of LVH are also reported to increase the probability of uncontrolled hypertension.<sup><xref ref-type="bibr" rid="EHT281C11">11</xref>
</sup>
</p>
<p>These findings raise questions regarding the temporal sequence of these abnormalities and development of both hypertension and diabetes.</p>
<p>It is unclear whether the presence of hypertensive preclinical CVD (target organ damage), such as LVH and/or CA, is associated with increased risk of incident diabetes, independent of metabolic risk factors and arterial hypertension.<sup><xref ref-type="bibr" rid="EHT281C8">8</xref>
</sup>
Accordingly, the present study was designed to test whether or not prevalent hypertensive preclinical CVD increases the risk of incident diabetes in the hypertensive participants of the Campania Salute Network Registry.</p>
</sec>
<sec sec-type="methods" id="s2"><title>Methods</title>
<sec id="s2a"><title>Participants</title>
<p>Hypertensive patients without diabetes and known CVD were studied, with at least 1-year follow-up, within the Campania Salute Network Registry. The Campania Salute is an open registry collecting information from a network of general practitioners and community hospitals networked with the Hypertension Center of the Federico II University Hospital. The database generation of the Campania Salute Network was approved by the Federico II University Hospital Ethic Committee. Signed informed consent was obtained from all the participants to use data for scientific purposes. Detailed characteristics of this population have been previously reported.<sup><xref ref-type="bibr" rid="EHT281C7">7</xref>
,<xref ref-type="bibr" rid="EHT281C12">12</xref>
</sup>
</p>
<p>Exclusion criteria for the present analysis were: pre-existing CVD, diabetes, secondary hypertension, chronic kidney disease more than grade 3 (GFR by simplified MDRD <30 mL/min/1.73 m<sup>2</sup>
), aortic and/or mitral regurgitation more than mild, any degree of aortic stenosis, and follow-up <1 year. Pre-existing CVD was defined as the history of previous myocardial infarction, angina, coronary revascularization, stroke, transitory ischaemic attack, and congestive heart failure at the time of the admission visit in our outpatient clinic. Thus, from the initial population of 10 254 hypertensive patients, 3157 patients were excluded due to the presence of pre-existing CVD or diabetes, 2392 for insufficient follow-up period or poor quality echocardiographic windows, and 529 because of the lack of same-day baseline echocardiogram and carotid ultrasound. Thus, the present analysis included 4176 hypertensive non-diabetic participants free of pre-existing CVD and renal failure, with at least 1-year follow-up.</p>
<p>During initial and follow-up visits, BP, heart rate, body mass index (BMI), fasting glucose, and lipid profile were measured for each patient by standard methods. All hypertensive patients of the network underwent baseline echocardiogram and carotid ultrasound.</p>
</sec>
<sec id="s2b"><title>Measurements and definitions</title>
<p>Impaired fasting glucose and diabetes were defined according to 1997 ADA criteria (fasting plasma glucose >110 mg/dL, or >125 mg/dL or anti-diabetic treatment, respectively). Family history of diabetes (in >1 family member) was recorded at the time of the first visit.</p>
<p>Obesity was defined as a BMI ≥30 kg/m<sup>2</sup>
. Metabolic syndrome (MetS) was defined according to modified ATPIII criteria,<sup><xref ref-type="bibr" rid="EHT281C13">13</xref>
</sup>
changing waist circumference with BMI ≥30 kg/m<sup>2</sup>
, as previously done when waist girth was not available.<sup><xref ref-type="bibr" rid="EHT281C14">14</xref>
,<xref ref-type="bibr" rid="EHT281C15">15</xref>
</sup>
</p>
<p>Fasting glucose and lipid profile were measured by standard methods. Systolic and diastolic BP were measured by standard aneroid sphygmomanometer after 5 min rest in the supine position, according to current guidelines.<sup><xref ref-type="bibr" rid="EHT281C16">16</xref>
</sup>
Three BP measurements were obtained in the sitting position at 2 min intervals. The averages of these measurements were used for the analysis. Incident diabetes was adjudicated based only on detection of abnormal fasting glucose.</p>
</sec>
<sec id="s2c"><title>Echocardiography</title>
<p>Echocardiograms were recorded in videotapes, using commercial machines and a standardized protocol, were digitally mastered and read offline by one expert reader under the supervision of a senior faculty member, using dedicated work-stations (MediMatic). Measurements were made according to the American Society of Echocardiography/European Association of Echocardiography recommendations.<sup><xref ref-type="bibr" rid="EHT281C17">17</xref>
</sup>
</p>
<p>Left ventricular mass was calculated from a necropsy-validated formula<sup><xref ref-type="bibr" rid="EHT281C18">18</xref>
</sup>
and normalized for height in metres to the power of 2.7 (LVMi).<sup><xref ref-type="bibr" rid="EHT281C11">11</xref>
,<xref ref-type="bibr" rid="EHT281C19">19</xref>
</sup>
</p>
<p>Left ventricular hypertrophy (LVH) was defined as LVMi ≥51 g/m<sup>2.7</sup>
.<sup><xref ref-type="bibr" rid="EHT281C11">11</xref>
</sup>
</p>
</sec>
<sec id="s2d"><title>Carotid ultrasound</title>
<p>Carotid ultrasound was carried out in the supine position with the neck extended in mild rotation. The scanning protocol was performed with an ultrasound device (SONOS 2500/5500, HP, Philips) equipped with a 7.5 MHz high-resolution transducer with an axial resolution of 0.1 mm. Examinations were recorded on S-VHS videotapes and analysed as previously described.<sup><xref ref-type="bibr" rid="EHT281C20">20</xref>
</sup>
The maximal arterial intima-media thickness (IMT) was estimated offline in up to 12 arterial walls, including the right and the left, near and far distal common carotid (1 cm), bifurcation, and proximal internal carotid artery, and using an image-processing dedicated workstation (MediMatic). Evidence of IMT value higher than 1.5 mm was considered as ‘plaque’.<sup><xref ref-type="bibr" rid="EHT281C16">16</xref>
</sup>
The presence of carotid plaque was considered a marker of CA.</p>
</sec>
<sec id="s2e"><title>Statistical analysis</title>
<p>Data were analysed using SPSS (version 20.0; SPSS, Chicago, IL, USA) and expressed as mean ± 1SD. Variables not normally distributed were log-transformed. Descriptive comparison between patients with or without initial LVH and/or evidence of CA was performed using <italic>t</italic>
-test. Unadjusted prevalence of specific conditions in population subgroups was compared using the <italic>χ</italic>
<sup>2</sup>
distribution, and Monte Carlo simulation to generate exact <italic>P</italic>
-values.</p>
<p>To account for therapy, single classes of medications, including anti-renin–angiotensin system drugs (anti-RAS, including ACE inhibitors and/or AT1 receptor antagonists), calcium channel blockers (CCBs), β-blockers, and thiazide diuretics, were dichotomized according to their overall use during the individual follow-up, based on the frequency of prescriptions during the control visits, considering as the end of follow-up time of diabetes diagnosis for patients with incident diabetes<italic>.</italic>
Thus, all medications used for more than 50% of control visits were considered as covariates in proportional hazards analysis, a method that has been previously reported.<sup><xref ref-type="bibr" rid="EHT281C7">7</xref>
</sup>
</p>
<p>Incident diabetes in relation to the presence of either initial LVH or CA was assessed using two models of the Cox regression analysis (one for each marker), controlling for demographic, haemodynamic, and metabolic variables participating to the phenotypes of MetS (age, sex, reported duration of hypertension, initial BP, heart rate, BMI, fasting glucose, HDL-cholesterol, triglycerides) and number and type of anti-hypertensive medications that were significantly different in exploratory statistics. In alternative Cox models, we assessed the effect of the generic presence of either one of the two markers of preclinical CVD (LVH or CA) or both, adjusting for the same covariates. Finally, the latter Cox model was also run by substituting individual risk factors (i.e. glucose, HDL-cholesterol, BP, BMI, and triglycerides) with MetS, in the whole, as well as in subsets of, study population.</p>
<p>A two-tailed <italic>α</italic>
-value of <0.05 was used to reject the null hypothesis.</p>
</sec>
</sec>
<sec sec-type="results" id="s3"><title>Results</title>
<p>Among the 4176 non-diabetic hypertensive outpatients included in this analysis (mean age 58.7 ± 8.9 years, 58% male), 992 (24%) were obese and 1158 met the criteria for the diagnosis of MetS (28%). Initial LVH was found in 1136 patients (27%). Initial CA was found in 1548 patients (37%).</p>
<p><italic>Table <xref ref-type="table" rid="EHT281TB1">1</xref>
</italic>
shows that patients with baseline LVH were older (<italic>P</italic>
< 0.0001) and more often male (<italic>P</italic>
< 0.003). They also exhibited longer history of hypertension, higher baseline BMI, systolic and diastolic BP, and lower heart rate than those without LVH (all <italic>P</italic>
< 0.0001). Baseline fasting glucose and triglycerides were also higher, HDL-cholesterol was lower, and MetS was more prevalent in the presence than in the absence of LVH (all <italic>P</italic>
< 0.0001, <italic>Table <xref ref-type="table" rid="EHT281TB1">1</xref>
</italic>
). No difference was found in the proportion of patients with a family history of diabetes among the two groups.
<table-wrap id="EHT281TB1" position="float"><label>Table 1</label>
<caption><p>Baseline demographic and clinical characteristics of participants with or without initial LV hypertrophy (LVH)</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="char" char="." span="1"></col>
</colgroup>
<thead><tr><th rowspan="1" colspan="1"></th>
<th align="left" rowspan="1" colspan="1">Non-LVH (<italic>n</italic>
= 3040)</th>
<th align="left" rowspan="1" colspan="1">LVH (<italic>n</italic>
= 1136)</th>
<th align="left" rowspan="1" colspan="1"><italic>P</italic>
≤</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1">Age (years)</td>
<td rowspan="1" colspan="1">57.61 ± 8.9</td>
<td rowspan="1" colspan="1">61.69 ± 8.3</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Sex (M/F %)</td>
<td rowspan="1" colspan="1">56.6/43.4</td>
<td rowspan="1" colspan="1">61.6/38.4</td>
<td rowspan="1" colspan="1">0.003</td>
</tr>
<tr><td rowspan="1" colspan="1">BMI (kg/m<sup>2</sup>
)</td>
<td rowspan="1" colspan="1">26.84 ± 3.6</td>
<td rowspan="1" colspan="1">29.77 ± 4.4</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Hypertension duration (years)</td>
<td rowspan="1" colspan="1">5.13 ± 6.0</td>
<td rowspan="1" colspan="1">7.39 ± 7.3</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Systolic BP (mmHg)</td>
<td rowspan="1" colspan="1">140.14 ± 15.8</td>
<td rowspan="1" colspan="1">146.54 ± 19.1</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Diastolic BP (mmHg)</td>
<td rowspan="1" colspan="1">89.37 ± 9.9</td>
<td rowspan="1" colspan="1">91.48 ± 11.2</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Heart rate (b.p.m.)</td>
<td rowspan="1" colspan="1">74.97 ± 11.4</td>
<td rowspan="1" colspan="1">73.09 ± 11.4</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Fasting plasma glucose (mg/dL)</td>
<td rowspan="1" colspan="1">93.36 ± 12.0</td>
<td rowspan="1" colspan="1">95.90 ± 12.0</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">HDL Cholesterol (mg/dL)</td>
<td rowspan="1" colspan="1">50.83 ± 12.7</td>
<td rowspan="1" colspan="1">48.99 ± 12.4</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Triglycerides (mg/dL)</td>
<td rowspan="1" colspan="1">130.9 ± 71.9</td>
<td rowspan="1" colspan="1">141.5 ± 79.2</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Metabolic syndrome (%)</td>
<td rowspan="1" colspan="1">28.2</td>
<td rowspan="1" colspan="1">46.9</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Family history of diabetes (%)</td>
<td rowspan="1" colspan="1">30.2</td>
<td rowspan="1" colspan="1">29.8</td>
<td rowspan="1" colspan="1">0.809</td>
</tr>
<tr><td rowspan="1" colspan="1">CCB (%)</td>
<td rowspan="1" colspan="1">18.8</td>
<td rowspan="1" colspan="1">32.2</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">β-Blockers (%)</td>
<td rowspan="1" colspan="1">26.5</td>
<td rowspan="1" colspan="1">27.3</td>
<td rowspan="1" colspan="1">0.614</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>BMI, body mass index; BP, blood pressure; HDL, high density lipoprotein; CCB, calcium channel blockers.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<p>Similarly, patients with baseline CA were more often men and older (both <italic>P</italic>
< 0.004), had longer history of hypertension, higher initial systolic but lower diastolic BP, higher fasting glucose and triglycerides, and lower baseline and heart rate than those without CA (0.004 < <italic>P</italic>
< 0.0001, <italic>Table <xref ref-type="table" rid="EHT281TB2">2</xref>
</italic>
), without statistical differences for HDL-cholesterol prevalence of MetS and family history of diabetes. Calcium channel blockers were more frequently used in patients with than in those without LVH or CA, whereas no difference was found for β-blockers and other classes of meds (<italic>Tables <xref ref-type="table" rid="EHT281TB1">1</xref>
</italic>
and <italic><xref ref-type="table" rid="EHT281TB2">2</xref>
</italic>
).
<table-wrap id="EHT281TB2" position="float"><label>Table 2</label>
<caption><p>Baseline demographic and clinical characteristics of participants with or without initial carotid atherosclerosis (CA)</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="char" char="." span="1"></col>
</colgroup>
<thead><tr><th rowspan="1" colspan="1"></th>
<th align="left" rowspan="1" colspan="1">Non-CA (<italic>n</italic>
= 2628)</th>
<th align="left" rowspan="1" colspan="1">CA (<italic>n</italic>
= 1548)</th>
<th align="left" rowspan="1" colspan="1"><italic>P</italic>
≤</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1">Age (years)</td>
<td rowspan="1" colspan="1">53.57 ± 8.9</td>
<td rowspan="1" colspan="1">62.37 ± 7.7</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Sex (M/F %)</td>
<td rowspan="1" colspan="1">56.2/43.8</td>
<td rowspan="1" colspan="1">60.9/39.1</td>
<td rowspan="1" colspan="1">0.004</td>
</tr>
<tr><td rowspan="1" colspan="1">BMI (kg/m<sup>2</sup>
)</td>
<td rowspan="1" colspan="1">27.64 ± 4.1</td>
<td rowspan="1" colspan="1">27.62 ± 3.9</td>
<td rowspan="1" colspan="1">0.891</td>
</tr>
<tr><td rowspan="1" colspan="1">Hypertension duration (years)</td>
<td rowspan="1" colspan="1">5.03 ± 5.9</td>
<td rowspan="1" colspan="1">6.95 ± 7.2</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Systolic BP (mmHg)</td>
<td rowspan="1" colspan="1">140.92 ± 16.3</td>
<td rowspan="1" colspan="1">143.50 ± 18.0</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Diastolic BP (mmHg)</td>
<td rowspan="1" colspan="1">90.38 ± 10.0</td>
<td rowspan="1" colspan="1">89.21 ± 10.6</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Heart rate (b.p.m.)</td>
<td rowspan="1" colspan="1">74.87 ± 11.5</td>
<td rowspan="1" colspan="1">73.76 ± 11.5</td>
<td rowspan="1" colspan="1">0.002</td>
</tr>
<tr><td rowspan="1" colspan="1">Fasting plasma glucose (mg/dL)</td>
<td rowspan="1" colspan="1">93.27 ± 11.8</td>
<td rowspan="1" colspan="1">95.38 ± 12.4</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">HDL Cholesterol (mg/dL)</td>
<td rowspan="1" colspan="1">50.51 ± 12.8</td>
<td rowspan="1" colspan="1">50.03 ± 12.3</td>
<td rowspan="1" colspan="1">0.233</td>
</tr>
<tr><td rowspan="1" colspan="1">Triglycerides
(mg/dL)</td>
<td rowspan="1" colspan="1">131.0 ± 74.0</td>
<td rowspan="1" colspan="1">138.5 ± 74.2</td>
<td rowspan="1" colspan="1">0.001</td>
</tr>
<tr><td rowspan="1" colspan="1">Metabolic syndrome (%)</td>
<td rowspan="1" colspan="1">33.1</td>
<td rowspan="1" colspan="1">33.5</td>
<td rowspan="1" colspan="1">0.780</td>
</tr>
<tr><td rowspan="1" colspan="1">Family history of diabetes (%)</td>
<td rowspan="1" colspan="1">30.0</td>
<td rowspan="1" colspan="1">30.1</td>
<td rowspan="1" colspan="1">0.954</td>
</tr>
<tr><td rowspan="1" colspan="1">CCB (%)</td>
<td rowspan="1" colspan="1">20.4</td>
<td rowspan="1" colspan="1">26.0</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">β-Blockers (%)</td>
<td rowspan="1" colspan="1">26.9</td>
<td rowspan="1" colspan="1">26.4</td>
<td rowspan="1" colspan="1">0.680</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>BMI, body mass index; BP, blood pressure; HDL, high-density lipoprotein; CCB, calcium channel blockers.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</p>
<sec id="s3a"><title>Incident diabetes</title>
<p>During follow-up (median: 3.57 years; inter-quartile range: 2.04–7.25), incident diabetes was adjudicated in 393 patients (9.4%). Diabetes developed near two-fold more frequently in patients with than in those without initial LVH [14.1 and 7.7%, respectively; odds ratio (OR) = 1.97, 95% confidence interval (CI): 1.59–2.45, <italic>P</italic>
< 0.0001] and similarly, the incidence of diabetes was significantly more frequent among patients with baseline evidence of carotid plaque (12.3 vs. 7.7%; OR = 1.67, 95% CI: 1.36–2.06, <italic>P</italic>
< 0.0001). Hypertensive patients developing diabetes during follow-up were given more often β-blockers and CCB than patients without incident diabetes (32.6 vs. 26.1%; 30.0 vs. 21.7%, respectively; both <italic>P</italic>
< 0.006), whereas no difference was found for the other classes of antihypertensive meds. Patients with incident diabetes also took a greater number of antihypertensive meds (1.8 ± 0.98) than those free of incident diabetes (1.5 ± 0.95, <italic>P</italic>
< 0.0001). No difference was found in the number of visit per year in patients with or without incident diabetes (1.29 ± 1.02 vs. 1.39 ± 1.03, respectively; <italic>P</italic>
= 0.620).</p>
<p>In the Cox regression, the presence of initial LVH remained associated with 30% higher risk of incident diabetes [hazards ratio (HR) = 1.30; (95% CI 1.02–1.64); <italic>P</italic>
= 0.03], independently of the type and number of anti-hypertensive medications, initial higher systolic BP (<italic>P</italic>
= 0.001), BMI, fasting glucose, and family history of diabetes (all <italic>P</italic>
< 0.0001). Similarly, the presence of CA was associated with nearly 40% higher risk of incident diabetes [HR = 1.38; (95% CI 1.11–1.70); <italic>P</italic>
= 0.003], independently of the type and number of anti-hypertensive medications, initial higher systolic BP, BMI, fasting glucose, and family history of diabetes (all <italic>P</italic>
< 0.0001).</p>
<p>The presence of either of the two markers of preclinical CVD (<italic>n</italic>
= 1582) increased the chance of incident diabetes by more than 60% [HR = 1.63; (95% CI 1.27–2.08); <italic>P</italic>
< 0.0001], a risk that remained similar in the presence of both markers [<italic>n</italic>
= 551; HR = 1.64; (95% CI 1.19–2.23); <italic>P</italic>
= 0.002], and was independent of initial higher systolic BP [HR = 1.05/5 mmHg; (95% CI 1.02–1.11); <italic>P</italic>
= 0.001], greater BMI [HR = 1.05/kg/m; (95% CI 1.02–1.08)], higher fasting glucose [HR = 1.08/mg/dL; (95% CI 1.07–1.09)], family history of diabetes [HR = 1.59; (95% CI 1.29–1.96); all <italic>P</italic>
< 0.0001], and type and number of anti-hypertensive medications (not significant).</p>
<p>The last model of the Cox regression was repeated clustering all the components of MetS in a single variable as initial presence or absence of MetS. In this analysis, incident diabetes was independently predicted by initial presence of one or both markers of preclinical CVD, with additional significant effects for MetS, older age, and family history of diabetes, with no detectable effect for the other covariates (<italic>Table <xref ref-type="table" rid="EHT281TB3">3</xref>
</italic>
, <italic>Figure <xref ref-type="fig" rid="EHT281F1">1</xref>
</italic>
).
<table-wrap id="EHT281TB3" position="float"><label>Table 3</label>
<caption><p>Baseline predictors of incident diabetes including either one of or both markers of preclinical CV disease</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="char" char="." span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="char" char="." span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="2" colspan="1">HR</th>
<th align="left" colspan="2" rowspan="1">CI 95.0% HR<hr></hr>
</th>
<th align="left" rowspan="2" colspan="1"><italic>P</italic>
≤</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1">Lower</th>
<th align="left" rowspan="1" colspan="1">Upper</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1">Age (years)</td>
<td rowspan="1" colspan="1">1.02</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.03</td>
<td rowspan="1" colspan="1">0.028</td>
</tr>
<tr><td rowspan="1" colspan="1">MetS (n/y)</td>
<td rowspan="1" colspan="1">2.73</td>
<td rowspan="1" colspan="1">2.21</td>
<td rowspan="1" colspan="1">3.37</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Family history of diabetes (n/y)</td>
<td rowspan="1" colspan="1">1.85</td>
<td rowspan="1" colspan="1">1.51</td>
<td rowspan="1" colspan="1">2.27</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">LVH or CA (n/y)</td>
<td rowspan="1" colspan="1">1.70</td>
<td rowspan="1" colspan="1">1.33</td>
<td rowspan="1" colspan="1">2.17</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">LVH and CA (n/y)</td>
<td rowspan="1" colspan="1">1.93</td>
<td rowspan="1" colspan="1">1.42</td>
<td rowspan="1" colspan="1">2.63</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1">Heart rate (b.p.m.)</td>
<td rowspan="1" colspan="1">0.99</td>
<td rowspan="1" colspan="1">0.99</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">0.762</td>
</tr>
<tr><td rowspan="1" colspan="1">Duration of hypertension (years)</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">0.99</td>
<td rowspan="1" colspan="1">1.02</td>
<td rowspan="1" colspan="1">0.270</td>
</tr>
<tr><td rowspan="1" colspan="1">Number of antihypertensive drugs</td>
<td rowspan="1" colspan="1">1.09</td>
<td rowspan="1" colspan="1">0.95</td>
<td rowspan="1" colspan="1">1.24</td>
<td rowspan="1" colspan="1">0.213</td>
</tr>
<tr><td rowspan="1" colspan="1">CCB (n/y)</td>
<td rowspan="1" colspan="1">0.99</td>
<td rowspan="1" colspan="1">0.78</td>
<td rowspan="1" colspan="1">1.27</td>
<td rowspan="1" colspan="1">0.920</td>
</tr>
<tr><td rowspan="1" colspan="1">β-Blockers (n/y)</td>
<td rowspan="1" colspan="1">1.04</td>
<td rowspan="1" colspan="1">0.82</td>
<td rowspan="1" colspan="1">1.32</td>
<td rowspan="1" colspan="1">0.749</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>MetS, metabolic syndrome; LVH, left ventricular hypertrophy; CA, carotid atherosclerosis; CCB, calcium channel blockers; β-blockers, beta-blockers.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<fig id="EHT281F1" position="float"><label>Figure 1</label>
<caption><p>Hazard of incident diabetes according to the initial presence of one (dotted line) or both markers (continuous black line) of preclinical cardiovascular disease (left ventricular hypertrophy, carotid atherosclerosis), compared with the absence of preclinical cardiovascular disease (continuous grey line).</p>
</caption>
<graphic xlink:href="eht28101"></graphic>
</fig>
</p>
<p>The Cox regression, adjusting for age, family history of diabetes, heart rate, duration of hypertension, number of anti-hypertensive meds, and use of CCB or β-blockers, was also run in specific subpopulations, based on the presence or absence of obesity or impaired fasting glucose. Patients with BMI ≥30 were younger, had higher baseline glucose, triglycerides, systolic and diastolic BP, heart rate and duration of hypertension, lower HDL cholesterol, and more frequent MetS and family history of diabetes (all <italic>P</italic>
< 0.04) than those without obesity. In the obese sub-population (<italic>n</italic>
= 992), incident diabetes was independently predicted by the combined presence of both markers of preclinical CVD (<italic>Table <xref ref-type="table" rid="EHT281TB4">4</xref>
</italic>
; <italic>Figure <xref ref-type="fig" rid="EHT281F2">2</xref>
</italic>
<italic>A</italic>
). In the non-obese sub-population (<italic>n</italic>
= 3184), incident diabetes was independently predicted also by the initial presence of one of the markers of preclinical CVD (<italic>Table <xref ref-type="table" rid="EHT281TB4">4</xref>
</italic>
; <italic>Figure <xref ref-type="fig" rid="EHT281F2">2</xref>
</italic>
<italic>B</italic>
). Similarly, incident diabetes was independently predicted by the initial presence of one of the markers of preclinical CVD either in the presence (<italic>n</italic>
= 1389) or in the absence of MetS (<italic>n</italic>
= 2787, all <italic>P</italic>
< 0.02, <italic>Table <xref ref-type="table" rid="EHT281TB4">4</xref>
</italic>
).
<table-wrap id="EHT281TB4" position="float"><label>Table 4</label>
<caption><p>Cox's regressions performed for subgroups stratified by BMI (obese vs. non-obese), presence or absence of MetS or impaired fasting glucose, adjusting for age, family history of diabetes, heart rate, duration of hypertension, number of anti-hypertensive meds, and the use of CCB or β-blockers</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="2" colspan="1">HR</th>
<th align="left" rowspan="1" colspan="1">CI 95.0% HR</th>
<th rowspan="1" colspan="1"></th>
<th align="left" rowspan="2" colspan="1"><italic>P</italic>
≤</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1">Lower</th>
<th align="left" rowspan="1" colspan="1">Upper</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1">BMI ≥30 (<italic>n</italic>
= 992)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH or CA</td>
<td rowspan="1" colspan="1">1.40</td>
<td rowspan="1" colspan="1">0.91</td>
<td rowspan="1" colspan="1">2.17</td>
<td rowspan="1" colspan="1">0.126</td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH and CA</td>
<td rowspan="1" colspan="1">1.76</td>
<td rowspan="1" colspan="1">1.06</td>
<td rowspan="1" colspan="1">2.92</td>
<td rowspan="1" colspan="1">0.030</td>
</tr>
<tr><td rowspan="1" colspan="1">BMI <30 (<italic>n</italic>
= 3184)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH or CA</td>
<td rowspan="1" colspan="1">1.73</td>
<td rowspan="1" colspan="1">1.28</td>
<td rowspan="1" colspan="1">2.33</td>
<td rowspan="1" colspan="1">0.0001</td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH and CA</td>
<td rowspan="1" colspan="1">1.83</td>
<td rowspan="1" colspan="1">1.22</td>
<td rowspan="1" colspan="1">2.74</td>
<td rowspan="1" colspan="1">0.003</td>
</tr>
<tr><td rowspan="1" colspan="1">With MetS (<italic>n</italic>
= 1389)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH or CA</td>
<td rowspan="1" colspan="1">1.50</td>
<td rowspan="1" colspan="1">1.08</td>
<td rowspan="1" colspan="1">2.08</td>
<td rowspan="1" colspan="1">0.015</td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH and CA</td>
<td rowspan="1" colspan="1">1.68</td>
<td rowspan="1" colspan="1">1.12</td>
<td rowspan="1" colspan="1">2.52</td>
<td rowspan="1" colspan="1">0.012</td>
</tr>
<tr><td rowspan="1" colspan="1">Without MetS (<italic>n</italic>
= 2787)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH or CA</td>
<td rowspan="1" colspan="1">1.97</td>
<td rowspan="1" colspan="1">1.37</td>
<td rowspan="1" colspan="1">2.83</td>
<td rowspan="1" colspan="1">0.001</td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH and CA</td>
<td rowspan="1" colspan="1">2.29</td>
<td rowspan="1" colspan="1">1.41</td>
<td rowspan="1" colspan="1">3.72</td>
<td rowspan="1" colspan="1">0.001</td>
</tr>
<tr><td rowspan="1" colspan="1">First fasting glucose ≥110 mg/dL (<italic>n</italic>
= 453)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH or CA</td>
<td rowspan="1" colspan="1">1.63</td>
<td rowspan="1" colspan="1">1.10</td>
<td rowspan="1" colspan="1">2.41</td>
<td rowspan="1" colspan="1">0.015</td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH and CA</td>
<td rowspan="1" colspan="1">1.70</td>
<td rowspan="1" colspan="1">1.05</td>
<td rowspan="1" colspan="1">2.76</td>
<td rowspan="1" colspan="1">0.029</td>
</tr>
<tr><td rowspan="1" colspan="1">First fasting glucose <110 mg/dL (<italic>n</italic>
= 3723)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH or CA</td>
<td rowspan="1" colspan="1">1.73</td>
<td rowspan="1" colspan="1">1.27</td>
<td rowspan="1" colspan="1">2.36</td>
<td rowspan="1" colspan="1">0.001</td>
</tr>
<tr><td rowspan="1" colspan="1"> LVH and CA</td>
<td rowspan="1" colspan="1">2.00</td>
<td rowspan="1" colspan="1">1.34</td>
<td rowspan="1" colspan="1">2.99</td>
<td rowspan="1" colspan="1">0.001</td>
</tr>
</tbody>
</table>
<table-wrap-foot><fn><p>MetS was also added as a covariate in the models using BMI or impaired fasting glucose.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<fig id="EHT281F2" position="float"><label>Figure 2</label>
<caption><p>Hazard of incident diabetes in subgroup with (<italic>A</italic>
) or without obesity (<italic>B</italic>
), according to the initial presence of one (dotted line) or both markers (continuous black line) of preclinical cardiovascular disease (left ventricular hypertrophy, carotid atherosclerosis), compared with the absence of preclinical cardiovascular disease (continuous grey line).</p>
</caption>
<graphic xlink:href="eht28102"></graphic>
</fig>
</p>
<p>Patients with impaired fasting glucose were older and more frequently men, had higher BMI, triglycerides, longer duration of hypertension, lower HDL cholesterol, and more frequent MetS and family history of diabetes (all <italic>P</italic>
< 0.01) than those with normal fasting glucose. In patients with impaired fasting glucose (<italic>n</italic>
= 453), the presence of one of the markers of preclinical CVD was associated with more than 1.6-fold greater risk of incident diabetes and the presence of both markers increased the risk to 1.7 folds (both <italic>P</italic>
< 0.001, <italic>Table <xref ref-type="table" rid="EHT281TB4">4</xref>
</italic>
; <italic>Figure <xref ref-type="fig" rid="EHT281F3">3</xref>
</italic>
<italic>A</italic>
). In patients with normal fasting glucose, incident diabetes was associated with more than 1.7-fold greater risk of incident diabetes in patients with either LVH or CA and more than two-fold in patients with both LVH and CA (both <italic>P</italic>
< 0.001, <italic>Table <xref ref-type="table" rid="EHT281TB4">4</xref>
</italic>
; <italic>Figure <xref ref-type="fig" rid="EHT281F3">3</xref>
</italic>
<italic>B</italic>
). No interaction was found between the presence of one or two markers of preclinical CV and BMI, MetS, or fasting plasma glucose at the first available visit, after adjusting for age, family history of diabetes, heart rate, duration of hypertension, number of anti-hypertensive meds, and use of CCB or β-blockers.
<fig id="EHT281F3" position="float"><label>Figure 3</label>
<caption><p>Hazard of incident diabetes in subgroup with (<italic>A</italic>
) or without impaired fasting glucose (<italic>B</italic>
) according to the initial presence of one (dotted line) or both markers (continuous black line) of preclinical cardiovascular disease (left ventricular hypertrophy, carotid atherosclerosis), compared with the absence of preclinical cardiovascular disease (continuous grey line).</p>
</caption>
<graphic xlink:href="eht28103"></graphic>
</fig>
</p>
<p>Finally, we compared the risk of incident diabetes in patients with different follow-up period (1, 2, and 5 years). The odds of diabetes referred to initial preclinical CVD increased with longer period of follow-up, but was already evident at a 2-year follow-up (<italic>Table <xref ref-type="table" rid="EHT281TB5">5</xref>
</italic>
).
<table-wrap id="EHT281TB5" position="float"><label>Table 5</label>
<caption><p>Risk of incident diabetes in patients with different follow-up period (1, 2, and 5 years) with the initial presence of one or both markers of preclinical cardiovascular disease</p>
</caption>
<table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col>
<col align="char" char="(" span="1"></col>
<col align="char" char="(" span="1"></col>
<col align="char" char="." span="1"></col>
<col align="char" char="." span="1"></col>
<col align="left" span="1"></col>
<col align="left" span="1"></col>
</colgroup>
<thead><tr><th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="2" colspan="1"> </th>
<th align="left" rowspan="2" colspan="1"><italic>P</italic>
≤</th>
<th align="left" rowspan="2" colspan="1">OR</th>
<th align="left" colspan="2" rowspan="1">CI 95.0% OR<hr></hr>
</th>
</tr>
<tr><th align="left" rowspan="1" colspan="1">Lower</th>
<th align="left" rowspan="1" colspan="1">Upper</th>
</tr>
</thead>
<tbody><tr><td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1">No LVH (<italic>n</italic>
= 3040)</td>
<td rowspan="1" colspan="1">LVH (<italic>n</italic>
= 1136)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td colspan="2" align="center" rowspan="1"> </td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 1 year follow-up</td>
<td rowspan="1" colspan="1">8 (0.3%)</td>
<td rowspan="1" colspan="1">7 (0.6%)</td>
<td rowspan="1" colspan="1">0.14</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.01</td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 2 years follow-up</td>
<td rowspan="1" colspan="1">23 (0.8%)</td>
<td rowspan="1" colspan="1">21 (1.8%)</td>
<td rowspan="1" colspan="1">0.003</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.02</td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 5 years follow-up</td>
<td rowspan="1" colspan="1">106 (3.6%)</td>
<td rowspan="1" colspan="1">74 (6.5%)</td>
<td rowspan="1" colspan="1">0.0001</td>
<td rowspan="1" colspan="1">1.03</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">1.05</td>
</tr>
<tr><td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1">No CA (<italic>n</italic>
= 2628)</td>
<td rowspan="1" colspan="1">CA (<italic>n</italic>
= 1548)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td colspan="2" align="center" rowspan="1"> </td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 1 year follow-up</td>
<td rowspan="1" colspan="1">6 (0.2%)</td>
<td rowspan="1" colspan="1">9 (0.6%)</td>
<td rowspan="1" colspan="1">0.104</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.01</td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 2 years follow-up</td>
<td rowspan="1" colspan="1">21 (0.8%)</td>
<td rowspan="1" colspan="1">23 (1.5%)</td>
<td rowspan="1" colspan="1">0.041</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.01</td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 5 years follow-up</td>
<td rowspan="1" colspan="1">92 (3.5%)</td>
<td rowspan="1" colspan="1">88 (5.7%)</td>
<td rowspan="1" colspan="1">0.001</td>
<td rowspan="1" colspan="1">1.02</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">1.04</td>
</tr>
<tr><td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1">No LVH+CA (<italic>n</italic>
= 3625)</td>
<td rowspan="1" colspan="1">LVH+CA (<italic>n</italic>
= 551)</td>
<td rowspan="1" colspan="1"></td>
<td rowspan="1" colspan="1"></td>
<td colspan="2" align="center" rowspan="1"> </td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 1 year follow-up</td>
<td rowspan="1" colspan="1">10 (0.3%)</td>
<td rowspan="1" colspan="1">5 (0.9%)</td>
<td rowspan="1" colspan="1">0.038</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.01</td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 2 years follow-up</td>
<td rowspan="1" colspan="1">33 (0.9%)</td>
<td rowspan="1" colspan="1">11 (2.0%)</td>
<td rowspan="1" colspan="1">0.039</td>
<td rowspan="1" colspan="1">1.01</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.02</td>
</tr>
<tr><td rowspan="1" colspan="1">Incident diabetes after 5 years follow-up</td>
<td rowspan="1" colspan="1">144 (4.0%)</td>
<td rowspan="1" colspan="1">36 (6.5%)</td>
<td rowspan="1" colspan="1">0.009</td>
<td rowspan="1" colspan="1">1.03</td>
<td rowspan="1" colspan="1">1.00</td>
<td rowspan="1" colspan="1">1.05</td>
</tr>
</tbody>
</table>
</table-wrap>
</p>
</sec>
</sec>
<sec sec-type="discussion" id="s4"><title>Discussion</title>
<p>This study indicates for the first time that the presence of hypertensive target organ damage (preclinical CVD), specifically LVH or CA or the combination of both, significantly increases the risk of future development of diabetes, independent of metabolic profile, BP, antihypertensive treatment and MetS, in a large outpatient-based cohort of clinically healthy, treated, non-diabetic hypertensive patients. This finding could be confirmed in the subgroups of non-obese patients, whereas in obese subjects, only the combination of both markers could add to the risk of diabetes. The explanation of the difference between non-obese and obese participants relies in the higher absolute risk of diabetes in the presence of obesity, which also tracks significant preclinical CVD, making reasonable that only the combination of both markers adds to the risk of incident diabetes, already high in the condition of obesity. In the non-obese subpopulation, the exposure is substantially lower and, therefore, the condition of preclinical CVD can better modulate risk, according to severity.</p>
<p>Compared with the hazard of incident diabetes in the Cox model including single components of MetS, the risk related to preclinical CVD increased when MetS was accounted for in the Cox regression, suggesting that hypertensive target organ damage is particularly discriminating when MetS is present. This finding is consistent with the evidence that MetS significantly increases CV risk, independently of the effect of its single components.<sup><xref ref-type="bibr" rid="EHT281C15">15</xref>
</sup>
</p>
<p>Similar to what has been already suggested regarding the temporal relation between hypertension and LV hypertrophy,<sup><xref ref-type="bibr" rid="EHT281C21">21</xref>
,<xref ref-type="bibr" rid="EHT281C22">22</xref>
</sup>
our results indicate that the traditional assumption that diabetes precedes preclinical CVD might be revised.<sup><xref ref-type="bibr" rid="EHT281C2">2</xref>
,<xref ref-type="bibr" rid="EHT281C3">3</xref>
</sup>
</p>
<p>In particular, diabetes is reported to be associated with greater LV mass, more concentric LV geometry, and lower myocardial function.<sup><xref ref-type="bibr" rid="EHT281C2">2</xref>
</sup>
These associations are also independent of potential confounders including age, sex, MetS, initial fasting glucose, and hypertension.<sup><xref ref-type="bibr" rid="EHT281C23">23</xref>
</sup>
The common vision about the temporal relations between these abnormalities and diabetes was that diabetes is a cause or a concurrent cause of them. Similarly, both impaired fasting glucose and diabetes have been demonstrated to be independently associated with increased carotid IMT, a subclinical measure of atherosclerosis, independently of several potentially important metabolic and coagulation factors.<sup><xref ref-type="bibr" rid="EHT281C24">24</xref>
</sup>
Similar to the temporal relation found with LVH, also CA could be demonstrated to precede diabetes, a finding contributing to overlook to scenarios different from the traditional cause–effect relation. The association between preclinical CVD and incident diabetes was not inflated by the presence in the study population of patients with impaired fasting glucose, as it could also be confirmed in the subpopulation without impaired fasting glucose, using the most conservative approach proposed by the ATPIII in the 2002.<sup><xref ref-type="bibr" rid="EHT281C25">25</xref>
</sup>
</p>
<p>Our findings may be conciliated with the evidence that endothelial dysfunction precedes and predicts incident diabetes, to raise the hypothesis that vascular disease precedes the β-cell failure, which signs the shift from a condition of insulin resistance to diabetes.<sup><xref ref-type="bibr" rid="EHT281C26">26</xref>
</sup>
Endothelial dysfunction and impaired nitric oxide-mediated vasodilatation have also been suggested to directly lead to reduced insulin delivery to skeletal muscles, resulting in peripheral insulin resistance and hyperglycaemia.<sup><xref ref-type="bibr" rid="EHT281C27">27</xref>
</sup>
</p>
<p>The association of insulin resistance with arterial hypertension<sup><xref ref-type="bibr" rid="EHT281C28">28</xref>
</sup>
further suggests that a vascular impairment might precede development of diabetes. The ability of arterial hypertension to predict incident diabetes<sup><xref ref-type="bibr" rid="EHT281C8">8</xref>
</sup>
also confirms that the vascular changes associated with diabetes cannot be simply considered as a consequence of the disease. These findings are eventually reinforced by the evidence that poor therapeutic control of BP further increases the risk of incident diabetes in hypertensive subjects.<sup><xref ref-type="bibr" rid="EHT281C7">7</xref>
</sup>
Considering this evidence, it is not surprising that we found that conditions of preclinical CVD, such as LVH and CA, precede and predict incident diabetes.</p>
<p>This scenario is also consistent with the evidence that most vascular damage associated with diabetes seems to be related to the coexisting MetS, more than to diabetes itself.<sup><xref ref-type="bibr" rid="EHT281C29">29</xref>
,<xref ref-type="bibr" rid="EHT281C30">30</xref>
</sup>
Taken together with our findings, this evidence also suggests that the potent atherogenic effect of insulin resistance might be part of the biological mechanism yielding β-cell failure. Under this scenario, diabetes might be at least in part a consequence more than a cause of vascular impairment.</p>
<p>Microvascular disease has been hypothesized as a possible pathogenic factor in development of diabetes.<sup><xref ref-type="bibr" rid="EHT281C31">31</xref>
</sup>
This hypothesis is largely based on observations of microvascular abnormalities, such as arteriolar narrowing and impaired microvascular blood flow in the skin and skeletal muscles of persons with, or at high risk of, diabetes (e.g. those with impaired glucose tolerance and a family history of diabetes).<sup><xref ref-type="bibr" rid="EHT281C32">32</xref>
</sup>
Retinal arteriolar narrowing and hypertension have been associated with incident diabetes, independent of known risk factors. Parallel pancreatic microvascular disease might also precede clinical manifestation of diabetes.<sup><xref ref-type="bibr" rid="EHT281C33">33</xref>
</sup>
The hypothesis that diabetes might be the consequence of pancreatic microvascular dysfunction and ischaemia has been raised,<sup><xref ref-type="bibr" rid="EHT281C34">34</xref>
</sup>
but never proven. However, this hypothesis is supported by the experimental evidence of massive necrosis (but not apoptosis) associated with development of diabetes in diabetes-prone rats.<sup><xref ref-type="bibr" rid="EHT281C35">35</xref>
</sup>
</p>
<sec id="s4a"><title>Limitations</title>
<p>We need to highlight some limitations of this study. First of all, this analysis has been performed in an observational registry, with the potential limitation related to this type of data repository.<sup><xref ref-type="bibr" rid="EHT281C36">36</xref>
</sup>
As a consequence, the frequency of follow-up visits was not standardized. However, we show that the number of visit/year was not different between patients developing or not developing diabetes. In addition, follow-up time was very variable, ranging from 1 to more than 20 years. However, sub-analyses performed at fixed duration of follow-up (1, 2, 5 years) could exclude a substantial bias related to the wide range of follow-up (<italic>Table <xref ref-type="table" rid="EHT281TB5">5</xref>
</italic>
), being the difference in incidence already significant after 2 years. Although the number of patients lost to follow-up is very low in the Campania Salute network (<9%), the possibility of a bias related to patients lost to follow-up cannot be excluded with certainty. β-Blockers were more used in patients developing diabetes than in those without incident diabetes. However, the proportion of patients taking β-blockers was not statistically different in the presence or absence of markers of preclinical CVD, making unlikely a confounding effect, which was in fact excluded in the Cox models.</p>
<p>Finally, direct assessments of endothelial function, β-cell function, or sympathetic activity could have helped substantially the understanding of our findings and should track future research.</p>
</sec>
</sec>
<sec sec-type="conclusions" id="s5"><title>Conclusions</title>
<p>We provide first evidence that initial LVH and CA are significant predictors of new onset diabetes in a large population of treated, relatively healthy hypertensive patients, independently of initial metabolic profile, anti-hypertensive therapy, and other significant covariates. This temporal sequence is likely to be attributable to risk factors both affecting CV system and yielding to diabetes, for which LVH and CA represent a more severe and advanced stage, but a vascular origin of diabetes cannot be excluded.</p>
<p>There are important implications of these findings for primary CV prevention, because they help identifying hypertensive patients at high risk of incident diabetes, a condition that would enormously increase CV risk in the setting of arterial hypertension. The possibility of refining identification of hypertensive patients at high risk to develop diabetes, by pooling ultrasound with clinical information, increases the chance to target individuals who might benefit from more aggressive pharmacological management, even independently of BP control, to reduce their vascular burden. Further studies are warranted to evaluate mechanisms explaining the reverse causation suggested by our findings.</p>
</sec>
<sec id="s6"><title>Authors’ contributions</title>
<p>R.I., G.d.S., and N.D.L. conceived the study, made the analysis, and wrote the manuscript. V.T. and R.G. gave substantial help in data management, contributed to the analysis, and edited the manuscript. E.G., B.T., and O.V. gave substantial conceptual help in writing, editing, and finalizing the manuscript. R.I. and G.d.S. edited the final version of the manuscript. B.T. and G.d.S. gave final approval for submission. The guarantors of the study are G.d.S., N.D.L., and B.T.</p>
</sec>
<sec id="s7"><title>Funding</title>
<p>This work has been supported in part by grant AIFA (Italian Agency for Drugs): AIFA/FARM5STRH9.</p>
<p><bold>Conflict of interest:</bold>
none declared.</p>
</sec>
</body>
<back><fn-group><fn><p><bold>See page 3395 for the editorial comment on this article (doi:10.1093/eurheartj/eht365)</bold>
</p>
</fn>
</fn-group>
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