Analyse de données transcriptomiques: Modélisation floue de profils d'expression différentielle et analyse fonctionnelle.
Identifieur interne : 005607 ( Hal/Curation ); précédent : 005606; suivant : 005608Analyse de données transcriptomiques: Modélisation floue de profils d'expression différentielle et analyse fonctionnelle.
Auteurs : Sidahmed Benabderrahmane [France] ; Marie-Dominique Devignes [France] ; Malika Smaïl-Tabbone [France] ; O. Poch [France] ; Amedeo Napoli [France] ; N. Nguyen N.-H [France] ; W. Raffelsberger [France]Source :
Descripteurs français
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Abstract
Les techniques de micro-réseaux d'ADN permettent de mesurer le niveau d'expression de plusieurs milliers de gènes dans diverses situations. Les niveaux d'expression mesurés pour chaque gène dans un certain nombre de situations conduisent à définir un profil d'expression pour ce gène. Classiquement une analyse fonctionnelle est ensuite appliquée aux gènes présentant les mêmes profils pour tenter de leur associer une ou des fonctions biologiques communes. Dans ce contexte il apparaît cependant que la définition des profils d'expression dépend de la nature des situations considérées. Nous proposons ici une nouvelle approche de modélisation floue de profils d'expression différentielle tenant compte l'existence de relations entre les situations étudiées. Cette approche est appliquée à un jeu de données expérimentales relatives au cancer colo-rectal. Les premiers résultats d'analyse fonctionnelle montrent que cette modélisation des profils d'expression permet de mettre en relation des fonctions biologiques et des comportements transcriptionnels particuliers.
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Nguyen N.-H</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-93800" status="VALID"><orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName><orgName type="acronym">IGBMC</orgName><desc><address><addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.igbmc.fr/</ref></desc><listRelation><relation active="#struct-302445" type="direct"></relation><relation name="U964" active="#struct-303623" type="direct"></relation><relation name="UMR7104" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302445" type="direct"><org type="institution" xml:id="struct-302445" status="VALID"><orgName>Université de Strasbourg</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle name="U964" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="UMR7104" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName><orgName type="university">Université de Strasbourg</orgName></affiliation></author><author><name sortKey="Raffelsberger, W" sort="Raffelsberger, W" uniqKey="Raffelsberger W" first="W." last="Raffelsberger">W. Raffelsberger</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-93800" status="VALID"><orgName>Institut de Génétique et de Biologie Moléculaire et Cellulaire</orgName><orgName type="acronym">IGBMC</orgName><desc><address><addrLine>Parc D'Innovation 1 Rue Laurent Fries - BP 10142 67404 Illkirch Cedex</addrLine><country key="FR"></country></address><ref type="url">http://www.igbmc.fr/</ref></desc><listRelation><relation active="#struct-302445" type="direct"></relation><relation name="U964" active="#struct-303623" type="direct"></relation><relation name="UMR7104" active="#struct-441569" type="direct"></relation></listRelation><tutelles><tutelle active="#struct-302445" type="direct"><org type="institution" xml:id="struct-302445" status="VALID"><orgName>Université de Strasbourg</orgName><desc><address><country key="FR"></country></address></desc></org></tutelle><tutelle name="U964" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"><idno type="IdRef">026388278</idno><orgName>Institut National de la Santé et de la Recherche Médicale</orgName><orgName type="acronym">INSERM</orgName><desc><address><addrLine>101, rue de Tolbiac, 75013 Paris </addrLine><country key="FR"></country></address><ref type="url">http://www.inserm.fr</ref></desc></org></tutelle><tutelle name="UMR7104" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"><idno type="ISNI">0000000122597504</idno><idno type="IdRef">02636817X</idno><orgName>Centre National de la Recherche Scientifique</orgName><orgName type="acronym">CNRS</orgName><date type="start">1939-10-19</date><desc><address><country key="FR"></country></address><ref type="url">http://www.cnrs.fr/</ref></desc></org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Strasbourg</settlement><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Alsace (région administrative)</region></placeName><orgName type="university">Université de Strasbourg</orgName></affiliation></author></analytic></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="fr"><term>Clustérisation</term><term>Clustérisation.</term><term>Logique floue</term><term>Profil d'expression différentielle</term><term>Transcriptomique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="fr">Les techniques de micro-réseaux d'ADN permettent de mesurer le niveau d'expression de plusieurs milliers de gènes dans diverses situations. Les niveaux d'expression mesurés pour chaque gène dans un certain nombre de situations conduisent à définir un profil d'expression pour ce gène. Classiquement une analyse fonctionnelle est ensuite appliquée aux gènes présentant les mêmes profils pour tenter de leur associer une ou des fonctions biologiques communes. Dans ce contexte il apparaît cependant que la définition des profils d'expression dépend de la nature des situations considérées. Nous proposons ici une nouvelle approche de modélisation floue de profils d'expression différentielle tenant compte l'existence de relations entre les situations étudiées. Cette approche est appliquée à un jeu de données expérimentales relatives au cancer colo-rectal. Les premiers résultats d'analyse fonctionnelle montrent que cette modélisation des profils d'expression permet de mettre en relation des fonctions biologiques et des comportements transcriptionnels particuliers.</div></front></TEI><hal api="V3"><titleStmt><title xml:lang="fr">Analyse de données transcriptomiques: Modélisation floue de profils d'expression différentielle et analyse fonctionnelle.</title><author role="crp"><persName><forename type="first">Sidahmed</forename><surname>Benabderrahmane</surname></persName><email>sidahmed.benabderrahmane@gmail.com</email><idno type="halauthor">679159</idno><orgName ref="#struct-206040"></orgName><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">Marie-Dominique</forename><surname>Devignes</surname></persName><email>devignes@loria.fr</email><idno type="halauthor">130177</idno><orgName ref="#struct-441569"></orgName><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">Malika</forename><surname>Smaïl-Tabbone</surname></persName><email>malika@loria.fr</email><idno type="idhal">malika-smail-tabbone</idno><idno type="halauthor">62326</idno><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">O.</forename><surname>Poch</surname></persName><email>poch@titus.u-strasbg.fr</email><idno type="halauthor">412530</idno><affiliation ref="#struct-1047"></affiliation></author><author role="aut"><persName><forename type="first">Amedeo</forename><surname>Napoli</surname></persName><email>Amedeo.Napoli@loria.fr</email><idno type="halauthor">61765</idno><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">N.</forename><surname>Nguyen N.-H</surname></persName><email>nguyen@titus.u-strasbg.fr</email><idno type="halauthor">412531</idno><affiliation ref="#struct-93800"></affiliation></author><author role="aut"><persName><forename type="first">W.</forename><surname>Raffelsberger</surname></persName><email>wraff@titus.u-strasbg.fr</email><idno type="halauthor">412532</idno><affiliation ref="#struct-93800"></affiliation></author><editor role="depositor"><persName><forename>Sidahmed</forename><surname>Benabderrahmane</surname></persName><email>sidahmed.benabderrahmane@gmail.com</email></editor></titleStmt><editionStmt><edition n="v1" type="current"><date type="whenSubmitted">2009-06-11 22:10:48</date><date type="whenWritten">2009</date><date type="whenModified">2016-05-18 08:52:51</date><date type="whenReleased">2009-06-11 22:10:48</date><date type="whenProduced">2009-05-27</date></edition><respStmt><resp>contributor</resp><name key="141812"><persName><forename>Sidahmed</forename><surname>Benabderrahmane</surname></persName><email>sidahmed.benabderrahmane@gmail.com</email></name></respStmt></editionStmt><publicationStmt><distributor>CCSD</distributor><idno type="halId">inria-00394530</idno><idno type="halUri">https://hal.inria.fr/inria-00394530</idno><idno type="halBibtex">benabderrahmane:inria-00394530</idno><idno type="halRefHtml">Actes du XXVIIième congrès Informatique des Organisations et Systèmes d'information et de décision - INFORSID 2009, May 2009, Toulouse, France. pp.413-428, 2009</idno><idno type="halRef">Actes du XXVIIième congrès Informatique des Organisations et Systèmes d'information et de décision - INFORSID 2009, May 2009, Toulouse, France. pp.413-428, 2009</idno></publicationStmt><seriesStmt><idno type="stamp" n="CNRS">CNRS - Centre national de la recherche scientifique</idno><idno type="stamp" n="INRIA">INRIA - Institut National de Recherche en Informatique et en Automatique</idno><idno type="stamp" n="UNIV-STRASBG1">Université Louis Pasteur - Strasbourg I</idno><idno type="stamp" n="INPL">Institut National Polytechnique de Lorraine</idno><idno type="stamp" n="UNIV-STRASBG">Université de Strasbourg</idno><idno type="stamp" n="IGBMC" p="INSERM">Institut Génétique de Biologie Moléculaire et Cellulaire</idno><idno type="stamp" n="LORIA2">Publications du LORIA</idno><idno type="stamp" n="INRIA-NANCY-GRAND-EST">INRIA Nancy - Grand Est</idno><idno type="stamp" n="LORIA-TALC" p="LORIA">Traitement automatique des langues et des connaissances</idno><idno type="stamp" n="LORIA">LORIA - Laboratoire Lorrain de Recherche en Informatique et ses Applications</idno><idno type="stamp" n="INRIA2">INRIA 2</idno><idno type="stamp" n="INRIA-LORRAINE">INRIA Nancy - Grand Est</idno><idno type="stamp" n="LABO-LORIA-SET" p="LORIA">LABO-LORIA-SET</idno><idno type="stamp" n="UNIV-LORRAINE">Université de Lorraine</idno></seriesStmt><notesStmt><note type="audience" n="3">National</note><note type="invited" n="0">No</note><note type="popular" n="0">No</note><note type="peer" n="1">Yes</note><note type="proceedings" n="1">Yes</note></notesStmt><sourceDesc><biblStruct><analytic><title xml:lang="fr">Analyse de données transcriptomiques: Modélisation floue de profils d'expression différentielle et analyse fonctionnelle.</title><author role="crp"><persName><forename type="first">Sidahmed</forename><surname>Benabderrahmane</surname></persName><email>sidahmed.benabderrahmane@gmail.com</email><idno type="halAuthorId">679159</idno><orgName ref="#struct-206040"></orgName><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">Marie-Dominique</forename><surname>Devignes</surname></persName><email>devignes@loria.fr</email><idno type="halAuthorId">130177</idno><orgName ref="#struct-441569"></orgName><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">Malika</forename><surname>Smaïl-Tabbone</surname></persName><email>malika@loria.fr</email><idno type="idHal">malika-smail-tabbone</idno><idno type="halAuthorId">62326</idno><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">O.</forename><surname>Poch</surname></persName><email>poch@titus.u-strasbg.fr</email><idno type="halAuthorId">412530</idno><affiliation ref="#struct-1047"></affiliation></author><author role="aut"><persName><forename type="first">Amedeo</forename><surname>Napoli</surname></persName><email>Amedeo.Napoli@loria.fr</email><idno type="halAuthorId">61765</idno><affiliation ref="#struct-2358"></affiliation></author><author role="aut"><persName><forename type="first">N.</forename><surname>Nguyen N.-H</surname></persName><email>nguyen@titus.u-strasbg.fr</email><idno type="halAuthorId">412531</idno><affiliation ref="#struct-93800"></affiliation></author><author role="aut"><persName><forename type="first">W.</forename><surname>Raffelsberger</surname></persName><email>wraff@titus.u-strasbg.fr</email><idno type="halAuthorId">412532</idno><affiliation ref="#struct-93800"></affiliation></author></analytic><monogr><meeting><title>Actes du XXVIIième congrès Informatique des Organisations et Systèmes d'information et de décision - INFORSID 2009</title><date type="start">2009-05-27</date><settlement>Toulouse</settlement><country key="FR">France</country></meeting><respStmt><resp>conferenceOrganizer</resp><name>IRIT-Toulouse</name></respStmt><imprint><biblScope unit="pp">413-428</biblScope><date type="datePub">2009</date></imprint></monogr></biblStruct></sourceDesc><profileDesc><langUsage><language ident="fr">French</language></langUsage><textClass><keywords scheme="author"><term xml:lang="fr">Clustérisation</term><term xml:lang="fr">Transcriptomique</term><term xml:lang="fr">Logique floue</term><term xml:lang="fr">Profil d'expression différentielle</term><term xml:lang="fr">Clustérisation.</term></keywords><classCode scheme="halDomain" n="info.info-ir">Computer Science [cs]/Information Retrieval [cs.IR]</classCode><classCode scheme="halTypology" n="COMM">Conference papers</classCode></textClass><abstract xml:lang="fr">Les techniques de micro-réseaux d'ADN permettent de mesurer le niveau d'expression de plusieurs milliers de gènes dans diverses situations. Les niveaux d'expression mesurés pour chaque gène dans un certain nombre de situations conduisent à définir un profil d'expression pour ce gène. Classiquement une analyse fonctionnelle est ensuite appliquée aux gènes présentant les mêmes profils pour tenter de leur associer une ou des fonctions biologiques communes. Dans ce contexte il apparaît cependant que la définition des profils d'expression dépend de la nature des situations considérées. Nous proposons ici une nouvelle approche de modélisation floue de profils d'expression différentielle tenant compte l'existence de relations entre les situations étudiées. Cette approche est appliquée à un jeu de données expérimentales relatives au cancer colo-rectal. Les premiers résultats d'analyse fonctionnelle montrent que cette modélisation des profils d'expression permet de mettre en relation des fonctions biologiques et des comportements transcriptionnels particuliers.</abstract></profileDesc></hal></record>Pour manipuler ce document sous Unix (Dilib)
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