TelematiV1, Pmc, Corpus, bibRecord, 000001

Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation

Identifieur interne : 000001 ( Pmc/Corpus ); précédent : 000000; suivant : 000002

Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation

Auteurs : D. Lettieri Barbato ; K. Aquilano ; S. Baldelli ; S M Cannata ; S. Bernardini ; G. Rotilio ; M R Ciriolo

Source :

Cell Death and Differentiation [ 1350-9047 ] ; 2013.

RBID : PMC:3857628

Abstract

The nutrient-sensing lipolytic enzyme adipose triglyceride lipase (ATGL) has a key role in adipose tissue function, and alterations in its activity have been implicated in many age-related metabolic disorders. In adipose tissue reduced blood vessel density is related to hypoxia state, cell death and inflammation. Here we demonstrate that adipocytes of poorly vascularized enlarged visceral adipose tissue (i.e. adipose tissue of old mice) suffer from limited nutrient delivery. In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL. We demonstrate that ATGL promotes the expression of genes related to mitochondrial oxidative metabolism (peroxisome proliferator-activated receptor-α, peroxisome proliferator-activated receptor-γ coactivator-1α), thus setting a metabolic switch towards fat utilization that supplies energy to starved adipocytes and prevents cell death, as well as adipose tissue inflammation. Taken together, these results identify ATGL as a stress resistance mediator in adipocytes, restraining visceral adipose tissue dysfunction typical of age-related metabolic disorders.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857628

DOI: 10.1038/cdd.2013.137
PubMed: 24096872
PubMed Central: 3857628

Links to Exploration step

PMC:3857628

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation</title>
<author><name sortKey="Lettieri Barbato, D" sort="Lettieri Barbato, D" uniqKey="Lettieri Barbato D" first="D" last="Lettieri Barbato">D. Lettieri Barbato</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aquilano, K" sort="Aquilano, K" uniqKey="Aquilano K" first="K" last="Aquilano">K. Aquilano</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baldelli, S" sort="Baldelli, S" uniqKey="Baldelli S" first="S" last="Baldelli">S. Baldelli</name>
<affiliation><nlm:aff id="aff2"><institution>Università Telematica San Raffaele Roma</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cannata, S M" sort="Cannata, S M" uniqKey="Cannata S" first="S M" last="Cannata">S M Cannata</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bernardini, S" sort="Bernardini, S" uniqKey="Bernardini S" first="S" last="Bernardini">S. Bernardini</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rotilio, G" sort="Rotilio, G" uniqKey="Rotilio G" first="G" last="Rotilio">G. Rotilio</name>
<affiliation><nlm:aff id="aff2"><institution>Università Telematica San Raffaele Roma</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciriolo, M R" sort="Ciriolo, M R" uniqKey="Ciriolo M" first="M R" last="Ciriolo">M R Ciriolo</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>IRCCS San Raffaele</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">24096872</idno>
<idno type="pmc">3857628</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3857628</idno>
<idno type="RBID">PMC:3857628</idno>
<idno type="doi">10.1038/cdd.2013.137</idno>
<date when="2013">2013</date>
<idno type="wicri:Area/Pmc/Corpus">000001</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000001</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation</title>
<author><name sortKey="Lettieri Barbato, D" sort="Lettieri Barbato, D" uniqKey="Lettieri Barbato D" first="D" last="Lettieri Barbato">D. Lettieri Barbato</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Aquilano, K" sort="Aquilano, K" uniqKey="Aquilano K" first="K" last="Aquilano">K. Aquilano</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Baldelli, S" sort="Baldelli, S" uniqKey="Baldelli S" first="S" last="Baldelli">S. Baldelli</name>
<affiliation><nlm:aff id="aff2"><institution>Università Telematica San Raffaele Roma</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Cannata, S M" sort="Cannata, S M" uniqKey="Cannata S" first="S M" last="Cannata">S M Cannata</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Bernardini, S" sort="Bernardini, S" uniqKey="Bernardini S" first="S" last="Bernardini">S. Bernardini</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rotilio, G" sort="Rotilio, G" uniqKey="Rotilio G" first="G" last="Rotilio">G. Rotilio</name>
<affiliation><nlm:aff id="aff2"><institution>Università Telematica San Raffaele Roma</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Ciriolo, M R" sort="Ciriolo, M R" uniqKey="Ciriolo M" first="M R" last="Ciriolo">M R Ciriolo</name>
<affiliation><nlm:aff id="aff1"><institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3"><institution>IRCCS San Raffaele</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Cell Death and Differentiation</title>
<idno type="ISSN">1350-9047</idno>
<idno type="eISSN">1476-5403</idno>
<imprint><date when="2013">2013</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>The nutrient-sensing lipolytic enzyme adipose triglyceride lipase (ATGL) has a key role in adipose tissue function, and alterations in its activity have been implicated in many age-related metabolic disorders. In adipose tissue reduced blood vessel density is related to hypoxia state, cell death and inflammation. Here we demonstrate that adipocytes of poorly vascularized enlarged visceral adipose tissue (i.e. adipose tissue of old mice) suffer from limited nutrient delivery. In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL. We demonstrate that ATGL promotes the expression of genes related to mitochondrial oxidative metabolism (peroxisome proliferator-activated receptor-<italic>α</italic>
, peroxisome proliferator-activated receptor-γ coactivator-1<italic>α</italic>
), thus setting a metabolic switch towards fat utilization that supplies energy to starved adipocytes and prevents cell death, as well as adipose tissue inflammation. Taken together, these results identify ATGL as a stress resistance mediator in adipocytes, restraining visceral adipose tissue dysfunction typical of age-related metabolic disorders.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Death Differ</journal-id>
<journal-id journal-id-type="iso-abbrev">Cell Death Differ</journal-id>
<journal-title-group><journal-title>Cell Death and Differentiation</journal-title>
</journal-title-group>
<issn pub-type="ppub">1350-9047</issn>
<issn pub-type="epub">1476-5403</issn>
<publisher><publisher-name>Nature Publishing Group</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24096872</article-id>
<article-id pub-id-type="pmc">3857628</article-id>
<article-id pub-id-type="pii">cdd2013137</article-id>
<article-id pub-id-type="doi">10.1038/cdd.2013.137</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject>
</subj-group>
</article-categories>
<title-group><article-title>Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation</article-title>
<alt-title alt-title-type="running">ATGL restrains death in starved adipocytes</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Lettieri Barbato</surname>
<given-names>D</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="author-notes" rid="note1"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aquilano</surname>
<given-names>K</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="author-notes" rid="note1"><sup>4</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baldelli</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cannata</surname>
<given-names>S M</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Bernardini</surname>
<given-names>S</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Rotilio</surname>
<given-names>G</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Ciriolo</surname>
<given-names>M R</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="corresp" rid="caf1">*</xref>
</contrib>
<aff id="aff1"><label>1</label>
<institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome,<country>Italy</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>Università Telematica San Raffaele Roma</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</aff>
<aff id="aff3"><label>3</label>
<institution>IRCCS San Raffaele</institution>
, via di Val Cannuta 247, 00166 Rome,<country>Italy</country>
</aff>
</contrib-group>
<author-notes><corresp id="caf1"><label>*</label>
<institution>Department of Biology, University of Rome Tor Vergata</institution>
, via della Ricerca Scientifica, 00133 Rome, <country>Italy</country>
. Tel: +390672594369; Fax: +390672594311; E-mail: <email>ciriolo@bio.uniroma2.it</email>
</corresp>
<fn fn-type="present-address" id="note1"><label>4</label>
<p>These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><month>01</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub"><day>04</day>
<month>10</month>
<year>2013</year>
</pub-date>
<volume>21</volume>
<issue>1</issue>
<fpage>113</fpage>
<lpage>123</lpage>
<history><date date-type="received"><day>05</day>
<month>06</month>
<year>2013</year>
</date>
<date date-type="rev-recd"><day>22</day>
<month>08</month>
<year>2013</year>
</date>
<date date-type="accepted"><day>29</day>
<month>08</month>
<year>2013</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2014 Macmillan Publishers Limited</copyright-statement>
<copyright-year>2014</copyright-year>
<copyright-holder>Macmillan Publishers Limited</copyright-holder>
</permissions>
<abstract><p>The nutrient-sensing lipolytic enzyme adipose triglyceride lipase (ATGL) has a key role in adipose tissue function, and alterations in its activity have been implicated in many age-related metabolic disorders. In adipose tissue reduced blood vessel density is related to hypoxia state, cell death and inflammation. Here we demonstrate that adipocytes of poorly vascularized enlarged visceral adipose tissue (i.e. adipose tissue of old mice) suffer from limited nutrient delivery. In particular, nutrient starvation elicits increased activity of mitochondrial proline oxidase/dehydrogenase (POX/PRODH) that is causal in triggering a ROS-dependent induction of ATGL. We demonstrate that ATGL promotes the expression of genes related to mitochondrial oxidative metabolism (peroxisome proliferator-activated receptor-<italic>α</italic>
, peroxisome proliferator-activated receptor-γ coactivator-1<italic>α</italic>
), thus setting a metabolic switch towards fat utilization that supplies energy to starved adipocytes and prevents cell death, as well as adipose tissue inflammation. Taken together, these results identify ATGL as a stress resistance mediator in adipocytes, restraining visceral adipose tissue dysfunction typical of age-related metabolic disorders.</p>
</abstract>
<kwd-group><kwd>ageing</kwd>
<kwd>adipocytes</kwd>
<kwd>lipid signalling</kwd>
<kwd>mitochondrial metabolism</kwd>
<kwd>reactive oxygen species</kwd>
<kwd>starvation</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/TelematiV1/Data/Pmc/Corpus

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000001 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 000001 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Ticri/CIDE
   |area=    TelematiV1
   |flux=    Pmc
   |étape=   Corpus
   |type=    RBID
   |clé=     PMC:3857628
   |texte=   Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i   -Sk "pubmed:24096872" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd   \
       | NlmPubMed2Wicri -a TelematiV1

This area was generated with Dilib version V0.6.31.
Data generation: Thu Nov 2 16:09:04 2017. Site generation: Sun Mar 10 16:42:28 2024

	Serveur d'exploration sur la télématique
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration sur la télématique

Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation

Proline oxidase–adipose triglyceride lipase pathway restrains adipose cell death and tissue inflammation

Source :

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki