Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High‐Risk Myocardial Infarction Database Initiative
Identifieur interne : 000767 ( Main/Merge ); précédent : 000766; suivant : 000768Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High‐Risk Myocardial Infarction Database Initiative
Auteurs : Thomas G. Von Lueder [Norvège] ; Nicolas Girerd [France] ; Dan Atar [Norvège] ; Stefan Agewall [Norvège] ; Zohra Lamiral [France] ; Mehmet Kanbay [Turquie] ; Bertram Pitt [États-Unis] ; Kenneth Dickstein [Norvège] ; Faiez Zannad [France] ; Patrick Rossignol [France]Source :
- European Journal of Heart Failure [ 1388-9842 ] ; 2015-11.
Abstract
Serum uric acid (SUA) levels are associated with poorer outcomes in healthy cohorts and patients with stable and unstable coronary heart disease. We investigated the relationship between SUA and clinical outcomes in subjects with acute myocardial infarction (MI) complicated by reduced left ventricular (LV) function, heart failure (HF), or both.
Univariable and multivariable Cox proportional hazards modelling was performed to study the association of baseline SUA and all‐cause mortality, cardiovascular (CV) mortality, and HF hospitalization in an individual patient meta‐analysis of four merged large randomized trials (CAPRICORN, EPHESUS, OPTIMAAL, and VALIANT). Three trials (excluding VALIANT) reported SUA, which was available in a total of 12 677 subjects. The ranges of SUA for quartiles I–IV were 45–280, 281–344, 345–420, and 420–1640 mmol/L, respectively. While almost 90% of patients in the lowest SUA quartile were alive after a mean follow‐up of 23 ± 11 months, <70% were alive in the highest SUA quartile. Compared with the lowest SUA quartile as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) of SUA quartiles III and IV showed an increase in all‐cause mortality [HR 1.18, 95% CI 0.95–1.46, and HR 1.36, 95% CI 1.11–1.67) and CV mortality (HR 1.27, 95% 1.01–1.61, and HR 1.47, 95% CI 1.17–1.83). SUA quartiles III and IV also exhibited increased HF hospitalization (HR 1.22, 95% CI 1.09–1.36, and HR 1.28, 95% CI 1.14–1.43; P < 0.001 for all comparisons) in multivariable analyses. The addition of SUA was associated with a significant improvement in reclassification to predict CV mortality (net reclassification improvement 17.6%, 95% CI 14.9–20.5%, P < 0.001).
Elevated SUA is associated with poor outcomes in patients after MI complicated by reduced LV function, HF, or both. The quantification of SUA, a low‐cost routinely available biomarker, could improve risk stratification of patients with complicated MI.
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DOI: 10.1002/ejhf.419
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nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>F‐CRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques‐1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>F‐CRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Heart Failure</title><title level="j" type="alt">EUROPEAN JOURNAL OF HEART FAILURE</title><idno type="ISSN">1388-9842</idno><idno type="eISSN">1879-0844</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1144">1144</biblScope><biblScope unit="page" to="1151">1151</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2015-11">2015-11</date></imprint><idno type="ISSN">1388-9842</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1388-9842</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Serum uric acid (SUA) levels are associated with poorer outcomes in healthy cohorts and patients with stable and unstable coronary heart disease. We investigated the relationship between SUA and clinical outcomes in subjects with acute myocardial infarction (MI) complicated by reduced left ventricular (LV) function, heart failure (HF), or both.</div><div type="abstract">Univariable and multivariable Cox proportional hazards modelling was performed to study the association of baseline SUA and all‐cause mortality, cardiovascular (CV) mortality, and HF hospitalization in an individual patient meta‐analysis of four merged large randomized trials (CAPRICORN, EPHESUS, OPTIMAAL, and VALIANT). Three trials (excluding VALIANT) reported SUA, which was available in a total of 12 677 subjects. The ranges of SUA for quartiles I–IV were 45–280, 281–344, 345–420, and 420–1640 mmol/L, respectively. While almost 90% of patients in the lowest SUA quartile were alive after a mean follow‐up of 23 ± 11 months, <70% were alive in the highest SUA quartile. Compared with the lowest SUA quartile as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) of SUA quartiles III and IV showed an increase in all‐cause mortality [HR 1.18, 95% CI 0.95–1.46, and HR 1.36, 95% CI 1.11–1.67) and CV mortality (HR 1.27, 95% 1.01–1.61, and HR 1.47, 95% CI 1.17–1.83). SUA quartiles III and IV also exhibited increased HF hospitalization (HR 1.22, 95% CI 1.09–1.36, and HR 1.28, 95% CI 1.14–1.43; P < 0.001 for all comparisons) in multivariable analyses. The addition of SUA was associated with a significant improvement in reclassification to predict CV mortality (net reclassification improvement 17.6%, 95% CI 14.9–20.5%, P < 0.001).</div><div type="abstract">Elevated SUA is associated with poor outcomes in patients after MI complicated by reduced LV function, HF, or both. The quantification of SUA, a low‐cost routinely available biomarker, could improve risk stratification of patients with complicated MI.</div></front></TEI><double doi="10.1002/ejhf.419"><ISTEX><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High‐Risk Myocardial Infarction Database Initiative</title><author><name sortKey="Von Lueder, Thomas G" sort="Von Lueder, Thomas G" uniqKey="Von Lueder T" first="Thomas G." last="Von Lueder">Thomas G. Von Lueder</name></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name></author><author><name sortKey="Atar, Dan" sort="Atar, Dan" uniqKey="Atar D" first="Dan" last="Atar">Dan Atar</name></author><author><name sortKey="Agewall, Stefan" sort="Agewall, Stefan" uniqKey="Agewall S" first="Stefan" last="Agewall">Stefan Agewall</name></author><author><name sortKey="Lamiral, Zohra" sort="Lamiral, Zohra" uniqKey="Lamiral Z" first="Zohra" last="Lamiral">Zohra Lamiral</name></author><author><name sortKey="Kanbay, Mehmet" sort="Kanbay, Mehmet" uniqKey="Kanbay M" first="Mehmet" last="Kanbay">Mehmet Kanbay</name></author><author><name sortKey="Pitt, Bertram" sort="Pitt, Bertram" uniqKey="Pitt B" first="Bertram" last="Pitt">Bertram Pitt</name></author><author><name sortKey="Dickstein, Kenneth" sort="Dickstein, Kenneth" uniqKey="Dickstein K" first="Kenneth" last="Dickstein">Kenneth Dickstein</name></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name></author><author><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:7333DBA3898FFC34E62822380EC3146D454D421C</idno><date when="2015" year="2015">2015</date><idno type="doi">10.1002/ejhf.419</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-SFFS0T2B-F/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">001A52</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001A52</idno><idno type="wicri:Area/Istex/Curation">001A32</idno><idno type="wicri:Area/Istex/Checkpoint">000012</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000012</idno><idno type="wicri:doubleKey">1388-9842:2015:Von Lueder T:serum:uric:acid</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High‐Risk Myocardial Infarction Database Initiative</title><author><name sortKey="Von Lueder, Thomas G" sort="Von Lueder, Thomas G" uniqKey="Von Lueder T" first="Thomas G." last="Von Lueder">Thomas G. Von Lueder</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Center for Heart Failure Research, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation><affiliation></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques‐1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>F‐CRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Atar, Dan" sort="Atar, Dan" uniqKey="Atar D" first="Dan" last="Atar">Dan Atar</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Center for Heart Failure Research, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Agewall, Stefan" sort="Agewall, Stefan" uniqKey="Agewall S" first="Stefan" last="Agewall">Stefan Agewall</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Center for Heart Failure Research, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Lamiral, Zohra" sort="Lamiral, Zohra" uniqKey="Lamiral Z" first="Zohra" last="Lamiral">Zohra Lamiral</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques‐1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>F‐CRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kanbay, Mehmet" sort="Kanbay, Mehmet" uniqKey="Kanbay M" first="Mehmet" last="Kanbay">Mehmet Kanbay</name><affiliation wicri:level="1"><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Pitt, Bertram" sort="Pitt, Bertram" uniqKey="Pitt B" first="Bertram" last="Pitt">Bertram Pitt</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan School of Medicine, MI, Ann Arbor</wicri:regionArea><wicri:noRegion>Ann Arbor</wicri:noRegion></affiliation></author><author><name sortKey="Dickstein, Kenneth" sort="Dickstein, Kenneth" uniqKey="Dickstein K" first="Kenneth" last="Dickstein">Kenneth Dickstein</name><affiliation wicri:level="1"><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Cardiology, University of Bergen, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques‐1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>F‐CRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques‐1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation><affiliation wicri:level="4"><country xml:lang="fr">France</country><wicri:regionArea>Université de Lorraine, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>F‐CRIN INI‐CRCT (Cardiovascular and Renal Clinical Trialists) Network, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">European Journal of Heart Failure</title><title level="j" type="alt">EUROPEAN JOURNAL OF HEART FAILURE</title><idno type="ISSN">1388-9842</idno><idno type="eISSN">1879-0844</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1144">1144</biblScope><biblScope unit="page" to="1151">1151</biblScope><biblScope unit="page-count">8</biblScope><publisher>John Wiley & Sons, Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2015-11">2015-11</date></imprint><idno type="ISSN">1388-9842</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1388-9842</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Serum uric acid (SUA) levels are associated with poorer outcomes in healthy cohorts and patients with stable and unstable coronary heart disease. We investigated the relationship between SUA and clinical outcomes in subjects with acute myocardial infarction (MI) complicated by reduced left ventricular (LV) function, heart failure (HF), or both.</div><div type="abstract">Univariable and multivariable Cox proportional hazards modelling was performed to study the association of baseline SUA and all‐cause mortality, cardiovascular (CV) mortality, and HF hospitalization in an individual patient meta‐analysis of four merged large randomized trials (CAPRICORN, EPHESUS, OPTIMAAL, and VALIANT). Three trials (excluding VALIANT) reported SUA, which was available in a total of 12 677 subjects. The ranges of SUA for quartiles I–IV were 45–280, 281–344, 345–420, and 420–1640 mmol/L, respectively. While almost 90% of patients in the lowest SUA quartile were alive after a mean follow‐up of 23 ± 11 months, <70% were alive in the highest SUA quartile. Compared with the lowest SUA quartile as reference, hazard ratios (HRs) and 95% confidence intervals (CIs) of SUA quartiles III and IV showed an increase in all‐cause mortality [HR 1.18, 95% CI 0.95–1.46, and HR 1.36, 95% CI 1.11–1.67) and CV mortality (HR 1.27, 95% 1.01–1.61, and HR 1.47, 95% CI 1.17–1.83). SUA quartiles III and IV also exhibited increased HF hospitalization (HR 1.22, 95% CI 1.09–1.36, and HR 1.28, 95% CI 1.14–1.43; P < 0.001 for all comparisons) in multivariable analyses. The addition of SUA was associated with a significant improvement in reclassification to predict CV mortality (net reclassification improvement 17.6%, 95% CI 14.9–20.5%, P < 0.001).</div><div type="abstract">Elevated SUA is associated with poor outcomes in patients after MI complicated by reduced LV function, HF, or both. The quantification of SUA, a low‐cost routinely available biomarker, could improve risk stratification of patients with complicated MI.</div></front></TEI></ISTEX><PubMed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High-Risk Myocardial Infarction Database Initiative.</title><author><name sortKey="Von Lueder, Thomas G" sort="Von Lueder, Thomas G" uniqKey="Von Lueder T" first="Thomas G" last="Von Lueder">Thomas G. Von Lueder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Atar, Dan" sort="Atar, Dan" uniqKey="Atar D" first="Dan" last="Atar">Dan Atar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Agewall, Stefan" sort="Agewall, Stefan" uniqKey="Agewall S" first="Stefan" last="Agewall">Stefan Agewall</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Lamiral, Zohra" sort="Lamiral, Zohra" uniqKey="Lamiral Z" first="Zohra" last="Lamiral">Zohra Lamiral</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kanbay, Mehmet" sort="Kanbay, Mehmet" uniqKey="Kanbay M" first="Mehmet" last="Kanbay">Mehmet Kanbay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Pitt, Bertram" sort="Pitt, Bertram" uniqKey="Pitt B" first="Bertram" last="Pitt">Bertram Pitt</name><affiliation wicri:level="1"><nlm:affiliation>University of Michigan School of Medicine, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan School of Medicine, Ann Arbor, MI</wicri:regionArea><wicri:noRegion>MI</wicri:noRegion></affiliation></author><author><name sortKey="Dickstein, Kenneth" sort="Dickstein, Kenneth" uniqKey="Dickstein K" first="Kenneth" last="Dickstein">Kenneth Dickstein</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, University of Bergen, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Cardiology, University of Bergen, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26424212</idno><idno type="pmid">26424212</idno><idno type="doi">10.1002/ejhf.419</idno><idno type="wicri:Area/PubMed/Corpus">000034</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000034</idno><idno type="wicri:Area/PubMed/Curation">000034</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000034</idno><idno type="wicri:Area/PubMed/Checkpoint">000033</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000033</idno><idno type="wicri:Area/Ncbi/Merge">000210</idno><idno type="wicri:Area/Ncbi/Curation">000203</idno><idno type="wicri:Area/Ncbi/Checkpoint">000203</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Serum uric acid is associated with mortality and heart failure hospitalizations in patients with complicated myocardial infarction: findings from the High-Risk Myocardial Infarction Database Initiative.</title><author><name sortKey="Von Lueder, Thomas G" sort="Von Lueder, Thomas G" uniqKey="Von Lueder T" first="Thomas G" last="Von Lueder">Thomas G. Von Lueder</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Atar, Dan" sort="Atar, Dan" uniqKey="Atar D" first="Dan" last="Atar">Dan Atar</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Agewall, Stefan" sort="Agewall, Stefan" uniqKey="Agewall S" first="Stefan" last="Agewall">Stefan Agewall</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Department of Cardiology B, Division of Medicine, Oslo University Hospital Ullevål, University of Oslo</wicri:regionArea><wicri:noRegion>University of Oslo</wicri:noRegion></affiliation></author><author><name sortKey="Lamiral, Zohra" sort="Lamiral, Zohra" uniqKey="Lamiral Z" first="Zohra" last="Lamiral">Zohra Lamiral</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Kanbay, Mehmet" sort="Kanbay, Mehmet" uniqKey="Kanbay M" first="Mehmet" last="Kanbay">Mehmet Kanbay</name><affiliation wicri:level="1"><nlm:affiliation>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul, Turkey.</nlm:affiliation><country xml:lang="fr">Turquie</country><wicri:regionArea>Department of Medicine, Division of Nephrology, Koc University School of Medicine, Istanbul</wicri:regionArea><wicri:noRegion>Istanbul</wicri:noRegion></affiliation></author><author><name sortKey="Pitt, Bertram" sort="Pitt, Bertram" uniqKey="Pitt B" first="Bertram" last="Pitt">Bertram Pitt</name><affiliation wicri:level="1"><nlm:affiliation>University of Michigan School of Medicine, Ann Arbor, MI, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>University of Michigan School of Medicine, Ann Arbor, MI</wicri:regionArea><wicri:noRegion>MI</wicri:noRegion></affiliation></author><author><name sortKey="Dickstein, Kenneth" sort="Dickstein, Kenneth" uniqKey="Dickstein K" first="Kenneth" last="Dickstein">Kenneth Dickstein</name><affiliation wicri:level="1"><nlm:affiliation>Division of Cardiology, University of Bergen, Stavanger University Hospital, Stavanger, Norway.</nlm:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>Division of Cardiology, University of Bergen, Stavanger University Hospital, Stavanger</wicri:regionArea><wicri:noRegion>Stavanger</wicri:noRegion></affiliation></author><author><name sortKey="Zannad, Faiez" sort="Zannad, Faiez" uniqKey="Zannad F" first="Faiez" last="Zannad">Faiez Zannad</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Rossignol, Patrick" sort="Rossignol, Patrick" uniqKey="Rossignol P" first="Patrick" last="Rossignol">Patrick Rossignol</name><affiliation wicri:level="3"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques-1433, and INSERM U1116, Nancy</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Nancy</settlement></placeName></affiliation></author></analytic><series><title level="j">European journal of heart failure</title><idno type="eISSN">1879-0844</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Serum uric acid (SUA) levels are associated with poorer outcomes in healthy cohorts and patients with stable and unstable coronary heart disease. We investigated the relationship between SUA and clinical outcomes in subjects with acute myocardial infarction (MI) complicated by reduced left ventricular (LV) function, heart failure (HF), or both.</div></front></TEI></PubMed></double></record>Pour manipuler ce document sous Unix (Dilib)
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