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Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.

Identifieur interne : 001937 ( PubMed/Corpus ); précédent : 001936; suivant : 001938

Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.

Auteurs : Liliana Werner ; Nick Mamalis ; Andrea M. Izak ; Suresh K. Pandey ; Brandon L. Davis ; Chistian D. Nilson ; Christopher Weight ; David J. Apple

Source :

RBID : pubmed:15899460

English descriptors

Abstract

To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1-piece hydrophobic acrylic intraocular lenses (IOLs) with square optic edges.

DOI: 10.1016/j.jcrs.2004.06.088
PubMed: 15899460

Links to Exploration step

pubmed:15899460

Le document en format XML

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<title xml:lang="en">Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.</title>
<author>
<name sortKey="Werner, Liliana" sort="Werner, Liliana" uniqKey="Werner L" first="Liliana" last="Werner">Liliana Werner</name>
<affiliation>
<nlm:affiliation>John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.</nlm:affiliation>
</affiliation>
</author>
<author>
<name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name>
</author>
<author>
<name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M" last="Izak">Andrea M. Izak</name>
</author>
<author>
<name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name>
</author>
<author>
<name sortKey="Davis, Brandon L" sort="Davis, Brandon L" uniqKey="Davis B" first="Brandon L" last="Davis">Brandon L. Davis</name>
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<name sortKey="Nilson, Chistian D" sort="Nilson, Chistian D" uniqKey="Nilson C" first="Chistian D" last="Nilson">Chistian D. Nilson</name>
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<name sortKey="Weight, Christopher" sort="Weight, Christopher" uniqKey="Weight C" first="Christopher" last="Weight">Christopher Weight</name>
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<name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name>
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<title xml:lang="en">Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.</title>
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<name sortKey="Mamalis, Nick" sort="Mamalis, Nick" uniqKey="Mamalis N" first="Nick" last="Mamalis">Nick Mamalis</name>
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<name sortKey="Izak, Andrea M" sort="Izak, Andrea M" uniqKey="Izak A" first="Andrea M" last="Izak">Andrea M. Izak</name>
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<name sortKey="Pandey, Suresh K" sort="Pandey, Suresh K" uniqKey="Pandey S" first="Suresh K" last="Pandey">Suresh K. Pandey</name>
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<name sortKey="Davis, Brandon L" sort="Davis, Brandon L" uniqKey="Davis B" first="Brandon L" last="Davis">Brandon L. Davis</name>
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<name sortKey="Nilson, Chistian D" sort="Nilson, Chistian D" uniqKey="Nilson C" first="Chistian D" last="Nilson">Chistian D. Nilson</name>
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<name sortKey="Weight, Christopher" sort="Weight, Christopher" uniqKey="Weight C" first="Christopher" last="Weight">Christopher Weight</name>
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<name sortKey="Apple, David J" sort="Apple, David J" uniqKey="Apple D" first="David J" last="Apple">David J. Apple</name>
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<title level="j">Journal of cataract and refractive surgery</title>
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<term>Acrylic Resins</term>
<term>Animals</term>
<term>Biocompatible Materials</term>
<term>Cataract (etiology)</term>
<term>Cataract (pathology)</term>
<term>Epithelial Cells (pathology)</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Lens Capsule, Crystalline (pathology)</term>
<term>Lens Implantation, Intraocular</term>
<term>Lenses, Intraocular (adverse effects)</term>
<term>Postoperative Complications</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en">
<term>Acrylic Resins</term>
<term>Biocompatible Materials</term>
</keywords>
<keywords scheme="MESH" qualifier="adverse effects" xml:lang="en">
<term>Lenses, Intraocular</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en">
<term>Cataract</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en">
<term>Cataract</term>
<term>Epithelial Cells</term>
<term>Lens Capsule, Crystalline</term>
</keywords>
<keywords scheme="MESH" xml:lang="en">
<term>Animals</term>
<term>Hydrophobic and Hydrophilic Interactions</term>
<term>Lens Implantation, Intraocular</term>
<term>Postoperative Complications</term>
<term>Prosthesis Design</term>
<term>Rabbits</term>
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<front>
<div type="abstract" xml:lang="en">To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1-piece hydrophobic acrylic intraocular lenses (IOLs) with square optic edges.</div>
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<PMID Version="1">15899460</PMID>
<DateCreated>
<Year>2005</Year>
<Month>05</Month>
<Day>18</Day>
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<DateCompleted>
<Year>2005</Year>
<Month>06</Month>
<Day>16</Day>
</DateCompleted>
<DateRevised>
<Year>2010</Year>
<Month>11</Month>
<Day>18</Day>
</DateRevised>
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<ISSN IssnType="Print">0886-3350</ISSN>
<JournalIssue CitedMedium="Print">
<Volume>31</Volume>
<Issue>4</Issue>
<PubDate>
<Year>2005</Year>
<Month>Apr</Month>
</PubDate>
</JournalIssue>
<Title>Journal of cataract and refractive surgery</Title>
<ISOAbbreviation>J Cataract Refract Surg</ISOAbbreviation>
</Journal>
<ArticleTitle>Posterior capsule opacification in rabbit eyes implanted with 1-piece and 3-piece hydrophobic acrylic intraocular lenses.</ArticleTitle>
<Pagination>
<MedlinePgn>805-11</MedlinePgn>
</Pagination>
<Abstract>
<AbstractText Label="PURPOSE" NlmCategory="OBJECTIVE">To evaluate the outcome of posterior capsule opacification (PCO) after implantation in rabbit eyes of currently available 3-piece and 1-piece hydrophobic acrylic intraocular lenses (IOLs) with square optic edges.</AbstractText>
<AbstractText Label="SETTING" NlmCategory="METHODS">John A. Moran Eye Center, University of Utah, Salt Lake City, Utah, USA.</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">The 3-piece designs evaluated were the AR40e (Advanced Medical Optics Inc.) and the MA60AC (Alcon, Inc.); the 1-piece designs were the SA60AT and the SA30AT (Alcon, Inc.). Nine lenses of each type were implanted in a randomized manner by the same surgeon in 18 Dutch Belted pigmented rabbits. After a follow-up of 3 weeks, the rabbits were killed and analyses of the enucleated eyes were performed from the posterior or Miyake-Apple view. The intensity of central PCO, peripheral PCO, and Soemmering's ring formation was scored from 0 to 4. The area of Soemmering's ring formation was also scored from 0 to 4 based on the number of quadrants involved. Other parameters analyzed were capsulorhexis coverage of the IOL anterior surface, IOL centration, fixation, and presence of striae. Results from the posterior view were complemented by histopathologic evaluation of the eyes.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">No statistically significant difference was found between the 4 groups of IOLs in the parameters analyzed from the posterior view. When cell ingrowth occurred with the 1-piece designs, causing peripheral and central PCO formation, it was more likely to start at the optic-haptic junctions, as observed during the clinical follow-up with slitlamp examination and confirmed by gross and histopathologic analyses of the enucleated eyes.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">The square, truncated optic edge is the most important IOL design feature for PCO prevention. The optic-haptic junctions of the 1-piece designs appear to be sites where the barrier effect of the truncated optic edge is less effective.</AbstractText>
</Abstract>
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<LastName>Werner</LastName>
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<DescriptorName MajorTopicYN="N" UI="D057927">Hydrophobic and Hydrophilic Interactions</DescriptorName>
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<DescriptorName MajorTopicYN="N" UI="D007903">Lens Capsule, Crystalline</DescriptorName>
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<DescriptorName MajorTopicYN="Y" UI="D019654">Lens Implantation, Intraocular</DescriptorName>
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