Drug use in children: cohort study in three European countries
Identifieur interne : 000610 ( Ncbi/Curation ); précédent : 000609; suivant : 000611Drug use in children: cohort study in three European countries
Auteurs : Miriam C J M. Sturkenboom [Pays-Bas] ; Katia M C. Verhamme [Pays-Bas] ; Alfredo Nicolosi [Italie, États-Unis] ; Macey L. Murray [Royaume-Uni] ; Antje Neubert [Royaume-Uni] ; Daan Caudri [Pays-Bas] ; Gino Picelli [Italie] ; Elif Fatma Sen [Pays-Bas] ; Carlo Giaquinto [Italie] ; Luigi Cantarutti [Italie] ; Paola Baiardi [Italie] ; Maria-Grazia Felisi [Italie] ; Adriana Ceci [Italie] ; Ian C K. Wong [Royaume-Uni]Source :
- The BMJ [ 0959-8138 ] ; 2008.
Abstract
Url:
DOI: 10.1136/bmj.a2245
PubMed: 19029175
PubMed Central: 2593449
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PMC:2593449Le document en format XML
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Drug use in children: cohort study in three European countries</title>
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<author><name sortKey="Verhamme, Katia M C" sort="Verhamme, Katia M C" uniqKey="Verhamme K" first="Katia M C" last="Verhamme">Katia M C. Verhamme</name>
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<author><name sortKey="Nicolosi, Alfredo" sort="Nicolosi, Alfredo" uniqKey="Nicolosi A" first="Alfredo" last="Nicolosi">Alfredo Nicolosi</name>
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<affiliation wicri:level="4"><nlm:aff id="aff4">GH Sergievsky Center, School of Public Health, Columbia University, New York, NY 10032, US</nlm:aff>
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<settlement type="city">New York</settlement>
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<orgName type="university">Université Columbia</orgName>
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<author><name sortKey="Murray, Macey L" sort="Murray, Macey L" uniqKey="Murray M" first="Macey L" last="Murray">Macey L. Murray</name>
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<orgName type="university">Université de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
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<author><name sortKey="Neubert, Antje" sort="Neubert, Antje" uniqKey="Neubert A" first="Antje" last="Neubert">Antje Neubert</name>
<affiliation wicri:level="4"><nlm:aff id="aff5">Centre for Paediatric Pharmacy Research, School of Pharmacy and Institute of Child Health, University of London, London WC1N 1AX</nlm:aff>
<orgName type="university">Université de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
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<author><name sortKey="Caudri, Daan" sort="Caudri, Daan" uniqKey="Caudri D" first="Daan" last="Caudri">Daan Caudri</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Informatics, Erasmus University Medical Centre, 3000CA Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Informatics, Erasmus University Medical Centre, 3000CA Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
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</placeName>
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<author><name sortKey="Picelli, Gino" sort="Picelli, Gino" uniqKey="Picelli G" first="Gino" last="Picelli">Gino Picelli</name>
<affiliation wicri:level="1"><nlm:aff id="aff6">International Pharmacoepidemiology and Pharmacoeconomics Research Centre, 20033 Desio, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>International Pharmacoepidemiology and Pharmacoeconomics Research Centre, 20033 Desio</wicri:regionArea>
<wicri:noRegion>20033 Desio</wicri:noRegion>
</affiliation>
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<author><name sortKey="Sen, Elif Fatma" sort="Sen, Elif Fatma" uniqKey="Sen E" first="Elif Fatma" last="Sen">Elif Fatma Sen</name>
<affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medical Informatics, Erasmus University Medical Centre, 3000CA Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Medical Informatics, Erasmus University Medical Centre, 3000CA Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
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<author><name sortKey="Giaquinto, Carlo" sort="Giaquinto, Carlo" uniqKey="Giaquinto C" first="Carlo" last="Giaquinto">Carlo Giaquinto</name>
<affiliation wicri:level="1"><nlm:aff id="aff7">Department of Paediatrics, University Hospital, Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Department of Paediatrics, University Hospital, Padua</wicri:regionArea>
<wicri:noRegion>Padua</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Cantarutti, Luigi" sort="Cantarutti, Luigi" uniqKey="Cantarutti L" first="Luigi" last="Cantarutti">Luigi Cantarutti</name>
<affiliation wicri:level="1"><nlm:aff id="aff8">Società Servizi Telematici 35138 Padua, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Società Servizi Telematici 35138 Padua</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Baiardi, Paola" sort="Baiardi, Paola" uniqKey="Baiardi P" first="Paola" last="Baiardi">Paola Baiardi</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia</wicri:regionArea>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Felisi, Maria Grazia" sort="Felisi, Maria Grazia" uniqKey="Felisi M" first="Maria-Grazia" last="Felisi">Maria-Grazia Felisi</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia</wicri:regionArea>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ceci, Adriana" sort="Ceci, Adriana" uniqKey="Ceci A" first="Adriana" last="Ceci">Adriana Ceci</name>
<affiliation wicri:level="1"><nlm:aff id="aff9">Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia, Italy</nlm:aff>
<country xml:lang="fr">Italie</country>
<wicri:regionArea>Consorzio per Valutazioni Biologiche e Farmacologiche, 27100 Pavia</wicri:regionArea>
<wicri:noRegion>27100 Pavia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wong, Ian C K" sort="Wong, Ian C K" uniqKey="Wong I" first="Ian C K" last="Wong">Ian C K. Wong</name>
<affiliation wicri:level="4"><nlm:aff id="aff5">Centre for Paediatric Pharmacy Research, School of Pharmacy and Institute of Child Health, University of London, London WC1N 1AX</nlm:aff>
<orgName type="university">Université de Londres</orgName>
<country>Royaume-Uni</country>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">The BMJ</title>
<idno type="ISSN">0959-8138</idno>
<idno type="eISSN">1756-1833</idno>
<imprint><date when="2008">2008</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p><bold>Objective</bold>
To provide an overview of drug use in children in three European countries.</p>
<p><bold>Design</bold>
Retrospective cohort study, 2000-5.</p>
<p><bold>Setting</bold>
Primary care research databases in the Netherlands (IPCI), United Kingdom (IMS-DA), and Italy (Pedianet).</p>
<p><bold>Participants</bold>
675 868 children aged up to 14 (Italy) or 18 (UK and Netherlands).</p>
<p><bold>Main outcome measure</bold>
Prevalence of use per year calculated by drug class (anatomical and therapeutic). Prevalence of “recurrent/chronic” use (three or more prescriptions a year) and “non-recurrent” or “acute” use (less than three prescriptions a year) within each therapeutic class. Descriptions of the top five most commonly used drugs evaluated for off label status within each anatomical class.</p>
<p><bold>Results</bold>
Three levels of drug use could be distinguished in the study population: high (>10/100 children per year), moderate (1-10/100 children per year), and low (<1/100 children per year). For all age categories, anti-infective, dermatological, and respiratory drugs were in the high use group, whereas cardiovascular and antineoplastic drugs were always in the low use group. Emollients, topical steroids, and asthma drugs had the highest prevalence of recurrent use, but relative use of low prevalence drugs was more often recurrent than acute. In the top five highest prevalence drugs topical inhaled and systemic steroids, oral contraceptives, and topical or systemic antifungal drugs were most commonly used off label.</p>
<p><bold>Conclusion</bold>
This overview of outpatient paediatric prescription patterns in a large European population could provide information to prioritise paediatric therapeutic research needs.</p>
</div>
</front>
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