Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients.
Identifieur interne : 000B83 ( PubMed/Curation ); précédent : 000B82; suivant : 000B84Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients.
Auteurs : Timothy L. Hanson [États-Unis] ; Andrew M. Fuller ; Mikhail A. Lebedev ; Dennis A. Turner ; Miguel A L. NicolelisSource :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2012.
English descriptors
- KwdEn :
- Algorithms, Biomechanical Phenomena, Brain (physiopathology), Cortical Synchronization, Deep Brain Stimulation, Electrodes, Implanted, Electroencephalography, Electromyography, Electrophysiological Phenomena, Essential Tremor (physiopathology), Essential Tremor (therapy), Female, Functional Laterality (physiology), Hand (physiology), Humans, Male, Movement (physiology), Nerve Net (physiopathology), Neurons (physiology), Parkinson Disease (physiopathology), Parkinson Disease (therapy), Psychomotor Performance (physiology), Subthalamic Nucleus (physiology), Thalamus (physiology), Tremor (physiopathology), Tremor (psychology), Tremor (therapy).
- MESH :
- physiology : Functional Laterality, Hand, Movement, Neurons, Psychomotor Performance, Subthalamic Nucleus, Thalamus.
- physiopathology : Brain, Essential Tremor, Nerve Net, Parkinson Disease, Tremor.
- psychology : Tremor.
- therapy : Essential Tremor, Parkinson Disease, Tremor.
- Algorithms, Biomechanical Phenomena, Cortical Synchronization, Deep Brain Stimulation, Electrodes, Implanted, Electroencephalography, Electromyography, Electrophysiological Phenomena, Female, Humans, Male.
Abstract
Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson's disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.
DOI: 10.1523/JNEUROSCI.0750-12.2012
PubMed: 22723703
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Nicolelis</name></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Algorithms</term><term>Biomechanical Phenomena</term><term>Brain (physiopathology)</term><term>Cortical Synchronization</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Electroencephalography</term><term>Electromyography</term><term>Electrophysiological Phenomena</term><term>Essential Tremor (physiopathology)</term><term>Essential Tremor (therapy)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Hand (physiology)</term><term>Humans</term><term>Male</term><term>Movement (physiology)</term><term>Nerve Net (physiopathology)</term><term>Neurons (physiology)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (therapy)</term><term>Psychomotor Performance (physiology)</term><term>Subthalamic Nucleus (physiology)</term><term>Thalamus (physiology)</term><term>Tremor (physiopathology)</term><term>Tremor (psychology)</term><term>Tremor (therapy)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term><term>Hand</term><term>Movement</term><term>Neurons</term><term>Psychomotor Performance</term><term>Subthalamic Nucleus</term><term>Thalamus</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Brain</term><term>Essential Tremor</term><term>Nerve Net</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Tremor</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Essential Tremor</term><term>Parkinson Disease</term><term>Tremor</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Algorithms</term><term>Biomechanical Phenomena</term><term>Cortical Synchronization</term><term>Deep Brain Stimulation</term><term>Electrodes, Implanted</term><term>Electroencephalography</term><term>Electromyography</term><term>Electrophysiological Phenomena</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson's disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22723703</PMID><DateCreated><Year>2012</Year><Month>06</Month><Day>22</Day></DateCreated><DateCompleted><Year>2012</Year><Month>08</Month><Day>30</Day></DateCompleted><DateRevised><Year>2015</Year><Month>02</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-2401</ISSN><JournalIssue CitedMedium="Internet"><Volume>32</Volume><Issue>25</Issue><PubDate><Year>2012</Year><Month>Jun</Month><Day>20</Day></PubDate></JournalIssue><Title>The Journal of neuroscience : the official journal of the Society for Neuroscience</Title><ISOAbbreviation>J. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>Subcortical neuronal ensembles: an analysis of motor task association, tremor, oscillations, and synchrony in human patients.</ArticleTitle><Pagination><MedlinePgn>8620-32</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1523/JNEUROSCI.0750-12.2012</ELocationID><Abstract><AbstractText>Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson's disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Hanson</LastName><ForeName>Timothy L</ForeName><Initials>TL</Initials><AffiliationInfo><Affiliation>Department of Neurobiology, Duke University, Durham, North Carolina 27710, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fuller</LastName><ForeName>Andrew M</ForeName><Initials>AM</Initials></Author><Author ValidYN="Y"><LastName>Lebedev</LastName><ForeName>Mikhail A</ForeName><Initials>MA</Initials></Author><Author ValidYN="Y"><LastName>Turner</LastName><ForeName>Dennis A</ForeName><Initials>DA</Initials></Author><Author ValidYN="Y"><LastName>Nicolelis</LastName><ForeName>Miguel A L</ForeName><Initials>MA</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>DP1 MH099903</GrantID><Acronym>MH</Acronym><Agency>NIMH NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DP1 OD006798</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>DP1OD006798</GrantID><Acronym>OD</Acronym><Agency>NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 NS073125</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01AG037599</GrantID><Acronym>AG</Acronym><Agency>NIA NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01NS073125</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21 NS066115</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R21NS066115</GrantID><Acronym>NS</Acronym><Agency>NINDS NIH 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Version="1">17017503</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Physiol. 2007 Mar 15;579(Pt 3):571-9</RefSource><PMID Version="1">17234689</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurotherapeutics. 2008 Jan;5(1):137-46</RefSource><PMID Version="1">18164493</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroreport. 2008 Mar 26;19(5):599-602</RefSource><PMID Version="1">18388746</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosci Lett. 2008 Sep 19;442(3):195-9</RefSource><PMID Version="1">18634849</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Inf Technol Biomed. 2009 Jan;13(1):49-56</RefSource><PMID Version="1">19129023</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2009 Apr 17;324(5925):354-9</RefSource><PMID Version="1">19299587</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Methods. 2000 Jan 31;95(1):13-28</RefSource><PMID Version="1">10776811</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Rehabil Eng. 2000 Jun;8(2):198-202</RefSource><PMID Version="1">10896186</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Eur J Neurosci. 2000 Jul;12(7):2597-607</RefSource><PMID Version="1">10947834</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2000 Oct 15;20(20):7766-75</RefSource><PMID Version="1">11027240</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2000 Nov 16;408(6810):361-5</RefSource><PMID Version="1">11099043</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2001 Jan 18;409(6818):403-7</RefSource><PMID Version="1">11201755</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2001 Feb;124(Pt 2):378-88</RefSource><PMID Version="1">11157565</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2001 May;16(3):464-8</RefSource><PMID Version="1">11391740</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2001 Sep;124(Pt 9):1777-90</RefSource><PMID Version="1">11522580</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2001 Nov;141(1):88-100</RefSource><PMID Version="1">11685413</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2002 Mar 14;416(6877):141-2</RefSource><PMID Version="1">11894084</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2002 Apr;87(4):2084-94</RefSource><PMID Version="1">11929926</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2002;17 Suppl 3:S145-9</RefSource><PMID Version="1">11948769</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2002 Jun;125(Pt 6):1196-209</RefSource><PMID Version="1">12023310</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Science. 2002 Jun 7;296(5574):1829-32</RefSource><PMID Version="1">12052948</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 2002 Nov;97(5):1167-72</RefSource><PMID Version="1">12450039</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Philos Trans R Soc Lond B Biol Sci. 2002 Dec 29;357(1428):1809-21</RefSource><PMID Version="1">12626014</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 2003 Jul;18(7):791-8</RefSource><PMID Version="1">12815658</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 2003 Dec 9;61(11):1601-4</RefSource><PMID Version="1">14663050</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2004 Jan;127(Pt 1):4-20</RefSource><PMID Version="1">14607789</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>PLoS Biol. 2003 Nov;1(2):E42</RefSource><PMID Version="1">14624244</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurosurgery. 2004 Jul;55(1):27-35; discussion 35-8</RefSource><PMID Version="1">15214971</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosurg. 2004 Jul;101(1):43-7</RefSource><PMID Version="1">15255250</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Neural Syst Rehabil Eng. 2004 Sep;12(3):339-44</RefSource><PMID Version="1">15473196</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 1988 Mar;8(3):754-64</RefSource><PMID Version="1">3346719</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 1989 May;61(5):900-17</RefSource><PMID Version="1">2723733</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1990 Dec;113 ( Pt 6):1795-821</RefSource><PMID Version="1">2276045</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Biomed Eng. 1993 Mar;40(3):276-83</RefSource><PMID Version="1">8335331</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>IEEE Trans Biomed Eng. 1993 Aug;40(8):836-41</RefSource><PMID Version="1">8258452</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 1994 Jun;117 ( Pt 3):531-43</RefSource><PMID Version="1">8032863</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 1994 Oct;72(4):1654-73</RefSource><PMID Version="1">7823093</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain Res Brain Res Rev. 1995 Jan;20(1):128-54</RefSource><PMID Version="1">7711765</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci Methods. 1997 Jun 27;74(2):155-66</RefSource><PMID Version="1">9219885</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 1998 Mar;83(1):107-21</RefSource><PMID Version="1">9466402</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroreport. 1998 Jun 1;9(8):1707-11</RefSource><PMID Version="1">9665587</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neurology. 1998 Oct;51(4):1063-9</RefSource><PMID Version="1">9781530</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Mov Disord. 1998;13 Suppl 3:2-23</RefSource><PMID Version="1">9827589</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuroscience. 1999 Jan;88(2):377-92</RefSource><PMID Version="1">10197761</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Neurosci. 1999 Jul;2(7):664-70</RefSource><PMID Version="1">10404201</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurosci. 2004 Dec 15;24(50):11302-6</RefSource><PMID Version="1">15601936</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2005 Jan;93(1):117-27</RefSource><PMID Version="1">15317839</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2005 May;93(5):2966-73</RefSource><PMID Version="1">15563555</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Brain Res. 2005 May;162(4):407-16</RefSource><PMID Version="1">15635456</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2005 Jun 23;435(7045):1102-7</RefSource><PMID Version="1">15973409</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Brain. 2005 Oct;128(Pt 10):2240-9</RefSource><PMID Version="1">15975946</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neurophysiol. 2006 Jan;95(1):119-33</RefSource><PMID Version="1">16120664</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nat Rev Neurosci. 2009 Jul;10(7):530-40</RefSource><PMID Version="1">19543222</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Exp Neurol. 2009 Sep;219(1):58-61</RefSource><PMID Version="1">19460368</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Arch Neurol. 2011 Feb;68(2):165</RefSource><PMID Version="1">20937936</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>J Neural Eng. 2011 Jun;8(3):036018</RefSource><PMID Version="1">21543839</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Clinics (Sao Paulo). 2011;66 Suppl 1:25-32</RefSource><PMID Version="1">21779720</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Neuron. 2011 Oct 20;72(2):370-84</RefSource><PMID Version="1">22017994</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>Nature. 2011 Nov 10;479(7372):228-31</RefSource><PMID Version="1">21976021</PMID></CommentsCorrections><CommentsCorrections RefType="Cites"><RefSource>N Engl J Med. 2006 Aug 31;355(9):896-908</RefSource><PMID Version="1">16943402</PMID></CommentsCorrections></CommentsCorrectionsList><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000465">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001696">Biomechanical Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001921">Brain</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D003344">Cortical Synchronization</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D046690">Deep Brain 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