Redox Imbalance and Viral Infections in Neurodegenerative Diseases
Identifieur interne : 000009 ( Pmc/Checkpoint ); précédent : 000008; suivant : 000010Redox Imbalance and Viral Infections in Neurodegenerative Diseases
Auteurs : Dolores Limongi [Italie] ; Sara Baldelli [Italie]Source :
- Oxidative Medicine and Cellular Longevity [ 1942-0900 ] ; 2016.
Abstract
Reactive oxygen species (ROS) are essential molecules for many physiological functions and act as second messengers in a large variety of tissues. An imbalance in the production and elimination of ROS is associated with human diseases including neurodegenerative disorders. In the last years the notion that neurodegenerative diseases are accompanied by chronic viral infections, which may result in an increase of neurodegenerative diseases progression, emerged. It is known in literature that enhanced viral infection risk, observed during neurodegeneration, is partly due to the increase of ROS accumulation in brain cells. However, the molecular mechanisms of viral infection, occurring during the progression of neurodegeneration, remain unclear. In this review, we discuss the recent knowledge regarding the role of influenza, herpes simplex virus type-1, and retroviruses infection in ROS/RNS-mediated Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS).
Url:
DOI: 10.1155/2016/6547248
PubMed: 27110325
PubMed Central: 4826696
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Redox Imbalance and Viral Infections in Neurodegenerative Diseases</title><author><name sortKey="Limongi, Dolores" sort="Limongi, Dolores" uniqKey="Limongi D" first="Dolores" last="Limongi">Dolores Limongi</name><affiliation wicri:level="1"><nlm:aff id="I1">Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Baldelli, Sara" sort="Baldelli, Sara" uniqKey="Baldelli S" first="Sara" last="Baldelli">Sara Baldelli</name><affiliation wicri:level="1"><nlm:aff id="I1">Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27110325</idno><idno type="pmc">4826696</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826696</idno><idno type="RBID">PMC:4826696</idno><idno type="doi">10.1155/2016/6547248</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000085</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000085</idno><idno type="wicri:Area/Pmc/Curation">000085</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000085</idno><idno type="wicri:Area/Pmc/Checkpoint">000009</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000009</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Redox Imbalance and Viral Infections in Neurodegenerative Diseases</title><author><name sortKey="Limongi, Dolores" sort="Limongi, Dolores" uniqKey="Limongi D" first="Dolores" last="Limongi">Dolores Limongi</name><affiliation wicri:level="1"><nlm:aff id="I1">Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Baldelli, Sara" sort="Baldelli, Sara" uniqKey="Baldelli S" first="Sara" last="Baldelli">Sara Baldelli</name><affiliation wicri:level="1"><nlm:aff id="I1">Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Oxidative Medicine and Cellular Longevity</title><idno type="ISSN">1942-0900</idno><idno type="eISSN">1942-0994</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Reactive oxygen species (ROS) are essential molecules for many physiological functions and act as second messengers in a large variety of tissues. An imbalance in the production and elimination of ROS is associated with human diseases including neurodegenerative disorders. In the last years the notion that neurodegenerative diseases are accompanied by chronic viral infections, which may result in an increase of neurodegenerative diseases progression, emerged. It is known in literature that enhanced viral infection risk, observed during neurodegeneration, is partly due to the increase of ROS accumulation in brain cells. However, the molecular mechanisms of viral infection, occurring during the progression of neurodegeneration, remain unclear. In this review, we discuss the recent knowledge regarding the role of influenza, herpes simplex virus type-1, and retroviruses infection in ROS/RNS-mediated Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Halliwell, B" uniqKey="Halliwell B">B. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Oxid Med Cell Longev</journal-id><journal-id journal-id-type="iso-abbrev">Oxid Med Cell Longev</journal-id><journal-id journal-id-type="publisher-id">OMCL</journal-id><journal-title-group><journal-title>Oxidative Medicine and Cellular Longevity</journal-title></journal-title-group><issn pub-type="ppub">1942-0900</issn><issn pub-type="epub">1942-0994</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27110325</article-id><article-id pub-id-type="pmc">4826696</article-id><article-id pub-id-type="doi">10.1155/2016/6547248</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Redox Imbalance and Viral Infections in Neurodegenerative Diseases</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Limongi</surname><given-names>Dolores</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-7003-3172</contrib-id><name><surname>Baldelli</surname><given-names>Sara</given-names></name><xref ref-type="aff" rid="I1"></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="I1">Università Telematica San Raffaele Roma, Via di Val Cannuta, 00167 Rome, Italy</aff><author-notes><corresp id="cor1">*Sara Baldelli: <email>sara.baldelli@unisanraffaele.gov.it</email></corresp><fn fn-type="other"><p>Academic Editor: Michael Courtney</p></fn></author-notes><pub-date pub-type="ppub"><year>2016</year></pub-date><pub-date pub-type="epub"><day>27</day><month>3</month><year>2016</year></pub-date><volume>2016</volume><elocation-id>6547248</elocation-id><history><date date-type="received"><day>3</day><month>12</month><year>2015</year></date><date date-type="rev-recd"><day>7</day><month>3</month><year>2016</year></date><date date-type="accepted"><day>10</day><month>3</month><year>2016</year></date></history><permissions><copyright-statement>Copyright © 2016 D. Limongi and S. Baldelli.</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Reactive oxygen species (ROS) are essential molecules for many physiological functions and act as second messengers in a large variety of tissues. An imbalance in the production and elimination of ROS is associated with human diseases including neurodegenerative disorders. In the last years the notion that neurodegenerative diseases are accompanied by chronic viral infections, which may result in an increase of neurodegenerative diseases progression, emerged. It is known in literature that enhanced viral infection risk, observed during neurodegeneration, is partly due to the increase of ROS accumulation in brain cells. However, the molecular mechanisms of viral infection, occurring during the progression of neurodegeneration, remain unclear. In this review, we discuss the recent knowledge regarding the role of influenza, herpes simplex virus type-1, and retroviruses infection in ROS/RNS-mediated Parkinson's disease (PD), Alzheimer's disease (AD), and amyotrophic lateral sclerosis (ALS).</p></abstract></article-meta></front><floats-group><fig id="fig1" orientation="portrait" position="float"><label>Figure 1</label><caption><p>Main characteristics that occur in neurodegenerative diseases.</p></caption><graphic xlink:href="OMCL2016-6547248.001"></graphic></fig><fig id="fig2" orientation="portrait" position="float"><label>Figure 2</label><caption><p>Different genetic and/or environmental factors lead to ROS increase during neurodegeneration. This accumulation triggered the activation of glia cells and the release of proinflammatory markers, stimulating thus a neuroinflammatory response. These events contribute to neuronal damage (DNA damage, lipid peroxidation, and protein oxidation) and axon degeneration, which ultimately caused neuronal death. In addition, virus infection can strengthen the ROS-mediated neurodegenerative signs in neurons and glia cells, producing functional and molecular hallmarks of neurodegeneration.</p></caption><graphic xlink:href="OMCL2016-6547248.002"></graphic></fig></floats-group></pmc><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Limongi, Dolores" sort="Limongi, Dolores" uniqKey="Limongi D" first="Dolores" last="Limongi">Dolores Limongi</name></region><name sortKey="Baldelli, Sara" sort="Baldelli, Sara" uniqKey="Baldelli S" first="Sara" last="Baldelli">Sara Baldelli</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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