Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan
Identifieur interne : 000439 ( Istex/Corpus ); précédent : 000438; suivant : 000440Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan
Auteurs : Chien-Wei Su ; Jaw-Ching Wu ; Yi-Shin Huang ; Teh-Ia Huo ; Yi-Hsiang Huang ; Chen-Chun Lin ; Full-Young Chang ; Shou-Dong LeeSource :
- Journal of Gastroenterology and Hepatology [ 0815-9319 ] ; 2002-11.
English descriptors
- Teeft :
- Acute hepatitis, Alanine aminotransferase, Aminotransferase, Aspartate aminotransferase, Bilirubin, Bilirubin levels, Blackwell publishing asia, Clinical manifestations, Clinical symptoms, Domestic swine, Endemic, Endemic area, Enzyme immunoassay, Epidemiological, Epidemiological characteristics, Epidemiological factors, Epidemiological survey, Hepatitis, Hepatitis factor, Important factor, Kindergarten children, Laboratory data, Laboratory examinations, Lower serum albumin, Lower serum levels, Multivariate analyses, Multivariate analysis, Older patients, Other words, Pregnant women, Previous study, Public health, Recent years, Regression model, Serum albumin, Serum albumin level, Serum bilirubin level, Serum samples, Sporadic cases, Statistical analysis, Synthetic peptides, Taipei, Taipei veterans, Travel history, Travel history albumin, Univariate analysis, Viral hepatitis, Virol, Virus infection, Virus infections, Wilcoxon test.
Abstract
Background and Aims : Acute hepatitis A (AHA) and acute hepatitis E (AHE) are endemic in developing countries. They share similar transmission routes and clinical manifestations. To compare the differences in epidemiology, clinical picture and prognosis between these two enterically transmitted forms of hepatitis, we enrolled 58 consecutive AHA or AHE patients (42 men and 16 women; age 16–74 years) from January 1990 to April 2001.
Results : In comparison to AHA, patients with AHE were older (56.2 ± 15.4 vs 30.7 ± 11.0 years, P < 0.0001), and more frequently had a history of travel within 3 months before onset of illness (68.8 vs 30.8%, P = 0.003). In laboratory data, AHE patients had lower serum levels of albumin (3.4 ± 0.4 vs 3.8 ± 0.4 g/dL, P = 0.016), alanine aminotransferase (1912 ± 1587 vs 3023 ± 1959 U/L, P = 0.015), and aspartate aminotransferase (1681 ± 1444 vs 2374 ± 2869 U/L, P = 0.24), but a higher serum bilirubin level (17.8 ± 12.3 vs 8.7 ± 5.0 mg/dL, P = 0.003) than AHA patients. Moreover, five (15.6%) patients with AHE compared with none with AHA died. This probably indicates that AHE had a worse outcome than AHA in our study. In analysis of epidemiological factors, older age of onset of illness was the only significant predicator of outcome. From an epidemiological survey, most AHE patients were imported while most AHA patients were not. However, native AHE and imported AHA did occur in Taiwan.
Conclusion : Patients with AHE in Taiwan had older age of onset, more records of traveling history, and poorer clinical manifestations than those with AHA, and age seemed to be the most important factor to influence outcome.
© 2002 Blackwell Publishing Asia Pty Ltd
Url:
DOI: 10.1046/j.1440-1746.2002.02858.x
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ISTEX:0FB8F1B552869C9B7F72E5D78C5C67B69A57E155Le document en format XML
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Hin" sort="Huang, Yi Hin" uniqKey="Huang Y" first="Yi-Shin" last="Huang">Yi-Shin Huang</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huo, Teh A" sort="Huo, Teh A" uniqKey="Huo T" first="Teh-Ia" last="Huo">Teh-Ia Huo</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huang, Yi Siang" sort="Huang, Yi Siang" uniqKey="Huang Y" first="Yi-Hsiang" last="Huang">Yi-Hsiang 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and</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: jcwu@vghtpe.gov.tw</mods:affiliation></affiliation></author><author><name sortKey="Huang, Yi Hin" sort="Huang, Yi Hin" uniqKey="Huang Y" first="Yi-Shin" last="Huang">Yi-Shin Huang</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huo, Teh A" sort="Huo, Teh A" uniqKey="Huo T" first="Teh-Ia" last="Huo">Teh-Ia Huo</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Huang, Yi Siang" sort="Huang, Yi Siang" uniqKey="Huang Y" first="Yi-Hsiang" last="Huang">Yi-Hsiang Huang</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lin, Chen Hun" sort="Lin, Chen Hun" uniqKey="Lin C" first="Chen-Chun" last="Lin">Chen-Chun Lin</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Chang, Full Oung" sort="Chang, Full Oung" uniqKey="Chang F" first="Full-Young" last="Chang">Full-Young Chang</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author><author><name sortKey="Lee, Shou Ong" sort="Lee, Shou Ong" uniqKey="Lee S" first="Shou-Dong" last="Lee">Shou-Dong Lee</name><affiliation><mods:affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</mods:affiliation></affiliation><affiliation><mods:affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Gastroenterology and Hepatology</title><title level="j" type="alt">JOURNAL OF GASTROENTEROLOGY HEPATOLOGY</title><idno type="ISSN">0815-9319</idno><idno type="eISSN">1440-1746</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1187">1187</biblScope><biblScope unit="page" to="1191">1191</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2002-11">2002-11</date></imprint><idno type="ISSN">0815-9319</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0815-9319</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acute hepatitis</term><term>Alanine aminotransferase</term><term>Aminotransferase</term><term>Aspartate aminotransferase</term><term>Bilirubin</term><term>Bilirubin levels</term><term>Blackwell publishing asia</term><term>Clinical manifestations</term><term>Clinical symptoms</term><term>Domestic swine</term><term>Endemic</term><term>Endemic area</term><term>Enzyme immunoassay</term><term>Epidemiological</term><term>Epidemiological characteristics</term><term>Epidemiological factors</term><term>Epidemiological survey</term><term>Hepatitis</term><term>Hepatitis factor</term><term>Important factor</term><term>Kindergarten children</term><term>Laboratory data</term><term>Laboratory examinations</term><term>Lower serum albumin</term><term>Lower serum levels</term><term>Multivariate analyses</term><term>Multivariate analysis</term><term>Older patients</term><term>Other words</term><term>Pregnant women</term><term>Previous study</term><term>Public health</term><term>Recent years</term><term>Regression model</term><term>Serum albumin</term><term>Serum albumin level</term><term>Serum bilirubin level</term><term>Serum samples</term><term>Sporadic cases</term><term>Statistical analysis</term><term>Synthetic peptides</term><term>Taipei</term><term>Taipei veterans</term><term>Travel history</term><term>Travel history albumin</term><term>Univariate analysis</term><term>Viral hepatitis</term><term>Virol</term><term>Virus infection</term><term>Virus infections</term><term>Wilcoxon test</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background and Aims : Acute hepatitis A (AHA) and acute hepatitis E (AHE) are endemic in developing countries. They share similar transmission routes and clinical manifestations. To compare the differences in epidemiology, clinical picture and prognosis between these two enterically transmitted forms of hepatitis, we enrolled 58 consecutive AHA or AHE patients (42 men and 16 women; age 16–74 years) from January 1990 to April 2001.</div><div type="abstract">Results : In comparison to AHA, patients with AHE were older (56.2 ± 15.4 vs 30.7 ± 11.0 years, P < 0.0001), and more frequently had a history of travel within 3 months before onset of illness (68.8 vs 30.8%, P = 0.003). In laboratory data, AHE patients had lower serum levels of albumin (3.4 ± 0.4 vs 3.8 ± 0.4 g/dL, P = 0.016), alanine aminotransferase (1912 ± 1587 vs 3023 ± 1959 U/L, P = 0.015), and aspartate aminotransferase (1681 ± 1444 vs 2374 ± 2869 U/L, P = 0.24), but a higher serum bilirubin level (17.8 ± 12.3 vs 8.7 ± 5.0 mg/dL, P = 0.003) than AHA patients. Moreover, five (15.6%) patients with AHE compared with none with AHA died. This probably indicates that AHE had a worse outcome than AHA in our study. In analysis of epidemiological factors, older age of onset of illness was the only significant predicator of outcome. From an epidemiological survey, most AHE patients were imported while most AHA patients were not. However, native AHE and imported AHA did occur in Taiwan.</div><div type="abstract">Conclusion : Patients with AHE in Taiwan had older age of onset, more records of traveling history, and poorer clinical manifestations than those with AHA, and age seemed to be the most important factor to influence outcome.</div><div type="abstract">© 2002 Blackwell Publishing Asia Pty Ltd</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>acute hepatitis</json:string><json:string>travel history</json:string><json:string>bilirubin</json:string><json:string>hepatitis</json:string><json:string>aminotransferase</json:string><json:string>virol</json:string><json:string>clinical manifestations</json:string><json:string>endemic</json:string><json:string>virus infection</json:string><json:string>epidemiological</json:string><json:string>aspartate aminotransferase</json:string><json:string>alanine aminotransferase</json:string><json:string>statistical 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Wu</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Institute of Clinical Medicine and</json:string><json:string>E-mail: jcwu@vghtpe.gov.tw</json:string></affiliations></json:item><json:item><name>Yi‐Shin Huang</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Teh‐Ia Huo</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Yi‐Hsiang Huang</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Chen‐Chun Lin</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Full‐Young Chang</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</json:string></affiliations></json:item><json:item><name>Shou‐Dong Lee</name><affiliations><json:string>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</json:string><json:string>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>acute hepatitis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>epidemiology</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hepatitis A</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hepatitis E</value></json:item></subject><articleId><json:string>JGH2858</json:string></articleId><arkIstex>ark:/67375/WNG-3C56KB33-G</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Background and Aims : Acute hepatitis A (AHA) and acute hepatitis E (AHE) are endemic in developing countries. They share similar transmission routes and clinical manifestations. To compare the differences in epidemiology, clinical picture and prognosis between these two enterically transmitted forms of hepatitis, we enrolled 58 consecutive AHA or AHE patients (42 men and 16 women; age 16–74 years) from January 1990 to April 2001.</abstract><qualityIndicators><score>6.083</score><pdfWordCount>3303</pdfWordCount><pdfCharCount>19989</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>5</pdfPageCount><pdfPageSize>595 x 779.638 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>65</abstractWordCount><abstractCharCount>434</abstractCharCount><keywordCount>4</keywordCount></qualityIndicators><title>Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan</title><pmid><json:string>12453278</json:string></pmid><genre><json:string>article</json:string></genre><host><title>Journal of Gastroenterology and Hepatology</title><language><json:string>unknown</json:string></language><doi><json:string>10.1111/(ISSN)1440-1746</json:string></doi><issn><json:string>0815-9319</json:string></issn><eissn><json:string>1440-1746</json:string></eissn><publisherId><json:string>JGH</json:string></publisherId><volume>17</volume><issue>11</issue><pages><first>1187</first><last>1191</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date></date><geogName></geogName><orgName></orgName><orgName_funder></orgName_funder><orgName_provider></orgName_provider><persName></persName><placeName></placeName><ref_url></ref_url><ref_bibl></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/WNG-3C56KB33-G</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - gastroenterology & hepatology</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - gastroenterology & hepatology</json:string></scienceMetrix><scopus><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Gastroenterology</json:string><json:string>1 - Health Sciences</json:string><json:string>2 - Medicine</json:string><json:string>3 - Hepatology</json:string></scopus></categories><publicationDate>2002</publicationDate><copyrightDate>2002</copyrightDate><doi><json:string>10.1046/j.1440-1746.2002.02858.x</json:string></doi><id>0FB8F1B552869C9B7F72E5D78C5C67B69A57E155</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3C56KB33-G/fulltext.pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3C56KB33-G/bundle.zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-3C56KB33-G/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2002-11"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan</title><title level="a" type="short">Acute hepatitis A and acute hepatitis E</title><author xml:id="author-0000"><persName><forename type="first">Chien‐Wei</forename><surname>Su</surname></persName><affiliation><address><addrLine>Division of Gastroenterology</addrLine><addrLine>Department of Medicine</addrLine><addrLine>Taipei Veterans General Hospital</addrLine></address></affiliation></author><author xml:id="author-0001" role="corresp"><persName><forename type="first">Jaw‐Ching</forename><surname>Wu</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation><affiliation>Dr J‐C Wu, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Email: jcwu@vghtpe.gov.tw</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Yi‐Shin</forename><surname>Huang</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">Teh‐Ia</forename><surname>Huo</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><author xml:id="author-0004"><persName><forename type="first"> Yi‐Hsiang</forename><surname>Huang</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><author xml:id="author-0005"><persName><forename type="first">Chen‐Chun</forename><surname>Lin</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><author xml:id="author-0006"><persName><forename type="first">Full‐Young</forename><surname>Chang</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><author xml:id="author-0007"><persName><forename type="first">Shou‐Dong</forename><surname>Lee</surname></persName><affiliation><address><addrLine></addrLine></address></affiliation><affiliation><address><addrLine></addrLine></address></affiliation></author><idno type="istex">0FB8F1B552869C9B7F72E5D78C5C67B69A57E155</idno><idno type="ark">ark:/67375/WNG-3C56KB33-G</idno><idno type="DOI">10.1046/j.1440-1746.2002.02858.x</idno><idno type="unit">JGH2858</idno><idno type="toTypesetVersion">file:JGH.JGH2858.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Gastroenterology and Hepatology</title><title level="j" type="alt">JOURNAL OF GASTROENTEROLOGY HEPATOLOGY</title><idno type="pISSN">0815-9319</idno><idno type="eISSN">1440-1746</idno><idno type="book-DOI">10.1111/(ISSN)1440-1746</idno><idno type="book-part-DOI">10.1111/jgh.2002.17.issue-11</idno><idno type="product">JGH</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">17</biblScope><biblScope unit="issue">11</biblScope><biblScope unit="page" from="1187">1187</biblScope><biblScope unit="page" to="1191">1191</biblScope><publisher>Blackwell Science Pty</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2002-11"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p><hi rend="italic"><hi rend="italic">Background and Aims</hi>
: </hi> Acute hepatitis A (AHA) and acute hepatitis E (AHE) are endemic in developing countries. They share similar transmission routes and clinical manifestations. To compare the differences in epidemiology, clinical picture and prognosis between these two enterically transmitted forms of hepatitis, we enrolled 58 consecutive AHA or AHE patients (42 men and 16 women; age 16–74 years) from January 1990 to April 2001.</p><p><hi rend="italic"><hi rend="italic">Results</hi>
: </hi> In comparison to AHA, patients with AHE were older (56.2 ± 15.4 <hi rend="italic">vs</hi> 30.7 ± 11.0 years, <hi rend="italic">P</hi> < 0.0001), and more frequently had a history of travel within 3 months before onset of illness (68.8 <hi rend="italic">vs</hi> 30.8%, <hi rend="italic">P</hi> = 0.003). In laboratory data, AHE patients had lower serum levels of albumin (3.4 ± 0.4 <hi rend="italic">vs</hi> 3.8 ± 0.4 g/dL, <hi rend="italic">P</hi> = 0.016), alanine aminotransferase (1912 ± 1587 <hi rend="italic">vs</hi> 3023 ± 1959 U/L, <hi rend="italic">P</hi> = 0.015), and aspartate aminotransferase (1681 ± 1444 <hi rend="italic">vs</hi> 2374 ± 2869 U/L, <hi rend="italic">P</hi> = 0.24), but a higher serum bilirubin level (17.8 ± 12.3 <hi rend="italic">vs</hi> 8.7 ± 5.0 mg/dL, <hi rend="italic">P =</hi> 0.003) than AHA patients. Moreover, five (15.6%) patients with AHE compared with none with AHA died. This probably indicates that AHE had a worse outcome than AHA in our study. In analysis of epidemiological factors, older age of onset of illness was the only significant predicator of outcome. From an epidemiological survey, most AHE patients were imported while most AHA patients were not. However, native AHE and imported AHA did occur in Taiwan.</p><p><hi rend="italic"><hi rend="italic">Conclusion</hi>
: </hi> Patients with AHE in Taiwan had older age of onset, more records of traveling history, and poorer clinical manifestations than those with AHA, and age seemed to be the most important factor to influence outcome.</p><p>© 2002 Blackwell Publishing Asia Pty Ltd</p></abstract><textClass><keywords xml:lang="en"><term xml:id="k1">acute hepatitis</term><term xml:id="k2">epidemiology</term><term xml:id="k3">hepatitis A</term><term xml:id="k4">hepatitis E</term></keywords><keywords rend="tocHeading1"><term>Clinical Studies of Hepatitis A Virus, Hepatitis E Virus and TT Virus in Taiwan</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3C56KB33-G/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Science Pty</publisherName><publisherLoc>Melbourne, Australia</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1440-1746</doi><issn type="print">0815-9319</issn><issn type="electronic">1440-1746</issn><idGroup><id type="product" value="JGH"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF GASTROENTEROLOGY HEPATOLOGY">Journal of Gastroenterology and Hepatology</title></titleGroup></publicationMeta><publicationMeta level="part" position="11011"><doi origin="wiley">10.1111/jgh.2002.17.issue-11</doi><numberingGroup><numbering type="journalVolume" number="17">17</numbering><numbering type="journalIssue" number="11">11</numbering></numberingGroup><coverDate startDate="2002-11">November 2002</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="0118700" status="forIssue"><doi origin="wiley">10.1046/j.1440-1746.2002.02858.x</doi><idGroup><id type="unit" value="JGH2858"></id></idGroup><titleGroup><title type="tocHeading1">Clinical Studies of Hepatitis A Virus, Hepatitis E Virus and TT Virus in Taiwan</title></titleGroup><eventGroup><event type="firstOnline" date="2002-10-01"></event><event type="publishedOnlineFinalForm" date="2002-10-01"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.4 mode:FullText source:FullText result:FullText" date="2010-03-30"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-30"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-30"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="1187">1187</numbering><numbering type="pageLast" number="1191">1191</numbering></numberingGroup><correspondenceTo> Dr J‐C Wu, Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital, Taipei, Taiwan. Email: <email>jcwu@vghtpe.gov.tw</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JGH.JGH2858.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Accepted for publication 3 June 2002.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="0"></count><count type="tableTotal" number="5"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="27"></count><count type="wordTotal" number="2620"></count><count type="linksPubMed" number="9"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan</title><title type="shortAuthors">C‐W Su <i>et al.</i></title><title type="short">Acute hepatitis A and acute hepatitis E</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>Chien‐Wei</givenNames><familyName>Su</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1 #a2" corresponding="yes"><personName><givenNames>Jaw‐Ching</givenNames><familyName>Wu</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1 #a3"><personName><givenNames>Yi‐Shin</givenNames><familyName>Huang</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1 #a3"><personName><givenNames>Teh‐Ia</givenNames><familyName>Huo</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1 #a3"><personName><givenNames> Yi‐Hsiang</givenNames><familyName>Huang</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1 #a3"><personName><givenNames>Chen‐Chun</givenNames><familyName>Lin</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1 #a3"><personName><givenNames>Full‐Young</givenNames><familyName>Chang</familyName></personName></creator><creator creatorRole="author" xml:id="cr8" affiliationRef="#a1 #a3"><personName><givenNames>Shou‐Dong</givenNames><familyName>Lee</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1"><unparsedAffiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</unparsedAffiliation></affiliation><affiliation xml:id="a2"><unparsedAffiliation>Institute of Clinical Medicine and</unparsedAffiliation></affiliation><affiliation xml:id="a3"><unparsedAffiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">acute hepatitis</keyword><keyword xml:id="k2">epidemiology</keyword><keyword xml:id="k3">hepatitis A</keyword><keyword xml:id="k4">hepatitis E</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b><i>Background and Aims</i>
: </b> Acute hepatitis A (AHA) and acute hepatitis E (AHE) are endemic in developing countries. They share similar transmission routes and clinical manifestations. To compare the differences in epidemiology, clinical picture and prognosis between these two enterically transmitted forms of hepatitis, we enrolled 58 consecutive AHA or AHE patients (42 men and 16 women; age 16–74 years) from January 1990 to April 2001.</p><p><b><i>Results</i>
: </b> In comparison to AHA, patients with AHE were older (56.2 ± 15.4 <i>vs</i> 30.7 ± 11.0 years, <i>P</i> < 0.0001), and more frequently had a history of travel within 3 months before onset of illness (68.8 <i>vs</i> 30.8%, <i>P</i> = 0.003). In laboratory data, AHE patients had lower serum levels of albumin (3.4 ± 0.4 <i>vs</i> 3.8 ± 0.4 g/dL, <i>P</i> = 0.016), alanine aminotransferase (1912 ± 1587 <i>vs</i> 3023 ± 1959 U/L, <i>P</i> = 0.015), and aspartate aminotransferase (1681 ± 1444 <i>vs</i> 2374 ± 2869 U/L, <i>P</i> = 0.24), but a higher serum bilirubin level (17.8 ± 12.3 <i>vs</i> 8.7 ± 5.0 mg/dL, <i>P =</i> 0.003) than AHA patients. Moreover, five (15.6%) patients with AHE compared with none with AHA died. This probably indicates that AHE had a worse outcome than AHA in our study. In analysis of epidemiological factors, older age of onset of illness was the only significant predicator of outcome. From an epidemiological survey, most AHE patients were imported while most AHA patients were not. However, native AHE and imported AHA did occur in Taiwan.</p><p><b><i>Conclusion</i>
: </b> Patients with AHE in Taiwan had older age of onset, more records of traveling history, and poorer clinical manifestations than those with AHA, and age seemed to be the most important factor to influence outcome.</p><p>© 2002 Blackwell Publishing Asia Pty Ltd</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Acute hepatitis A and acute hepatitis E</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Comparison of clinical manifestations and epidemiology between acute hepatitis A and acute hepatitis E in Taiwan</title></titleInfo><name type="personal"><namePart type="given">Chien‐Wei</namePart><namePart type="family">Su</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Jaw‐Ching</namePart><namePart type="family">Wu</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Institute of Clinical Medicine and</affiliation><affiliation>E-mail: jcwu@vghtpe.gov.tw</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yi‐Shin</namePart><namePart type="family">Huang</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Teh‐Ia</namePart><namePart type="family">Huo</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yi‐Hsiang</namePart><namePart type="family">Huang</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Chen‐Chun</namePart><namePart type="family">Lin</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Full‐Young</namePart><namePart type="family">Chang</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Shou‐Dong</namePart><namePart type="family">Lee</namePart><affiliation>Division of Gastroenterology, Department of Medicine, Taipei Veterans General Hospital,</affiliation><affiliation>Department of Medicine, National Yang‐Ming University School of Medicine, Taipei, Taiwan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Science Pty</publisher><place><placeTerm type="text">Melbourne, Australia</placeTerm></place><dateIssued encoding="w3cdtf">2002-11</dateIssued><edition>Accepted for publication 3 June 2002.</edition><copyrightDate encoding="w3cdtf">2002</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">0</extent><extent unit="tables">5</extent><extent unit="formulas">0</extent><extent unit="references">27</extent><extent unit="linksCrossRef">0</extent><extent unit="words">2620</extent></physicalDescription><abstract>Background and Aims : Acute hepatitis A (AHA) and acute hepatitis E (AHE) are endemic in developing countries. They share similar transmission routes and clinical manifestations. To compare the differences in epidemiology, clinical picture and prognosis between these two enterically transmitted forms of hepatitis, we enrolled 58 consecutive AHA or AHE patients (42 men and 16 women; age 16–74 years) from January 1990 to April 2001.</abstract><abstract>Results : In comparison to AHA, patients with AHE were older (56.2 ± 15.4 vs 30.7 ± 11.0 years, P < 0.0001), and more frequently had a history of travel within 3 months before onset of illness (68.8 vs 30.8%, P = 0.003). In laboratory data, AHE patients had lower serum levels of albumin (3.4 ± 0.4 vs 3.8 ± 0.4 g/dL, P = 0.016), alanine aminotransferase (1912 ± 1587 vs 3023 ± 1959 U/L, P = 0.015), and aspartate aminotransferase (1681 ± 1444 vs 2374 ± 2869 U/L, P = 0.24), but a higher serum bilirubin level (17.8 ± 12.3 vs 8.7 ± 5.0 mg/dL, P = 0.003) than AHA patients. Moreover, five (15.6%) patients with AHE compared with none with AHA died. This probably indicates that AHE had a worse outcome than AHA in our study. In analysis of epidemiological factors, older age of onset of illness was the only significant predicator of outcome. From an epidemiological survey, most AHE patients were imported while most AHA patients were not. However, native AHE and imported AHA did occur in Taiwan.</abstract><abstract>Conclusion : Patients with AHE in Taiwan had older age of onset, more records of traveling history, and poorer clinical manifestations than those with AHA, and age seemed to be the most important factor to influence outcome.</abstract><abstract>© 2002 Blackwell Publishing Asia Pty Ltd</abstract><subject lang="en"><genre>keywords</genre><topic>acute hepatitis</topic><topic>epidemiology</topic><topic>hepatitis A</topic><topic>hepatitis E</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Gastroenterology and Hepatology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">0815-9319</identifier><identifier type="eISSN">1440-1746</identifier><identifier type="DOI">10.1111/(ISSN)1440-1746</identifier><identifier type="PublisherID">JGH</identifier><part><date>2002</date><detail type="volume"><caption>vol.</caption><number>17</number></detail><detail type="issue"><caption>no.</caption><number>11</number></detail><extent unit="pages"><start>1187</start><end>1191</end></extent></part></relatedItem><identifier type="istex">0FB8F1B552869C9B7F72E5D78C5C67B69A57E155</identifier><identifier type="ark">ark:/67375/WNG-3C56KB33-G</identifier><identifier type="DOI">10.1046/j.1440-1746.2002.02858.x</identifier><identifier type="ArticleID">JGH2858</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource><recordOrigin>Blackwell Science Pty</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-3C56KB33-G/record.json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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