No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults
Identifieur interne : 001C70 ( Istex/Corpus ); précédent : 001C69; suivant : 001C71No effect of bicarbonate treatment on insulin sensitivity and glucose control in non-diabetic older adults
Auteurs : Susan S. Harris ; Bess Dawson-HughesSource :
- Endocrine [ 1355-008X ] ; 2010-10-01.
English descriptors
Abstract
Abstract: Chronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes. This analysis was conducted to determine whether bicarbonate supplementation, an alkalinizing treatment, improves insulin sensitivity or glucose control in non-diabetic older adults. Fasting blood glucose and insulin were measured in stored samples from subjects who had completed a 3-month clinical trial of bicarbonate supplementation to improve indicators of bone and muscle health. One hundred and fifty three ambulatory, non-diabetic adults aged 50 years and older were studied. Subjects were randomized to one of two bicarbonate groups (67.5 mmol/day of potassium bicarbonate or sodium bicarbonate) or to one of two no-bicarbonate groups (67.5 mmol/day of placebo or potassium chloride). Subjects remained on treatment throughout the 3-month study. The primary outcome measures were changes in fasting plasma glucose, serum insulin and HOMA-IR, an index of insulin resistance. Bicarbonate supplementation reduced net acid excretion (adjusted mean ± SEM for the change in NAE/creatinine, mmol/mmol, was 0.23 ± 0.22 in the no-bicarbonate group compared with −3.53 ± 0.22 in the bicarbonate group, P < 0.001) but had no effect on fasting plasma glucose, serum insulin, or HOMA-IR. In conclusion, bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults.
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DOI: 10.1007/s12020-010-9377-6
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<front><div type="abstract" xml:lang="en">Abstract: Chronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes. This analysis was conducted to determine whether bicarbonate supplementation, an alkalinizing treatment, improves insulin sensitivity or glucose control in non-diabetic older adults. Fasting blood glucose and insulin were measured in stored samples from subjects who had completed a 3-month clinical trial of bicarbonate supplementation to improve indicators of bone and muscle health. One hundred and fifty three ambulatory, non-diabetic adults aged 50 years and older were studied. Subjects were randomized to one of two bicarbonate groups (67.5 mmol/day of potassium bicarbonate or sodium bicarbonate) or to one of two no-bicarbonate groups (67.5 mmol/day of placebo or potassium chloride). Subjects remained on treatment throughout the 3-month study. The primary outcome measures were changes in fasting plasma glucose, serum insulin and HOMA-IR, an index of insulin resistance. Bicarbonate supplementation reduced net acid excretion (adjusted mean ± SEM for the change in NAE/creatinine, mmol/mmol, was 0.23 ± 0.22 in the no-bicarbonate group compared with −3.53 ± 0.22 in the bicarbonate group, P < 0.001) but had no effect on fasting plasma glucose, serum insulin, or HOMA-IR. In conclusion, bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults.</div>
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<abstract lang="en">Abstract: Chronic mild metabolic acidosis is common among older adults, and limited evidence suggests that it may contribute to insulin resistance and type-2 diabetes. This analysis was conducted to determine whether bicarbonate supplementation, an alkalinizing treatment, improves insulin sensitivity or glucose control in non-diabetic older adults. Fasting blood glucose and insulin were measured in stored samples from subjects who had completed a 3-month clinical trial of bicarbonate supplementation to improve indicators of bone and muscle health. One hundred and fifty three ambulatory, non-diabetic adults aged 50 years and older were studied. Subjects were randomized to one of two bicarbonate groups (67.5 mmol/day of potassium bicarbonate or sodium bicarbonate) or to one of two no-bicarbonate groups (67.5 mmol/day of placebo or potassium chloride). Subjects remained on treatment throughout the 3-month study. The primary outcome measures were changes in fasting plasma glucose, serum insulin and HOMA-IR, an index of insulin resistance. Bicarbonate supplementation reduced net acid excretion (adjusted mean ± SEM for the change in NAE/creatinine, mmol/mmol, was 0.23 ± 0.22 in the no-bicarbonate group compared with −3.53 ± 0.22 in the bicarbonate group, P < 0.001) but had no effect on fasting plasma glucose, serum insulin, or HOMA-IR. In conclusion, bicarbonate supplementation does not appear to improve insulin sensitivity or glucose control in non-diabetic older adults.</abstract>
<note>Original Article</note>
<subject lang="en"><genre>Keywords</genre>
<topic>Metabolic acidosis</topic>
<topic>Insulin resistance</topic>
<topic>Glucose control</topic>
<topic>Bicarbonate</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Endocrine</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Endocr</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<originInfo><publisher>Springer</publisher>
<dateIssued encoding="w3cdtf">2010-11-03</dateIssued>
<copyrightDate encoding="w3cdtf">2010</copyrightDate>
</originInfo>
<subject><genre>Medicine & Public Health</genre>
<topic>Science, general</topic>
<topic>Internal Medicine</topic>
<topic>Diabetes</topic>
<topic>Endocrinology</topic>
</subject>
<identifier type="ISSN">1355-008X</identifier>
<identifier type="eISSN">1559-0100</identifier>
<identifier type="JournalID">12020</identifier>
<identifier type="IssueArticleCount">26</identifier>
<identifier type="VolumeIssueCount">3</identifier>
<part><date>2010</date>
<detail type="volume"><number>38</number>
<caption>vol.</caption>
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<detail type="issue"><number>2</number>
<caption>no.</caption>
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<extent unit="pages"><start>221</start>
<end>226</end>
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<identifier type="DOI">10.1007/s12020-010-9377-6</identifier>
<identifier type="ArticleID">9377</identifier>
<identifier type="ArticleID">s12020-010-9377-6</identifier>
<accessCondition type="use and reproduction" contentType="copyright">Springer Science+Business Media, LLC, 2010</accessCondition>
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