Proteomic Approaches to the Study of Papillomavirus-Host Interactions
Identifieur interne : 000121 ( Main/Exploration ); précédent : 000120; suivant : 000122Proteomic Approaches to the Study of Papillomavirus-Host Interactions
Auteurs : Elizabeth A. White ; Peter M. HowleySource :
- Virology [ 0042-6822 ] ; 2013.
Abstract
The identification of interactions between viral and host cellular proteins has provided major insights into papillomavirus research, and these interactions are especially relevant to the role of papillomaviruses in the cancers with which they are associated. Recent advances in mass spectrometry technology and data processing now allow the systematic identification of such interactions. This has led to an improved understanding of the different pathologies associated with the many papillomavirus types, and the diverse nature of these viruses is reflected in the spectrum of interactions with host proteins. Here we review a history of proteomic approaches, particularly as applied to the papillomaviruses, and summarize current techniques. Current proteomic studies on the papillomaviruses use yeast-two-hybrid or affinity purification-mass spectrometry approaches. We detail the advantages and disadvantages of each and describe current examples of papillomavirus proteomic studies, with a particular focus on the HPV E6 and E7 oncoproteins.
Url:
DOI: 10.1016/j.virol.2012.09.046
PubMed: 23217616
PubMed Central: 3522865
Affiliations:
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