Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes
Identifieur interne : 000082 ( Pmc/Checkpoint ); précédent : 000081; suivant : 000083Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes
Auteurs : Valentina Loria [Italie] ; Ilaria Dato [Italie] ; Francesca Graziani [Italie] ; Luigi M. Biasucci [Italie]Source :
- Mediators of Inflammation [ 0962-9351 ] ; 2008.
Abstract
Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).
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DOI: 10.1155/2008/135625
PubMed: 18382609
PubMed Central: 2276594
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Biasucci</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">18382609</idno><idno type="pmc">2276594</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276594</idno><idno type="RBID">PMC:2276594</idno><idno type="doi">10.1155/2008/135625</idno><date when="2008">2008</date><idno type="wicri:Area/Pmc/Corpus">000092</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000092</idno><idno type="wicri:Area/Pmc/Curation">000092</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000092</idno><idno type="wicri:Area/Pmc/Checkpoint">000082</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000082</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes</title><author><name sortKey="Loria, Valentina" sort="Loria, Valentina" uniqKey="Loria V" first="Valentina" last="Loria">Valentina Loria</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Dato, Ilaria" sort="Dato, Ilaria" uniqKey="Dato I" first="Ilaria" last="Dato">Ilaria Dato</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Graziani, Francesca" sort="Graziani, Francesca" uniqKey="Graziani F" first="Francesca" last="Graziani">Francesca Graziani</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author><author><name sortKey="Biasucci, Luigi M" sort="Biasucci, Luigi M" uniqKey="Biasucci L" first="Luigi M." last="Biasucci">Luigi M. Biasucci</name><affiliation wicri:level="1"><nlm:aff id="I1">Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea>Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome</wicri:regionArea><placeName><settlement type="city">Rome</settlement><region nuts="2">Latium</region></placeName></affiliation></author></analytic><series><title level="j">Mediators of Inflammation</title><idno type="ISSN">0962-9351</idno><idno type="eISSN">1466-1861</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article" xml:lang="EN"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Mediators Inflamm</journal-id><journal-id journal-id-type="publisher-id">MI</journal-id><journal-title>Mediators of Inflammation</journal-title><issn pub-type="ppub">0962-9351</issn><issn pub-type="epub">1466-1861</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">18382609</article-id><article-id pub-id-type="pmc">2276594</article-id><article-id pub-id-type="doi">10.1155/2008/135625</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title>Myeloperoxidase: A New Biomarker of Inflammation in Ischemic Heart Disease and Acute Coronary Syndromes</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Loria</surname><given-names>Valentina</given-names></name><xref ref-type="aff" rid="I1"></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>Dato</surname><given-names>Ilaria</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Graziani</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib><contrib contrib-type="author"><name><surname>Biasucci</surname><given-names>Luigi M.</given-names></name><xref ref-type="aff" rid="I1"></xref></contrib></contrib-group><aff id="I1">Institute of Cardiology, Catholic University of the Sacred Heart, 8 Largo Gemelli, 00168 Rome, Italy</aff><author-notes><corresp id="cor1">*Valentina Loria: <email>valentinaloriavl@libero.it</email></corresp><fn fn-type="other"><p>Recommended by Rod J. Flower</p></fn></author-notes><pub-date pub-type="ppub"><year>2008</year></pub-date><pub-date pub-type="epub"><day>11</day><month>3</month><year>2008</year></pub-date><volume>2008</volume><elocation-id>135625</elocation-id><history><date date-type="received"><day>17</day><month>10</month><year>2007</year></date><date date-type="accepted"><day>21</day><month>1</month><year>2008</year></date></history><permissions><copyright-statement>Copyright © 2008 Valentina Loria et al.</copyright-statement><copyright-year>2008</copyright-year><license license-type="open-access"><p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p></license></permissions><abstract><p>Myeloperoxidase (MPO) is an enzyme stored in azurophilic granules of polymorphonuclear neutrophils and macrophages and released into extracellular fluid in the setting of inflammatory process. The observation that myeloperoxidase is involved in oxidative stress and inflammation has been a leading factor to study myeloperoxidase as a possible marker of plaque instability and a useful clinical tool in the evaluation of patients with coronary heart disease. The purpose of this review is to provide an overview of the pathophysiological, analytical, and clinical characteristics of MPO and to summarize the state of art about the possible clinical use of MPO as a marker for diagnosis and risk stratification of patients with acute coronary syndrome (ACS).</p></abstract></article-meta></front><floats-wrap><fig id="fig1" position="float"><label>Figure 1</label><caption><p>Increase in risk of death (D) plus MI (myocardial infarction) with increasing
tertiles of MPO [<xref ref-type="bibr" rid="B11">11</xref>].</p></caption><graphic xlink:href="MI2008-135625.001"></graphic></fig><table-wrap id="tab1" position="float"><label>Table 1</label><caption><p>Prognostic and diagnostic value and analytical performance of inflammatory markers in CAD:
myeloperoxidase (MPO), C reactive protein (CRP), pregnancy-associated plasma
protein-A (PAPP-A), CD40 ligand (CD40L), and interleukins.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="center" colspan="4" rowspan="1">Inflammatory markers in CAD</th></tr><tr><th rowspan="1" colspan="1"></th><th align="center" rowspan="1" colspan="1">Prognosis</th><th align="center" rowspan="1" colspan="1">Diagnosis</th><th align="center" rowspan="1" colspan="1">Analyt. perform.</th></tr></thead><tbody><tr><td rowspan="1" colspan="1">MPO</td><td align="center" rowspan="1" colspan="1">+++</td><td align="center" rowspan="1" colspan="1">++</td><td align="center" rowspan="1" colspan="1">++ (more?)</td></tr><tr><td rowspan="1" colspan="1">CRP</td><td align="center" rowspan="1" colspan="1">++++</td><td align="center" rowspan="1" colspan="1">+/−</td><td align="center" rowspan="1" colspan="1">++++</td></tr><tr><td rowspan="1" colspan="1">PAPP-A</td><td align="center" rowspan="1" colspan="1">++</td><td align="center" rowspan="1" colspan="1">+</td><td align="center" rowspan="1" colspan="1">−</td></tr><tr><td rowspan="1" colspan="1">CD40L</td><td align="center" rowspan="1" colspan="1">++</td><td align="center" rowspan="1" colspan="1">+/−</td><td align="center" rowspan="1" colspan="1">−</td></tr><tr><td rowspan="1" colspan="1">Interleukins</td><td align="center" rowspan="1" colspan="1">+++</td><td align="center" rowspan="1" colspan="1">+/−</td><td align="center" rowspan="1" colspan="1">−</td></tr></tbody></table></table-wrap></floats-wrap></pmc><affiliations><list><country><li>Italie</li></country><region><li>Latium</li></region><settlement><li>Rome</li></settlement></list><tree><country name="Italie"><region name="Latium"><name sortKey="Loria, Valentina" sort="Loria, Valentina" uniqKey="Loria V" first="Valentina" last="Loria">Valentina Loria</name></region><name sortKey="Biasucci, Luigi M" sort="Biasucci, Luigi M" uniqKey="Biasucci L" first="Luigi M." last="Biasucci">Luigi M. Biasucci</name><name sortKey="Dato, Ilaria" sort="Dato, Ilaria" uniqKey="Dato I" first="Ilaria" last="Dato">Ilaria Dato</name><name sortKey="Graziani, Francesca" sort="Graziani, Francesca" uniqKey="Graziani F" first="Francesca" last="Graziani">Francesca Graziani</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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