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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">TET2 and CSMD1genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives</title><author><name sortKey="Chittani, Martina" sort="Chittani, Martina" uniqKey="Chittani M" first="Martina" last="Chittani">Martina Chittani</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Zaninello, Roberta" sort="Zaninello, Roberta" uniqKey="Zaninello R" first="Roberta" last="Zaninello">Roberta Zaninello</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Lanzani, Chiara" sort="Lanzani, Chiara" uniqKey="Lanzani C" first="Chiara" last="Lanzani">Chiara Lanzani</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Ortu, Maria F" sort="Ortu, Maria F" uniqKey="Ortu M" first="Maria F." last="Ortu">Maria F. Ortu</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Fresu, Giovanni" sort="Fresu, Giovanni" uniqKey="Fresu G" first="Giovanni" last="Fresu">Giovanni Fresu</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Citterio, Lorena" sort="Citterio, Lorena" uniqKey="Citterio L" first="Lorena" last="Citterio">Lorena Citterio</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Braga, Daniele" sort="Braga, Daniele" uniqKey="Braga D" first="Daniele" last="Braga">Daniele Braga</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Piras, Daniela A" sort="Piras, Daniela A" uniqKey="Piras D" first="Daniela A." last="Piras">Daniela A. Piras</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Carpini, Simona Delli" sort="Carpini, Simona Delli" uniqKey="Carpini S" first="Simona Delli" last="Carpini">Simona Delli Carpini</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Velayutham, Dinesh" sort="Velayutham, Dinesh" uniqKey="Velayutham D" first="Dinesh" last="Velayutham">Dinesh Velayutham</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Simonini, Marco" sort="Simonini, Marco" uniqKey="Simonini M" first="Marco" last="Simonini">Marco Simonini</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Argiolas, Giuseppe" sort="Argiolas, Giuseppe" uniqKey="Argiolas G" first="Giuseppe" last="Argiolas">Giuseppe Argiolas</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Pozzoli, Simona" sort="Pozzoli, Simona" uniqKey="Pozzoli S" first="Simona" last="Pozzoli">Simona Pozzoli</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Valeria" sort="Glorioso, Valeria" uniqKey="Glorioso V" first="Valeria" last="Glorioso">Valeria Glorioso</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Kontula, Kimmo K" sort="Kontula, Kimmo K" uniqKey="Kontula K" first="Kimmo K." last="Kontula">Kimmo K. Kontula</name><affiliation><nlm:aff id="A4">Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Timo P" sort="Hiltunen, Timo P" uniqKey="Hiltunen T" first="Timo P." last="Hiltunen">Timo P. Hiltunen</name><affiliation><nlm:aff id="A4">Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Donner, Kati M" sort="Donner, Kati M" uniqKey="Donner K" first="Kati M." last="Donner">Kati M. Donner</name><affiliation><nlm:aff id="A5">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation><nlm:aff id="A6">Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A7">Human Genetics and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Chapman, Arlene B" sort="Chapman, Arlene B" uniqKey="Chapman A" first="Arlene B." last="Chapman">Arlene B. Chapman</name><affiliation><nlm:aff id="A8">Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:aff id="A9">Institute of Cardiovascular and Medical Sciences, College of Medicine Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><affiliation><nlm:aff id="A9">Institute of Cardiovascular and Medical Sciences, College of Medicine Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:aff id="A10">Department of Clinical Sciences, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A." last="Johnson">Julie A. Johnson</name><affiliation><nlm:aff id="A11">Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper Dehoff, Rhonda M" sort="Cooper Dehoff, Rhonda M" uniqKey="Cooper Dehoff R" first="Rhonda M" last="Cooper-Dehoff">Rhonda M. Cooper-Dehoff</name><affiliation><nlm:aff id="A11">Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Gong, Yan" sort="Gong, Yan" uniqKey="Gong Y" first="Yan" last="Gong">Yan Gong</name><affiliation><nlm:aff id="A11">Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Rivera, Natalia V" sort="Rivera, Natalia V" uniqKey="Rivera N" first="Natalia V." last="Rivera">Natalia V. Rivera</name><affiliation><nlm:aff id="A12">Respiratory Medicine Unit, Department of Medicine and CMM, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Condorelli, Gianluigi" sort="Condorelli, Gianluigi" uniqKey="Condorelli G" first="Gianluigi" last="Condorelli">Gianluigi Condorelli</name><affiliation><nlm:aff id="A13">Department of Medical Biotechnologies and Translational Medicine, University of Milan, and Humanitas Clinical and Research Center, University of Milan, and National Research Council of Italy, Rozzano (MI)</nlm:aff></affiliation></author><author><name sortKey="Trimarco, Bruno" sort="Trimarco, Bruno" uniqKey="Trimarco B" first="Bruno" last="Trimarco">Bruno Trimarco</name><affiliation><nlm:aff id="A14">Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples ‘Federico II’, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">25695618</idno><idno type="pmc">4484731</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4484731</idno><idno type="RBID">PMC:4484731</idno><idno type="doi">10.1097/HJH.0000000000000541</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000416</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000416</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">TET2 and CSMD1genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives</title><author><name sortKey="Chittani, Martina" sort="Chittani, Martina" uniqKey="Chittani M" first="Martina" last="Chittani">Martina Chittani</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Zaninello, Roberta" sort="Zaninello, Roberta" uniqKey="Zaninello R" first="Roberta" last="Zaninello">Roberta Zaninello</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Lanzani, Chiara" sort="Lanzani, Chiara" uniqKey="Lanzani C" first="Chiara" last="Lanzani">Chiara Lanzani</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Frau, Francesca" sort="Frau, Francesca" uniqKey="Frau F" first="Francesca" last="Frau">Francesca Frau</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Ortu, Maria F" sort="Ortu, Maria F" uniqKey="Ortu M" first="Maria F." last="Ortu">Maria F. Ortu</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Salvi, Erika" sort="Salvi, Erika" uniqKey="Salvi E" first="Erika" last="Salvi">Erika Salvi</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Fresu, Giovanni" sort="Fresu, Giovanni" uniqKey="Fresu G" first="Giovanni" last="Fresu">Giovanni Fresu</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Citterio, Lorena" sort="Citterio, Lorena" uniqKey="Citterio L" first="Lorena" last="Citterio">Lorena Citterio</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Braga, Daniele" sort="Braga, Daniele" uniqKey="Braga D" first="Daniele" last="Braga">Daniele Braga</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Piras, Daniela A" sort="Piras, Daniela A" uniqKey="Piras D" first="Daniela A." last="Piras">Daniela A. Piras</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Carpini, Simona Delli" sort="Carpini, Simona Delli" uniqKey="Carpini S" first="Simona Delli" last="Carpini">Simona Delli Carpini</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Velayutham, Dinesh" sort="Velayutham, Dinesh" uniqKey="Velayutham D" first="Dinesh" last="Velayutham">Dinesh Velayutham</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Simonini, Marco" sort="Simonini, Marco" uniqKey="Simonini M" first="Marco" last="Simonini">Marco Simonini</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Argiolas, Giuseppe" sort="Argiolas, Giuseppe" uniqKey="Argiolas G" first="Giuseppe" last="Argiolas">Giuseppe Argiolas</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Pozzoli, Simona" sort="Pozzoli, Simona" uniqKey="Pozzoli S" first="Simona" last="Pozzoli">Simona Pozzoli</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Troffa, Chiara" sort="Troffa, Chiara" uniqKey="Troffa C" first="Chiara" last="Troffa">Chiara Troffa</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Valeria" sort="Glorioso, Valeria" uniqKey="Glorioso V" first="Valeria" last="Glorioso">Valeria Glorioso</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Kontula, Kimmo K" sort="Kontula, Kimmo K" uniqKey="Kontula K" first="Kimmo K." last="Kontula">Kimmo K. Kontula</name><affiliation><nlm:aff id="A4">Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Hiltunen, Timo P" sort="Hiltunen, Timo P" uniqKey="Hiltunen T" first="Timo P." last="Hiltunen">Timo P. Hiltunen</name><affiliation><nlm:aff id="A4">Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Donner, Kati M" sort="Donner, Kati M" uniqKey="Donner K" first="Kati M." last="Donner">Kati M. Donner</name><affiliation><nlm:aff id="A5">Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland</nlm:aff></affiliation></author><author><name sortKey="Turner, Stephen T" sort="Turner, Stephen T" uniqKey="Turner S" first="Stephen T." last="Turner">Stephen T. Turner</name><affiliation><nlm:aff id="A6">Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota</nlm:aff></affiliation></author><author><name sortKey="Boerwinkle, Eric" sort="Boerwinkle, Eric" uniqKey="Boerwinkle E" first="Eric" last="Boerwinkle">Eric Boerwinkle</name><affiliation><nlm:aff id="A7">Human Genetics and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas</nlm:aff></affiliation></author><author><name sortKey="Chapman, Arlene B" sort="Chapman, Arlene B" uniqKey="Chapman A" first="Arlene B." last="Chapman">Arlene B. Chapman</name><affiliation><nlm:aff id="A8">Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA</nlm:aff></affiliation></author><author><name sortKey="Padmanabhan, Sandosh" sort="Padmanabhan, Sandosh" uniqKey="Padmanabhan S" first="Sandosh" last="Padmanabhan">Sandosh Padmanabhan</name><affiliation><nlm:aff id="A9">Institute of Cardiovascular and Medical Sciences, College of Medicine Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Dominiczak, Anna F" sort="Dominiczak, Anna F" uniqKey="Dominiczak A" first="Anna F." last="Dominiczak">Anna F. Dominiczak</name><affiliation><nlm:aff id="A9">Institute of Cardiovascular and Medical Sciences, College of Medicine Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</nlm:aff></affiliation></author><author><name sortKey="Melander, Olle" sort="Melander, Olle" uniqKey="Melander O" first="Olle" last="Melander">Olle Melander</name><affiliation><nlm:aff id="A10">Department of Clinical Sciences, Lund University, Malmö, Sweden</nlm:aff></affiliation></author><author><name sortKey="Johnson, Julie A" sort="Johnson, Julie A" uniqKey="Johnson J" first="Julie A." last="Johnson">Julie A. Johnson</name><affiliation><nlm:aff id="A11">Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Cooper Dehoff, Rhonda M" sort="Cooper Dehoff, Rhonda M" uniqKey="Cooper Dehoff R" first="Rhonda M" last="Cooper-Dehoff">Rhonda M. Cooper-Dehoff</name><affiliation><nlm:aff id="A11">Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Gong, Yan" sort="Gong, Yan" uniqKey="Gong Y" first="Yan" last="Gong">Yan Gong</name><affiliation><nlm:aff id="A11">Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</nlm:aff></affiliation></author><author><name sortKey="Rivera, Natalia V" sort="Rivera, Natalia V" uniqKey="Rivera N" first="Natalia V." last="Rivera">Natalia V. Rivera</name><affiliation><nlm:aff id="A12">Respiratory Medicine Unit, Department of Medicine and CMM, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden</nlm:aff></affiliation></author><author><name sortKey="Condorelli, Gianluigi" sort="Condorelli, Gianluigi" uniqKey="Condorelli G" first="Gianluigi" last="Condorelli">Gianluigi Condorelli</name><affiliation><nlm:aff id="A13">Department of Medical Biotechnologies and Translational Medicine, University of Milan, and Humanitas Clinical and Research Center, University of Milan, and National Research Council of Italy, Rozzano (MI)</nlm:aff></affiliation></author><author><name sortKey="Trimarco, Bruno" sort="Trimarco, Bruno" uniqKey="Trimarco B" first="Bruno" last="Trimarco">Bruno Trimarco</name><affiliation><nlm:aff id="A14">Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples ‘Federico II’, Naples, Italy</nlm:aff></affiliation></author><author><name sortKey="Manunta, Paolo" sort="Manunta, Paolo" uniqKey="Manunta P" first="Paolo" last="Manunta">Paolo Manunta</name><affiliation><nlm:aff id="A3">Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</nlm:aff></affiliation></author><author><name sortKey="Cusi, Daniele" sort="Cusi, Daniele" uniqKey="Cusi D" first="Daniele" last="Cusi">Daniele Cusi</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author><author><name sortKey="Glorioso, Nicola" sort="Glorioso, Nicola" uniqKey="Glorioso N" first="Nicola" last="Glorioso">Nicola Glorioso</name><affiliation><nlm:aff id="A2">Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</nlm:aff></affiliation></author><author><name sortKey="Barlassina, Cristina" sort="Barlassina, Cristina" uniqKey="Barlassina C" first="Cristina" last="Barlassina">Cristina Barlassina</name><affiliation><nlm:aff id="A1">Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</nlm:aff></affiliation></author></analytic><series><title level="j">Journal of hypertension</title><idno type="ISSN">0263-6352</idno><idno type="eISSN">1473-5598</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P2">Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of ‘the right drug in the individual essential hypertensive patient’ remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient’s genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.</p></sec><sec id="S2"><title>Methods and results</title><p id="P3">We looked for variants associated with blood pressure response to hydrochlorothiazide over an 8-week follow-up by means of a genome-wide association analysis in two Italian cohorts of never-treated essential hypertensive patients: 343 samples from Sardinia and 142 from Milan. TET2 and CSMD1 as plausible candidate genes to affect SBP response to hydrochlorothiazide were identified. The specificity of our findings for hydrochlorothiazide was confirmed in an independent cohort of essential hypertensive patients treated with losartan. Our best findings were also tested for replication in four independent hypertensive samples of European Ancestry, such as GENetics of drug RESponsiveness in essential hypertension, Genetic Epidemiology of Responses to Antihypertensives, NORdic DILtiazem intervention, Pharmacogenomics Evaluation of Antihypertensive Responses, and Campania Salute Network-StayOnDiur. We validated a polymorphism in CSMD1 and UGGT2.</p></sec><sec id="S3"><title>Conclusion</title><p id="P4">This exploratory study reports two plausible loci associated with SBP response to hydrochlorothiazide: TET2, an aldosterone-responsive mediator of αENaC gene transcription; and CSMD1, previously described as associated with hypertension in a case–control study.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8306882</journal-id><journal-id journal-id-type="pubmed-jr-id">4814</journal-id><journal-id journal-id-type="nlm-ta">J Hypertens</journal-id><journal-id journal-id-type="iso-abbrev">J. Hypertens.</journal-id><journal-title-group><journal-title>Journal of hypertension</journal-title></journal-title-group><issn pub-type="ppub">0263-6352</issn><issn pub-type="epub">1473-5598</issn></journal-meta><article-meta><article-id pub-id-type="pmid">25695618</article-id><article-id pub-id-type="pmc">4484731</article-id><article-id pub-id-type="doi">10.1097/HJH.0000000000000541</article-id><article-id pub-id-type="manuscript">NIHMS701112</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>TET2 and CSMD1genes affect SBP response to hydrochlorothiazide in never-treated essential hypertensives</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Chittani</surname><given-names>Martina</given-names></name><xref ref-type="aff" rid="A1">a</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Zaninello</surname><given-names>Roberta</given-names></name><xref ref-type="aff" rid="A2">b</xref><xref ref-type="author-notes" rid="FN1">*</xref></contrib><contrib contrib-type="author"><name><surname>Lanzani</surname><given-names>Chiara</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Frau</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Ortu</surname><given-names>Maria F.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Salvi</surname><given-names>Erika</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Fresu</surname><given-names>Giovanni</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Citterio</surname><given-names>Lorena</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Braga</surname><given-names>Daniele</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Piras</surname><given-names>Daniela A.</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Carpini</surname><given-names>Simona Delli</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Velayutham</surname><given-names>Dinesh</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Simonini</surname><given-names>Marco</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Argiolas</surname><given-names>Giuseppe</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Pozzoli</surname><given-names>Simona</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Troffa</surname><given-names>Chiara</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Glorioso</surname><given-names>Valeria</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Kontula</surname><given-names>Kimmo K.</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Hiltunen</surname><given-names>Timo P.</given-names></name><xref ref-type="aff" rid="A4">d</xref></contrib><contrib contrib-type="author"><name><surname>Donner</surname><given-names>Kati M.</given-names></name><xref ref-type="aff" rid="A5">e</xref></contrib><contrib contrib-type="author"><name><surname>Turner</surname><given-names>Stephen T.</given-names></name><xref ref-type="aff" rid="A6">f</xref></contrib><contrib contrib-type="author"><name><surname>Boerwinkle</surname><given-names>Eric</given-names></name><xref ref-type="aff" rid="A7">g</xref></contrib><contrib contrib-type="author"><name><surname>Chapman</surname><given-names>Arlene B.</given-names></name><xref ref-type="aff" rid="A8">h</xref></contrib><contrib contrib-type="author"><name><surname>Padmanabhan</surname><given-names>Sandosh</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Dominiczak</surname><given-names>Anna F.</given-names></name><xref ref-type="aff" rid="A9">i</xref></contrib><contrib contrib-type="author"><name><surname>Melander</surname><given-names>Olle</given-names></name><xref ref-type="aff" rid="A10">j</xref></contrib><contrib contrib-type="author"><name><surname>Johnson</surname><given-names>Julie A.</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Cooper-Dehoff</surname><given-names>Rhonda M</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Yan</given-names></name><xref ref-type="aff" rid="A11">k</xref></contrib><contrib contrib-type="author"><name><surname>Rivera</surname><given-names>Natalia V.</given-names></name><xref ref-type="aff" rid="A12">l</xref></contrib><contrib contrib-type="author"><name><surname>Condorelli</surname><given-names>Gianluigi</given-names></name><xref ref-type="aff" rid="A13">m</xref></contrib><contrib contrib-type="author"><name><surname>Trimarco</surname><given-names>Bruno</given-names></name><xref ref-type="aff" rid="A14">n</xref></contrib><contrib contrib-type="author"><name><surname>Manunta</surname><given-names>Paolo</given-names></name><xref ref-type="aff" rid="A3">c</xref></contrib><contrib contrib-type="author"><name><surname>Cusi</surname><given-names>Daniele</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib><contrib contrib-type="author"><name><surname>Glorioso</surname><given-names>Nicola</given-names></name><xref ref-type="aff" rid="A2">b</xref></contrib><contrib contrib-type="author"><name><surname>Barlassina</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="A1">a</xref></contrib></contrib-group><aff id="A1"><label>a</label>Department of Health Sciences, University of Milan at San Paolo Hospital, and Filarete Foundation, Genomic and Bioinformatics Unit, Milan</aff><aff id="A2"><label>b</label>Hypertension and Related Disease Centre, AOU-University of Sassari, Sassari</aff><aff id="A3"><label>c</label>Università Vita Salute San Raffaele, Nephrology and Dialysis and Hypertension Unit, San Raffaele Scientific Institute, Milan, Italy</aff><aff id="A4"><label>d</label>Department of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</aff><aff id="A5"><label>e</label>Institute for Molecular Medicine Finland FIMM, University of Helsinki, Helsinki, Finland</aff><aff id="A6"><label>f</label>Division of Nephrology and Hypertension, Department of Medicine, Mayo Clinic, Rochester, Minnesota</aff><aff id="A7"><label>g</label>Human Genetics and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas</aff><aff id="A8"><label>h</label>Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA</aff><aff id="A9"><label>i</label>Institute of Cardiovascular and Medical Sciences, College of Medicine Veterinary and Life Sciences, University of Glasgow, Glasgow, UK</aff><aff id="A10"><label>j</label>Department of Clinical Sciences, Lund University, Malmö, Sweden</aff><aff id="A11"><label>k</label>Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, College of Pharmacy, University of Florida, Gainesville, Florida, USA</aff><aff id="A12"><label>l</label>Respiratory Medicine Unit, Department of Medicine and CMM, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden</aff><aff id="A13"><label>m</label>Department of Medical Biotechnologies and Translational Medicine, University of Milan, and Humanitas Clinical and Research Center, University of Milan, and National Research Council of Italy, Rozzano (MI)</aff><aff id="A14"><label>n</label>Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples ‘Federico II’, Naples, Italy</aff><author-notes><corresp id="cor1">Correspondence to Nicola Glorioso, MD, Hypertension and Related Diseases Centre-AOU, University of Sassari, Viale San Pietro 8, 07100 Sassari, Italy. Tel: +39 079 228388; <email>glorioso@uniss.it</email></corresp><fn id="FN1" fn-type="equal"><label>*</label><p id="P1">Martina Chittani and Roberta Zaninello contributed equally to the writing of this article.</p></fn></author-notes><pub-date pub-type="nihms-submitted"><day>22</day><month>6</month><year>2015</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2015</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>6</month><year>2016</year></pub-date><volume>33</volume><issue>6</issue><fpage>1301</fpage><lpage>1309</lpage><pmc-comment>elocation-id from pubmed: 10.1097/HJH.0000000000000541</pmc-comment>
<permissions><copyright-statement>Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved.</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec id="S1"><title>Background</title><p id="P2">Thiazide diuretics have been recommended as a first-line antihypertensive treatment, although the choice of ‘the right drug in the individual essential hypertensive patient’ remains still empirical. Essential hypertension is a complex, polygenic disease derived from the interaction of patient’s genetic background with the environment. Pharmacogenomics could be a useful tool to pinpoint gene variants involved in antihypertensive drug response, thus optimizing therapeutic advantages and minimizing side effects.</p></sec><sec id="S2"><title>Methods and results</title><p id="P3">We looked for variants associated with blood pressure response to hydrochlorothiazide over an 8-week follow-up by means of a genome-wide association analysis in two Italian cohorts of never-treated essential hypertensive patients: 343 samples from Sardinia and 142 from Milan. TET2 and CSMD1 as plausible candidate genes to affect SBP response to hydrochlorothiazide were identified. The specificity of our findings for hydrochlorothiazide was confirmed in an independent cohort of essential hypertensive patients treated with losartan. Our best findings were also tested for replication in four independent hypertensive samples of European Ancestry, such as GENetics of drug RESponsiveness in essential hypertension, Genetic Epidemiology of Responses to Antihypertensives, NORdic DILtiazem intervention, Pharmacogenomics Evaluation of Antihypertensive Responses, and Campania Salute Network-StayOnDiur. We validated a polymorphism in CSMD1 and UGGT2.</p></sec><sec id="S3"><title>Conclusion</title><p id="P4">This exploratory study reports two plausible loci associated with SBP response to hydrochlorothiazide: TET2, an aldosterone-responsive mediator of αENaC gene transcription; and CSMD1, previously described as associated with hypertension in a case–control study.</p></sec></abstract><kwd-group><kwd>essential hypertension</kwd><kwd>genome-wide association study</kwd><kwd>genomics</kwd><kwd>pharmacogenomics</kwd><kwd>thiazides diuretics</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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