The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve
Identifieur interne : 002314 ( Istex/Corpus ); précédent : 002313; suivant : 002315The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve
Auteurs : R. Saxod ; S. Torch ; A. Vila ; A. Laurent ; P. StoebnerSource :
- Journal of the Neurological Sciences [ 0022-510X ] ; 1985.
English descriptors
- Teeft :
- Abrupt variations, Acta neuropath, Aneurysm, Average fibre densities, Axon, Biopsy, Confidence interval, Confidence limit, Corresponding diameters, Diagnostic tool, Different sizes, Electron microscopy, Extreme values, Fascicle, Fascicular area, Fibre, Fibre density, Fibre distribution, Fibre number, Fibre size, Gherardi, Greater surface, Grid squares, Human nerves, Individual variations, Internal border, Large variations, Lower density, Morphometric analysis, Myelinated, Myelinated axons, Myelinated fibre densities, Myelinated fibres, Narrow range, Nerve, Nerve fascicle, Nerve fascicles, Normal sural nerve, Other variables, Particular nerve, Pathologie nerveuse, Peripheral nerve, Peripheral nerves, Peripheral neuropathies, Peroneal, Peroneal nerve, Peroneal nerves, Regression curve, Relative interval, Right side, Same nerve, Same time, Sampling procedures, Semithin sections, Significant difference, Single nerve, Spatial distribution, Superficial peroneal nerve, Superficial peroneal nerves, Sural, Sural nerves, Surface area, Systematic study, Total fibre numbers, Uniform distribution, Upper density, Valid sampling system, Whole nerve, Whole nerve fascicle.
Abstract
Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.
Url:
DOI: 10.1016/0022-510X(85)90036-X
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ISTEX:9648A10F26E34BB41354EB2DF0823026456428D8Le document en format XML
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Vila</name><affiliation><mods:affiliation>Laboratoire d'Electromyographie, Centre Hospitalier Régional de Grenoble, Grenoble France</mods:affiliation></affiliation></author><author><name sortKey="Laurent, A" sort="Laurent, A" uniqKey="Laurent A" first="A." last="Laurent">A. Laurent</name><affiliation><mods:affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</mods:affiliation></affiliation></author><author><name sortKey="Stoebner, P" sort="Stoebner, P" uniqKey="Stoebner P" first="P." last="Stoebner">P. 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Saxod</name><affiliation><mods:affiliation>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</mods:affiliation></affiliation></author><author><name sortKey="Torch, S" sort="Torch, S" uniqKey="Torch S" first="S." last="Torch">S. Torch</name><affiliation><mods:affiliation>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</mods:affiliation></affiliation></author><author><name sortKey="Vila, A" sort="Vila, A" uniqKey="Vila A" first="A." last="Vila">A. Vila</name><affiliation><mods:affiliation>Laboratoire d'Electromyographie, Centre Hospitalier Régional de Grenoble, Grenoble France</mods:affiliation></affiliation></author><author><name sortKey="Laurent, A" sort="Laurent, A" uniqKey="Laurent A" first="A." last="Laurent">A. Laurent</name><affiliation><mods:affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</mods:affiliation></affiliation></author><author><name sortKey="Stoebner, P" sort="Stoebner, P" uniqKey="Stoebner P" first="P." last="Stoebner">P. Stoebner</name><affiliation><mods:affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="ISSN">0022-510X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="64">64</biblScope></imprint><idno type="ISSN">0022-510X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-510X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abrupt variations</term><term>Acta neuropath</term><term>Aneurysm</term><term>Average fibre densities</term><term>Axon</term><term>Biopsy</term><term>Confidence interval</term><term>Confidence limit</term><term>Corresponding diameters</term><term>Diagnostic tool</term><term>Different sizes</term><term>Electron microscopy</term><term>Extreme values</term><term>Fascicle</term><term>Fascicular area</term><term>Fibre</term><term>Fibre density</term><term>Fibre distribution</term><term>Fibre number</term><term>Fibre size</term><term>Gherardi</term><term>Greater surface</term><term>Grid squares</term><term>Human nerves</term><term>Individual variations</term><term>Internal border</term><term>Large variations</term><term>Lower density</term><term>Morphometric analysis</term><term>Myelinated</term><term>Myelinated axons</term><term>Myelinated fibre densities</term><term>Myelinated fibres</term><term>Narrow range</term><term>Nerve</term><term>Nerve fascicle</term><term>Nerve fascicles</term><term>Normal sural nerve</term><term>Other variables</term><term>Particular nerve</term><term>Pathologie nerveuse</term><term>Peripheral nerve</term><term>Peripheral nerves</term><term>Peripheral neuropathies</term><term>Peroneal</term><term>Peroneal nerve</term><term>Peroneal nerves</term><term>Regression curve</term><term>Relative interval</term><term>Right side</term><term>Same nerve</term><term>Same time</term><term>Sampling procedures</term><term>Semithin sections</term><term>Significant difference</term><term>Single nerve</term><term>Spatial distribution</term><term>Superficial peroneal nerve</term><term>Superficial peroneal nerves</term><term>Sural</term><term>Sural nerves</term><term>Surface area</term><term>Systematic study</term><term>Total fibre numbers</term><term>Uniform distribution</term><term>Upper density</term><term>Valid sampling system</term><term>Whole nerve</term><term>Whole nerve fascicle</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>fibre</json:string><json:string>fascicle</json:string><json:string>myelinated</json:string><json:string>myelinated fibres</json:string><json:string>peroneal</json:string><json:string>nerve fascicle</json:string><json:string>fibre density</json:string><json:string>sural</json:string><json:string>surface area</json:string><json:string>axon</json:string><json:string>nerve fascicles</json:string><json:string>gherardi</json:string><json:string>aneurysm</json:string><json:string>spatial distribution</json:string><json:string>peripheral nerves</json:string><json:string>superficial peroneal nerve</json:string><json:string>greater surface</json:string><json:string>nerve</json:string><json:string>semithin sections</json:string><json:string>acta neuropath</json:string><json:string>myelinated axons</json:string><json:string>peroneal nerve</json:string><json:string>fibre distribution</json:string><json:string>sural nerves</json:string><json:string>fibre number</json:string><json:string>fascicular area</json:string><json:string>morphometric analysis</json:string><json:string>uniform distribution</json:string><json:string>biopsy</json:string><json:string>right side</json:string><json:string>fibre size</json:string><json:string>valid sampling system</json:string><json:string>systematic study</json:string><json:string>grid squares</json:string><json:string>whole nerve fascicle</json:string><json:string>same time</json:string><json:string>sampling procedures</json:string><json:string>same nerve</json:string><json:string>particular nerve</json:string><json:string>other variables</json:string><json:string>internal border</json:string><json:string>corresponding diameters</json:string><json:string>different sizes</json:string><json:string>individual variations</json:string><json:string>significant difference</json:string><json:string>large variations</json:string><json:string>superficial peroneal nerves</json:string><json:string>myelinated fibre densities</json:string><json:string>extreme values</json:string><json:string>single nerve</json:string><json:string>narrow range</json:string><json:string>diagnostic tool</json:string><json:string>regression curve</json:string><json:string>confidence limit</json:string><json:string>upper density</json:string><json:string>lower density</json:string><json:string>relative interval</json:string><json:string>confidence interval</json:string><json:string>peroneal nerves</json:string><json:string>total fibre numbers</json:string><json:string>average fibre densities</json:string><json:string>whole nerve</json:string><json:string>peripheral nerve</json:string><json:string>electron microscopy</json:string><json:string>pathologie nerveuse</json:string><json:string>normal sural nerve</json:string><json:string>peripheral neuropathies</json:string><json:string>human nerves</json:string><json:string>abrupt variations</json:string></teeft></keywords><author><json:item><name>R. Saxod</name><affiliations><json:string>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</json:string></affiliations></json:item><json:item><name>S. Torch</name><affiliations><json:string>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</json:string></affiliations></json:item><json:item><name>A. Vila</name><affiliations><json:string>Laboratoire d'Electromyographie, Centre Hospitalier Régional de Grenoble, Grenoble France</json:string></affiliations></json:item><json:item><name>A. Laurent</name><affiliations><json:string>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</json:string></affiliations></json:item><json:item><name>P. Stoebner</name><affiliations><json:string>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Fibre density</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Human peripheral nerve</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Myelinated fibres</value></json:item></subject><arkIstex>ark:/67375/6H6-V4WMTPRS-L</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</abstract><qualityIndicators><refBibsNative>true</refBibsNative><abstractWordCount>179</abstractWordCount><abstractCharCount>1131</abstractCharCount><keywordCount>3</keywordCount><score>9.148</score><pdfWordCount>5761</pdfWordCount><pdfCharCount>32655</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>16</pdfPageCount><pdfPageSize>504 x 735 pts</pdfPageSize></qualityIndicators><title>The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</title><pmid><json:string>4087019</json:string></pmid><pii><json:string>0022-510X(85)90036-X</json:string></pii><genre><json:string>research-article</json:string></genre><serie><title>Thesis Faculté de Médecine</title><language><json:string>unknown</json:string></language></serie><host><title>Journal of the Neurological Sciences</title><language><json:string>unknown</json:string></language><publicationDate>1985</publicationDate><issn><json:string>0022-510X</json:string></issn><pii><json:string>S0022-510X(00)X0198-0</json:string></pii><volume>71</volume><issue>1</issue><pages><first>49</first><last>64</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>7229</json:string><json:string>6832</json:string><json:string>5759</json:string><json:string>1985</json:string></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>G. Drouet</json:string><json:string>M.Y. Usson</json:string><json:string>R. Saxod</json:string></persName><placeName><json:string>Grenoble</json:string><json:string>France</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Ohnishi et al. 1974a, b</json:string><json:string>Tang and Ebbesson (1972)</json:string><json:string>Stevens et al. 1973</json:string><json:string>Barioz et al. 1982</json:string><json:string>O'Sullivan and Swallow 1966</json:string><json:string>Kirschner and Hollingshead 1980</json:string><json:string>Escourolle and Poirier 1967</json:string><json:string>Berthold et al. 1982</json:string><json:string>Asbury and Johnson 1978</json:string><json:string>Stoebner et al. 1981</json:string><json:string>Tang and Ebbesson 1972</json:string><json:string>Origuchi 1981</json:string><json:string>Schwartz 1969</json:string><json:string>Fardeau et al. (1978)</json:string><json:string>Mayhew et al. (1981)</json:string><json:string>Saxod et al. 1983</json:string><json:string>Garven et al. (1962)</json:string><json:string>Swallow 1968</json:string><json:string>Received 12 February, 1985</json:string><json:string>Accepted 13 June, 1985</json:string><json:string>Grosse et al. 1981 a,b</json:string><json:string>Grosse et al. 1981b</json:string><json:string>O'Sullivan and Swallow (1968)</json:string><json:string>Tohgi et al. (1977)</json:string><json:string>O'Sullivan and Swallow 1968</json:string><json:string>Miyamoto et al. 1982</json:string><json:string>Grosse et al. 1981a</json:string><json:string>Selva et al. 1981</json:string><json:string>Gherardi 1982</json:string><json:string>Bronson et al. 1978</json:string><json:string>Grosse et al. (1981a, b)</json:string><json:string>Arnold and Harriman 1970</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-V4WMTPRS-L</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - clinical neurology</json:string></wos><scienceMetrix></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Clinical Neurology</json:string><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Neurology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string><json:string>4 - informatique, statistique et modelisations biomedicales</json:string></inist></categories><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><doi><json:string>10.1016/0022-510X(85)90036-X</json:string></doi><id>9648A10F26E34BB41354EB2DF0823026456428D8</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-V4WMTPRS-L/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-V4WMTPRS-L/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-V4WMTPRS-L/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</title><title level="a" type="sub">Statistical study of 41 normal samples</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1985</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>This work was supported by a grant (C.R.E. 836026) from the Institut National de la Santé et de la Recherche Médicale (INSERM).</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</title><title level="a" type="sub">Statistical study of 41 normal samples</title><author xml:id="author-0000"><persName><forename type="first">R.</forename><surname>Saxod</surname></persName><note type="biography">Address for reprints: Professeur R. Saxod, Laboratoire de Biologie Animale, Université Scientifique et Médicale de Grenoble, BP 68, 38402 Saint-Martin-d'Hères, Cedex, France.</note><affiliation>Address for reprints: Professeur R. Saxod, Laboratoire de Biologie Animale, Université Scientifique et Médicale de Grenoble, BP 68, 38402 Saint-Martin-d'Hères, Cedex, France.</affiliation><affiliation>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">S.</forename><surname>Torch</surname></persName><affiliation>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">A.</forename><surname>Vila</surname></persName><affiliation>Laboratoire d'Electromyographie, Centre Hospitalier Régional de Grenoble, Grenoble France</affiliation></author><author xml:id="author-0003"><persName><forename type="first">A.</forename><surname>Laurent</surname></persName><affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</affiliation></author><author xml:id="author-0004"><persName><forename type="first">P.</forename><surname>Stoebner</surname></persName><affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</affiliation></author><idno type="istex">9648A10F26E34BB41354EB2DF0823026456428D8</idno><idno type="ark">ark:/67375/6H6-V4WMTPRS-L</idno><idno type="DOI">10.1016/0022-510X(85)90036-X</idno><idno type="PII">0022-510X(85)90036-X</idno></analytic><monogr><title level="j">Journal of the Neurological Sciences</title><title level="j" type="abbrev">JNS</title><idno type="pISSN">0022-510X</idno><idno type="PII">S0022-510X(00)X0198-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985"></date><biblScope unit="volume">71</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="49">49</biblScope><biblScope unit="page" to="64">64</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Fibre density</term></item><item><term>Human peripheral nerve</term></item><item><term>Myelinated fibres</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985-06-13">Modified</change><change when="1985">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-V4WMTPRS-L/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JNS</jid><aid>8590036X</aid><ce:pii>0022-510X(85)90036-X</ce:pii><ce:doi>10.1016/0022-510X(85)90036-X</ce:doi><ce:copyright type="unknown" year="1985"></ce:copyright></item-info><head><ce:article-footnote><ce:label>☆</ce:label><ce:note-para>This work was supported by a grant (C.R.E. 836026) from the Institut National de la Santé et de la Recherche Médicale (INSERM).</ce:note-para></ce:article-footnote><ce:title>The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</ce:title><ce:subtitle>Statistical study of 41 normal samples</ce:subtitle><ce:author-group><ce:author><ce:given-name>R.</ce:given-name><ce:surname>Saxod</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Torch</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Vila</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Laurent</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>P.</ce:given-name><ce:surname>Stoebner</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Laboratoire d'Electromyographie, Centre Hospitalier Régional de Grenoble, Grenoble France</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>c</ce:label><ce:textfn>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Address for reprints: Professeur R. Saxod, Laboratoire de Biologie Animale, Université Scientifique et Médicale de Grenoble, BP 68, 38402 Saint-Martin-d'Hères, Cedex, France.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="12" month="2" year="1985"></ce:date-received><ce:date-revised day="13" month="6" year="1985"></ce:date-revised><ce:date-accepted day="13" month="6" year="1985"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Fibre density</ce:text></ce:keyword><ce:keyword><ce:text>Human peripheral nerve</ce:text></ce:keyword><ce:keyword><ce:text>Myelinated fibres</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</title><subTitle>Statistical study of 41 normal samples</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>The density of myelinated fibres is related to the fascicle diameter in human superficial peroneal nerve</title><subTitle>Statistical study of 41 normal samples</subTitle></titleInfo><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Saxod</namePart><affiliation>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</affiliation><description>Address for reprints: Professeur R. Saxod, Laboratoire de Biologie Animale, Université Scientifique et Médicale de Grenoble, BP 68, 38402 Saint-Martin-d'Hères, Cedex, France.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Torch</namePart><affiliation>Laboratoire de Biologie Animale, Unité Associée au CNRS No. 682, Université Scientifique et Médicale de Grenoble, Grenoble France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Vila</namePart><affiliation>Laboratoire d'Electromyographie, Centre Hospitalier Régional de Grenoble, Grenoble France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Laurent</namePart><affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Stoebner</namePart><affiliation>Laboratoire de Pathologie Cellulaire, Centre Hospitalier Régional de Grenoble, Grenoble France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued><dateModified encoding="w3cdtf">1985-06-13</dateModified><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: The density of myelinated fibres in the superficial peroneal nerve was studied in 41 samples from 24 control human subjects. Photographic montages of the whole nerve fascicle were made from semithin and ultrathin transverse sections and used for a statistical analysis of sampling procedures, range of variations and relations between density and other variables. The results indicate that the spatial distribution of myelinated fibres within a nerve is often non-uniform. Therefore, it was not possible to define a statistically valid sampling system. The study of relations between variables shows the lack of any correlation between density and age and a considerable variation in the density. In contrast, there is a strong positive linear correlation between the surface area of the nerve fascicle and its content of myelinated fibres. That is, the fibre density of a given normal nerve is related to its diameter and can be predicted within a narrow range of error. We propose the term “derived density” for this value, and its application as a tool in the diagnosis of peripheral neuropathies is now being studied.</abstract><note>This work was supported by a grant (C.R.E. 836026) from the Institut National de la Santé et de la Recherche Médicale (INSERM).</note><subject><genre>Keywords</genre><topic>Fibre density</topic><topic>Human peripheral nerve</topic><topic>Myelinated fibres</topic></subject><relatedItem type="host"><titleInfo><title>Journal of the Neurological Sciences</title></titleInfo><titleInfo type="abbreviated"><title>JNS</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued></originInfo><identifier type="ISSN">0022-510X</identifier><identifier type="PII">S0022-510X(00)X0198-0</identifier><part><date>1985</date><detail type="volume"><number>71</number><caption>vol.</caption></detail><detail type="issue"><number>1</number><caption>no.</caption></detail><extent unit="issue-pages"><start>1</start><end>136</end></extent><extent unit="pages"><start>49</start><end>64</end></extent></part></relatedItem><identifier type="istex">9648A10F26E34BB41354EB2DF0823026456428D8</identifier><identifier type="ark">ark:/67375/6H6-V4WMTPRS-L</identifier><identifier type="DOI">10.1016/0022-510X(85)90036-X</identifier><identifier type="PII">0022-510X(85)90036-X</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-V4WMTPRS-L/record.json</uri></json:item></metadata></istex></record>Pour manipuler ce document sous Unix (Dilib)
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