Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection
Identifieur interne : 000030 ( PascalFrancis/Corpus ); précédent : 000029; suivant : 000031Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection
Auteurs : Achille Ambrosetti ; Roberta Zanotti ; Cristian Pattaro ; Lorenza Lenzi ; Marco Chilosi ; Paola Caramaschi ; Luca Arcaini ; Felice Pasini ; Domenico Biasi ; Ester Orlandi ; Mariella D'Adda ; Marco Lucioni ; Giovanni PizzoloSource :
- British journal of haematology [ 0007-1048 ] ; 2004.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.
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Format Inist (serveur)
NO : | PASCAL 04-0352747 INIST |
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ET : | Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection |
AU : | AMBROSETTI (Achille); ZANOTTI (Roberta); PATTARO (Cristian); LENZI (Lorenza); CHILOSI (Marco); CARAMASCHI (Paola); ARCAINI (Luca); PASINI (Felice); BIASI (Domenico); ORLANDI (Ester); D'ADDA (Mariella); LUCIONI (Marco); PIZZOLO (Giovanni) |
AF : | Department of Clinical and Experimental Medicine, University of Verona/Verona/Italie (1 aut., 2 aut., 4 aut., 6 aut., 8 aut., 9 aut., 11 aut., 13 aut.); Department of Medicine and Public Health, University of Verona/Verona/Italie (3 aut.); Department of Pathology, University of Verona/Verona/Italie (5 aut.); Division of Hematology, University of Pavia/Pavia/Italie (7 aut., 10 aut.); Department of Pathology, University of Pavia/Pavia/Italie (12 aut.) |
DT : | Publication en série; Papier de recherche; Niveau analytique |
SO : | British journal of haematology; ISSN 0007-1048; Coden BJHEAL; Royaume-Uni; Da. 2004; Vol. 126; No. 1; Pp. 43-49; Bibl. 1 p.1/2 |
LA : | Anglais |
EA : | Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas. |
CC : | 002B19B; 002B05C02G |
FD : | Lymphome MALT; Primaire; Salive; Hépatite virale C; Glande salivaire; Pronostic; Hématologie |
FG : | Virose; Infection; Hémopathie maligne; Lymphome non hodgkinien; Lymphoprolifératif syndrome; Appareil digestif pathologie; Foie pathologie; Appareil digestif |
ED : | MALT lymphoma; Primary; Saliva; Viral hepatitis C; Salivary gland; Prognosis; Hematology |
EG : | Viral disease; Infection; Malignant hemopathy; Non Hodgkin lymphoma; Lymphoproliferative syndrome; Digestive diseases; Hepatic disease; Digestive system |
SD : | Linfoma MALT; Primario; Saliva; Hepatitis virica C; Glándula salival; Pronóstico; Hematología |
LO : | INIST-7597.354000110476370060 |
ID : | 04-0352747 |
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Pascal:04-0352747Le document en format XML
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<series><title level="j" type="main">British journal of haematology</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Hematology</term>
<term>MALT lymphoma</term>
<term>Primary</term>
<term>Prognosis</term>
<term>Saliva</term>
<term>Salivary gland</term>
<term>Viral hepatitis C</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Lymphome MALT</term>
<term>Primaire</term>
<term>Salive</term>
<term>Hépatite virale C</term>
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<front><div type="abstract" xml:lang="en">Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection</s1>
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<fA11 i1="01" i2="1"><s1>AMBROSETTI (Achille)</s1>
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<fA11 i1="07" i2="1"><s1>ARCAINI (Luca)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>PASINI (Felice)</s1>
</fA11>
<fA11 i1="09" i2="1"><s1>BIASI (Domenico)</s1>
</fA11>
<fA11 i1="10" i2="1"><s1>ORLANDI (Ester)</s1>
</fA11>
<fA11 i1="11" i2="1"><s1>D'ADDA (Mariella)</s1>
</fA11>
<fA11 i1="12" i2="1"><s1>LUCIONI (Marco)</s1>
</fA11>
<fA11 i1="13" i2="1"><s1>PIZZOLO (Giovanni)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Clinical and Experimental Medicine, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>8 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Medicine and Public Health, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Pathology, University of Verona</s1>
<s2>Verona</s2>
<s3>ITA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Division of Hematology, University of Pavia</s1>
<s2>Pavia</s2>
<s3>ITA</s3>
<sZ>7 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Pathology, University of Pavia</s1>
<s2>Pavia</s2>
<s3>ITA</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA20><s1>43-49</s1>
</fA20>
<fA21><s1>2004</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>7597</s2>
<s5>354000110476370060</s5>
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<s1>© 2004 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>1 p.1/2</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>04-0352747</s0>
</fA47>
<fA60><s1>P</s1>
<s3>PR</s3>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>British journal of haematology</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B19B</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B05C02G</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Lymphome MALT</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>MALT lymphoma</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Linfoma MALT</s0>
<s2>NM</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Primaire</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Primary</s0>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Primario</s0>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Salive</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Saliva</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Saliva</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Hépatite virale C</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Viral hepatitis C</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Hepatitis virica C</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Glande salivaire</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Salivary gland</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Glándula salival</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Pronostic</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Prognosis</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Pronóstico</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Hématologie</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Hematology</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Hematología</s0>
<s5>08</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Virose</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Viral disease</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Virosis</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Infection</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Infección</s0>
<s2>NM</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Hémopathie maligne</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Malignant hemopathy</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Hemopatía maligna</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Lymphome non hodgkinien</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Non Hodgkin lymphoma</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Linfoma no Hodgkin</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Lymphoprolifératif syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Lymphoproliferative syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Linfoproliferativo síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Appareil digestif pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Digestive diseases</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Aparato digestivo patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Foie pathologie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Hepatic disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Hígado patología</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Appareil digestif</s0>
<s5>43</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Digestive system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Aparato digestivo</s0>
<s5>43</s5>
</fC07>
<fN21><s1>208</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 04-0352747 INIST</NO>
<ET>Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection</ET>
<AU>AMBROSETTI (Achille); ZANOTTI (Roberta); PATTARO (Cristian); LENZI (Lorenza); CHILOSI (Marco); CARAMASCHI (Paola); ARCAINI (Luca); PASINI (Felice); BIASI (Domenico); ORLANDI (Ester); D'ADDA (Mariella); LUCIONI (Marco); PIZZOLO (Giovanni)</AU>
<AF>Department of Clinical and Experimental Medicine, University of Verona/Verona/Italie (1 aut., 2 aut., 4 aut., 6 aut., 8 aut., 9 aut., 11 aut., 13 aut.); Department of Medicine and Public Health, University of Verona/Verona/Italie (3 aut.); Department of Pathology, University of Verona/Verona/Italie (5 aut.); Division of Hematology, University of Pavia/Pavia/Italie (7 aut., 10 aut.); Department of Pathology, University of Pavia/Pavia/Italie (12 aut.)</AF>
<DT>Publication en série; Papier de recherche; Niveau analytique</DT>
<SO>British journal of haematology; ISSN 0007-1048; Coden BJHEAL; Royaume-Uni; Da. 2004; Vol. 126; No. 1; Pp. 43-49; Bibl. 1 p.1/2</SO>
<LA>Anglais</LA>
<EA>Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.</EA>
<CC>002B19B; 002B05C02G</CC>
<FD>Lymphome MALT; Primaire; Salive; Hépatite virale C; Glande salivaire; Pronostic; Hématologie</FD>
<FG>Virose; Infection; Hémopathie maligne; Lymphome non hodgkinien; Lymphoprolifératif syndrome; Appareil digestif pathologie; Foie pathologie; Appareil digestif</FG>
<ED>MALT lymphoma; Primary; Saliva; Viral hepatitis C; Salivary gland; Prognosis; Hematology</ED>
<EG>Viral disease; Infection; Malignant hemopathy; Non Hodgkin lymphoma; Lymphoproliferative syndrome; Digestive diseases; Hepatic disease; Digestive system</EG>
<SD>Linfoma MALT; Primario; Saliva; Hepatitis virica C; Glándula salival; Pronóstico; Hematología</SD>
<LO>INIST-7597.354000110476370060</LO>
<ID>04-0352747</ID>
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