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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early life stress sensitizes the renal and systemic sympathetic system in rats</title><author><name sortKey="Loria, Analia S" sort="Loria, Analia S" uniqKey="Loria A" first="Analia S." last="Loria">Analia S. Loria</name><affiliation><nlm:aff id="aff1">Section of Experimental Medicine,</nlm:aff></affiliation></author><author><name sortKey="Brands, Michael W" sort="Brands, Michael W" uniqKey="Brands M" first="Michael W." last="Brands">Michael W. Brands</name><affiliation><nlm:aff id="aff2">Department of Physiology, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Pollock, David M" sort="Pollock, David M" uniqKey="Pollock D" first="David M." last="Pollock">David M. Pollock</name><affiliation><nlm:aff id="aff1">Section of Experimental Medicine,</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Physiology, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Pollock, Jennifer S" sort="Pollock, Jennifer S" uniqKey="Pollock J" first="Jennifer S." last="Pollock">Jennifer S. Pollock</name><affiliation><nlm:aff id="aff1">Section of Experimental Medicine,</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Physiology, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23678041</idno><idno type="pmc">3742864</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3742864</idno><idno type="RBID">PMC:3742864</idno><idno type="doi">10.1152/ajprenal.00008.2013</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000056</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000056</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early life stress sensitizes the renal and systemic sympathetic system in rats</title><author><name sortKey="Loria, Analia S" sort="Loria, Analia S" uniqKey="Loria A" first="Analia S." last="Loria">Analia S. Loria</name><affiliation><nlm:aff id="aff1">Section of Experimental Medicine,</nlm:aff></affiliation></author><author><name sortKey="Brands, Michael W" sort="Brands, Michael W" uniqKey="Brands M" first="Michael W." last="Brands">Michael W. Brands</name><affiliation><nlm:aff id="aff2">Department of Physiology, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Pollock, David M" sort="Pollock, David M" uniqKey="Pollock D" first="David M." last="Pollock">David M. Pollock</name><affiliation><nlm:aff id="aff1">Section of Experimental Medicine,</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Physiology, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author><author><name sortKey="Pollock, Jennifer S" sort="Pollock, Jennifer S" uniqKey="Pollock J" first="Jennifer S." last="Pollock">Jennifer S. Pollock</name><affiliation><nlm:aff id="aff1">Section of Experimental Medicine,</nlm:aff></affiliation><affiliation><nlm:aff id="aff2">Department of Physiology, Georgia Regents University, Augusta, Georgia</nlm:aff></affiliation></author></analytic><series><title level="j">American Journal of Physiology - Renal Physiology</title><idno type="ISSN">1931-857X</idno><idno type="eISSN">1522-1466</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>We hypothesized that maternal separation (MS), an early life stress model, induces a sensitization of the sympathetic system. To test this hypothesis, we evaluated the renal and systemic sympathetic system in 12- to 14-wk-old male control or MS rats with the following parameters: <italic>1</italic>) effect of renal denervation on conscious renal filtration capacity, <italic>2</italic>) norepinephrine (NE) content in key organs involved in blood pressure control, and <italic>3</italic>) acute systemic pressor responses to adrenergic stimulation or ganglion blockade. MS was performed by separating pups from their mothers for 3 h/day from <italic>day 2</italic> to <italic>14</italic>; controls were nonhandled littermates. Glomerular filtration rate (GFR) was examined in renal denervated (DnX; within 2 wk) or sham rats using I<sup>125</sup>-iothalamate plasma clearance. MS-DnX rats showed significantly increased GFR compared with MS-SHAM rats (3.8 ± 0.4 vs. 2.4 ± 0.2 ml/min, respectively, <italic>P</italic> < 0.05), whereas DnX had no effect in controls, indicating that renal nerves regulate GFR in MS rats. NE content was significantly increased in organ tissues from MS rats (<italic>P</italic> < 0.05, <italic>n</italic> = 6–8), suggesting a sensitization of the renal and systemic sympathetic system. Conscious MS rats displayed a significantly greater increase in mean arterial pressure (MAP) in response to NE (2 μg/kg ip) and a greater reduction in MAP in response to mecamylamine (2 mg/kg ip, <italic>P</italic> < 0.05, <italic>n</italic> = 4) monitored by telemetry, indicating that MS rats exhibit exaggerated responses to sympathetic stimulation. In conclusion, these data indicate that MS sensitizes the renal and systemic sympathetic system ultimately impairing blood pressure regulation.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Physiol Renal Physiol</journal-id><journal-id journal-id-type="iso-abbrev">Am. J. Physiol. Renal Physiol</journal-id><journal-id journal-id-type="hwp">ajprenal</journal-id><journal-id journal-id-type="pmc">ajprenal</journal-id><journal-id journal-id-type="publisher-id">AJPRENAL</journal-id><journal-title-group><journal-title>American Journal of Physiology - Renal Physiology</journal-title></journal-title-group><issn pub-type="ppub">1931-857X</issn><issn pub-type="epub">1522-1466</issn><publisher><publisher-name>American Physiological Society</publisher-name><publisher-loc>Bethesda, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23678041</article-id><article-id pub-id-type="pmc">3742864</article-id><article-id pub-id-type="publisher-id">F-00008-2013</article-id><article-id pub-id-type="doi">10.1152/ajprenal.00008.2013</article-id><article-categories><subj-group subj-group-type="heading"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Early life stress sensitizes the renal and systemic sympathetic system in rats</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Loria</surname><given-names>Analia S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Brands</surname><given-names>Michael W.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pollock</surname><given-names>David M.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pollock</surname><given-names>Jennifer S.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><sup>1</sup>Section of Experimental Medicine,</aff><aff id="aff2"><sup>2</sup>Department of Physiology, Georgia Regents University, Augusta, Georgia</aff></contrib-group><author-notes><corresp id="cor1">Address for reprint requests and other correspondence: A. S. Loria, <addr-line>Section of Experimental Medicine, CB 2200, 1459 Laney Walker Blvd., Dept. of Medicine, Georgia Regents Univ., Augusta, GA 30912</addr-line> (e-mail: <email>aloria@gru.edu</email>).</corresp></author-notes><pub-date pub-type="epub"><day>15</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="ppub"><day>1</day><month>8</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>8</month><year>2014</year></pub-date><pmc-comment> PMC Release delay is 12 months and
0 days and was based on the
<volume>305</volume><issue>3</issue><fpage>F390</fpage><lpage>F395</lpage><history><date date-type="received"><day>7</day><month>1</month><year>2013</year></date><date date-type="accepted"><day>9</day><month>5</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2013 the American Physiological Society</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>American Physiological Society</copyright-holder></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zh201513000390.pdf"></self-uri><abstract><p>We hypothesized that maternal separation (MS), an early life stress model, induces a sensitization of the sympathetic system. To test this hypothesis, we evaluated the renal and systemic sympathetic system in 12- to 14-wk-old male control or MS rats with the following parameters: <italic>1</italic>) effect of renal denervation on conscious renal filtration capacity, <italic>2</italic>) norepinephrine (NE) content in key organs involved in blood pressure control, and <italic>3</italic>) acute systemic pressor responses to adrenergic stimulation or ganglion blockade. MS was performed by separating pups from their mothers for 3 h/day from <italic>day 2</italic> to <italic>14</italic>; controls were nonhandled littermates. Glomerular filtration rate (GFR) was examined in renal denervated (DnX; within 2 wk) or sham rats using I<sup>125</sup>-iothalamate plasma clearance. MS-DnX rats showed significantly increased GFR compared with MS-SHAM rats (3.8 ± 0.4 vs. 2.4 ± 0.2 ml/min, respectively, <italic>P</italic> < 0.05), whereas DnX had no effect in controls, indicating that renal nerves regulate GFR in MS rats. NE content was significantly increased in organ tissues from MS rats (<italic>P</italic> < 0.05, <italic>n</italic> = 6–8), suggesting a sensitization of the renal and systemic sympathetic system. Conscious MS rats displayed a significantly greater increase in mean arterial pressure (MAP) in response to NE (2 μg/kg ip) and a greater reduction in MAP in response to mecamylamine (2 mg/kg ip, <italic>P</italic> < 0.05, <italic>n</italic> = 4) monitored by telemetry, indicating that MS rats exhibit exaggerated responses to sympathetic stimulation. In conclusion, these data indicate that MS sensitizes the renal and systemic sympathetic system ultimately impairing blood pressure regulation.</p></abstract><kwd-group><kwd>early life stress</kwd><kwd>denervation</kwd><kwd>glomerular filtration rate</kwd><kwd>maternal separation</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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