Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.
Identifieur interne : 000008 ( PubMed/Corpus ); précédent : 000007; suivant : 000009Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.
Auteurs : Yuji Ueno ; Kazuo Yamashiro ; Yasutaka Tanaka ; Masao Watanabe ; Nobukazu Miyamoto ; Yoshiaki Shimada ; Takuma Kuroki ; Ryota Tanaka ; Katsumi Miyauchi ; Hiroyuki Daida ; Nobutaka Hattori ; Takao UrabeSource :
- Atherosclerosis [ 1879-1484 ] ; 2015.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Aorta, Thoracic (metabolism), Aorta, Thoracic (ultrasonography), Aortic Diseases (blood), Aortic Diseases (complications), Aortic Diseases (drug therapy), Aortic Diseases (ultrasonography), Atherosclerosis (blood), Atherosclerosis (complications), Atherosclerosis (drug therapy), Atherosclerosis (ultrasonography), Biomarkers (blood), Brain Ischemia (diagnosis), Brain Ischemia (etiology), Brain Ischemia (prevention & control), Chi-Square Distribution, Cholesterol, LDL (blood), Echocardiography, Transesophageal, Female, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use), Intracranial Embolism (diagnosis), Intracranial Embolism (etiology), Intracranial Embolism (prevention & control), Japan, Linear Models, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prospective Studies, Rosuvastatin Calcium (therapeutic use), Stroke (diagnosis), Stroke (etiology), Stroke (prevention & control), Time Factors, Treatment Outcome.
- MESH :
- chemical , blood : Biomarkers, Cholesterol, LDL.
- chemical , therapeutic use : Rosuvastatin Calcium.
- geographic : Japan.
- blood : Aortic Diseases, Atherosclerosis.
- complications : Aortic Diseases, Atherosclerosis.
- diagnosis : Brain Ischemia, Intracranial Embolism, Stroke.
- drug therapy : Aortic Diseases, Atherosclerosis.
- etiology : Brain Ischemia, Intracranial Embolism, Stroke.
- metabolism : Aorta, Thoracic.
- prevention & control : Brain Ischemia, Intracranial Embolism, Stroke.
- chemical , therapeutic use : Hydroxymethylglutaryl-CoA Reductase Inhibitors.
- ultrasonography : Aorta, Thoracic, Aortic Diseases, Atherosclerosis.
- Aged, Aged, 80 and over, Chi-Square Distribution, Echocardiography, Transesophageal, Female, Humans, Linear Models, Male, Middle Aged, Plaque, Atherosclerotic, Predictive Value of Tests, Prospective Studies, Time Factors, Treatment Outcome.
Abstract
Large atheromatous aortic plaques (AAPs) have been associated with ischemic stroke. There is little evidence to guide the therapeutic strategy for ischemic stroke associated with large AAPs. This study sought to analyze the temporal profile of AAPs after rosuvastatin therapy in Japanese patients with acute ischemic stroke.
DOI: 10.1016/j.atherosclerosis.2015.02.021
PubMed: 25702618
Links to Exploration step
pubmed:25702618Le document en format XML
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Electronic address: yuji-u@juntendo.ac.jp.</nlm:affiliation></affiliation></author><author><name sortKey="Yamashiro, Kazuo" sort="Yamashiro, Kazuo" uniqKey="Yamashiro K" first="Kazuo" last="Yamashiro">Kazuo Yamashiro</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Yasutaka" sort="Tanaka, Yasutaka" uniqKey="Tanaka Y" first="Yasutaka" last="Tanaka">Yasutaka Tanaka</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Watanabe, Masao" sort="Watanabe, Masao" uniqKey="Watanabe M" first="Masao" last="Watanabe">Masao Watanabe</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Miyamoto, Nobukazu" sort="Miyamoto, Nobukazu" uniqKey="Miyamoto N" first="Nobukazu" last="Miyamoto">Nobukazu Miyamoto</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Shimada, Yoshiaki" sort="Shimada, Yoshiaki" uniqKey="Shimada Y" first="Yoshiaki" last="Shimada">Yoshiaki Shimada</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kuroki, Takuma" sort="Kuroki, Takuma" uniqKey="Kuroki T" first="Takuma" last="Kuroki">Takuma Kuroki</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Ryota" sort="Tanaka, Ryota" uniqKey="Tanaka R" first="Ryota" last="Tanaka">Ryota Tanaka</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Miyauchi, Katsumi" sort="Miyauchi, Katsumi" uniqKey="Miyauchi K" first="Katsumi" last="Miyauchi">Katsumi Miyauchi</name><affiliation><nlm:affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Daida, Hiroyuki" sort="Daida, Hiroyuki" uniqKey="Daida H" first="Hiroyuki" last="Daida">Hiroyuki Daida</name><affiliation><nlm:affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Urabe, Takao" sort="Urabe, Takao" uniqKey="Urabe T" first="Takao" last="Urabe">Takao Urabe</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25702618</idno><idno type="pmid">25702618</idno><idno type="doi">10.1016/j.atherosclerosis.2015.02.021</idno><idno type="wicri:Area/PubMed/Corpus">000008</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000008</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.</title><author><name sortKey="Ueno, Yuji" sort="Ueno, Yuji" uniqKey="Ueno Y" first="Yuji" last="Ueno">Yuji Ueno</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan; Department of Neurology, Juntendo University School of Medicine, Japan. Electronic address: yuji-u@juntendo.ac.jp.</nlm:affiliation></affiliation></author><author><name sortKey="Yamashiro, Kazuo" sort="Yamashiro, Kazuo" uniqKey="Yamashiro K" first="Kazuo" last="Yamashiro">Kazuo Yamashiro</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Yasutaka" sort="Tanaka, Yasutaka" uniqKey="Tanaka Y" first="Yasutaka" last="Tanaka">Yasutaka Tanaka</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Watanabe, Masao" sort="Watanabe, Masao" uniqKey="Watanabe M" first="Masao" last="Watanabe">Masao Watanabe</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Miyamoto, Nobukazu" sort="Miyamoto, Nobukazu" uniqKey="Miyamoto N" first="Nobukazu" last="Miyamoto">Nobukazu Miyamoto</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Shimada, Yoshiaki" sort="Shimada, Yoshiaki" uniqKey="Shimada Y" first="Yoshiaki" last="Shimada">Yoshiaki Shimada</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Kuroki, Takuma" sort="Kuroki, Takuma" uniqKey="Kuroki T" first="Takuma" last="Kuroki">Takuma Kuroki</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Tanaka, Ryota" sort="Tanaka, Ryota" uniqKey="Tanaka R" first="Ryota" last="Tanaka">Ryota Tanaka</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Miyauchi, Katsumi" sort="Miyauchi, Katsumi" uniqKey="Miyauchi K" first="Katsumi" last="Miyauchi">Katsumi Miyauchi</name><affiliation><nlm:affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Daida, Hiroyuki" sort="Daida, Hiroyuki" uniqKey="Daida H" first="Hiroyuki" last="Daida">Hiroyuki Daida</name><affiliation><nlm:affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Hattori, Nobutaka" sort="Hattori, Nobutaka" uniqKey="Hattori N" first="Nobutaka" last="Hattori">Nobutaka Hattori</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</nlm:affiliation></affiliation></author><author><name sortKey="Urabe, Takao" sort="Urabe, Takao" uniqKey="Urabe T" first="Takao" last="Urabe">Takao Urabe</name><affiliation><nlm:affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Atherosclerosis</title><idno type="eISSN">1879-1484</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Aorta, Thoracic (metabolism)</term><term>Aorta, Thoracic (ultrasonography)</term><term>Aortic Diseases (blood)</term><term>Aortic Diseases (complications)</term><term>Aortic Diseases (drug therapy)</term><term>Aortic Diseases (ultrasonography)</term><term>Atherosclerosis (blood)</term><term>Atherosclerosis (complications)</term><term>Atherosclerosis (drug therapy)</term><term>Atherosclerosis (ultrasonography)</term><term>Biomarkers (blood)</term><term>Brain Ischemia (diagnosis)</term><term>Brain Ischemia (etiology)</term><term>Brain Ischemia (prevention & control)</term><term>Chi-Square Distribution</term><term>Cholesterol, LDL (blood)</term><term>Echocardiography, Transesophageal</term><term>Female</term><term>Humans</term><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)</term><term>Intracranial Embolism (diagnosis)</term><term>Intracranial Embolism (etiology)</term><term>Intracranial Embolism (prevention & control)</term><term>Japan</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Plaque, Atherosclerotic</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Rosuvastatin Calcium (therapeutic use)</term><term>Stroke (diagnosis)</term><term>Stroke (etiology)</term><term>Stroke (prevention & control)</term><term>Time Factors</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Biomarkers</term><term>Cholesterol, LDL</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Rosuvastatin Calcium</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Japan</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Brain Ischemia</term><term>Intracranial Embolism</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Brain Ischemia</term><term>Intracranial Embolism</term><term>Stroke</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aorta, Thoracic</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Brain Ischemia</term><term>Intracranial Embolism</term><term>Stroke</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Hydroxymethylglutaryl-CoA Reductase Inhibitors</term></keywords><keywords scheme="MESH" qualifier="ultrasonography" xml:lang="en"><term>Aorta, Thoracic</term><term>Aortic Diseases</term><term>Atherosclerosis</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Chi-Square Distribution</term><term>Echocardiography, Transesophageal</term><term>Female</term><term>Humans</term><term>Linear Models</term><term>Male</term><term>Middle Aged</term><term>Plaque, Atherosclerotic</term><term>Predictive Value of Tests</term><term>Prospective Studies</term><term>Time Factors</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Large atheromatous aortic plaques (AAPs) have been associated with ischemic stroke. There is little evidence to guide the therapeutic strategy for ischemic stroke associated with large AAPs. This study sought to analyze the temporal profile of AAPs after rosuvastatin therapy in Japanese patients with acute ischemic stroke.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25702618</PMID><DateCreated><Year>2015</Year><Month>03</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>14</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1879-1484</ISSN><JournalIssue CitedMedium="Internet"><Volume>239</Volume><Issue>2</Issue><PubDate><Year>2015</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Atherosclerosis</Title><ISOAbbreviation>Atherosclerosis</ISOAbbreviation></Journal><ArticleTitle>Rosuvastatin may stabilize atherosclerotic aortic plaque: transesophageal echocardiographic study in the EPISTEME trial.</ArticleTitle><Pagination><MedlinePgn>476-82</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.atherosclerosis.2015.02.021</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0021-9150(15)00111-2</ELocationID><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Large atheromatous aortic plaques (AAPs) have been associated with ischemic stroke. There is little evidence to guide the therapeutic strategy for ischemic stroke associated with large AAPs. This study sought to analyze the temporal profile of AAPs after rosuvastatin therapy in Japanese patients with acute ischemic stroke.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">The Efficacy of Post-stroke Intensive Rosuvastatin Treatment for aortogenic Embolic stroke (EPISTEME) trial was a prospective, randomized, open-label study. Acute ischemic stroke patients with dyslipidemia and AAPs ≥4-mm-thick on transesophageal echocardiography (TEE) were enrolled and randomly allocated to either the group treated with 5 mg/day rosuvastatin or the control group. The primary endpoint was the changes in volume and composition of AAPs on repeat TEE after 6 months. High-echoic plaque area was analyzed using binary images.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">A total of 24 Japanese patients (rosuvastatin 12; control 12) were included in the primary analysis. Rosuvastatin substantially reduced low-density lipoprotein cholesterol (LDL-C) compared to control (-42.1% vs. 1.4%, P < 0.001). Percent changes of high-echoic plaque areas were significantly increased in the rosuvastatin group, while they were decreased in the control group (65.8% vs -14.7%, P < 0.001). There was a significant linear correlation between percent increase in high-echoic plaque area and LDL-C decrease (r=-0.434, P=0.002).</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Treatment with 5-mg rosuvastatin for 6 months might induce atheromatous aortic plaque stabilization together with marked LDL-C reduction in Japanese patients with ischemic stroke, which could provide evidence on which to base the therapeutic strategy for aortogenic brain embolism.</AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ueno</LastName><ForeName>Yuji</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan; Department of Neurology, Juntendo University School of Medicine, Japan. Electronic address: yuji-u@juntendo.ac.jp.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yamashiro</LastName><ForeName>Kazuo</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Yasutaka</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Watanabe</LastName><ForeName>Masao</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyamoto</LastName><ForeName>Nobukazu</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shimada</LastName><ForeName>Yoshiaki</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kuroki</LastName><ForeName>Takuma</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tanaka</LastName><ForeName>Ryota</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Miyauchi</LastName><ForeName>Katsumi</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Daida</LastName><ForeName>Hiroyuki</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Cardiology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hattori</LastName><ForeName>Nobutaka</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University School of Medicine, Japan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Urabe</LastName><ForeName>Takao</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Neurology, Juntendo University Urayasu Hospital, Japan.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2015</Year><Month>02</Month><Day>16</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Atherosclerosis</MedlineTA><NlmUniqueID>0242543</NlmUniqueID><ISSNLinking>0021-9150</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015415">Biomarkers</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008078">Cholesterol, LDL</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</NameOfSubstance></Chemical><Chemical><RegistryNumber>83MVU38M7Q</RegistryNumber><NameOfSubstance UI="D000068718">Rosuvastatin Calcium</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000369">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001013">Aorta, Thoracic</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000378">metabolism</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001018">Aortic Diseases</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D050197">Atherosclerosis</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000736">ultrasonography</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015415">Biomarkers</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002545">Brain Ischemia</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016009">Chi-Square Distribution</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008078">Cholesterol, LDL</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000097">blood</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D017548">Echocardiography, Transesophageal</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019161">Hydroxymethylglutaryl-CoA Reductase Inhibitors</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020766">Intracranial Embolism</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" Type="Geographic" UI="D007564">Japan</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016014">Linear Models</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D058226">Plaque, Atherosclerotic</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011237">Predictive Value of Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011446">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000068718">Rosuvastatin Calcium</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020521">Stroke</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000175">diagnosis</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000517">prevention & control</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013997">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Aortogenic brain embolism</Keyword><Keyword MajorTopicYN="N">Atheromatous aortic plaque</Keyword><Keyword MajorTopicYN="N">Rosuvastatin</Keyword><Keyword MajorTopicYN="N">Stroke</Keyword><Keyword MajorTopicYN="N">Transesophageal echocardiography</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>12</Month><Day>3</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2015</Year><Month>1</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2015</Year><Month>2</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2015</Year><Month>2</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25702618</ArticleId><ArticleId IdType="pii">S0021-9150(15)00111-2</ArticleId><ArticleId IdType="doi">10.1016/j.atherosclerosis.2015.02.021</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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