The patient cohort of the German competence network for HIV/AIDS (KompNet):a profile
Identifieur interne : 000F56 ( Main/Merge ); précédent : 000F55; suivant : 000F57The patient cohort of the German competence network for HIV/AIDS (KompNet):a profile
Auteurs : K. Jansen ; C. Michalik ; M. Hahn ; S. Dupke [Allemagne] ; S. Esser ; H. Jaeger [Allemagne] ; S. Köppe [Allemagne] ; A. Moll [Allemagne] ; A. Plettenberg [Allemagne] ; Re Schmidt ; A. Skaletz-Rorowski ; Nh Brockmeyer [Allemagne]Source :
- European Journal of Medical Research [ 0949-2321 ] ; 2009.
Abstract
In this paper, we describe the main objectives, the study design and the onset of the patient cohort of the German Competence Network for HIV/AIDS (KompNet). Furthermore, we depict sociodemographic and clinical baseline characteristics and an estimation of the coverage and representativity as to the composition of persons living with HIV/AIDS (PLWHA) in Germany.
The KompNet cohort is an open, retrospective and prospective, multicenter, disease-specific and nationwide cohort study that started gathering data in June 2004. Semi-annually, follow up visits of the patients are documented, covering clinical and sociodemographic data. At enrolment and three years afterwards, an EDTA-sample is taken; a serum-sample is taken at every follow up visit.
As of 14.9.2008, a total of 15,541 patients were enrolled by 44 documenting sites. In September 2007, the cohort size was reduced to 10 outpatient clinics and fifteen private practitioners, covering a total of 9,410 patients. The documentation of these patients comprises 24,117 years of follow up-time since enrolment (mean: 2.6 years), 62,862 person years inclusive data documented retrospectively on course of HIV-infection and combined antiretroviral therapy (cART, mean: 6.7 years). 1,008 patients (10.7%) were lost to follow up and 175 (1.9%) died since enrolment. 84.9% of patients were men. Main risks of transmission were sex between men (MSM: 62.9%), heterosexual contacts (18.4%), intravenous drug use (IVDU: 7.0%) and origin from a high prevalence country (HPL: 5.2%). Mean age was 45 years.
The KompNet cohort covers about a quarter of all patients being under treatment in Germany. The composition of the cohort represents well the most important risks of transmission in Germany. The cohort contains a high proportion of patients being older than 49 years (28.1%). On basis of its comprehensive database and its biomaterials banks, the KompNet cohort serves as an important instrument to monitor and analyse the effects of combined antiretroviral therapy (cART) in Germany, interdigidating basis, clinical and psychosocial research in view to translational research.
Url:
DOI: 10.1186/2047-783X-14-8-323
PubMed: 19666392
PubMed Central: 3352164
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PMC:3352164Le document en format XML
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Hahn</name><affiliation><nlm:aff id="I3">Institut für Medizinische Statistik, Informatik und Epidemiologie, Köln</nlm:aff><wicri:noCountry code="subfield">Köln</wicri:noCountry></affiliation></author><author><name sortKey="Dupke, S" sort="Dupke, S" uniqKey="Dupke S" first="S" last="Dupke">S. Dupke</name><affiliation wicri:level="3"><nlm:aff id="I4">Gemeinschaftspraxis Driesener Straße, Berlin</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Berlin</settlement><region type="land" nuts="2">Berlin</region></placeName><wicri:orgArea>Gemeinschaftspraxis Driesener Straße</wicri:orgArea></affiliation></author><author><name sortKey="Esser, S" sort="Esser, S" uniqKey="Esser S" first="S" last="Esser">S. Esser</name><affiliation><nlm:aff id="I5">Universitätsklinik, Essen</nlm:aff><wicri:noCountry code="subfield">Essen</wicri:noCountry></affiliation></author><author><name sortKey="Jaeger, H" sort="Jaeger, H" uniqKey="Jaeger H" first="H" last="Jaeger">H. 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Plettenberg</name><affiliation wicri:level="3"><nlm:aff id="I9">Ifi-Institut, Hamburg</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName><wicri:orgArea>Ifi-Institut</wicri:orgArea></affiliation></author><author><name sortKey="Schmidt, Re" sort="Schmidt, Re" uniqKey="Schmidt R" first="Re" last="Schmidt">Re Schmidt</name><affiliation><nlm:aff id="I10">Medizinische Hochschule, Hannover</nlm:aff><wicri:noCountry code="subfield">Hannover</wicri:noCountry></affiliation></author><author><name sortKey="Skaletz Rorowski, A" sort="Skaletz Rorowski, A" uniqKey="Skaletz Rorowski A" first="A" last="Skaletz-Rorowski">A. Skaletz-Rorowski</name><affiliation><nlm:aff id="I1">Kompetenznetz HIV/AIDS, Ruhruniversität, Bochum</nlm:aff><wicri:noCountry code="subfield">Bochum</wicri:noCountry></affiliation></author><author><name sortKey="Brockmeyer, Nh" sort="Brockmeyer, Nh" uniqKey="Brockmeyer N" first="Nh" last="Brockmeyer">Nh Brockmeyer</name><affiliation><nlm:aff id="I1">Kompetenznetz HIV/AIDS, Ruhruniversität, Bochum</nlm:aff><wicri:noCountry code="subfield">Bochum</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="I11">Universitätsklinik, Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinik, Bochum</wicri:regionArea><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19666392</idno><idno type="pmc">3352164</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3352164</idno><idno type="RBID">PMC:3352164</idno><idno type="doi">10.1186/2047-783X-14-8-323</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000446</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000446</idno><idno type="wicri:Area/Pmc/Curation">000446</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000446</idno><idno type="wicri:Area/Pmc/Checkpoint">000432</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000432</idno><idno type="wicri:Area/Ncbi/Merge">000643</idno><idno type="wicri:Area/Ncbi/Curation">000643</idno><idno type="wicri:Area/Ncbi/Checkpoint">000643</idno><idno type="wicri:doubleKey">0949-2321:2009:Jansen K:the:patient:cohort</idno><idno type="wicri:Area/Main/Merge">000F56</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The patient cohort of the German competence network for HIV/AIDS (KompNet):a profile</title><author><name sortKey="Jansen, K" sort="Jansen, K" uniqKey="Jansen K" first="K" last="Jansen">K. Jansen</name><affiliation><nlm:aff id="I1">Kompetenznetz HIV/AIDS, Ruhruniversität, Bochum</nlm:aff><wicri:noCountry code="subfield">Bochum</wicri:noCountry></affiliation></author><author><name sortKey="Michalik, C" sort="Michalik, C" uniqKey="Michalik C" first="C" last="Michalik">C. Michalik</name><affiliation><nlm:aff id="I2">Zentrum für Klinische Studien, Köln</nlm:aff><wicri:noCountry code="subfield">Köln</wicri:noCountry></affiliation></author><author><name sortKey="Hahn, M" sort="Hahn, M" uniqKey="Hahn M" first="M" last="Hahn">M. Hahn</name><affiliation><nlm:aff id="I3">Institut für Medizinische Statistik, Informatik und Epidemiologie, Köln</nlm:aff><wicri:noCountry code="subfield">Köln</wicri:noCountry></affiliation></author><author><name sortKey="Dupke, S" sort="Dupke, S" uniqKey="Dupke S" first="S" last="Dupke">S. Dupke</name><affiliation wicri:level="3"><nlm:aff id="I4">Gemeinschaftspraxis Driesener Straße, Berlin</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Berlin</settlement><region type="land" nuts="2">Berlin</region></placeName><wicri:orgArea>Gemeinschaftspraxis Driesener Straße</wicri:orgArea></affiliation></author><author><name sortKey="Esser, S" sort="Esser, S" uniqKey="Esser S" first="S" last="Esser">S. Esser</name><affiliation><nlm:aff id="I5">Universitätsklinik, Essen</nlm:aff><wicri:noCountry code="subfield">Essen</wicri:noCountry></affiliation></author><author><name sortKey="Jaeger, H" sort="Jaeger, H" uniqKey="Jaeger H" first="H" last="Jaeger">H. Jaeger</name><affiliation wicri:level="3"><nlm:aff id="I6">MVZ Karlsplatz, HIV Research and Clinical Centre, München</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><wicri:orgArea>MVZ Karlsplatz, HIV Research and Clinical Centre</wicri:orgArea></affiliation></author><author><name sortKey="Koppe, S" sort="Koppe, S" uniqKey="Koppe S" first="S" last="Köppe">S. Köppe</name><affiliation wicri:level="3"><nlm:aff id="I7">Gemeinschaftspraxis Mehringdamm, Berlin</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Berlin</settlement><region type="land" nuts="2">Berlin</region></placeName><wicri:orgArea>Gemeinschaftspraxis Mehringdamm</wicri:orgArea></affiliation></author><author><name sortKey="Moll, A" sort="Moll, A" uniqKey="Moll A" first="A" last="Moll">A. Moll</name><affiliation wicri:level="3"><nlm:aff id="I8">Praxiszentrum Kaiserdamm, Berlin</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Berlin</settlement><region type="land" nuts="2">Berlin</region></placeName><wicri:orgArea>Praxiszentrum Kaiserdamm</wicri:orgArea></affiliation></author><author><name sortKey="Plettenberg, A" sort="Plettenberg, A" uniqKey="Plettenberg A" first="A" last="Plettenberg">A. Plettenberg</name><affiliation wicri:level="3"><nlm:aff id="I9">Ifi-Institut, Hamburg</nlm:aff><country>Allemagne</country><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName><wicri:orgArea>Ifi-Institut</wicri:orgArea></affiliation></author><author><name sortKey="Schmidt, Re" sort="Schmidt, Re" uniqKey="Schmidt R" first="Re" last="Schmidt">Re Schmidt</name><affiliation><nlm:aff id="I10">Medizinische Hochschule, Hannover</nlm:aff><wicri:noCountry code="subfield">Hannover</wicri:noCountry></affiliation></author><author><name sortKey="Skaletz Rorowski, A" sort="Skaletz Rorowski, A" uniqKey="Skaletz Rorowski A" first="A" last="Skaletz-Rorowski">A. Skaletz-Rorowski</name><affiliation><nlm:aff id="I1">Kompetenznetz HIV/AIDS, Ruhruniversität, Bochum</nlm:aff><wicri:noCountry code="subfield">Bochum</wicri:noCountry></affiliation></author><author><name sortKey="Brockmeyer, Nh" sort="Brockmeyer, Nh" uniqKey="Brockmeyer N" first="Nh" last="Brockmeyer">Nh Brockmeyer</name><affiliation><nlm:aff id="I1">Kompetenznetz HIV/AIDS, Ruhruniversität, Bochum</nlm:aff><wicri:noCountry code="subfield">Bochum</wicri:noCountry></affiliation><affiliation wicri:level="1"><nlm:aff id="I11">Universitätsklinik, Bochum, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Universitätsklinik, Bochum</wicri:regionArea><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion><wicri:noRegion>Bochum</wicri:noRegion></affiliation></author></analytic><series><title level="j">European Journal of Medical Research</title><idno type="ISSN">0949-2321</idno><idno type="eISSN">2047-783X</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective</title><p>In this paper, we describe the main objectives, the study design and the onset of the patient cohort of the German Competence Network for HIV/AIDS (KompNet). Furthermore, we depict sociodemographic and clinical baseline characteristics and an estimation of the coverage and representativity as to the composition of persons living with HIV/AIDS (PLWHA) in Germany.</p></sec><sec><title>Methods</title><p>The KompNet cohort is an open, retrospective and prospective, multicenter, disease-specific and nationwide cohort study that started gathering data in June 2004. Semi-annually, follow up visits of the patients are documented, covering clinical and sociodemographic data. At enrolment and three years afterwards, an EDTA-sample is taken; a serum-sample is taken at every follow up visit.</p></sec><sec><title>Results</title><p>As of 14.9.2008, a total of 15,541 patients were enrolled by 44 documenting sites. In September 2007, the cohort size was reduced to 10 outpatient clinics and fifteen private practitioners, covering a total of 9,410 patients. The documentation of these patients comprises 24,117 years of follow up-time since enrolment (mean: 2.6 years), 62,862 person years inclusive data documented retrospectively on course of HIV-infection and combined antiretroviral therapy (cART, mean: 6.7 years). 1,008 patients (10.7%) were lost to follow up and 175 (1.9%) died since enrolment. 84.9% of patients were men. Main risks of transmission were sex between men (MSM: 62.9%), heterosexual contacts (18.4%), intravenous drug use (IVDU: 7.0%) and origin from a high prevalence country (HPL: 5.2%). Mean age was 45 years.</p></sec><sec><title>Conclusion</title><p>The KompNet cohort covers about a quarter of all patients being under treatment in Germany. The composition of the cohort represents well the most important risks of transmission in Germany. The cohort contains a high proportion of patients being older than 49 years (28.1%). On basis of its comprehensive database and its biomaterials banks, the KompNet cohort serves as an important instrument to monitor and analyse the effects of combined antiretroviral therapy (cART) in Germany, interdigidating basis, clinical and psychosocial research in view to translational research.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Franz, A" uniqKey="Franz A">A Franz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kouznetsov, L" uniqKey="Kouznetsov L">L Kouznetsov</name></author><author><name sortKey="Kuznetsov, Av" uniqKey="Kuznetsov A">AV Kuznetsov</name></author><author><name sortKey="Wienecke, R" uniqKey="Wienecke R">R Wienecke</name></author><author><name sortKey="Zippel, Sa" uniqKey="Zippel S">SA Zippel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steffan, E" uniqKey="Steffan E">E Steffan</name></author><author><name sortKey="Kerschl, V" uniqKey="Kerschl V">V Kerschl</name></author><author><name sortKey="Sokolowski, S" uniqKey="Sokolowski S">S Sokolowski</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Jansen, K" uniqKey="Jansen K">K Jansen</name></author><author><name sortKey="Brockmeyer, Nh" uniqKey="Brockmeyer N">NH Brockmeyer</name></author><author><name sortKey="Haastert, B" uniqKey="Haastert B">B Haastert</name></author><author><name sortKey="Baumgarten, A" uniqKey="Baumgarten A">A Baumgarten</name></author><author><name sortKey="Stoehr, A" uniqKey="Stoehr A">A Stoehr</name></author><author><name sortKey="Behrens, G" uniqKey="Behrens G">G Behrens</name></author><author><name sortKey="Jaeger, H" uniqKey="Jaeger H">H Jaeger</name></author><author><name sortKey="Hartl, H" uniqKey="Hartl H">H Hartl</name></author><author><name sortKey="Mutz, A" uniqKey="Mutz A">A Mutz</name></author><author><name sortKey="Skaletz Rorowski, A" uniqKey="Skaletz Rorowski A">A Skaletz-Rorowski</name></author><author><name sortKey="Esser, S" uniqKey="Esser S">S Esser</name></author><author><name sortKey="Michalik, C" uniqKey="Michalik C">C Michalik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marcus, U" uniqKey="Marcus U">U Marcus</name></author><author><name sortKey="Michalik, C" uniqKey="Michalik C">C Michalik</name></author><author><name sortKey="Brockmeyer, Nh" uniqKey="Brockmeyer N">NH Brockmeyer</name></author><author><name sortKey="Duglay, V" uniqKey="Duglay V">V Duglay</name></author><author><name sortKey="Zeitz, M" uniqKey="Zeitz M">M Zeitz</name></author><author><name sortKey="Lauenroth Mai, E" uniqKey="Lauenroth Mai E">E Lauenroth-Mai</name></author><author><name sortKey="Hower, M" uniqKey="Hower M">M 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uniqKey="Debold P">P Debold</name></author><author><name sortKey="Specker, C" uniqKey="Specker C">C Specker</name></author><author><name sortKey="Pommenering, K" uniqKey="Pommenering K">K Pommenering</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Wyen, C" uniqKey="Wyen C">C Wyen</name></author><author><name sortKey="Hendra, H" uniqKey="Hendra H">H Hendra</name></author><author><name sortKey="Vogel, M" uniqKey="Vogel M">M Vogel</name></author><author><name sortKey="Hoffmann, C" uniqKey="Hoffmann C">C Hoffmann</name></author><author><name sortKey="Knechten, H" uniqKey="Knechten H">H Knechten</name></author><author><name sortKey="Brockmeyer, Nh" uniqKey="Brockmeyer N">NH Brockmeyer</name></author><author><name sortKey="Bogner, Jr" uniqKey="Bogner J">JR Bogner</name></author><author><name sortKey="Rockstroh, J" uniqKey="Rockstroh J">J Rockstroh</name></author><author><name sortKey="Esser, S" uniqKey="Esser S">S Esser</name></author><author><name sortKey="Jaeger, H" uniqKey="Jaeger H">H Jaeger</name></author><author><name sortKey="Harrer, T" uniqKey="Harrer T">T Harrer</name></author><author><name sortKey="Mauss, S" uniqKey="Mauss S">S Mauss</name></author><author><name sortKey="Van Lunzen, J" uniqKey="Van Lunzen J">J van Lunzen</name></author><author><name sortKey="Skoetz, N" uniqKey="Skoetz N">N Skoetz</name></author><author><name sortKey="Jetter, A" uniqKey="Jetter A">A Jetter</name></author><author><name sortKey="Groneuer, C" uniqKey="Groneuer C">C Groneuer</name></author><author><name sortKey="F Tkenheuer, G" uniqKey="F Tkenheuer G">G Fätkenheuer</name></author><author><name sortKey="Khoo, Sh" uniqKey="Khoo S">SH Khoo</name></author><author><name sortKey="Egan, D" uniqKey="Egan D">D Egan</name></author><author><name sortKey="Back, Dj" uniqKey="Back D">DJ Back</name></author><author><name sortKey="Owen, A" uniqKey="Owen A">A Owen</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kreuter, A" uniqKey="Kreuter A">A Kreuter</name></author><author><name sortKey="Wieland, U" uniqKey="Wieland U">U Wieland</name></author><author><name sortKey="Gambichler, T" uniqKey="Gambichler T">T Gambichler</name></author><author><name sortKey="Altmeyer, P" uniqKey="Altmeyer P">P Altmeyer</name></author><author><name sortKey="Pfister, H" uniqKey="Pfister H">H Pfister</name></author><author><name sortKey="Tenner Racz, K" uniqKey="Tenner Racz K">K Tenner-Racz</name></author><author><name sortKey="Racz, P" uniqKey="Racz P">P Racz</name></author><author><name sortKey="Potthoff, A" uniqKey="Potthoff A">A Potthoff</name></author><author><name sortKey="Brockmeyer, Nh" uniqKey="Brockmeyer N">NH Brockmeyer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arendt, G" uniqKey="Arendt G">G Arendt</name></author><author><name sortKey="Nolting, T" uniqKey="Nolting T">T Nolting</name></author><author><name sortKey="Frisch, C" uniqKey="Frisch C">C Frisch</name></author><author><name sortKey="Husstedt, Iw" uniqKey="Husstedt I">IW Husstedt</name></author><author><name sortKey="Gregor, N" uniqKey="Gregor N">N Gregor</name></author><author><name sortKey="Koutsilieri, E" uniqKey="Koutsilieri E">E Koutsilieri</name></author><author><name sortKey="Maschke, M" uniqKey="Maschke M">M Maschke</name></author><author><name sortKey="Angerer, A" uniqKey="Angerer A">A Angerer</name></author><author><name sortKey="Obermann, M" uniqKey="Obermann M">M Obermann</name></author><author><name sortKey="Neuen Jacob, E" uniqKey="Neuen Jacob E">E Neuen-Jacob</name></author><author><name sortKey="Adams, O" uniqKey="Adams O">O Adams</name></author><author><name sortKey="Loeffert, S" uniqKey="Loeffert S">S Loeffert</name></author><author><name sortKey="Riederer, P" uniqKey="Riederer P">P Riederer</name></author><author><name sortKey="Ter Meulen, V" uniqKey="Ter Meulen V">V ter Meulen</name></author><author><name sortKey="Sopper, S" uniqKey="Sopper S">S Sopper</name></author></analytic></biblStruct></listBibl></div1></back></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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