OcrV1, PascalFrancis, Curation, bibRecord, 000579

Calcium scores and matrix Gla protein levels: association with vitamin K status

Identifieur interne : 000579 ( PascalFrancis/Curation ); précédent : 000578; suivant : 000580

Calcium scores and matrix Gla protein levels: association with vitamin K status

Auteurs : Roger J. M. W. Rennenberg [Pays-Bas] ; Peter W. De Leeuw [Pays-Bas] ; Alphons G. H. Kessels [Pays-Bas] ; Leon J. Schurgers [Pays-Bas] ; Cees Vermeer [Pays-Bas] ; Jos M. A. Van Engelshoven [Pays-Bas] ; Gerrit J. Kemerink [Pays-Bas] ; Abraham A. Kroon [Pays-Bas]

Source :

European journal of clinical investigation [ 0014-2972 ] ; 2010.

RBID : Pascal:10-0166437

Descripteurs français

Pascal (Inist)
- Hypertension artérielle, Calcium, Association, Vitamine K, Calcification, Ordinateur, Assistance ordinateur, Tomographie, Ostéocalcine, Ratio, Médecine, Score, Protéine MGP.
Wicri :
- topic : Calcium, Association, Ordinateur, Ratio, Médecine.

English descriptors

KwdEn :
- Association, Calcification, Calcium, Computer, Computer aid, Hypertension, Matrix Gla protein, Medicine, Osteocalcin, Ratio, Score, Tomography, Vitamin K.

Abstract

Background Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long-term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods In 36 hypertensive patients, we determined the Agatston score with computer tomography scans of the abdominal aorta, carotid and coronary arteries. The total calcium score was calculated as the sum of the separate Z-scores. Results The total calcium Z-score was significantly correlated to age (r = 0.683, P < 0.001), smoking (r = 0.372, P = 0.026), total cholesterol (r = 0.353, P = 0.034), LDL cholesterol (r = 0.490, P = 0.003), triglycerides (r = 0.506, P = 0.002), fasting glucose (r = 0.454, P = 0.005), systolic blood pressure (r = 0.363, P = 0.029) and pulse pressure (r = 0.685, P < 0.001). In multivariate regression analyses, OCR and total calcium score were significantly associated with ucMGP. Conclusions We found a positive association of total arterial calcium score and a high OCR (reflecting low vitamin K status) with ucMGP serum levels. This warrants further studies to explore the pathophysiological background of this phenomenon.

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A03		`1`		`@0 Eur. j. clin. invest.`
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A08	`01`	`1`	`ENG`	`@1 Calcium scores and matrix Gla protein levels: association with vitamin K status`
A11	`01`	`1`		`@1 RENNENBERG (Roger J. M. W.)`
A11	`02`	`1`		`@1 DE LEEUW (Peter W.)`
A11	`03`	`1`		`@1 KESSELS (Alphons G. H.)`
A11	`04`	`1`		`@1 SCHURGERS (Leon J.)`
A11	`05`	`1`		`@1 VERMEER (Cees)`
A11	`06`	`1`		`@1 VAN ENGELSHOVEN (Jos M. A.)`
A11	`07`	`1`		`@1 KEMERINK (Gerrit J.)`
A11	`08`	`1`		`@1 KROON (Abraham A.)`
A14	`01`			`@1 Department of Internal Medicine, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM) @2 Maastricht @3 NLD @Z 1 aut. @Z 2 aut. @Z 8 aut.`
A14	`02`			`@1 Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC+) @2 Maastricht @3 NLD @Z 3 aut.`
A14	`03`			`@1 Department of Biochemistry, Maastricht University, CARIM and VitaK B.V. @2 Maastricht @3 NLD @Z 4 aut. @Z 5 aut.`
A14	`04`			`@1 Department of Radiology, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM) @2 Maastricht @3 NLD @Z 6 aut. @Z 7 aut.`
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C01	`01`		`ENG`	@0 Background Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long-term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods In 36 hypertensive patients, we determined the Agatston score with computer tomography scans of the abdominal aorta, carotid and coronary arteries. The total calcium score was calculated as the sum of the separate Z-scores. Results The total calcium Z-score was significantly correlated to age (r = 0.683, P < 0.001), smoking (r = 0.372, P = 0.026), total cholesterol (r = 0.353, P = 0.034), LDL cholesterol (r = 0.490, P = 0.003), triglycerides (r = 0.506, P = 0.002), fasting glucose (r = 0.454, P = 0.005), systolic blood pressure (r = 0.363, P = 0.029) and pulse pressure (r = 0.685, P < 0.001). In multivariate regression analyses, OCR and total calcium score were significantly associated with ucMGP. Conclusions We found a positive association of total arterial calcium score and a high OCR (reflecting low vitamin K status) with ucMGP serum levels. This warrants further studies to explore the pathophysiological background of this phenomenon.
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C03	`13`	`X`	`FRE`	`@0 Protéine MGP @4 CD @5 97`
C03	`13`	`X`	`ENG`	`@0 Matrix Gla protein @4 CD @5 97`
C07	`01`	`X`	`FRE`	`@0 Elément minéral @5 37`
C07	`01`	`X`	`ENG`	`@0 Inorganic element @5 37`
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C07	`02`	`X`	`FRE`	`@0 Radiodiagnostic @5 38`
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Le document en format XML

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<series><title level="j" type="main">European journal of clinical investigation</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Association</term>
<term>Calcification</term>
<term>Calcium</term>
<term>Computer</term>
<term>Computer aid</term>
<term>Hypertension</term>
<term>Matrix Gla protein</term>
<term>Medicine</term>
<term>Osteocalcin</term>
<term>Ratio</term>
<term>Score</term>
<term>Tomography</term>
<term>Vitamin K</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle</term>
<term>Calcium</term>
<term>Association</term>
<term>Vitamine K</term>
<term>Calcification</term>
<term>Ordinateur</term>
<term>Assistance ordinateur</term>
<term>Tomographie</term>
<term>Ostéocalcine</term>
<term>Ratio</term>
<term>Médecine</term>
<term>Score</term>
<term>Protéine MGP</term>
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<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Calcium</term>
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<front><div type="abstract" xml:lang="en">Background Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long-term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods In 36 hypertensive patients, we determined the Agatston score with computer tomography scans of the abdominal aorta, carotid and coronary arteries. The total calcium score was calculated as the sum of the separate Z-scores. Results The total calcium Z-score was significantly correlated to age (r = 0.683, P < 0.001), smoking (r = 0.372, P = 0.026), total cholesterol (r = 0.353, P = 0.034), LDL cholesterol (r = 0.490, P = 0.003), triglycerides (r = 0.506, P = 0.002), fasting glucose (r = 0.454, P = 0.005), systolic blood pressure (r = 0.363, P = 0.029) and pulse pressure (r = 0.685, P < 0.001). In multivariate regression analyses, OCR and total calcium score were significantly associated with ucMGP. Conclusions We found a positive association of total arterial calcium score and a high OCR (reflecting low vitamin K status) with ucMGP serum levels. This warrants further studies to explore the pathophysiological background of this phenomenon.</div>
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<fA11 i1="01" i2="1"><s1>RENNENBERG (Roger J. M. W.)</s1>
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<fA11 i1="02" i2="1"><s1>DE LEEUW (Peter W.)</s1>
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<fA11 i1="03" i2="1"><s1>KESSELS (Alphons G. H.)</s1>
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<fA11 i1="04" i2="1"><s1>SCHURGERS (Leon J.)</s1>
</fA11>
<fA11 i1="05" i2="1"><s1>VERMEER (Cees)</s1>
</fA11>
<fA11 i1="06" i2="1"><s1>VAN ENGELSHOVEN (Jos M. A.)</s1>
</fA11>
<fA11 i1="07" i2="1"><s1>KEMERINK (Gerrit J.)</s1>
</fA11>
<fA11 i1="08" i2="1"><s1>KROON (Abraham A.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Internal Medicine, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM)</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Clinical Epidemiology and Medical Technology Assessment, Maastricht University Medical Centre (MUMC+)</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Biochemistry, Maastricht University, CARIM and VitaK B.V.</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Department of Radiology, Maastricht University Medical Centre (MUMC+) and Cardiovascular Research Institute Maastricht (CARIM)</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA20><s1>344-349</s1>
</fA20>
<fA21><s1>2010</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>5808</s2>
<s5>354000181483050080</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2010 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>36 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>10-0166437</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>European journal of clinical investigation</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background Vascular calcification in humans is associated with an increased cardiovascular risk. Carboxylated matrix Gla protein (cMGP) inhibits vascular calcification. Vitamin K is an essential cofactor for the activation of uncarboxylated matrix Gla protein (ucMGP). It has been suggested that patients on long-term treatment with vitamin K antagonists develop aortic valve calcifications because of lower levels of circulating MGP. We therefore hypothesized that arterial calcification and a low vitamin K status are associated with ucMGP. To that aim, we measured arterial calcium scores, the osteocalcin ratio (OCR), as a proxy for vitamin K status, and ucMGP. Materials and methods In 36 hypertensive patients, we determined the Agatston score with computer tomography scans of the abdominal aorta, carotid and coronary arteries. The total calcium score was calculated as the sum of the separate Z-scores. Results The total calcium Z-score was significantly correlated to age (r = 0.683, P < 0.001), smoking (r = 0.372, P = 0.026), total cholesterol (r = 0.353, P = 0.034), LDL cholesterol (r = 0.490, P = 0.003), triglycerides (r = 0.506, P = 0.002), fasting glucose (r = 0.454, P = 0.005), systolic blood pressure (r = 0.363, P = 0.029) and pulse pressure (r = 0.685, P < 0.001). In multivariate regression analyses, OCR and total calcium score were significantly associated with ucMGP. Conclusions We found a positive association of total arterial calcium score and a high OCR (reflecting low vitamin K status) with ucMGP serum levels. This warrants further studies to explore the pathophysiological background of this phenomenon.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B01</s0>
</fC02>
<fC02 i1="02" i2="X"><s0>002B12B05</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Hypertension artérielle</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Hypertension</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Hipertensión arterial</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Calcium</s0>
<s2>NC</s2>
<s2>FR</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Calcium</s0>
<s2>NC</s2>
<s2>FR</s2>
<s5>02</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Calcio</s0>
<s2>NC</s2>
<s2>FR</s2>
<s5>02</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Association</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Association</s0>
<s5>03</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Asociación</s0>
<s5>03</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Vitamine K</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Vitamin K</s0>
<s5>05</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Vitamina K</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Calcification</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Calcification</s0>
<s5>06</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Calcificación</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Ordinateur</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Computer</s0>
<s5>08</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Computadora</s0>
<s5>08</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Assistance ordinateur</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Computer aid</s0>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Asistencia ordenador</s0>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Tomographie</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Tomography</s0>
<s5>11</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Tomografía</s0>
<s5>11</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Ostéocalcine</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Osteocalcin</s0>
<s5>12</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Osteocalcina</s0>
<s5>12</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Ratio</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Ratio</s0>
<s5>17</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Ratio</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Médecine</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Medicine</s0>
<s5>18</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Medicina</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Score</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Score</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Protéine MGP</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Matrix Gla protein</s0>
<s4>CD</s4>
<s5>97</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Elément minéral</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Inorganic element</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Elemento inorgánico</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Radiodiagnostic</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Radiodiagnosis</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Radiodiagnóstico</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'appareil circulatoire</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Cardiovascular disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Aparato circulatorio patología</s0>
<s5>39</s5>
</fC07>
<fN21><s1>109</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Calcium scores and matrix Gla protein levels: association with vitamin K status

Calcium scores and matrix Gla protein levels: association with vitamin K status

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