Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver
Identifieur interne : 000627 ( Istex/Corpus ); précédent : 000626; suivant : 000628Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver
Auteurs : Véronique Grando-Lemaire ; Catherine Guettier ; Sylvie Chevret ; Michel Beaugrand ; Jean-Claude TrinchetSource :
- Journal of Hepatology [ 0168-8278 ] ; 1999.
English descriptors
- Teeft :
- Abou rached, Activity score, Alcohol consumption, Alcohol intake, Alcoholic hepatitis, Alcoholic liver disease, Carcinoma, Carcinome hcpatocellulaire, Cedex, Cell dysplasia, Centre hospitalier, Chemical carcinogens, Chronic hepatitis, Chronic liver disease, Cigarette smoking, Cirrhosis, Cirrhotic, Cirrhotic liver, Clin gastroenterol, Dysplasia, Epidemiological factors, Genetic hemochromatosis, Hepatic fibrosis, Hepatitis, Hepatocellular, Hepatocellular carcinoma, Hepatology, High prevalence, Histological, Histological activity, Hopital, Hopital beaujon, Hopital guillaume, Hopital jean verdier, Hotel dieu, Inflammation, Iron overload, Large cell dysplasia, Liver, Liver carcinogenesis, Liver cell dysplasia, Nantes cedex, Noncirrhotic liver, Normal liver, Normal livers, Oral contraceptives, Other patients, Overload, Pathological changes, Pathological liver changes, Present study, Primary liver cancer, Risk factor, Risk factors, Serological, Serological hepatitis, Serological markers, Steatosis, Strasbourg cedex, Tobacco consumption, Viral infection.
Abstract
Abstract: Background/Aim: In the West, hepatocellular carcinoma rarely occurs in patients without cirrhosis. In these patients, epidemiological factors and the histopathology of the non-neoplastic liver are not well known. The aim of this study was to clarify these points. Methods: We studied 30 patients (26 men, 28–87 years) with hepatocellular carcinoma and histologically-proven non-cirrhotic livers. Serological markers of HBV and HCV infection, as well as alcohol and tobacco consumption were evaluated. Pathological changes in the non-tumorous liver (fibrosis, inflammation, steatosis, alcoholic hepatitis lesions, iron overload, and large cell dysplasia) were systematically assessed using semi-quantitative scores. Results: Twenty patients had alcohol intake ≥30 g/d and 16 were smokers. Serological HBV or HCV markers were positive in 10 patients. Only four patients had no exposure to alcohol or tobacco and no serological markers of HBV or HCV. Histological examination showed that all livers had pathological changes. Seventeen patients (57%) had clearly-identified chronic liver disease: chronic hepatitis (n=10) or alcoholic liver disease (n=7). Non-specific and moderate pathological changes were observed in the 13 other patients (43%), with different degrees of fibrosis, activity, steatosis, and iron overload. Large cell dysplasia was present in 12 patients (40%). Conclusions: In our study, all patients with hepatocellular carcinoma and non-cirrhotic livers had non-tumorous pathological liver changes, especially iron overload and large cell dysplasia. These results suggest that hepatocellular carcinoma originates from an abnormal histological background, even in non-cirrhotic liver.
Url:
DOI: 10.1016/S0168-8278(99)80044-0
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ISTEX:1BE1EE7CA8CCEB8F7BA196B3212D8E84782878CFLe document en format XML
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sort="Chevret, Sylvie" uniqKey="Chevret S" first="Sylvie" last="Chevret">Sylvie Chevret</name><affiliation><mods:affiliation>Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Beaugrand, Michel" sort="Beaugrand, Michel" uniqKey="Beaugrand M" first="Michel" last="Beaugrand">Michel Beaugrand</name><affiliation><mods:affiliation>Service d'Hépato-Gastroentérologie, France</mods:affiliation></affiliation></author><author><name sortKey="Trinchet, Jean Claude" sort="Trinchet, Jean Claude" uniqKey="Trinchet J" first="Jean-Claude" last="Trinchet">Jean-Claude Trinchet</name><affiliation><mods:affiliation>Service d'Hépato-Gastroentérologie, France</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1BE1EE7CA8CCEB8F7BA196B3212D8E84782878CF</idno><date when="1999" 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C" first="Catherine" last="Guettier">Catherine Guettier</name><affiliation><mods:affiliation>Service d'Anatomie Pathologique, Hôpital Jean Verdier, Assistance publique-Hôpitaux de Paris, Bondy, France</mods:affiliation></affiliation></author><author><name sortKey="Chevret, Sylvie" sort="Chevret, Sylvie" uniqKey="Chevret S" first="Sylvie" last="Chevret">Sylvie Chevret</name><affiliation><mods:affiliation>Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France</mods:affiliation></affiliation></author><author><name sortKey="Beaugrand, Michel" sort="Beaugrand, Michel" uniqKey="Beaugrand M" first="Michel" last="Beaugrand">Michel Beaugrand</name><affiliation><mods:affiliation>Service d'Hépato-Gastroentérologie, France</mods:affiliation></affiliation></author><author><name sortKey="Trinchet, Jean Claude" sort="Trinchet, Jean Claude" uniqKey="Trinchet J" first="Jean-Claude" last="Trinchet">Jean-Claude Trinchet</name><affiliation><mods:affiliation>Service d'Hépato-Gastroentérologie, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Journal of Hepatology</title><title level="j" type="abbrev">JHEPAT</title><idno type="ISSN">0168-8278</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999">1999</date><biblScope unit="volume">31</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="508">508</biblScope><biblScope unit="page" to="513">513</biblScope></imprint><idno type="ISSN">0168-8278</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0168-8278</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Abou rached</term><term>Activity score</term><term>Alcohol consumption</term><term>Alcohol intake</term><term>Alcoholic hepatitis</term><term>Alcoholic liver disease</term><term>Carcinoma</term><term>Carcinome hcpatocellulaire</term><term>Cedex</term><term>Cell dysplasia</term><term>Centre hospitalier</term><term>Chemical carcinogens</term><term>Chronic hepatitis</term><term>Chronic liver disease</term><term>Cigarette smoking</term><term>Cirrhosis</term><term>Cirrhotic</term><term>Cirrhotic liver</term><term>Clin gastroenterol</term><term>Dysplasia</term><term>Epidemiological factors</term><term>Genetic hemochromatosis</term><term>Hepatic fibrosis</term><term>Hepatitis</term><term>Hepatocellular</term><term>Hepatocellular carcinoma</term><term>Hepatology</term><term>High prevalence</term><term>Histological</term><term>Histological activity</term><term>Hopital</term><term>Hopital beaujon</term><term>Hopital guillaume</term><term>Hopital jean verdier</term><term>Hotel dieu</term><term>Inflammation</term><term>Iron overload</term><term>Large cell dysplasia</term><term>Liver</term><term>Liver carcinogenesis</term><term>Liver cell dysplasia</term><term>Nantes cedex</term><term>Noncirrhotic liver</term><term>Normal liver</term><term>Normal livers</term><term>Oral contraceptives</term><term>Other patients</term><term>Overload</term><term>Pathological changes</term><term>Pathological liver changes</term><term>Present study</term><term>Primary liver cancer</term><term>Risk factor</term><term>Risk factors</term><term>Serological</term><term>Serological hepatitis</term><term>Serological markers</term><term>Steatosis</term><term>Strasbourg cedex</term><term>Tobacco consumption</term><term>Viral infection</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Background/Aim: In the West, hepatocellular carcinoma rarely occurs in patients without cirrhosis. In these patients, epidemiological factors and the histopathology of the non-neoplastic liver are not well known. The aim of this study was to clarify these points. Methods: We studied 30 patients (26 men, 28–87 years) with hepatocellular carcinoma and histologically-proven non-cirrhotic livers. Serological markers of HBV and HCV infection, as well as alcohol and tobacco consumption were evaluated. Pathological changes in the non-tumorous liver (fibrosis, inflammation, steatosis, alcoholic hepatitis lesions, iron overload, and large cell dysplasia) were systematically assessed using semi-quantitative scores. Results: Twenty patients had alcohol intake ≥30 g/d and 16 were smokers. Serological HBV or HCV markers were positive in 10 patients. Only four patients had no exposure to alcohol or tobacco and no serological markers of HBV or HCV. Histological examination showed that all livers had pathological changes. Seventeen patients (57%) had clearly-identified chronic liver disease: chronic hepatitis (n=10) or alcoholic liver disease (n=7). Non-specific and moderate pathological changes were observed in the 13 other patients (43%), with different degrees of fibrosis, activity, steatosis, and iron overload. Large cell dysplasia was present in 12 patients (40%). Conclusions: In our study, all patients with hepatocellular carcinoma and non-cirrhotic livers had non-tumorous pathological liver changes, especially iron overload and large cell dysplasia. These results suggest that hepatocellular carcinoma originates from an abnormal histological background, even in non-cirrhotic liver.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>hepatocellular</json:string><json:string>hepatocellular carcinoma</json:string><json:string>hopital</json:string><json:string>cirrhosis</json:string><json:string>carcinoma</json:string><json:string>histological</json:string><json:string>iron overload</json:string><json:string>cedex</json:string><json:string>steatosis</json:string><json:string>pathological changes</json:string><json:string>dysplasia</json:string><json:string>large cell dysplasia</json:string><json:string>hepatology</json:string><json:string>cirrhotic</json:string><json:string>liver cell dysplasia</json:string><json:string>alcohol consumption</json:string><json:string>chronic hepatitis</json:string><json:string>hepatitis</json:string><json:string>alcoholic liver disease</json:string><json:string>serological markers</json:string><json:string>inflammation</json:string><json:string>overload</json:string><json:string>tobacco consumption</json:string><json:string>alcoholic hepatitis</json:string><json:string>noncirrhotic liver</json:string><json:string>normal liver</json:string><json:string>risk factor</json:string><json:string>liver carcinogenesis</json:string><json:string>alcohol intake</json:string><json:string>cell dysplasia</json:string><json:string>liver</json:string><json:string>chemical carcinogens</json:string><json:string>oral contraceptives</json:string><json:string>present study</json:string><json:string>hepatic fibrosis</json:string><json:string>histological activity</json:string><json:string>activity score</json:string><json:string>cigarette smoking</json:string><json:string>epidemiological factors</json:string><json:string>risk factors</json:string><json:string>chronic liver disease</json:string><json:string>serological hepatitis</json:string><json:string>genetic hemochromatosis</json:string><json:string>cirrhotic liver</json:string><json:string>normal livers</json:string><json:string>other patients</json:string><json:string>high prevalence</json:string><json:string>pathological liver changes</json:string><json:string>abou rached</json:string><json:string>carcinome hcpatocellulaire</json:string><json:string>hopital jean verdier</json:string><json:string>hopital beaujon</json:string><json:string>hopital guillaume</json:string><json:string>nantes cedex</json:string><json:string>hotel dieu</json:string><json:string>centre hospitalier</json:string><json:string>strasbourg cedex</json:string><json:string>primary liver cancer</json:string><json:string>clin gastroenterol</json:string><json:string>viral infection</json:string><json:string>serological</json:string></teeft></keywords><author><json:item><name>Véronique Grando-Lemaire</name><affiliations><json:string>E-mail: secmed.hge@jvr.ap-hop-paris.fr</json:string><json:string>Service d'Hépato-Gastroentérologie, France</json:string></affiliations></json:item><json:item><name>Catherine Guettier</name><affiliations><json:string>Service d'Anatomie Pathologique, Hôpital Jean Verdier, Assistance publique-Hôpitaux de Paris, Bondy, France</json:string></affiliations></json:item><json:item><name>Sylvie Chevret</name><affiliations><json:string>Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France</json:string></affiliations></json:item><json:item><name>Michel Beaugrand</name><affiliations><json:string>Service d'Hépato-Gastroentérologie, France</json:string></affiliations></json:item><json:item><name>Jean-Claude Trinchet</name><affiliations><json:string>Service d'Hépato-Gastroentérologie, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Hepatocellular carcinoma</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Histopathology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Iron overload</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Large cell dysplasia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Non-cirrhotic liver</value></json:item></subject><arkIstex>ark:/67375/6H6-0KCDN3C6-9</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Background/Aim: In the West, hepatocellular carcinoma rarely occurs in patients without cirrhosis. In these patients, epidemiological factors and the histopathology of the non-neoplastic liver are not well known. The aim of this study was to clarify these points. Methods: We studied 30 patients (26 men, 28–87 years) with hepatocellular carcinoma and histologically-proven non-cirrhotic livers. Serological markers of HBV and HCV infection, as well as alcohol and tobacco consumption were evaluated. Pathological changes in the non-tumorous liver (fibrosis, inflammation, steatosis, alcoholic hepatitis lesions, iron overload, and large cell dysplasia) were systematically assessed using semi-quantitative scores. Results: Twenty patients had alcohol intake ≥30 g/d and 16 were smokers. Serological HBV or HCV markers were positive in 10 patients. Only four patients had no exposure to alcohol or tobacco and no serological markers of HBV or HCV. Histological examination showed that all livers had pathological changes. Seventeen patients (57%) had clearly-identified chronic liver disease: chronic hepatitis (n=10) or alcoholic liver disease (n=7). Non-specific and moderate pathological changes were observed in the 13 other patients (43%), with different degrees of fibrosis, activity, steatosis, and iron overload. Large cell dysplasia was present in 12 patients (40%). Conclusions: In our study, all patients with hepatocellular carcinoma and non-cirrhotic livers had non-tumorous pathological liver changes, especially iron overload and large cell dysplasia. These results suggest that hepatocellular carcinoma originates from an abnormal histological background, even in non-cirrhotic liver.</abstract><qualityIndicators><score>8.378</score><pdfWordCount>3594</pdfWordCount><pdfCharCount>23957</pdfCharCount><pdfVersion>1.2</pdfVersion><pdfPageCount>6</pdfPageCount><pdfPageSize>576 x 792 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>232</abstractWordCount><abstractCharCount>1710</abstractCharCount><keywordCount>5</keywordCount></qualityIndicators><title>Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver</title><pmid><json:string>10488711</json:string></pmid><pii><json:string>S0168-8278(99)80044-0</json:string></pii><corporate><json:item><name>for the Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire</name></json:item></corporate><genre><json:string>research-article</json:string></genre><host><title>Journal of Hepatology</title><language><json:string>unknown</json:string></language><publicationDate>1999</publicationDate><issn><json:string>0168-8278</json:string></issn><pii><json:string>S0168-8278(00)X0058-X</json:string></pii><volume>31</volume><issue>3</issue><pages><first>508</first><last>513</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>1999</json:string></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName><json:string>D. Valla</json:string><json:string>M. Beaugrand</json:string><json:string>C. Duvoux</json:string><json:string>J. Rahiers</json:string><json:string>J. Pringot</json:string><json:string>L. Le Bodic</json:string><json:string>S. Erlinger</json:string><json:string>H. Gibaud</json:string><json:string>T. Martin</json:string><json:string>C. Caron-Poitreau</json:string><json:string>General</json:string><json:string>Nazaire Cedex</json:string><json:string>D. Perrin</json:string><json:string>Lyon</json:string><json:string>Jean Verdier</json:string><json:string>P. J. Valette</json:string><json:string>Michel Beaugrand</json:string><json:string>Sylvie Chevret</json:string><json:string>R. Lapointe</json:string><json:string>S. Pol</json:string><json:string>Y. Ajavon</json:string><json:string>A. Hadengue</json:string><json:string>F. Oberti</json:string><json:string>D. Mathieu</json:string><json:string>Albert Michallon</json:string><json:string>S. Chevret</json:string><json:string>A. 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Floquet</json:string><json:string>CHU Nancy-Brabois</json:string><json:string>J. Drouillard</json:string><json:string>Tran Van Nhieu</json:string><json:string>V. Bas</json:string><json:string>M. Le Rhun</json:string><json:string>M. Dagenais</json:string><json:string>Renee Laennec</json:string><json:string>J. Frexinos</json:string><json:string>C. Hoang</json:string><json:string>F. Berger</json:string><json:string>M. Chevalier</json:string><json:string>CHU Rangueil</json:string><json:string>Le Bodic</json:string><json:string>R. Poupon</json:string><json:string>N. Mostefa-Kara</json:string><json:string>C. Laboisse</json:string><json:string>C. Masliah</json:string><json:string>A. Pauwels</json:string><json:string>M. Melange</json:string><json:string>L. Descos</json:string><json:string>C. Guettier</json:string><json:string>D. Regent</json:string><json:string>S. Claudel-Bonvoisin</json:string><json:string>H. Labadie</json:string><json:string>de Pontoise</json:string><json:string>Universitaire</json:string><json:string>C. Buffet</json:string><json:string>E. Zafrani</json:string><json:string>D. Vetter</json:string></persName><placeName><json:string>Paris</json:string><json:string>Bordeaux</json:string><json:string>Nancy</json:string><json:string>Saint-Denis</json:string><json:string>Saint Maur</json:string><json:string>Saint Luc</json:string><json:string>Grenoble</json:string><json:string>Montreal</json:string><json:string>Canada</json:string><json:string>Nantes</json:string><json:string>Strasbourg</json:string><json:string>Toulouse</json:string><json:string>Saint Antoine</json:string><json:string>France</json:string><json:string>Quebec</json:string><json:string>Lyon</json:string><json:string>Belgium</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Deugnier et al.</json:string><json:string>Anthony et al.</json:string><json:string>Turlin et al.</json:string><json:string>Okuda et al.</json:string><json:string>Grando-Lemaire et al.</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-0KCDN3C6-9</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - gastroenterology & hepatology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - gastroenterology & hepatology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Hepatology</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences medicales</json:string></inist></categories><publicationDate>1999</publicationDate><copyrightDate>1999</copyrightDate><doi><json:string>10.1016/S0168-8278(99)80044-0</json:string></doi><id>1BE1EE7CA8CCEB8F7BA196B3212D8E84782878CF</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-0KCDN3C6-9/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-0KCDN3C6-9/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/6H6-0KCDN3C6-9/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a">Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://scientific-publisher.data.istex.fr">ELSEVIER</publisher><availability><licence><p>elsevier</p></licence></availability><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M"></p><date>1999</date></publicationStmt><notesStmt><note type="research-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note type="content">TABLE 1: Initial characteristics of 30 patients with hepatocellular carcinoma and non-cirrhotic liver</note><note type="content">TABLE 2: Pathological changes in the non-tumorous liver in 30 patients with hepatocellular carcinoma and non-cirrhotic liver</note><note type="content">TABLE 3: Pathological changes according to the pathological group of the nontumorous liver in 30 patients with hepatocellular carcinoma and noncirrhotic liver</note><note type="content">TABLE 4: Epidemiological risk factors according to the pathological group of the non-tumorous liver in 30 patients with hepatocellular carcinoma and non-cirrhotic liver</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver</title><author role="org"><orgName>for the Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire</orgName></author><author xml:id="author-0000"><persName><forename type="first">Véronique</forename><surname>Grando-Lemaire</surname></persName><email>secmed.hge@jvr.ap-hop-paris.fr</email><note type="biography">Véronique Grando-Lemaire, Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier, Avenue du 14 juillet, 93143 Bondy Cedex, France. Tel: 33 1 48 02 62 80. Fax: 33 1 48 02 62 02.</note><affiliation>Véronique Grando-Lemaire, Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier, Avenue du 14 juillet, 93143 Bondy Cedex, France. Tel: 33 1 48 02 62 80. Fax: 33 1 48 02 62 02.</affiliation><affiliation>Service d'Hépato-Gastroentérologie, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Catherine</forename><surname>Guettier</surname></persName><affiliation>Service d'Anatomie Pathologique, Hôpital Jean Verdier, Assistance publique-Hôpitaux de Paris, Bondy, France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Sylvie</forename><surname>Chevret</surname></persName><affiliation>Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France</affiliation></author><author xml:id="author-0003"><persName><forename type="first">Michel</forename><surname>Beaugrand</surname></persName><affiliation>Service d'Hépato-Gastroentérologie, France</affiliation></author><author xml:id="author-0004"><persName><forename type="first">Jean-Claude</forename><surname>Trinchet</surname></persName><affiliation>Service d'Hépato-Gastroentérologie, France</affiliation></author><idno type="istex">1BE1EE7CA8CCEB8F7BA196B3212D8E84782878CF</idno><idno type="ark">ark:/67375/6H6-0KCDN3C6-9</idno><idno type="DOI">10.1016/S0168-8278(99)80044-0</idno><idno type="PII">S0168-8278(99)80044-0</idno></analytic><monogr><title level="j">Journal of Hepatology</title><title level="j" type="abbrev">JHEPAT</title><idno type="pISSN">0168-8278</idno><idno type="PII">S0168-8278(00)X0058-X</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1999"></date><biblScope unit="volume">31</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="508">508</biblScope><biblScope unit="page" to="513">513</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1999</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Background/Aim: In the West, hepatocellular carcinoma rarely occurs in patients without cirrhosis. In these patients, epidemiological factors and the histopathology of the non-neoplastic liver are not well known. The aim of this study was to clarify these points. Methods: We studied 30 patients (26 men, 28–87 years) with hepatocellular carcinoma and histologically-proven non-cirrhotic livers. Serological markers of HBV and HCV infection, as well as alcohol and tobacco consumption were evaluated. Pathological changes in the non-tumorous liver (fibrosis, inflammation, steatosis, alcoholic hepatitis lesions, iron overload, and large cell dysplasia) were systematically assessed using semi-quantitative scores. Results: Twenty patients had alcohol intake ≥30 g/d and 16 were smokers. Serological HBV or HCV markers were positive in 10 patients. Only four patients had no exposure to alcohol or tobacco and no serological markers of HBV or HCV. Histological examination showed that all livers had pathological changes. Seventeen patients (57%) had clearly-identified chronic liver disease: chronic hepatitis (n=10) or alcoholic liver disease (n=7). Non-specific and moderate pathological changes were observed in the 13 other patients (43%), with different degrees of fibrosis, activity, steatosis, and iron overload. Large cell dysplasia was present in 12 patients (40%). Conclusions: In our study, all patients with hepatocellular carcinoma and non-cirrhotic livers had non-tumorous pathological liver changes, especially iron overload and large cell dysplasia. These results suggest that hepatocellular carcinoma originates from an abnormal histological background, even in non-cirrhotic liver.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Hepatocellular carcinoma</term></item><item><term>Histopathology</term></item><item><term>Iron overload</term></item><item><term>Large cell dysplasia</term></item><item><term>Non-cirrhotic liver</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1999-03-04">Modified</change><change when="1999">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-0KCDN3C6-9/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: ce:floats; body; tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>JHEPAT</jid><aid>99800440</aid><ce:pii>S0168-8278(99)80044-0</ce:pii><ce:doi>10.1016/S0168-8278(99)80044-0</ce:doi><ce:copyright type="unknown" year="1999"></ce:copyright></item-info><head><ce:title>Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver</ce:title><ce:author-group><ce:author><ce:given-name>Véronique</ce:given-name><ce:surname>Grando-Lemaire</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref><ce:e-address>secmed.hge@jvr.ap-hop-paris.fr</ce:e-address></ce:author><ce:author><ce:given-name>Catherine</ce:given-name><ce:surname>Guettier</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Sylvie</ce:given-name><ce:surname>Chevret</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Michel</ce:given-name><ce:surname>Beaugrand</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Jean-Claude</ce:given-name><ce:surname>Trinchet</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:collaboration><ce:text>for the Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire</ce:text><ce:cross-ref refid="FN1"><ce:sup>∗</ce:sup></ce:cross-ref></ce:collaboration><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Service d'Hépato-Gastroentérologie, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Service d'Anatomie Pathologique, Hôpital Jean Verdier, Assistance publique-Hôpitaux de Paris, Bondy, France</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>3</ce:label><ce:textfn>Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Véronique Grando-Lemaire, Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier, Avenue du 14 juillet, 93143 Bondy Cedex, France. Tel: 33 1 48 02 62 80. Fax: 33 1 48 02 62 02.</ce:text></ce:correspondence><ce:footnote id="FN1"><ce:label>*</ce:label><ce:note-para>The members of the Group are listed in the <ce:cross-ref refid="APP">Appendix</ce:cross-ref>.</ce:note-para></ce:footnote></ce:author-group><ce:date-received day="7" month="9" year="1998"></ce:date-received><ce:date-revised day="4" month="3" year="1999"></ce:date-revised><ce:date-accepted day="25" month="3" year="1999"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para><ce:italic>Background/Aim:</ce:italic> In the West, hepatocellular carcinoma rarely occurs in patients without cirrhosis. In these patients, epidemiological factors and the histopathology of the non-neoplastic liver are not well known. The aim of this study was to clarify these points.</ce:simple-para><ce:simple-para><ce:italic>Methods:</ce:italic> We studied 30 patients (26 men, 28–87 years) with hepatocellular carcinoma and histologically-proven non-cirrhotic livers. Serological markers of HBV and HCV infection, as well as alcohol and tobacco consumption were evaluated. Pathological changes in the non-tumorous liver (fibrosis, inflammation, steatosis, alcoholic hepatitis lesions, iron overload, and large cell dysplasia) were systematically assessed using semi-quantitative scores.</ce:simple-para><ce:simple-para><ce:italic>Results:</ce:italic> Twenty patients had alcohol intake ≥30 g/d and 16 were smokers. Serological HBV or HCV markers were positive in 10 patients. Only four patients had no exposure to alcohol or tobacco and no serological markers of HBV or HCV. Histological examination showed that all livers had pathological changes. Seventeen patients (57%) had clearly-identified chronic liver disease: chronic hepatitis (<ce:italic>n</ce:italic>=10) or alcoholic liver disease (<ce:italic>n</ce:italic>=7). Non-specific and moderate pathological changes were observed in the 13 other patients (43%), with different degrees of fibrosis, activity, steatosis, and iron overload. Large cell dysplasia was present in 12 patients (40%).</ce:simple-para><ce:simple-para><ce:italic>Conclusions:</ce:italic> In our study, all patients with hepatocellular carcinoma and non-cirrhotic livers had non-tumorous pathological liver changes, especially iron overload and large cell dysplasia. These results suggest that hepatocellular carcinoma originates from an abnormal histological background, even in non-cirrhotic liver.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Hepatocellular carcinoma</ce:text></ce:keyword><ce:keyword><ce:text>Histopathology</ce:text></ce:keyword><ce:keyword><ce:text>Iron overload</ce:text></ce:keyword><ce:keyword><ce:text>Large cell dysplasia</ce:text></ce:keyword><ce:keyword><ce:text>Non-cirrhotic liver</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Hepatocellular carcinoma without cirrhosis in the West: epidemiological factors and histopathology of the non-tumorous liver</title></titleInfo><name type="corporate"><namePart>for the Groupe d'Etude et de Traitement du Carcinome Hépatocellulaire</namePart><description>The members of the Group are listed in the Appendix.</description></name><name type="personal"><namePart type="given">Véronique</namePart><namePart type="family">Grando-Lemaire</namePart><affiliation>E-mail: secmed.hge@jvr.ap-hop-paris.fr</affiliation><affiliation>Service d'Hépato-Gastroentérologie, France</affiliation><description>Véronique Grando-Lemaire, Service d'Hépato-Gastroentérologie, Hôpital Jean Verdier, Avenue du 14 juillet, 93143 Bondy Cedex, France. Tel: 33 1 48 02 62 80. Fax: 33 1 48 02 62 02.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Catherine</namePart><namePart type="family">Guettier</namePart><affiliation>Service d'Anatomie Pathologique, Hôpital Jean Verdier, Assistance publique-Hôpitaux de Paris, Bondy, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sylvie</namePart><namePart type="family">Chevret</namePart><affiliation>Département de Biostatistique et Informatique Médicale, Hôpital Saint-Louis, Assistance Publique-Hôpitaux de Paris, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Michel</namePart><namePart type="family">Beaugrand</namePart><affiliation>Service d'Hépato-Gastroentérologie, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jean-Claude</namePart><namePart type="family">Trinchet</namePart><affiliation>Service d'Hépato-Gastroentérologie, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued><dateModified encoding="w3cdtf">1999-03-04</dateModified><copyrightDate encoding="w3cdtf">1999</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Background/Aim: In the West, hepatocellular carcinoma rarely occurs in patients without cirrhosis. In these patients, epidemiological factors and the histopathology of the non-neoplastic liver are not well known. The aim of this study was to clarify these points. Methods: We studied 30 patients (26 men, 28–87 years) with hepatocellular carcinoma and histologically-proven non-cirrhotic livers. Serological markers of HBV and HCV infection, as well as alcohol and tobacco consumption were evaluated. Pathological changes in the non-tumorous liver (fibrosis, inflammation, steatosis, alcoholic hepatitis lesions, iron overload, and large cell dysplasia) were systematically assessed using semi-quantitative scores. Results: Twenty patients had alcohol intake ≥30 g/d and 16 were smokers. Serological HBV or HCV markers were positive in 10 patients. Only four patients had no exposure to alcohol or tobacco and no serological markers of HBV or HCV. Histological examination showed that all livers had pathological changes. Seventeen patients (57%) had clearly-identified chronic liver disease: chronic hepatitis (n=10) or alcoholic liver disease (n=7). Non-specific and moderate pathological changes were observed in the 13 other patients (43%), with different degrees of fibrosis, activity, steatosis, and iron overload. Large cell dysplasia was present in 12 patients (40%). Conclusions: In our study, all patients with hepatocellular carcinoma and non-cirrhotic livers had non-tumorous pathological liver changes, especially iron overload and large cell dysplasia. These results suggest that hepatocellular carcinoma originates from an abnormal histological background, even in non-cirrhotic liver.</abstract><note type="content">TABLE 1: Initial characteristics of 30 patients with hepatocellular carcinoma and non-cirrhotic liver</note><note type="content">TABLE 2: Pathological changes in the non-tumorous liver in 30 patients with hepatocellular carcinoma and non-cirrhotic liver</note><note type="content">TABLE 3: Pathological changes according to the pathological group of the nontumorous liver in 30 patients with hepatocellular carcinoma and noncirrhotic liver</note><note type="content">TABLE 4: Epidemiological risk factors according to the pathological group of the non-tumorous liver in 30 patients with hepatocellular carcinoma and non-cirrhotic liver</note><subject><genre>Keywords</genre><topic>Hepatocellular carcinoma</topic><topic>Histopathology</topic><topic>Iron overload</topic><topic>Large cell dysplasia</topic><topic>Non-cirrhotic liver</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Hepatology</title></titleInfo><titleInfo type="abbreviated"><title>JHEPAT</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1999</dateIssued></originInfo><identifier type="ISSN">0168-8278</identifier><identifier type="PII">S0168-8278(00)X0058-X</identifier><part><date>1999</date><detail type="volume"><number>31</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue-pages"><start>389</start><end>578</end></extent><extent unit="pages"><start>508</start><end>513</end></extent></part></relatedItem><identifier type="istex">1BE1EE7CA8CCEB8F7BA196B3212D8E84782878CF</identifier><identifier type="ark">ark:/67375/6H6-0KCDN3C6-9</identifier><identifier type="DOI">10.1016/S0168-8278(99)80044-0</identifier><identifier type="PII">S0168-8278(99)80044-0</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/6H6-0KCDN3C6-9/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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