TelematiV1, Ncbi, Curation, bibRecord, 000962

Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients

Identifieur interne : 000962 ( Ncbi/Curation ); précédent : 000961; suivant : 000963

Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients

Auteurs : Hong Sun ; Maria J. Buzon ; Amy Shaw ; Randi Karteebahn Berg [Danemark] ; Xu G. Yu ; Sara Ferrando-Martinez ; Manuel Leal ; Ezequiel Ruiz-Mateos ; Mathias Lichterfeld

Source :

The Journal of Infectious Diseases [ 0022-1899 ] ; 2013.

RBID : PMC:3982848

Abstract

Combined treatment with interferon alpha (IFN-α) and ribavirin (RBV) can effectively cure HCV infection in a significant proportion of patients, but effects of this regimen on cellular reservoirs for human immunodeficiency virus type 1 (HIV-1) are unknown. Here, we show that treatment with IFN-α/RBV led to a moderate but significant and sustained decline of HIV-1 DNA in CD4 T cells from HIV-1/hepatitis C virus–coinfected patients receiving highly active antiretroviral therapy (n = 12). However, in vitro experiments failed to demonstrate an effect of pharmacological doses of IFN-α on HIV-1 reactivation. Together, these data suggest that treatment with IFN-α/RBV can moderately reduce the reservoir of HIV-1–infected CD4 T cells that persists despite suppressive antiretroviral therapy.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982848

DOI: 10.1093/infdis/jit628
PubMed: 24277743
PubMed Central: 3982848

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PMC:3982848

Le document en format XML

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<author><name sortKey="Sun, Hong" sort="Sun, Hong" uniqKey="Sun H" first="Hong" last="Sun">Hong Sun</name>
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,<institution>First Affiliated Hospital of China Medical University</institution>
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<author><name sortKey="Yu, Xu G" sort="Yu, Xu G" uniqKey="Yu X" first="Xu G." last="Yu">Xu G. Yu</name>
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</nlm:aff>
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<author><name sortKey="Ferrando Martinez, Sara" sort="Ferrando Martinez, Sara" uniqKey="Ferrando Martinez S" first="Sara" last="Ferrando-Martinez">Sara Ferrando-Martinez</name>
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,<institution>Virgen del Rocío University Hospital, University of Seville</institution>
</nlm:aff>
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</nlm:aff>
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,<addr-line>Madrid</addr-line>
</nlm:aff>
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</nlm:aff>
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,<addr-line>Sevilla</addr-line>
</nlm:aff>
</affiliation>
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<author><name sortKey="Ruiz Mateos, Ezequiel" sort="Ruiz Mateos, Ezequiel" uniqKey="Ruiz Mateos E" first="Ezequiel" last="Ruiz-Mateos">Ezequiel Ruiz-Mateos</name>
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<front><div type="abstract" xml:lang="en"><p>Combined treatment with interferon alpha (IFN-α) and ribavirin (RBV) can effectively cure HCV infection in a significant proportion of patients, but effects of this regimen on cellular reservoirs for human immunodeficiency virus type 1 (HIV-1) are unknown. Here, we show that treatment with IFN-α/RBV led to a moderate but significant and sustained decline of HIV-1 DNA in CD4 T cells from HIV-1/hepatitis C virus–coinfected patients receiving highly active antiretroviral therapy (n = 12). However, in vitro experiments failed to demonstrate an effect of pharmacological doses of IFN-α on HIV-1 reactivation. Together, these data suggest that treatment with IFN-α/RBV can moderately reduce the reservoir of HIV-1–infected CD4 T cells that persists despite suppressive antiretroviral therapy.</p>
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Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients

Hepatitis C Therapy With Interferon-α and Ribavirin Reduces CD4 T-Cell–Associated HIV-1 DNA in HIV-1/Hepatitis C Virus–Coinfected Patients

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Abstract

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