Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection
Identifieur interne : 003242 ( Istex/Corpus ); précédent : 003241; suivant : 003243Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection
Auteurs : Dar-In Tai ; Chien-Hung Chen ; Ting-Tsung Chang ; Shinn-Cherng Chen ; Li-Ying Liao ; Chung-Huang Kuo ; Yangyuan Chen ; Gran-Hum Chen ; Sien-Sing Yang ; Huang-Shang Tang ; Hsien Hong Lin ; Deng-Yn Lin ; Sing Kai Lo ; Jeng-Ming Du ; Kwo-Chuan Lin ; Chi-Sin Changchien ; Wen-Yu Chang ; Jin-Chuan Sheu ; Yun-Fan Liaw ; Ding-Shinn Chen ; Juei-Low SungSource :
- Journal of Gastroenterology and Hepatology [ 0815-9319 ] ; 2002-06.
English descriptors
- Teeft :
- Carcinoma, Chang, Chen, Chronic hepatitis, Cumulative mortality, Decompensated liver diseases, Dual infection, Familial tendency, Fatality, Gastroenterol, General population, Hbcv, Hbcv group, Hbcv groups, Hbsag, Hbsag carriers, Hepatitis, Hepatocellular, Hepatocellular carcinoma, Hepatology, Higher mortality, Higher prevalence, Infection, Infection groups, Internal medicine, Liaw, Liver disease, Liver diseases, Maternal transmission, None group, Present study, Prevalence, Risk factors, Surface antigen, Survival analysis, Total fatalities, Viral, Virus infection.
Abstract
Abstract Background: Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8‐year period to understand the risk and cause of HCC in relatives of patients with HCC.
Methods: From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α‐fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.
Results: Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti‐hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti‐HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti‐HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti‐HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.
Conclusions: Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.
Url:
DOI: 10.1046/j.1440-1746.2002.02747.x
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Kaohsiung,</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yangyuan" sort="Chen, Yangyuan" uniqKey="Chen Y" first="Yangyuan" last="Chen">Yangyuan Chen</name><affiliation><mods:affiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</mods:affiliation></affiliation></author><author><name sortKey="Chen, Gran Um" sort="Chen, Gran Um" uniqKey="Chen G" first="Gran-Hum" last="Chen">Gran-Hum Chen</name><affiliation><mods:affiliation>Department of Internal Medicine, Taichung Veterans General Hospital, Taichung,</mods:affiliation></affiliation></author><author><name sortKey="Yang, Sien Ing" sort="Yang, Sien Ing" uniqKey="Yang S" first="Sien-Sing" last="Yang">Sien-Sing Yang</name><affiliation><mods:affiliation>Liver Unit, Clinical Research Center, Cathay General Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Tang, Huang Hang" sort="Tang, Huang Hang" uniqKey="Tang H" first="Huang-Shang" last="Tang">Huang-Shang Tang</name><affiliation><mods:affiliation>Department of Internal Medicine, Tri‐service General Hospital, National Defence Medical Center,</mods:affiliation></affiliation></author><author><name sortKey="Lin, Hsien Hong" sort="Lin, Hsien Hong" uniqKey="Lin H" first="Hsien Hong" last="Lin">Hsien Hong Lin</name><affiliation><mods:affiliation>Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan and</mods:affiliation></affiliation></author><author><name sortKey="Lin, Deng N" sort="Lin, Deng N" uniqKey="Lin D" first="Deng-Yn" last="Lin">Deng-Yn Lin</name><affiliation><mods:affiliation>Liver Research Unit and</mods:affiliation></affiliation></author><author><name sortKey="Lo, Sing Kai" sort="Lo, Sing Kai" uniqKey="Lo S" first="Sing Kai" last="Lo">Sing Kai Lo</name><affiliation><mods:affiliation>Institute for International Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia</mods:affiliation></affiliation></author><author><name sortKey="Du, Jeng Ing" sort="Du, Jeng Ing" uniqKey="Du J" first="Jeng-Ming" last="Du">Jeng-Ming Du</name><affiliation><mods:affiliation>Department of Medical Information Management, Chang Gung Memorial Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Lin, Kwo Huan" sort="Lin, Kwo Huan" uniqKey="Lin K" first="Kwo-Chuan" last="Lin">Kwo-Chuan Lin</name><affiliation><mods:affiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</mods:affiliation></affiliation></author><author><name sortKey="Changchien, Chi In" sort="Changchien, Chi In" uniqKey="Changchien C" first="Chi-Sin" last="Changchien">Chi-Sin Changchien</name><affiliation><mods:affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</mods:affiliation></affiliation></author><author><name sortKey="Chang, Wen U" sort="Chang, Wen U" uniqKey="Chang W" first="Wen-Yu" last="Chang">Wen-Yu Chang</name><affiliation><mods:affiliation>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Sheu, Jin Huan" sort="Sheu, Jin Huan" uniqKey="Sheu J" first="Jin-Chuan" last="Sheu">Jin-Chuan Sheu</name><affiliation><mods:affiliation>Department of Internal Medicine, National Taiwan University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Liaw, Yun An" sort="Liaw, Yun An" uniqKey="Liaw Y" first="Yun-Fan" last="Liaw">Yun-Fan Liaw</name><affiliation><mods:affiliation>Liver Research Unit and</mods:affiliation></affiliation></author><author><name sortKey="Chen, Ding Hinn" sort="Chen, Ding Hinn" uniqKey="Chen D" first="Ding-Shinn" last="Chen">Ding-Shinn Chen</name><affiliation><mods:affiliation>Department of Internal Medicine, National Taiwan University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Sung, Juei Ow" sort="Sung, Juei Ow" uniqKey="Sung J" first="Juei-Low" last="Sung">Juei-Low Sung</name><affiliation><mods:affiliation>Sun Yat‐Sen Cancer Center Hospital, Taipei,</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:C3664FE0E4E3F5661A504A36E6BEC38739E74E53</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1046/j.1440-1746.2002.02747.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-MF3SRRTR-Q/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">003242</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">003242</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title><author><name sortKey="Tai, Dar N" sort="Tai, Dar N" uniqKey="Tai D" first="Dar-In" last="Tai">Dar-In Tai</name><affiliation><mods:affiliation>Liver Research Unit and</mods:affiliation></affiliation><affiliation><mods:affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</mods:affiliation></affiliation></author><author><name sortKey="Chen, Chien Ung" sort="Chen, Chien Ung" uniqKey="Chen C" first="Chien-Hung" last="Chen">Chien-Hung Chen</name><affiliation><mods:affiliation>Department of Internal Medicine, National Taiwan University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Chang, Ting Sung" sort="Chang, Ting Sung" uniqKey="Chang T" first="Ting-Tsung" last="Chang">Ting-Tsung Chang</name><affiliation><mods:affiliation>Department of Internal Medicine, National Cheng Kung University Hospital, Tainan,</mods:affiliation></affiliation></author><author><name sortKey="Chen, Shinn Herng" sort="Chen, Shinn Herng" uniqKey="Chen S" first="Shinn-Cherng" last="Chen">Shinn-Cherng Chen</name><affiliation><mods:affiliation>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Liao, Li Ing" sort="Liao, Li Ing" uniqKey="Liao L" first="Li-Ying" last="Liao">Li-Ying Liao</name><affiliation><mods:affiliation>Department of Gastroenterology, Taipei Municipal Jen‐Ai Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Kuo, Chung Uang" sort="Kuo, Chung Uang" uniqKey="Kuo C" first="Chung-Huang" last="Kuo">Chung-Huang Kuo</name><affiliation><mods:affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</mods:affiliation></affiliation></author><author><name sortKey="Chen, Yangyuan" sort="Chen, Yangyuan" uniqKey="Chen Y" first="Yangyuan" last="Chen">Yangyuan Chen</name><affiliation><mods:affiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</mods:affiliation></affiliation></author><author><name sortKey="Chen, Gran Um" sort="Chen, Gran Um" uniqKey="Chen G" first="Gran-Hum" last="Chen">Gran-Hum Chen</name><affiliation><mods:affiliation>Department of Internal Medicine, Taichung Veterans General Hospital, Taichung,</mods:affiliation></affiliation></author><author><name sortKey="Yang, Sien Ing" sort="Yang, Sien Ing" uniqKey="Yang S" first="Sien-Sing" last="Yang">Sien-Sing Yang</name><affiliation><mods:affiliation>Liver Unit, Clinical Research Center, Cathay General Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Tang, Huang Hang" sort="Tang, Huang Hang" uniqKey="Tang H" first="Huang-Shang" last="Tang">Huang-Shang Tang</name><affiliation><mods:affiliation>Department of Internal Medicine, Tri‐service General Hospital, National Defence Medical Center,</mods:affiliation></affiliation></author><author><name sortKey="Lin, Hsien Hong" sort="Lin, Hsien Hong" uniqKey="Lin H" first="Hsien Hong" last="Lin">Hsien Hong Lin</name><affiliation><mods:affiliation>Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan and</mods:affiliation></affiliation></author><author><name sortKey="Lin, Deng N" sort="Lin, Deng N" uniqKey="Lin D" first="Deng-Yn" last="Lin">Deng-Yn Lin</name><affiliation><mods:affiliation>Liver Research Unit and</mods:affiliation></affiliation></author><author><name sortKey="Lo, Sing Kai" sort="Lo, Sing Kai" uniqKey="Lo S" first="Sing Kai" last="Lo">Sing Kai Lo</name><affiliation><mods:affiliation>Institute for International Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia</mods:affiliation></affiliation></author><author><name sortKey="Du, Jeng Ing" sort="Du, Jeng Ing" uniqKey="Du J" first="Jeng-Ming" last="Du">Jeng-Ming Du</name><affiliation><mods:affiliation>Department of Medical Information Management, Chang Gung Memorial Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Lin, Kwo Huan" sort="Lin, Kwo Huan" uniqKey="Lin K" first="Kwo-Chuan" last="Lin">Kwo-Chuan Lin</name><affiliation><mods:affiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</mods:affiliation></affiliation></author><author><name sortKey="Changchien, Chi In" sort="Changchien, Chi In" uniqKey="Changchien C" first="Chi-Sin" last="Changchien">Chi-Sin Changchien</name><affiliation><mods:affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</mods:affiliation></affiliation></author><author><name sortKey="Chang, Wen U" sort="Chang, Wen U" uniqKey="Chang W" first="Wen-Yu" last="Chang">Wen-Yu Chang</name><affiliation><mods:affiliation>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Sheu, Jin Huan" sort="Sheu, Jin Huan" uniqKey="Sheu J" first="Jin-Chuan" last="Sheu">Jin-Chuan Sheu</name><affiliation><mods:affiliation>Department of Internal Medicine, National Taiwan University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Liaw, Yun An" sort="Liaw, Yun An" uniqKey="Liaw Y" first="Yun-Fan" last="Liaw">Yun-Fan Liaw</name><affiliation><mods:affiliation>Liver Research Unit and</mods:affiliation></affiliation></author><author><name sortKey="Chen, Ding Hinn" sort="Chen, Ding Hinn" uniqKey="Chen D" first="Ding-Shinn" last="Chen">Ding-Shinn Chen</name><affiliation><mods:affiliation>Department of Internal Medicine, National Taiwan University Hospital,</mods:affiliation></affiliation></author><author><name sortKey="Sung, Juei Ow" sort="Sung, Juei Ow" uniqKey="Sung J" first="Juei-Low" last="Sung">Juei-Low Sung</name><affiliation><mods:affiliation>Sun Yat‐Sen Cancer Center Hospital, Taipei,</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Gastroenterology and Hepatology</title><title level="j" type="alt">JOURNAL OF GASTROENTEROLOGY HEPATOLOGY</title><idno type="ISSN">0815-9319</idno><idno type="eISSN">1440-1746</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="682">682</biblScope><biblScope unit="page" to="689">689</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2002-06">2002-06</date></imprint><idno type="ISSN">0815-9319</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0815-9319</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Carcinoma</term><term>Chang</term><term>Chen</term><term>Chronic hepatitis</term><term>Cumulative mortality</term><term>Decompensated liver diseases</term><term>Dual infection</term><term>Familial tendency</term><term>Fatality</term><term>Gastroenterol</term><term>General population</term><term>Hbcv</term><term>Hbcv group</term><term>Hbcv groups</term><term>Hbsag</term><term>Hbsag carriers</term><term>Hepatitis</term><term>Hepatocellular</term><term>Hepatocellular carcinoma</term><term>Hepatology</term><term>Higher mortality</term><term>Higher prevalence</term><term>Infection</term><term>Infection groups</term><term>Internal medicine</term><term>Liaw</term><term>Liver disease</term><term>Liver diseases</term><term>Maternal transmission</term><term>None group</term><term>Present study</term><term>Prevalence</term><term>Risk factors</term><term>Surface antigen</term><term>Survival analysis</term><term>Total fatalities</term><term>Viral</term><term>Virus infection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Abstract Background: Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8‐year period to understand the risk and cause of HCC in relatives of patients with HCC.</div><div type="abstract">Methods: From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α‐fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.</div><div type="abstract">Results: Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti‐hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti‐HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti‐HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti‐HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.</div><div type="abstract">Conclusions: Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>hbcv</json:string><json:string>hbsag</json:string><json:string>hepatocellular</json:string><json:string>hepatocellular carcinoma</json:string><json:string>hbcv group</json:string><json:string>carcinoma</json:string><json:string>none group</json:string><json:string>chang</json:string><json:string>hepatitis</json:string><json:string>higher mortality</json:string><json:string>virus infection</json:string><json:string>viral</json:string><json:string>liaw</json:string><json:string>dual infection</json:string><json:string>chronic hepatitis</json:string><json:string>gastroenterol</json:string><json:string>hbcv groups</json:string><json:string>hepatology</json:string><json:string>fatality</json:string><json:string>infection groups</json:string><json:string>liver diseases</json:string><json:string>liver disease</json:string><json:string>internal medicine</json:string><json:string>familial tendency</json:string><json:string>decompensated liver diseases</json:string><json:string>higher prevalence</json:string><json:string>surface antigen</json:string><json:string>risk factors</json:string><json:string>hbsag carriers</json:string><json:string>prevalence</json:string><json:string>chen</json:string><json:string>cumulative mortality</json:string><json:string>total fatalities</json:string><json:string>maternal transmission</json:string><json:string>present study</json:string><json:string>survival analysis</json:string><json:string>general population</json:string><json:string>infection</json:string></teeft></keywords><author><json:item><name>Dar‐In Tai</name><affiliations><json:string>Liver Research Unit and</json:string><json:string>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</json:string></affiliations></json:item><json:item><name>Chien‐Hung Chen</name><affiliations><json:string>Department of Internal Medicine, National Taiwan University Hospital,</json:string></affiliations></json:item><json:item><name>Ting‐Tsung Chang</name><affiliations><json:string>Department of Internal Medicine, National Cheng Kung University Hospital, Tainan,</json:string></affiliations></json:item><json:item><name>Shinn‐Cherng Chen</name><affiliations><json:string>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</json:string></affiliations></json:item><json:item><name>Li‐Ying Liao</name><affiliations><json:string>Department of Gastroenterology, Taipei Municipal Jen‐Ai Hospital,</json:string></affiliations></json:item><json:item><name>Chung‐Huang Kuo</name><affiliations><json:string>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</json:string></affiliations></json:item><json:item><name>YangYuan Chen</name><affiliations><json:string>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</json:string></affiliations></json:item><json:item><name>Gran‐Hum Chen</name><affiliations><json:string>Department of Internal Medicine, Taichung Veterans General Hospital, Taichung,</json:string></affiliations></json:item><json:item><name>Sien‐Sing Yang</name><affiliations><json:string>Liver Unit, Clinical Research Center, Cathay General Hospital,</json:string></affiliations></json:item><json:item><name>Huang‐Shang Tang</name><affiliations><json:string>Department of Internal Medicine, Tri‐service General Hospital, National Defence Medical Center,</json:string></affiliations></json:item><json:item><name>Hsien Hong Lin</name><affiliations><json:string>Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan and</json:string></affiliations></json:item><json:item><name>Deng‐Yn Lin</name><affiliations><json:string>Liver Research Unit and</json:string></affiliations></json:item><json:item><name>Sing Kai Lo</name><affiliations><json:string>Institute for International Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia</json:string></affiliations></json:item><json:item><name>Jeng‐Ming Du</name><affiliations><json:string>Department of Medical Information Management, Chang Gung Memorial Hospital,</json:string></affiliations></json:item><json:item><name>Kwo‐Chuan Lin</name><affiliations><json:string>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</json:string></affiliations></json:item><json:item><name>Chi‐Sin Changchien</name><affiliations><json:string>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</json:string></affiliations></json:item><json:item><name>Wen‐Yu Chang</name><affiliations><json:string>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</json:string></affiliations></json:item><json:item><name>Jin‐Chuan Sheu</name><affiliations><json:string>Department of Internal Medicine, National Taiwan University Hospital,</json:string></affiliations></json:item><json:item><name>Yun‐Fan Liaw</name><affiliations><json:string>Liver Research Unit and</json:string></affiliations></json:item><json:item><name>Ding‐Shinn Chen</name><affiliations><json:string>Department of Internal Medicine, National Taiwan University Hospital,</json:string></affiliations></json:item><json:item><name>Juei‐Low Sung</name><affiliations><json:string>Sun Yat‐Sen Cancer Center Hospital, Taipei,</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>familial tendency</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hepatitis B</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hepatitis C</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hepatocellular carcinoma</value></json:item></subject><articleId><json:string>JGH2747</json:string></articleId><arkIstex>ark:/67375/WNG-MF3SRRTR-Q</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Abstract Background: Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8‐year period to understand the risk and cause of HCC in relatives of patients with HCC.</abstract><qualityIndicators><score>7.511</score><pdfWordCount>4971</pdfWordCount><pdfCharCount>29519</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>8</pdfPageCount><pdfPageSize>595 x 842 pts (A4)</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>45</abstractWordCount><abstractCharCount>280</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title><pmid><json:string>12100614</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Gastroenterology and 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uri="https://api.istex.fr/ark:/67375/WNG-MF3SRRTR-Q/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2002-06"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title><title level="a" type="short">Mortality in HCC families</title><author xml:id="author-0000"><persName><forename type="first">Dar‐In</forename><surname>Tai</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">Chien‐Hung</forename><surname>Chen</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><orgName type="institution">National Taiwan University Hospital</orgName></affiliation></author><author xml:id="author-0002"><persName><forename type="first">Ting‐Tsung</forename><surname>Chang</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><orgName type="institution">National Cheng Kung University Hospital</orgName><address><addrLine>Tainan</addrLine></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Shinn‐Cherng</forename><surname>Chen</surname></persName><affiliation><address><addrLine>Hepatobiliary Division</addrLine><addrLine>Department of Internal Medicine</addrLine><addrLine>Kaohsiung Medical University Hospital</addrLine></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first">Li‐Ying</forename><surname>Liao</surname></persName><affiliation><orgName type="department">Department of Gastroenterology</orgName><address><addrLine>Taipei Municipal Jen‐Ai Hospital</addrLine></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Chung‐Huang</forename><surname>Kuo</surname></persName><affiliation><orgName type="laboratory">Liver Unit</orgName><address><addrLine>Kaohsiung Chang Gung Memorial Hospital</addrLine><addrLine>Kaohsiung</addrLine></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">YangYuan</forename><surname>Chen</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><address><addrLine>Changhua Christian Hospital</addrLine><addrLine>Changhua</addrLine></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Gran‐Hum</forename><surname>Chen</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><address><addrLine>Taichung Veterans General Hospital</addrLine><addrLine>Taichung</addrLine></address></affiliation></author><author xml:id="author-0008"><persName><forename type="first">Sien‐Sing</forename><surname>Yang</surname></persName><affiliation><orgName type="laboratory">Liver Unit</orgName><address><addrLine>Clinical Research Center</addrLine><addrLine>Cathay General Hospital</addrLine></address></affiliation></author><author xml:id="author-0009"><persName><forename type="first">Huang‐Shang</forename><surname>Tang</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><address><addrLine>Tri‐service General Hospital</addrLine><addrLine>National Defence Medical Center</addrLine></address></affiliation></author><author xml:id="author-0010"><persName><forename type="first">Hsien Hong</forename><surname>Lin</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><address><addrLine>Buddhist Tzu Chi General Hospital</addrLine><addrLine>Hualien</addrLine><addrLine>Taiwan and</addrLine></address></affiliation></author><author xml:id="author-0011"><persName><forename type="first">Deng‐Yn
</forename><surname>Lin</surname></persName><affiliation><orgName type="laboratory">Liver Research Unit and</orgName></affiliation></author><author xml:id="author-0012"><persName><forename type="first">Sing Kai</forename><surname>Lo</surname></persName><affiliation><orgName type="institution">Institute for International Health</orgName><orgName type="department">Faculty of Medicine</orgName><orgName type="institution">University of Sydney</orgName><address><addrLine>Sydney</addrLine><addrLine>New South Wales</addrLine><country key="AU">AUSTRALIA</country><country key="AU"></country></address></affiliation></author><author xml:id="author-0013"><persName><forename type="first">Jeng‐Ming</forename><surname>Du</surname></persName><affiliation><orgName type="department">Department of Medical Information Management</orgName><address><addrLine>Chang Gung Memorial Hospital</addrLine></address></affiliation></author><author xml:id="author-0014"><persName><forename type="first">Kwo‐Chuan</forename><surname>Lin</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><address><addrLine>Changhua Christian Hospital</addrLine><addrLine>Changhua</addrLine></address></affiliation></author><author xml:id="author-0015"><persName><forename type="first">Chi‐Sin</forename><surname>Changchien</surname></persName><affiliation><orgName type="laboratory">Liver Unit</orgName><address><addrLine>Kaohsiung Chang Gung Memorial Hospital</addrLine><addrLine>Kaohsiung</addrLine></address></affiliation></author><author xml:id="author-0016"><persName><forename type="first">Wen‐Yu</forename><surname>Chang</surname></persName><affiliation><address><addrLine>Hepatobiliary Division</addrLine><addrLine>Department of Internal Medicine</addrLine><addrLine>Kaohsiung Medical University Hospital</addrLine></address></affiliation></author><author xml:id="author-0017"><persName><forename type="first">Jin‐Chuan</forename><surname>Sheu</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><orgName type="institution">National Taiwan University Hospital</orgName></affiliation></author><author xml:id="author-0018"><persName><forename type="first">Yun‐Fan</forename><surname>Liaw</surname></persName><affiliation><orgName type="laboratory">Liver Research Unit and</orgName></affiliation></author><author xml:id="author-0019"><persName><forename type="first">Ding‐Shinn</forename><surname>Chen</surname></persName><affiliation><orgName type="department">Department of Internal Medicine</orgName><orgName type="institution">National Taiwan University Hospital</orgName></affiliation></author><author xml:id="author-0020"><persName><forename type="first">Juei‐Low</forename><surname>Sung</surname></persName><affiliation><address><addrLine>Sun Yat‐Sen Cancer Center Hospital</addrLine><addrLine>Taipei</addrLine></address></affiliation></author><idno type="istex">C3664FE0E4E3F5661A504A36E6BEC38739E74E53</idno><idno type="ark">ark:/67375/WNG-MF3SRRTR-Q</idno><idno type="DOI">10.1046/j.1440-1746.2002.02747.x</idno><idno type="unit">JGH2747</idno><idno type="toTypesetVersion">file:JGH.JGH2747.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Gastroenterology and Hepatology</title><title level="j" type="alt">JOURNAL OF GASTROENTEROLOGY HEPATOLOGY</title><idno type="pISSN">0815-9319</idno><idno type="eISSN">1440-1746</idno><idno type="book-DOI">10.1111/(ISSN)1440-1746</idno><idno type="book-part-DOI">10.1111/jgh.2002.17.issue-6</idno><idno type="product">JGH</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="682">682</biblScope><biblScope unit="page" to="689">689</biblScope><biblScope unit="page-count">8</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2002-06"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><p><hi rend="italic">Abstract</hi><hi rend="italic"> Background:</hi> Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8‐year period to understand the risk and cause of HCC in relatives of patients with HCC.</p><p><hi rend="italic">Methods:</hi> From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α‐fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.</p><p><hi rend="italic">Results:</hi> Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti‐hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti‐HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti‐HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti‐HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.</p><p><hi rend="italic">Conclusions:</hi> Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">familial tendency</term><term xml:id="k2">hepatitis B</term><term xml:id="k3">hepatitis C</term><term xml:id="k4">hepatocellular carcinoma</term></keywords><keywords rend="tocHeading1"><term>Survival of Relatives of Patients with Hepatocellular Carcinoma</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MF3SRRTR-Q/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Pty</publisherName><publisherLoc>Melbourne, Australia</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1440-1746</doi><issn type="print">0815-9319</issn><issn type="electronic">1440-1746</issn><idGroup><id type="product" value="JGH"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF GASTROENTEROLOGY HEPATOLOGY">Journal of Gastroenterology and Hepatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="06006"><doi origin="wiley">10.1111/jgh.2002.17.issue-6</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="6">6</numbering></numberingGroup><coverDate startDate="2002-06">June 2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0068200" status="forIssue"><doi origin="wiley">10.1046/j.1440-1746.2002.02747.x</doi><idGroup><id type="unit" value="JGH2747"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="tocHeading1">Survival of Relatives of Patients with Hepatocellular Carcinoma</title></titleGroup><eventGroup><event type="firstOnline" date="2002-07-03"></event><event type="publishedOnlineFinalForm" date="2002-07-03"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-30"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="682">682</numbering><numbering type="pageLast" number="689">689</numbering></numberingGroup><correspondenceTo> Juei‐Low Sung, President Emeritus, Sun Yat‐Sen Cancer Center Hospital, No. 125 Lih‐Der Road, Pei‐Tou District, Taipei, Taiwan 112. Email: <email>rosa@mail.kfcc.org.tw</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JGH.JGH2747.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="2"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="48"></count><count type="wordTotal" number="3609"></count><count type="linksPubMed" number="21"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title><title type="shortAuthors">D‐I Tai <i>et al.</i></title><title type="short">Mortality in HCC families</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1 #a2"><personName><givenNames>Dar‐In</givenNames><familyName>Tai</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a3"><personName><givenNames>Chien‐Hung</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a4"><personName><givenNames>Ting‐Tsung</givenNames><familyName>Chang</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a5"><personName><givenNames>Shinn‐Cherng</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a6"><personName><givenNames>Li‐Ying</givenNames><familyName>Liao</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a2"><personName><givenNames>Chung‐Huang</givenNames><familyName>Kuo</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a7"><personName><givenNames>YangYuan</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a8"><personName><givenNames>Gran‐Hum</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr9" affiliationRef="#a9"><personName><givenNames>Sien‐Sing</givenNames><familyName>Yang</familyName></personName></creator><creator creatorRole="author" xml:id="cr10" affiliationRef="#a10"><personName><givenNames>Huang‐Shang</givenNames><familyName>Tang</familyName></personName></creator><creator creatorRole="author" xml:id="cr11" affiliationRef="#a11"><personName><givenNames>Hsien Hong</givenNames><familyName>Lin</familyName></personName></creator><creator creatorRole="author" xml:id="cr12" affiliationRef="#a1"><personName><givenNames>Deng‐Yn
</givenNames><familyName>Lin</familyName></personName></creator><creator creatorRole="author" xml:id="cr13" affiliationRef="#a12"><personName><givenNames>Sing Kai</givenNames><familyName>Lo</familyName></personName></creator><creator creatorRole="author" xml:id="cr14" affiliationRef="#a13"><personName><givenNames>Jeng‐Ming</givenNames><familyName>Du</familyName></personName></creator><creator creatorRole="author" xml:id="cr15" affiliationRef="#a7"><personName><givenNames>Kwo‐Chuan</givenNames><familyName>Lin</familyName></personName></creator><creator creatorRole="author" xml:id="cr16" affiliationRef="#a2"><personName><givenNames>Chi‐Sin</givenNames><familyName>Changchien</familyName></personName></creator><creator creatorRole="author" xml:id="cr17" affiliationRef="#a5"><personName><givenNames>Wen‐Yu</givenNames><familyName>Chang</familyName></personName></creator><creator creatorRole="author" xml:id="cr18" affiliationRef="#a3"><personName><givenNames>Jin‐Chuan</givenNames><familyName>Sheu</familyName></personName></creator><creator creatorRole="author" xml:id="cr19" affiliationRef="#a1"><personName><givenNames>Yun‐Fan</givenNames><familyName>Liaw</familyName></personName></creator><creator creatorRole="author" xml:id="cr20" affiliationRef="#a3"><personName><givenNames>Ding‐Shinn</givenNames><familyName>Chen</familyName></personName></creator><creator creatorRole="author" xml:id="cr21" affiliationRef="#a14"><personName><givenNames>Juei‐Low</givenNames><familyName>Sung</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Liver Research Unit and</unparsedAffiliation></affiliation><affiliation xml:id="a13"><unparsedAffiliation>Department of Medical Information Management, Chang Gung Memorial Hospital,</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Department of Internal Medicine, National Taiwan University Hospital,</unparsedAffiliation></affiliation><affiliation xml:id="a6"><unparsedAffiliation>Department of Gastroenterology, Taipei Municipal Jen‐Ai Hospital,</unparsedAffiliation></affiliation><affiliation xml:id="a9"><unparsedAffiliation>Liver Unit, Clinical Research Center, Cathay General Hospital,</unparsedAffiliation></affiliation><affiliation xml:id="a10"><unparsedAffiliation>Department of Internal Medicine, Tri‐service General Hospital, National Defence Medical Center,</unparsedAffiliation></affiliation><affiliation xml:id="a14"><unparsedAffiliation>Sun Yat‐Sen Cancer Center Hospital, Taipei,</unparsedAffiliation></affiliation><affiliation xml:id="a4"><unparsedAffiliation>Department of Internal Medicine, National Cheng Kung University Hospital, Tainan,</unparsedAffiliation></affiliation><affiliation xml:id="a5"><unparsedAffiliation>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</unparsedAffiliation></affiliation><affiliation xml:id="a7"><unparsedAffiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</unparsedAffiliation></affiliation><affiliation xml:id="a8"><unparsedAffiliation>Department of Internal Medicine, Taichung Veterans General Hospital, Taichung,</unparsedAffiliation></affiliation><affiliation xml:id="a11"><unparsedAffiliation>Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan and</unparsedAffiliation></affiliation><affiliation xml:id="a12" countryCode="AU"><unparsedAffiliation>Institute for International Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">familial tendency</keyword><keyword xml:id="k2">hepatitis B</keyword><keyword xml:id="k3">hepatitis C</keyword><keyword xml:id="k4">hepatocellular carcinoma</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>Abstract</b><b> Background:</b> Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8‐year period to understand the risk and cause of HCC in relatives of patients with HCC.</p><p><b>Methods:</b> From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α‐fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.</p><p><b>Results:</b> Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti‐hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti‐HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti‐HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti‐HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.</p><p><b>Conclusions:</b> Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Mortality in HCC families</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Eight‐year nationwide survival analysis in relatives of patients with hepatocellular carcinoma: Role of viral infection</title></titleInfo><name type="personal"><namePart type="given">Dar‐In</namePart><namePart type="family">Tai</namePart><affiliation>Liver Research Unit and</affiliation><affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chien‐Hung</namePart><namePart type="family">Chen</namePart><affiliation>Department of Internal Medicine, National Taiwan University Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ting‐Tsung</namePart><namePart type="family">Chang</namePart><affiliation>Department of Internal Medicine, National Cheng Kung University Hospital, Tainan,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shinn‐Cherng</namePart><namePart type="family">Chen</namePart><affiliation>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Li‐Ying</namePart><namePart type="family">Liao</namePart><affiliation>Department of Gastroenterology, Taipei Municipal Jen‐Ai Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chung‐Huang</namePart><namePart type="family">Kuo</namePart><affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">YangYuan</namePart><namePart type="family">Chen</namePart><affiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gran‐Hum</namePart><namePart type="family">Chen</namePart><affiliation>Department of Internal Medicine, Taichung Veterans General Hospital, Taichung,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sien‐Sing</namePart><namePart type="family">Yang</namePart><affiliation>Liver Unit, Clinical Research Center, Cathay General Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Huang‐Shang</namePart><namePart type="family">Tang</namePart><affiliation>Department of Internal Medicine, Tri‐service General Hospital, National Defence Medical Center,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hsien Hong</namePart><namePart type="family">Lin</namePart><affiliation>Department of Internal Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Deng‐Yn</namePart><namePart type="family">Lin</namePart><affiliation>Liver Research Unit and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Sing Kai</namePart><namePart type="family">Lo</namePart><affiliation>Institute for International Health, Faculty of Medicine, University of Sydney, Sydney, New South Wales, Australia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jeng‐Ming</namePart><namePart type="family">Du</namePart><affiliation>Department of Medical Information Management, Chang Gung Memorial Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Kwo‐Chuan</namePart><namePart type="family">Lin</namePart><affiliation>Department of Internal Medicine,Changhua Christian Hospital, Changhua,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chi‐Sin</namePart><namePart type="family">Changchien</namePart><affiliation>Liver Unit, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Wen‐Yu</namePart><namePart type="family">Chang</namePart><affiliation>Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jin‐Chuan</namePart><namePart type="family">Sheu</namePart><affiliation>Department of Internal Medicine, National Taiwan University Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yun‐Fan</namePart><namePart type="family">Liaw</namePart><affiliation>Liver Research Unit and</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Ding‐Shinn</namePart><namePart type="family">Chen</namePart><affiliation>Department of Internal Medicine, National Taiwan University Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Juei‐Low</namePart><namePart type="family">Sung</namePart><affiliation>Sun Yat‐Sen Cancer Center Hospital, Taipei,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Science Pty</publisher><place><placeTerm type="text">Melbourne, Australia</placeTerm></place><dateIssued encoding="w3cdtf">2002-06</dateIssued><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">2</extent><extent unit="formulas">0</extent><extent unit="references">48</extent><extent unit="linksCrossRef">0</extent><extent unit="words">3609</extent></physicalDescription><abstract>Abstract Background: Families of patients with hepatocellular carcinoma (HCC) carry a high risk of developing HCC. We determine the number of fatalities in relatives of HCC patients during an 8‐year period to understand the risk and cause of HCC in relatives of patients with HCC.</abstract><abstract>Methods: From 1992 to 1997, 15 410 relatives of HCC patients in three generations were screened prospectively for HCC by ultrasonography, α‐fetoprotein, liver biochemistry and viral markers. By using national citizen identification numbers, we searched the total fatalities in relatives of HCC patients between 1992 and 1999 from the national mortality data bank. The results were compared among different viral infection groups.</abstract><abstract>Results: Of the relatives studied, 37.8% were hepatitis B s antigen (HBsAg) positive (+), 4.3% were anti‐hepatitis C virus (HCV) (+) and 1.7% were both HBsAg (+) and anti‐HCV (+). A total of 399 fatalities, including 139 because of HCC (34.8%), 37 because of liver diseases (9.3%), 88 because of other cancers (22.1%) and 135 because of other diseases (33.8%), were found. Relatives who were HBsAg (+) or anti‐HCV (+)showed a lower cumulative survival than did relatives who were negative for both HBsAg and anti‐HCV. Relatives with dual infection of hepatitis B and C virus showed the highest mortality due to HCC or terminal liver diseases.</abstract><abstract>Conclusions: Chronic viral infection rather than a hereditary factor is the main cause of a familial tendency for HCC. Dual infection of hepatitis B and C virus increases the risk of HCC or decompensated liver diseases.</abstract><subject lang="en"><genre>keywords</genre><topic>familial tendency</topic><topic>hepatitis B</topic><topic>hepatitis C</topic><topic>hepatocellular carcinoma</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Gastroenterology and Hepatology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0815-9319</identifier><identifier type="eISSN">1440-1746</identifier><identifier type="DOI">10.1111/(ISSN)1440-1746</identifier><identifier type="PublisherID">JGH</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>682</start><end>689</end><total>8</total></extent></part></relatedItem><identifier type="istex">C3664FE0E4E3F5661A504A36E6BEC38739E74E53</identifier><identifier type="ark">ark:/67375/WNG-MF3SRRTR-Q</identifier><identifier type="DOI">10.1046/j.1440-1746.2002.02747.x</identifier><identifier type="ArticleID">JGH2747</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Science Pty</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-MF3SRRTR-Q/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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