Neural and behavioral correlates of drawing in an early blind painter: a case study.
Identifieur interne : 001411 ( PubMed/Corpus ); précédent : 001410; suivant : 001412Neural and behavioral correlates of drawing in an early blind painter: a case study.
Auteurs : Amir Amedi ; Lotfi B. Merabet ; Joan Camprodon ; Felix Bermpohl ; Sharon Fox ; Itamar Ronen ; Dae-Shik Kim ; Alvaro Pascual-LeoneSource :
- Brain research [ 1872-6240 ] ; 2008.
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Abstract
Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three-dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.
DOI: 10.1016/j.brainres.2008.07.088
PubMed: 18710656
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Merabet</name></author><author><name sortKey="Camprodon, Joan" sort="Camprodon, Joan" uniqKey="Camprodon J" first="Joan" last="Camprodon">Joan Camprodon</name></author><author><name sortKey="Bermpohl, Felix" sort="Bermpohl, Felix" uniqKey="Bermpohl F" first="Felix" last="Bermpohl">Felix Bermpohl</name></author><author><name sortKey="Fox, Sharon" sort="Fox, Sharon" uniqKey="Fox S" first="Sharon" last="Fox">Sharon Fox</name></author><author><name sortKey="Ronen, Itamar" sort="Ronen, Itamar" uniqKey="Ronen I" first="Itamar" last="Ronen">Itamar Ronen</name></author><author><name sortKey="Kim, Dae Shik" sort="Kim, Dae Shik" uniqKey="Kim D" first="Dae-Shik" last="Kim">Dae-Shik Kim</name></author><author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2008">2008</date><idno type="doi">10.1016/j.brainres.2008.07.088</idno><idno type="RBID">pubmed:18710656</idno><idno type="pmid">18710656</idno><idno type="wicri:Area/PubMed/Corpus">001411</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Neural and behavioral correlates of drawing in an early blind painter: a case study.</title><author><name sortKey="Amedi, Amir" sort="Amedi, Amir" uniqKey="Amedi A" first="Amir" last="Amedi">Amir Amedi</name><affiliation><nlm:affiliation>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. amir.amedi@ekmd.huji.ac.il</nlm:affiliation></affiliation></author><author><name sortKey="Merabet, Lotfi B" sort="Merabet, Lotfi B" uniqKey="Merabet L" first="Lotfi B" last="Merabet">Lotfi B. Merabet</name></author><author><name sortKey="Camprodon, Joan" sort="Camprodon, Joan" uniqKey="Camprodon J" first="Joan" last="Camprodon">Joan Camprodon</name></author><author><name sortKey="Bermpohl, Felix" sort="Bermpohl, Felix" uniqKey="Bermpohl F" first="Felix" last="Bermpohl">Felix Bermpohl</name></author><author><name sortKey="Fox, Sharon" sort="Fox, Sharon" uniqKey="Fox S" first="Sharon" last="Fox">Sharon Fox</name></author><author><name sortKey="Ronen, Itamar" sort="Ronen, Itamar" uniqKey="Ronen I" first="Itamar" last="Ronen">Itamar Ronen</name></author><author><name sortKey="Kim, Dae Shik" sort="Kim, Dae Shik" uniqKey="Kim D" first="Dae-Shik" last="Kim">Dae-Shik Kim</name></author><author><name sortKey="Pascual Leone, Alvaro" sort="Pascual Leone, Alvaro" uniqKey="Pascual Leone A" first="Alvaro" last="Pascual-Leone">Alvaro Pascual-Leone</name></author></analytic><series><title level="j">Brain research</title><idno type="eISSN">1872-6240</idno><imprint><date when="2008" type="published">2008</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Art</term><term>Behavior (physiology)</term><term>Blindness</term><term>Brain (physiology)</term><term>Brain Mapping</term><term>Humans</term><term>Image Interpretation, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Psychomotor Performance (physiology)</term><term>Touch Perception (physiology)</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Behavior</term><term>Brain</term><term>Psychomotor Performance</term><term>Touch Perception</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Art</term><term>Blindness</term><term>Brain Mapping</term><term>Humans</term><term>Image Interpretation, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three-dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">18710656</PMID><DateCreated><Year>2008</Year><Month>11</Month><Day>17</Day></DateCreated><DateCompleted><Year>2009</Year><Month>02</Month><Day>09</Day></DateCompleted><DateRevised><Year>2015</Year><Month>07</Month><Day>31</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1872-6240</ISSN><JournalIssue CitedMedium="Internet"><Volume>1242</Volume><PubDate><Year>2008</Year><Month>Nov</Month><Day>25</Day></PubDate></JournalIssue><Title>Brain research</Title><ISOAbbreviation>Brain Res.</ISOAbbreviation></Journal><ArticleTitle>Neural and behavioral correlates of drawing in an early blind painter: a case study.</ArticleTitle><Pagination><MedlinePgn>252-62</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.brainres.2008.07.088</ELocationID><Abstract><AbstractText>Humans rely heavily on vision to identify objects in the world and can create mental representations of the objects they encounter. Objects can also be identified and mentally represented through haptic exploration. However, it is unclear whether prior visual experience is necessary to generate these internal representations. Subject EA, an early blind artist, provides insight into this question. Like other blind individuals, EA captures the external world by touch. However, he is also able to reveal his internal representations through highly detailed drawings that are unequivocally understandable by a sighted person. We employed fMRI to investigate the neural correlates associated with EA's ability to transform tactilely explored three-dimensional objects into drawings and contrasted these findings with a series of control conditions (e.g. nonsensical scribbling as a sensory-motor control). Activation during drawing (compared to scribbling) occurred in brain areas normally associated with vision, including the striate cortex along with frontal and parietal cortical regions. Some of these areas showed overlap when EA was asked to mentally imagine the pictures he had to draw (albeit to a lesser anatomical extent and signal magnitude). These results have important implications as regards our understanding of the ways in which tactile information can generate mental representations of shapes and scenes in the absence of normal visual development. Furthermore, these findings suggest the occipital cortex plays a key role in supporting mental representations even without prior visual experience.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Amedi</LastName><ForeName>Amir</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02115, USA. amir.amedi@ekmd.huji.ac.il</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Merabet</LastName><ForeName>Lotfi B</ForeName><Initials>LB</Initials></Author><Author ValidYN="Y"><LastName>Camprodon</LastName><ForeName>Joan</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Bermpohl</LastName><ForeName>Felix</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Sharon</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Ronen</LastName><ForeName>Itamar</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Dae-Shik</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Pascual-Leone</LastName><ForeName>Alvaro</ForeName><Initials>A</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>K 23 EY016131-01</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K23 EY016131</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K24 RR018875</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>K24 RR018875</GrantID><Acronym>RR</Acronym><Agency>NCRR NIH HHS</Agency><Country>United States</Country></Grant><Grant><GrantID>R01 EY012091</GrantID><Acronym>EY</Acronym><Agency>NEI NIH HHS</Agency><Country>United 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