A hotspot for transition mutations in the rIIB gene of bacteriophage T4
Identifieur interne : 000626 ( Istex/Corpus ); précédent : 000625; suivant : 000627A hotspot for transition mutations in the rIIB gene of bacteriophage T4
Auteurs : Britta Swebilius SingerSource :
- Molecular and General Genetics MGG [ 0026-8925 ] ; 1984-01-01.
English descriptors
- Teeft :
- Bacteriophage, Benzer, Biol, Champe, Coding region, Codon, Cytosine, Deletion, Detoxifying, Detoxifying mutations, Dispensable region, Frameshift, Frameshift mutation, Frameshift mutations, Frameshifts, Guanine, Hotspot, Hydroxylamine, Lysogen, Missense, Missense mutations, Mutability, Mutable, Mutant, Mutation, Napiv2, Nitrous, Nitrous acid, Nonsense mutations, Plaque, Point mutations, Polypeptide, Pribnow, Pseudowild, Recombinant, Recombine, Riia, Riib, Tabr3, Tggcaa, Wild type sequence.
Abstract
Summary: We have previously demonstrated that the sequence 5′TGGCAA 3′ located at codons 32–33 of the rIIB gene of bacteriophage T4 is a hotspot for transition mutations (Nelson et al. 1981). Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11–12. The sequence is highly mutable in both locations, suggesting that its high mutability is due to features of the TGGCAA itself and is not dependent on the immediate juxtaposition of additional external sequences. Within this sequence, at either location, only the transition at the central G:C pair frequently arises spontaneously or by 2-aminopurine or ethylmethane sulfonate mutagenesis. However, the 3′ G:C pair, in addition, is highly mutable after nitrous acid or hydroxylamine treatment. This suggests that, within the TGGCAA sequence, there are two hotspots which are targeted by different mutagens.
Url:
DOI: 10.1007/BF00327422
Links to Exploration step
ISTEX:1BCA4327C67BF00D059FBBF9F451FAD0AAB6AD4BLe document en format XML
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Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11–12. The sequence is highly mutable in both locations, suggesting that its high mutability is due to features of the TGGCAA itself and is not dependent on the immediate juxtaposition of additional external sequences. Within this sequence, at either location, only the transition at the central G:C pair frequently arises spontaneously or by 2-aminopurine or ethylmethane sulfonate mutagenesis. However, the 3′ G:C pair, in addition, is highly mutable after nitrous acid or hydroxylamine treatment. 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The extent of the hotspot</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Britta</forename><surname>Singer</surname></persName><affiliation>Department of Molecular, Cellular and Developmental Biology, University of Colorado, 80309, Boulder, Colorado, USA</affiliation></author><idno type="istex">1BCA4327C67BF00D059FBBF9F451FAD0AAB6AD4B</idno><idno type="ark">ark:/67375/1BB-R7XTH1WQ-M</idno><idno type="DOI">10.1007/BF00327422</idno><idno type="article-id">BF00327422</idno><idno type="article-id">Art17</idno></analytic><monogr><title level="j">Molecular and General Genetics MGG</title><title level="j" type="abbrev">Molec. Gen. Genet.</title><idno type="pISSN">0026-8925</idno><idno type="eISSN">1432-1874</idno><idno type="journal-ID">true</idno><idno type="issue-article-count">33</idno><idno type="volume-issue-count">3</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1984-01-01"></date><biblScope unit="volume">193</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="104">104</biblScope><biblScope unit="page" to="109">109</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1983-09-12</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Summary: We have previously demonstrated that the sequence 5′TGGCAA 3′ located at codons 32–33 of the rIIB gene of bacteriophage T4 is a hotspot for transition mutations (Nelson et al. 1981). Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11–12. The sequence is highly mutable in both locations, suggesting that its high mutability is due to features of the TGGCAA itself and is not dependent on the immediate juxtaposition of additional external sequences. Within this sequence, at either location, only the transition at the central G:C pair frequently arises spontaneously or by 2-aminopurine or ethylmethane sulfonate mutagenesis. However, the 3′ G:C pair, in addition, is highly mutable after nitrous acid or hydroxylamine treatment. 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Genet.</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Life Sciences</JournalSubject><JournalSubject Type="Secondary">Biochemistry, general</JournalSubject><JournalSubject Type="Secondary">Cell Biology</JournalSubject><JournalSubject Type="Secondary">Microbial Genetics and Genomics</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>193</VolumeIDStart><VolumeIDEnd>193</VolumeIDEnd><VolumeIssueCount>3</VolumeIssueCount></VolumeInfo><Issue IssueType="Regular"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd><IssueArticleCount>33</IssueArticleCount><IssueHistory><CoverDate><Year>1984</Year><Month>1</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1984</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art17"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF00327422</ArticleID><ArticleDOI>10.1007/BF00327422</ArticleDOI><ArticleSequenceNumber>17</ArticleSequenceNumber><ArticleTitle Language="En">A hotspot for transition mutations in the rIIB gene of bacteriophage T4</ArticleTitle><ArticleSubTitle Language="En">I. The extent of the hotspot</ArticleSubTitle><ArticleFirstPage>104</ArticleFirstPage><ArticleLastPage>109</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2004</Year><Month>8</Month><Day>27</Day></RegistrationDate><Received><Year>1983</Year><Month>9</Month><Day>12</Day></Received></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1984</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>438</JournalID><VolumeIDStart>193</VolumeIDStart><VolumeIDEnd>193</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>1</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff1"><AuthorName DisplayOrder="Western"><GivenName>Britta</GivenName><GivenName>Swebilius</GivenName><FamilyName>Singer</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgDivision>Department of Molecular, Cellular and Developmental Biology</OrgDivision><OrgName>University of Colorado</OrgName><OrgAddress><Postcode>80309</Postcode><City>Boulder</City><State>Colorado</State><Country>USA</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Summary</Heading><Para>We have previously demonstrated that the sequence 5′TGGCAA 3′ located at codons 32–33 of the <Emphasis Type="Italic">rIIB</Emphasis> gene of bacteriophage T4 is a hotspot for transition mutations (Nelson et al. 1981). Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11–12. The sequence is highly mutable in both locations, suggesting that its high mutability is due to features of the TGGCAA itself and is not dependent on the immediate juxtaposition of additional external sequences. Within this sequence, at either location, only the transition at the central G:C pair frequently arises spontaneously or by 2-aminopurine or ethylmethane sulfonate mutagenesis. However, the 3′ G:C pair, in addition, is highly mutable after nitrous acid or hydroxylamine treatment. This suggests that, within the TGGCAA sequence, there are two hotspots which are targeted by different mutagens.</Para></Abstract><ArticleNote Type="CommunicatedBy"><SimplePara>Communicated by G.R. Smith</SimplePara></ArticleNote></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A hotspot for transition mutations in the rIIB gene of bacteriophage T4</title><subTitle>I. The extent of the hotspot</subTitle></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>A hotspot for transition mutations in the rIIB gene of bacteriophage T4</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Britta</namePart><namePart type="given">Swebilius</namePart><namePart type="family">Singer</namePart><affiliation>Department of Molecular, Cellular and Developmental Biology, University of Colorado, 80309, Boulder, Colorado, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1983-09-12</dateCreated><dateIssued encoding="w3cdtf">1984-01-01</dateIssued><copyrightDate encoding="w3cdtf">1984</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><abstract lang="en">Summary: We have previously demonstrated that the sequence 5′TGGCAA 3′ located at codons 32–33 of the rIIB gene of bacteriophage T4 is a hotspot for transition mutations (Nelson et al. 1981). Here I report the properties of the same TGGCAA sequence introduced into the gene at codons 11–12. The sequence is highly mutable in both locations, suggesting that its high mutability is due to features of the TGGCAA itself and is not dependent on the immediate juxtaposition of additional external sequences. Within this sequence, at either location, only the transition at the central G:C pair frequently arises spontaneously or by 2-aminopurine or ethylmethane sulfonate mutagenesis. However, the 3′ G:C pair, in addition, is highly mutable after nitrous acid or hydroxylamine treatment. This suggests that, within the TGGCAA sequence, there are two hotspots which are targeted by different mutagens.</abstract><relatedItem type="host"><titleInfo><title>Molecular and General Genetics MGG</title></titleInfo><titleInfo type="abbreviated"><title>Molec. Gen. 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