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Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.

Identifieur interne : 000010 ( PubMed/Curation ); précédent : 000009; suivant : 000011

Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.

Auteurs : Hun Kim [Corée du Sud] ; Sungwook Song [Corée du Sud] ; Jinyeong Yim [Corée du Sud] ; Hyun Ok Kim [Corée du Sud] ; Chulmin Joo [Corée du Sud]

Source :

RBID : pubmed:25312865

English descriptors

Abstract

We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients.

DOI: 10.1016/j.cca.2014.10.001
PubMed: 25312865

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pubmed:25312865

Le document en format XML

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<name sortKey="Kim, Hun" sort="Kim, Hun" uniqKey="Kim H" first="Hun" last="Kim">Hun Kim</name>
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<nlm:affiliation>School of Mechanical Engineering, Yonsei University, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-749, Republic of Korea.</nlm:affiliation>
<country xml:lang="fr">Corée du Sud</country>
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<name sortKey="Song, Sungwook" sort="Song, Sungwook" uniqKey="Song S" first="Sungwook" last="Song">Sungwook Song</name>
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<name sortKey="Yim, Jinyeong" sort="Yim, Jinyeong" uniqKey="Yim J" first="Jinyeong" last="Yim">Jinyeong Yim</name>
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<name sortKey="Joo, Chulmin" sort="Joo, Chulmin" uniqKey="Joo C" first="Chulmin" last="Joo">Chulmin Joo</name>
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<name sortKey="Kim, Hyun Ok" sort="Kim, Hyun Ok" uniqKey="Kim H" first="Hyun Ok" last="Kim">Hyun Ok Kim</name>
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<title level="j">Clinica chimica acta; international journal of clinical chemistry</title>
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<term>Thermography</term>
<term>Tomography, Optical Coherence</term>
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<term>Hemoglobins</term>
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<term>Anemia</term>
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<div type="abstract" xml:lang="en">We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients.</div>
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<Day>03</Day>
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<Month>08</Month>
<Day>26</Day>
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<Title>Clinica chimica acta; international journal of clinical chemistry</Title>
<ISOAbbreviation>Clin. Chim. Acta</ISOAbbreviation>
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<ArticleTitle>Hemoglobin assay in anemic patients with a photothermal spectral-domain optical coherence reflectometric sensor.</ArticleTitle>
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<AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">We recently introduced an optical sensor, termed photothermal spectral-domain optical coherence reflectometer (PT SD-OCR), capable of direct measurement of hemoglobin concentration ([Hb]) without chemicals and pre-processing of blood. PT SD-OCR measures [Hb] by quantifying refractive index changes of blood samples due to photothermal effect under the irradiation of 532-nm light. We evaluated diagnostic accuracy and precision of PT SD-OCR in anemic patients.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">We used PT SD-OCR to measure [Hb] in 50 anemic patients, and examined its accuracy against a hematology analyzer (ADVIA 2120i, Siemens AG). Its precision was assessed by examining the SD and CV based on 20 repeated measurements on 3 blood samples. Its performance was also compared with a hemoglobinometer (HemoCue 201+, HemoCue).</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">The PT SD-OCR demonstrated good correspondence with the hematology analyzer with a Pearson's correlation coefficient of 0.992 and a bias of -0.055 g/dl. Standard deviation and CV were measured to be <0.25 g/dl and <2.05%.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Simple and chemical-free operation of PT SD-OCR enabled rapid and accurate measurement of [Hb] in anemic patients. The sensor is expected to facilitate clinical procedures related to blood-related disorders in patient care.</AbstractText>
<CopyrightInformation>Copyright © 2014 Elsevier B.V. All rights reserved.</CopyrightInformation>
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<Keyword MajorTopicYN="N">Anemia</Keyword>
<Keyword MajorTopicYN="N">Hemoglobin concentration</Keyword>
<Keyword MajorTopicYN="N">Optical interferometer</Keyword>
<Keyword MajorTopicYN="N">Optical sensor</Keyword>
<Keyword MajorTopicYN="N">Photothermal effect</Keyword>
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