The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve
Identifieur interne : 002314 ( Istex/Corpus ); précédent : 002313; suivant : 002315The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve
Auteurs : R. Saxod ; S. Torch ; A. Vila ; A. Laurent ; P. StoebnerSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1985.
English descriptors
- Teeft :
- Abrupt variations, Acta neuropath, Aneurysm, Average fibre densities, Axon, Biopsy, Confidence interval, Confidence limit, Corresponding diameters, Diagnostic tool, Different sizes, Electron microscopy, Extreme values, Fascicle, Fascicular area, Fibre, Fibre density, Fibre distribution, Fibre number, Fibre size, Gherardi, Greater surface, Grid squares, Human nerves, Individual variations, Internal border, Large variations, Lower density, Morphometric analysis, Myelinated, Myelinated axons, Myelinated fibre densities, Myelinated fibres, Narrow range, Nerve, Nerve fascicle, Nerve fascicles, Normal sural nerve, Other variables, Particular nerve, Pathologie nerveuse, Peripheral nerve, Peripheral nerves, Peripheral neuropathies, Peroneal, Peroneal nerve, Peroneal nerves, Regression curve, Relative interval, Right side, Same nerve, Same time, Sampling procedures, Semithin sections, Significant difference, Single nerve, Spatial distribution, Superficial peroneal nerve, Superficial peroneal nerves, Sural, Sural nerves, Surface area, Systematic study, Total fibre numbers, Uniform distribution, Upper density, Valid sampling system, Whole nerve, Whole nerve fascicle.
Abstract
Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.
Url:
DOI: 10.1016/0022-510X(85)90036-X
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</div>
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<abstract>Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</abstract>
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<note type="biography">Address for reprints: Professeur R. Saxod, Laboratoire de Biologie Animale, Université Scientifique et Médicale de Grenoble, BP 68, 38402 Saint-Martin-d'Hères, Cedex, France.</note>
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<abstract xml:lang="en"><p>Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</p>
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<ce:note-para>This work was supported by a grant (C.R.E. 836026) from the Institut National de la Santé et de la Recherche Médicale (INSERM).</ce:note-para>
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<ce:title>The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</ce:title>
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<ce:text>Address for reprints: Professeur R. Saxod, Laboratoire de Biologie Animale, Université Scientifique et Médicale de Grenoble, BP 68, 38402 Saint-Martin-d'Hères, Cedex, France.</ce:text>
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<ce:abstract-sec><ce:simple-para>The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</ce:simple-para>
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<abstract lang="en">Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</abstract>
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