Clinical value of studies with radioiodinated heptadecanoic acid in patients with coronary artery disease
Identifieur interne : 001186 ( Istex/Curation ); précédent : 001185; suivant : 001187Clinical value of studies with radioiodinated heptadecanoic acid in patients with coronary artery disease
Auteurs : M. J. Van Eenige [Pays-Bas] ; F. C. Visser [Pays-Bas] ; C. M. B. Duwel [Pays-Bas] ; J. P. Roos [Pays-Bas]Source :
- European Heart Journal [ 0195-668X ] ; 1990-03.
Abstract
The results described in the literature of myocardial scintigraphy with radioiodinated heptadecanoic acid (IHDA) to detect coronary stenoses are contradictory. In the present study, IHDA scintigraphy was performed in nine control subjects and 67 patients with coronary artery disease. The acquisition time was 75 min and background correction was not applied. The time-activity curves of regions of interest were analysed by curve fitting with a monoexponential plus constant. Two parameters were used: the half time value of the monoexponential (T2 in min) and the ratio of the amplitude (A) of the monoexponential and the total activity at time t = 0 (amplitude + constant = A + C): A/A + C as a percentage. Based on the control group, a region of normal T2 values and A/A + C ratios was defined, for each calculated T2-A/A + C pair the probability of originating from a normal region was calculated. The value of the IHDA test, using the index of merit (sensitivity + specificity-100% ), increased in the patient group without MI with the severity of the stenosis (21%,24% and 47% for stenoses≥ 75%, ≥90% and ≥99%). In patients with MI, only small positive values in regions ofnon-infarct-related vessels were found ( − 1 %−16% ). It is concluded that the value of the IHDA test to detect stenoses of coronary arteries is too low to apply this test in clinical practice. However, a new type of analysis is offered, based on curve fitting of individual pixels. Preliminary results indicate better results than analysis of regions of interest. In the pilot study a sensitivity of 72% and a specificity of 89% was found to detect significant coronary stenoses
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DOI: 10.1093/oxfordjournals.eurheartj.a059692
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Ennige van, Department of Cardiology, Fre University Hospital, De Boelelaan 1117, 1007 MB Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Visser, F C" sort="Visser, F C" uniqKey="Visser F" first="F. C." last="Visser">F. C. Visser</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Free University, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Free University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Duwel, C M B" sort="Duwel, C M B" uniqKey="Duwel C" first="C. M. B." last="Duwel">C. M. B. 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J." last="Van Eenige">M. J. Van Eenige</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Free University, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Free University, Amsterdam</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>Address for correspondence: M. J. Ennige van, Department of Cardiology, Fre University Hospital, De Boelelaan 1117, 1007 MB Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Address for correspondence: M. J. Ennige van, Department of Cardiology, Fre University Hospital, De Boelelaan 1117, 1007 MB Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Visser, F C" sort="Visser, F C" uniqKey="Visser F" first="F. C." last="Visser">F. C. Visser</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Free University, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Free University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Duwel, C M B" sort="Duwel, C M B" uniqKey="Duwel C" first="C. M. B." last="Duwel">C. M. B. Duwel</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Free University, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Free University, Amsterdam</wicri:regionArea></affiliation></author><author><name sortKey="Roos, J P" sort="Roos, J P" uniqKey="Roos J" first="J. P." last="Roos">J. P. Roos</name><affiliation wicri:level="1"><mods:affiliation>Department of Cardiology, Free University, Amsterdam, The Netherlands</mods:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Cardiology, Free University, Amsterdam</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">European Heart Journal</title><idno type="ISSN">0195-668X</idno><idno type="eISSN">1522-9645</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-03">1990-03</date><biblScope unit="volume">11</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="258">258</biblScope><biblScope unit="page" to="268">268</biblScope></imprint><idno type="ISSN">0195-668X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0195-668X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">The results described in the literature of myocardial scintigraphy with radioiodinated heptadecanoic acid (IHDA) to detect coronary stenoses are contradictory. In the present study, IHDA scintigraphy was performed in nine control subjects and 67 patients with coronary artery disease. The acquisition time was 75 min and background correction was not applied. The time-activity curves of regions of interest were analysed by curve fitting with a monoexponential plus constant. Two parameters were used: the half time value of the monoexponential (T2 in min) and the ratio of the amplitude (A) of the monoexponential and the total activity at time t = 0 (amplitude + constant = A + C): A/A + C as a percentage. Based on the control group, a region of normal T2 values and A/A + C ratios was defined, for each calculated T2-A/A + C pair the probability of originating from a normal region was calculated. The value of the IHDA test, using the index of merit (sensitivity + specificity-100% ), increased in the patient group without MI with the severity of the stenosis (21%,24% and 47% for stenoses≥ 75%, ≥90% and ≥99%). In patients with MI, only small positive values in regions ofnon-infarct-related vessels were found ( − 1 %−16% ). It is concluded that the value of the IHDA test to detect stenoses of coronary arteries is too low to apply this test in clinical practice. However, a new type of analysis is offered, based on curve fitting of individual pixels. Preliminary results indicate better results than analysis of regions of interest. In the pilot study a sensitivity of 72% and a specificity of 89% was found to detect significant coronary stenoses</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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