Serveur d'exploration sur SGML

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Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection

Identifieur interne : 000030 ( PascalFrancis/Corpus ); précédent : 000029; suivant : 000031

Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection

Auteurs : Achille Ambrosetti ; Roberta Zanotti ; Cristian Pattaro ; Lorenza Lenzi ; Marco Chilosi ; Paola Caramaschi ; Luca Arcaini ; Felice Pasini ; Domenico Biasi ; Ester Orlandi ; Mariella D'Adda ; Marco Lucioni ; Giovanni Pizzolo

Source :

RBID : Pascal:04-0352747

Descripteurs français

English descriptors

Abstract

Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0007-1048
A02 01      @0 BJHEAL
A03   1    @0 Br. j. haematol.
A05       @2 126
A06       @2 1
A08 01  1  ENG  @1 Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection
A11 01  1    @1 AMBROSETTI (Achille)
A11 02  1    @1 ZANOTTI (Roberta)
A11 03  1    @1 PATTARO (Cristian)
A11 04  1    @1 LENZI (Lorenza)
A11 05  1    @1 CHILOSI (Marco)
A11 06  1    @1 CARAMASCHI (Paola)
A11 07  1    @1 ARCAINI (Luca)
A11 08  1    @1 PASINI (Felice)
A11 09  1    @1 BIASI (Domenico)
A11 10  1    @1 ORLANDI (Ester)
A11 11  1    @1 D'ADDA (Mariella)
A11 12  1    @1 LUCIONI (Marco)
A11 13  1    @1 PIZZOLO (Giovanni)
A14 01      @1 Department of Clinical and Experimental Medicine, University of Verona @2 Verona @3 ITA @Z 1 aut. @Z 2 aut. @Z 4 aut. @Z 6 aut. @Z 8 aut. @Z 9 aut. @Z 11 aut. @Z 13 aut.
A14 02      @1 Department of Medicine and Public Health, University of Verona @2 Verona @3 ITA @Z 3 aut.
A14 03      @1 Department of Pathology, University of Verona @2 Verona @3 ITA @Z 5 aut.
A14 04      @1 Division of Hematology, University of Pavia @2 Pavia @3 ITA @Z 7 aut. @Z 10 aut.
A14 05      @1 Department of Pathology, University of Pavia @2 Pavia @3 ITA @Z 12 aut.
A20       @1 43-49
A21       @1 2004
A23 01      @0 ENG
A43 01      @1 INIST @2 7597 @5 354000110476370060
A44       @0 0000 @1 © 2004 INIST-CNRS. All rights reserved.
A45       @0 1 p.1/2
A47 01  1    @0 04-0352747
A60       @1 P @3 PR
A61       @0 A
A64 01  1    @0 British journal of haematology
A66 01      @0 GBR
C01 01    ENG  @0 Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.
C02 01  X    @0 002B19B
C02 02  X    @0 002B05C02G
C03 01  X  FRE  @0 Lymphome MALT @2 NM @5 01
C03 01  X  ENG  @0 MALT lymphoma @2 NM @5 01
C03 01  X  SPA  @0 Linfoma MALT @2 NM @5 01
C03 02  X  FRE  @0 Primaire @5 02
C03 02  X  ENG  @0 Primary @5 02
C03 02  X  SPA  @0 Primario @5 02
C03 03  X  FRE  @0 Salive @5 03
C03 03  X  ENG  @0 Saliva @5 03
C03 03  X  SPA  @0 Saliva @5 03
C03 04  X  FRE  @0 Hépatite virale C @5 04
C03 04  X  ENG  @0 Viral hepatitis C @5 04
C03 04  X  SPA  @0 Hepatitis virica C @5 04
C03 05  X  FRE  @0 Glande salivaire @5 05
C03 05  X  ENG  @0 Salivary gland @5 05
C03 05  X  SPA  @0 Glándula salival @5 05
C03 06  X  FRE  @0 Pronostic @5 06
C03 06  X  ENG  @0 Prognosis @5 06
C03 06  X  SPA  @0 Pronóstico @5 06
C03 07  X  FRE  @0 Hématologie @5 08
C03 07  X  ENG  @0 Hematology @5 08
C03 07  X  SPA  @0 Hematología @5 08
C07 01  X  FRE  @0 Virose @2 NM
C07 01  X  ENG  @0 Viral disease @2 NM
C07 01  X  SPA  @0 Virosis @2 NM
C07 02  X  FRE  @0 Infection @2 NM
C07 02  X  ENG  @0 Infection @2 NM
C07 02  X  SPA  @0 Infección @2 NM
C07 03  X  FRE  @0 Hémopathie maligne @5 37
C07 03  X  ENG  @0 Malignant hemopathy @5 37
C07 03  X  SPA  @0 Hemopatía maligna @5 37
C07 04  X  FRE  @0 Lymphome non hodgkinien @5 38
C07 04  X  ENG  @0 Non Hodgkin lymphoma @5 38
C07 04  X  SPA  @0 Linfoma no Hodgkin @5 38
C07 05  X  FRE  @0 Lymphoprolifératif syndrome @5 39
C07 05  X  ENG  @0 Lymphoproliferative syndrome @5 39
C07 05  X  SPA  @0 Linfoproliferativo síndrome @5 39
C07 06  X  FRE  @0 Appareil digestif pathologie @5 40
C07 06  X  ENG  @0 Digestive diseases @5 40
C07 06  X  SPA  @0 Aparato digestivo patología @5 40
C07 07  X  FRE  @0 Foie pathologie @5 41
C07 07  X  ENG  @0 Hepatic disease @5 41
C07 07  X  SPA  @0 Hígado patología @5 41
C07 08  X  FRE  @0 Appareil digestif @5 43
C07 08  X  ENG  @0 Digestive system @5 43
C07 08  X  SPA  @0 Aparato digestivo @5 43
N21       @1 208
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 04-0352747 INIST
ET : Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection
AU : AMBROSETTI (Achille); ZANOTTI (Roberta); PATTARO (Cristian); LENZI (Lorenza); CHILOSI (Marco); CARAMASCHI (Paola); ARCAINI (Luca); PASINI (Felice); BIASI (Domenico); ORLANDI (Ester); D'ADDA (Mariella); LUCIONI (Marco); PIZZOLO (Giovanni)
AF : Department of Clinical and Experimental Medicine, University of Verona/Verona/Italie (1 aut., 2 aut., 4 aut., 6 aut., 8 aut., 9 aut., 11 aut., 13 aut.); Department of Medicine and Public Health, University of Verona/Verona/Italie (3 aut.); Department of Pathology, University of Verona/Verona/Italie (5 aut.); Division of Hematology, University of Pavia/Pavia/Italie (7 aut., 10 aut.); Department of Pathology, University of Pavia/Pavia/Italie (12 aut.)
DT : Publication en série; Papier de recherche; Niveau analytique
SO : British journal of haematology; ISSN 0007-1048; Coden BJHEAL; Royaume-Uni; Da. 2004; Vol. 126; No. 1; Pp. 43-49; Bibl. 1 p.1/2
LA : Anglais
EA : Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.
CC : 002B19B; 002B05C02G
FD : Lymphome MALT; Primaire; Salive; Hépatite virale C; Glande salivaire; Pronostic; Hématologie
FG : Virose; Infection; Hémopathie maligne; Lymphome non hodgkinien; Lymphoprolifératif syndrome; Appareil digestif pathologie; Foie pathologie; Appareil digestif
ED : MALT lymphoma; Primary; Saliva; Viral hepatitis C; Salivary gland; Prognosis; Hematology
EG : Viral disease; Infection; Malignant hemopathy; Non Hodgkin lymphoma; Lymphoproliferative syndrome; Digestive diseases; Hepatic disease; Digestive system
SD : Linfoma MALT; Primario; Saliva; Hepatitis virica C; Glándula salival; Pronóstico; Hematología
LO : INIST-7597.354000110476370060
ID : 04-0352747

Links to Exploration step

Pascal:04-0352747

Le document en format XML

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<name sortKey="Caramaschi, Paola" sort="Caramaschi, Paola" uniqKey="Caramaschi P" first="Paola" last="Caramaschi">Paola Caramaschi</name>
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<ET>Most cases of primary salivary mucosa-associated lymphoid tissue lymphoma are associated either with Sjoegren syndrome or hepatitis C virus infection</ET>
<AU>AMBROSETTI (Achille); ZANOTTI (Roberta); PATTARO (Cristian); LENZI (Lorenza); CHILOSI (Marco); CARAMASCHI (Paola); ARCAINI (Luca); PASINI (Felice); BIASI (Domenico); ORLANDI (Ester); D'ADDA (Mariella); LUCIONI (Marco); PIZZOLO (Giovanni)</AU>
<AF>Department of Clinical and Experimental Medicine, University of Verona/Verona/Italie (1 aut., 2 aut., 4 aut., 6 aut., 8 aut., 9 aut., 11 aut., 13 aut.); Department of Medicine and Public Health, University of Verona/Verona/Italie (3 aut.); Department of Pathology, University of Verona/Verona/Italie (5 aut.); Division of Hematology, University of Pavia/Pavia/Italie (7 aut., 10 aut.); Department of Pathology, University of Pavia/Pavia/Italie (12 aut.)</AF>
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<EA>Salivary gland mucosa-associated lymphoid tissue (MALT) lymphomas (SGML) are rare, as are data concerning their behaviour. We analysed clinical features at presentation, particularly the association with Sjoegren syndrome (SS) and hepatitis C virus (HCV) infection, and outcome in 33 cases of SGML diagnosed between March 1985 and April 2003. There were five males and 28 females, with a median age of 61 years. At presentation, 12/33 (36%) had multiple salivary glands or mucosal involvement and four had bone marrow infiltration. Ann Arbor stage was IE in 15 (46%), IIE in four (12%) and IV in 14 patients (42%). Fifteen patients had a history of SS (46%), two of other autoimmune diseases, seven of HCV infection. No case had both SS and HCV. Of the 29 treated patients, 17 received surgery or local radiotherapy; 69% achieved complete remission. Histological transformation occurred in four (12%). Five patients died (three of lymphoma, two of unrelated causes). The 5 year-overall survival (OS), cause-specific survival and progression-free survival was 85 ± 8%, 94 ± 6% and 65 ± 10% respectively. Overall, the disease course was indolent, despite the advanced stage at diagnosis, and local therapy often appeared to be adequate. The only prognostic factors influencing OS were histological transformation and age. The close association of SGML with either autoimmune diseases or HCV infection in our series (73%) confirms their possible role in the pathogenesis of these lymphomas.</EA>
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