Drug context differently regulates cocaine versus heroin self-administration and cocaine-versus heroin-induced Fos mRNA expression in the rat
Identifieur interne : 000289 ( PascalFrancis/Corpus ); précédent : 000288; suivant : 000290Drug context differently regulates cocaine versus heroin self-administration and cocaine-versus heroin-induced Fos mRNA expression in the rat
Auteurs : Michele Celentano ; Daniele Caprioli ; Pasqua Di Pasquale ; Veronica Cardill ; Paolo Nencini ; Silvana Gaetani ; Aldo BadianiSource :
- Psychopharmacologia [ 0033-3158 ] ; 2009.
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- Pascal (Inist)
English descriptors
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Abstract
Rationale We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin. Materials and methods We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 μg/kg) and cocaine (400 μg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of "self-administration doses" of heroin (25.0 μg/kg) and cocaine (400 μg/kg). Results We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression. Conclusions Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat.
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Format Inist (serveur)
| NO : | FRANCIS 09-0219985 INIST |
|---|---|
| ET : | Drug context differently regulates cocaine versus heroin self-administration and cocaine-versus heroin-induced Fos mRNA expression in the rat |
| AU : | CELENTANO (Michele); CAPRIOLI (Daniele); DI PASQUALE (Pasqua); CARDILL (Veronica); NENCINI (Paolo); GAETANI (Silvana); BADIANI (Aldo) |
| AF : | Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome/Rome/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); CRiN "Daniel Bovet", Sapienza University of Rome/Rome/Italie (5 aut., 7 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Psychopharmacologia; ISSN 0033-3158; Coden PSYPAG; Allemagne; Da. 2009; Vol. 204; No. 2; Pp. 349-360; Bibl. 1 p.1/2 |
| LA : | Anglais |
| EA : | Rationale We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin. Materials and methods We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 μg/kg) and cocaine (400 μg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of "self-administration doses" of heroin (25.0 μg/kg) and cocaine (400 μg/kg). Results We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression. Conclusions Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat. |
| CC : | 770E02; 770D03E01 |
| FD : | Médicament; Contexte; Cocaïne; Etude comparative; Héroïne; Substance toxicomanogène; Autoadministration; Expression génique; Gène fos; Rat; Animal; Opiacés; Peptide opioïde; Stimulant SNC; Récompense; Addiction; Toxicomanie; Abus de substance; Noyau caudé; Corps strié |
| FG : | Rodentia; Mammalia; Vertebrata; Ester; Psychotrope; Encéphale; Noyau gris central; Système nerveux central |
| ED : | Drug; Context; Cocaine; Comparative study; Heroin; Drug of abuse; Self administration; Gene expression; fos Gene; Rat; Animal; Opiates; Opioid peptide; CNS stimulant; Reward; Addiction; Drug addiction; Substance abuse; Caudate nucleus; Corpus striatum |
| EG : | Rodentia; Mammalia; Vertebrata; Ester; Psychotropic; Encephalon; Basal ganglion; Central nervous system |
| SD : | Medicamento; Contexto; Cocaína; Estudio comparativo; Heroína; Sustancia toxicomanógena; Autoadministración; Expresión genética; Gen fos; Rata; Animal; Opiados; Péptido opioide; Estimulante SNC; Recompensa; Adicción; Toxicomanía; Abuso de sustancias; Núcleo caudado; Cuerpo estriado |
| LO : | INIST-1761.354000186087870140 |
| ID : | 09-0219985 |
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type="wicri:Area/PascalFrancis/Corpus">000289</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Drug context differently regulates cocaine versus heroin self-administration and cocaine-versus heroin-induced Fos mRNA expression in the rat</title><author><name sortKey="Celentano, Michele" sort="Celentano, Michele" uniqKey="Celentano M" first="Michele" last="Celentano">Michele Celentano</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Caprioli, Daniele" sort="Caprioli, Daniele" uniqKey="Caprioli D" first="Daniele" last="Caprioli">Daniele Caprioli</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Di Pasquale, Pasqua" sort="Di Pasquale, Pasqua" uniqKey="Di Pasquale P" first="Pasqua" last="Di Pasquale">Pasqua Di Pasquale</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Cardill, Veronica" sort="Cardill, Veronica" uniqKey="Cardill V" first="Veronica" last="Cardill">Veronica Cardill</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Nencini, Paolo" sort="Nencini, Paolo" uniqKey="Nencini P" first="Paolo" last="Nencini">Paolo Nencini</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>CRiN "Daniel Bovet", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Gaetani, Silvana" sort="Gaetani, Silvana" uniqKey="Gaetani S" first="Silvana" last="Gaetani">Silvana Gaetani</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Badiani, Aldo" sort="Badiani, Aldo" uniqKey="Badiani A" first="Aldo" last="Badiani">Aldo Badiani</name><affiliation><inist:fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>CRiN "Daniel Bovet", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Psychopharmacologia</title><title level="j" type="abbreviated">Psychopharmacologia</title><idno type="ISSN">0033-3158</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Psychopharmacologia</title><title level="j" type="abbreviated">Psychopharmacologia</title><idno type="ISSN">0033-3158</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Addiction</term><term>Animal</term><term>CNS stimulant</term><term>Caudate nucleus</term><term>Cocaine</term><term>Comparative study</term><term>Context</term><term>Corpus striatum</term><term>Drug</term><term>Drug addiction</term><term>Drug of abuse</term><term>Gene expression</term><term>Heroin</term><term>Opiates</term><term>Opioid peptide</term><term>Rat</term><term>Reward</term><term>Self administration</term><term>Substance abuse</term><term>fos Gene</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Médicament</term><term>Contexte</term><term>Cocaïne</term><term>Etude comparative</term><term>Héroïne</term><term>Substance toxicomanogène</term><term>Autoadministration</term><term>Expression génique</term><term>Gène fos</term><term>Rat</term><term>Animal</term><term>Opiacés</term><term>Peptide opioïde</term><term>Stimulant SNC</term><term>Récompense</term><term>Addiction</term><term>Toxicomanie</term><term>Abus de substance</term><term>Noyau caudé</term><term>Corps strié</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Rationale We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin. Materials and methods We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 μg/kg) and cocaine (400 μg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of "self-administration doses" of heroin (25.0 μg/kg) and cocaine (400 μg/kg). Results We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression. Conclusions Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0033-3158</s0></fA01><fA02 i1="01"><s0>PSYPAG</s0></fA02><fA03 i2="1"><s0>Psychopharmacologia</s0></fA03><fA05><s2>204</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Drug context differently regulates cocaine versus heroin self-administration and cocaine-versus heroin-induced Fos mRNA expression in the rat</s1></fA08><fA11 i1="01" i2="1"><s1>CELENTANO (Michele)</s1></fA11><fA11 i1="02" i2="1"><s1>CAPRIOLI (Daniele)</s1></fA11><fA11 i1="03" i2="1"><s1>DI PASQUALE (Pasqua)</s1></fA11><fA11 i1="04" i2="1"><s1>CARDILL (Veronica)</s1></fA11><fA11 i1="05" i2="1"><s1>NENCINI (Paolo)</s1></fA11><fA11 i1="06" i2="1"><s1>GAETANI (Silvana)</s1></fA11><fA11 i1="07" i2="1"><s1>BADIANI (Aldo)</s1></fA11><fA14 i1="01"><s1>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>CRiN "Daniel Bovet", Sapienza University of Rome</s1><s2>Rome</s2><s3>ITA</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ></fA14><fA20><s1>349-360</s1></fA20><fA21><s1>2009</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>1761</s2><s5>354000186087870140</s5></fA43><fA44><s0>0000</s0><s1>© 2009 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/2</s0></fA45><fA47 i1="01" i2="1"><s0>09-0219985</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Psychopharmacologia</s0></fA64><fA66 i1="01"><s0>DEU</s0></fA66><fC01 i1="01" l="ENG"><s0>Rationale We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin. Materials and methods We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 μg/kg) and cocaine (400 μg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of "self-administration doses" of heroin (25.0 μg/kg) and cocaine (400 μg/kg). Results We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression. Conclusions Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat.</s0></fC01><fC02 i1="01" i2="X"><s0>770E02</s0><s1>V</s1></fC02><fC02 i1="02" i2="X"><s0>770D03E01</s0><s1>IV</s1></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Médicament</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Drug</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Medicamento</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Contexte</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Context</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Contexto</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Cocaïne</s0><s2>NK</s2><s2>FR</s2><s2>FX</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Cocaine</s0><s2>NK</s2><s2>FR</s2><s2>FX</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Cocaína</s0><s2>NK</s2><s2>FR</s2><s2>FX</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Etude comparative</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Comparative study</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Estudio comparativo</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Héroïne</s0><s2>NK</s2><s2>FX</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Heroin</s0><s2>NK</s2><s2>FX</s2><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Heroína</s0><s2>NK</s2><s2>FX</s2><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Substance toxicomanogène</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Drug of abuse</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Sustancia toxicomanógena</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Autoadministration</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Self administration</s0><s5>08</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Autoadministración</s0><s5>08</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Expression génique</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Gene expression</s0><s5>09</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Expresión genética</s0><s5>09</s5></fC03><fC03 i1="09" i2="X" l="FRE"><s0>Gène fos</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="ENG"><s0>fos Gene</s0><s5>10</s5></fC03><fC03 i1="09" i2="X" l="SPA"><s0>Gen fos</s0><s5>10</s5></fC03><fC03 i1="10" i2="X" l="FRE"><s0>Rat</s0><s5>11</s5></fC03><fC03 i1="10" i2="X" l="ENG"><s0>Rat</s0><s5>11</s5></fC03><fC03 i1="10" i2="X" l="SPA"><s0>Rata</s0><s5>11</s5></fC03><fC03 i1="11" i2="X" l="FRE"><s0>Animal</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="ENG"><s0>Animal</s0><s5>12</s5></fC03><fC03 i1="11" i2="X" l="SPA"><s0>Animal</s0><s5>12</s5></fC03><fC03 i1="12" i2="X" l="FRE"><s0>Opiacés</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="ENG"><s0>Opiates</s0><s5>13</s5></fC03><fC03 i1="12" i2="X" l="SPA"><s0>Opiados</s0><s5>13</s5></fC03><fC03 i1="13" i2="X" l="FRE"><s0>Peptide opioïde</s0><s5>14</s5></fC03><fC03 i1="13" i2="X" l="ENG"><s0>Opioid peptide</s0><s5>14</s5></fC03><fC03 i1="13" i2="X" l="SPA"><s0>Péptido opioide</s0><s5>14</s5></fC03><fC03 i1="14" i2="X" l="FRE"><s0>Stimulant SNC</s0><s5>15</s5></fC03><fC03 i1="14" i2="X" l="ENG"><s0>CNS stimulant</s0><s5>15</s5></fC03><fC03 i1="14" i2="X" l="SPA"><s0>Estimulante SNC</s0><s5>15</s5></fC03><fC03 i1="15" i2="X" l="FRE"><s0>Récompense</s0><s5>16</s5></fC03><fC03 i1="15" i2="X" l="ENG"><s0>Reward</s0><s5>16</s5></fC03><fC03 i1="15" i2="X" l="SPA"><s0>Recompensa</s0><s5>16</s5></fC03><fC03 i1="16" i2="X" l="FRE"><s0>Addiction</s0><s2>NM</s2><s5>17</s5></fC03><fC03 i1="16" i2="X" l="ENG"><s0>Addiction</s0><s2>NM</s2><s5>17</s5></fC03><fC03 i1="16" i2="X" l="SPA"><s0>Adicción</s0><s2>NM</s2><s5>17</s5></fC03><fC03 i1="17" i2="X" l="FRE"><s0>Toxicomanie</s0><s5>18</s5></fC03><fC03 i1="17" i2="X" l="ENG"><s0>Drug addiction</s0><s5>18</s5></fC03><fC03 i1="17" i2="X" l="SPA"><s0>Toxicomanía</s0><s5>18</s5></fC03><fC03 i1="18" i2="X" l="FRE"><s0>Abus de substance</s0><s2>NM</s2><s5>19</s5></fC03><fC03 i1="18" i2="X" l="ENG"><s0>Substance abuse</s0><s2>NM</s2><s5>19</s5></fC03><fC03 i1="18" i2="X" l="SPA"><s0>Abuso de sustancias</s0><s2>NM</s2><s5>19</s5></fC03><fC03 i1="19" i2="X" l="FRE"><s0>Noyau caudé</s0><s5>20</s5></fC03><fC03 i1="19" i2="X" l="ENG"><s0>Caudate nucleus</s0><s5>20</s5></fC03><fC03 i1="19" i2="X" l="SPA"><s0>Núcleo caudado</s0><s5>20</s5></fC03><fC03 i1="20" i2="X" l="FRE"><s0>Corps strié</s0><s5>21</s5></fC03><fC03 i1="20" i2="X" l="ENG"><s0>Corpus striatum</s0><s5>21</s5></fC03><fC03 i1="20" i2="X" l="SPA"><s0>Cuerpo estriado</s0><s5>21</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Rodentia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Mammalia</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Vertebrata</s0><s2>NS</s2></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Ester</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Ester</s0><s5>37</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Ester</s0><s5>37</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Psychotrope</s0><s2>FX</s2><s5>38</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Psychotropic</s0><s2>FX</s2><s5>38</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Psicotropo</s0><s2>FX</s2><s5>38</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Encéphale</s0><s5>39</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Encephalon</s0><s5>39</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo</s0><s5>39</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Noyau gris central</s0><s5>40</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Basal ganglion</s0><s5>40</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Núcleo basal</s0><s5>40</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>41</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system</s0><s5>41</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>41</s5></fC07><fN21><s1>159</s1></fN21></pA></standard><server><NO>FRANCIS 09-0219985 INIST</NO><ET>Drug context differently regulates cocaine versus heroin self-administration and cocaine-versus heroin-induced Fos mRNA expression in the rat</ET><AU>CELENTANO (Michele); CAPRIOLI (Daniele); DI PASQUALE (Pasqua); CARDILL (Veronica); NENCINI (Paolo); GAETANI (Silvana); BADIANI (Aldo)</AU><AF>Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza University of Rome/Rome/Italie (1 aut., 2 aut., 3 aut., 4 aut., 5 aut., 6 aut., 7 aut.); CRiN "Daniel Bovet", Sapienza University of Rome/Rome/Italie (5 aut., 7 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Psychopharmacologia; ISSN 0033-3158; Coden PSYPAG; Allemagne; Da. 2009; Vol. 204; No. 2; Pp. 349-360; Bibl. 1 p.1/2</SO><LA>Anglais</LA><EA>Rationale We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin. Materials and methods We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 μg/kg) and cocaine (400 μg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of "self-administration doses" of heroin (25.0 μg/kg) and cocaine (400 μg/kg). Results We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression. Conclusions Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat.</EA><CC>770E02; 770D03E01</CC><FD>Médicament; Contexte; Cocaïne; Etude comparative; Héroïne; Substance toxicomanogène; Autoadministration; Expression génique; Gène fos; Rat; Animal; Opiacés; Peptide opioïde; Stimulant SNC; Récompense; Addiction; Toxicomanie; Abus de substance; Noyau caudé; Corps strié</FD><FG>Rodentia; Mammalia; Vertebrata; Ester; Psychotrope; Encéphale; Noyau gris central; Système nerveux central</FG><ED>Drug; Context; Cocaine; Comparative study; Heroin; Drug of abuse; Self administration; Gene expression; fos Gene; Rat; Animal; Opiates; Opioid peptide; CNS stimulant; Reward; Addiction; Drug addiction; Substance abuse; Caudate nucleus; Corpus striatum</ED><EG>Rodentia; Mammalia; Vertebrata; Ester; Psychotropic; Encephalon; Basal ganglion; Central nervous system</EG><SD>Medicamento; Contexto; Cocaína; Estudio comparativo; Heroína; Sustancia toxicomanógena; Autoadministración; Expresión genética; Gen fos; Rata; Animal; Opiados; Péptido opioide; Estimulante SNC; Recompensa; Adicción; Toxicomanía; Abuso de sustancias; Núcleo caudado; Cuerpo estriado</SD><LO>INIST-1761.354000186087870140</LO><ID>09-0219985</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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