The effect of dopamine replacement therapy on haptic sensitivity in Parkinson's disease.
Identifieur interne : 001064 ( PubMed/Corpus ); précédent : 001063; suivant : 001065The effect of dopamine replacement therapy on haptic sensitivity in Parkinson's disease.
Auteurs : Kuan-Yi Li ; Kristen Pickett ; Igor Nestrasil ; Paul Tuite ; Jürgen KonczakSource :
- Journal of neurology [ 1432-1459 ] ; 2010.
English descriptors
- KwdEn :
- Aged, Dopamine Agonists (pharmacology), Dopamine Agonists (therapeutic use), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Perceptual Disorders (drug therapy), Perceptual Disorders (etiology), Perceptual Disorders (physiopathology), Somatosensory Disorders (drug therapy), Somatosensory Disorders (etiology), Somatosensory Disorders (physiopathology).
- MESH :
- chemical , pharmacology : Dopamine Agonists.
- chemical , therapeutic use : Dopamine Agonists.
- complications : Parkinson Disease.
- drug therapy : Parkinson Disease, Perceptual Disorders, Somatosensory Disorders.
- etiology : Perceptual Disorders, Somatosensory Disorders.
- physiopathology : Parkinson Disease, Perceptual Disorders, Somatosensory Disorders.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Increasing evidence indicates that processing of proprioceptive information is altered in Parkinson's disease (PD), leading to reduced kinaesthetic and haptic sensitivity. However, there is inconclusive evidence whether dopamine replacement therapy (DRT) ameliorates or worsens kinaesthetic and haptic function in PD. For assessing perceptual function, we employed a task that did not require active motion or stressed working memory function, which may become impaired in PD. A group of mild to moderate stage PD patients (n = 9) and a group of age-matched healthy controls participated in this study. Without vision, a subject's hand was moved by a robotic manipulandum along the contours of a small "virtual box" (5 × 15 cm). At the end of each trial, they indicated whether the contour was "curved" or "straight". PD patients were tested ON and OFF antiparkinsonian medication. Psychophysical detection thresholds were determined (curvature at which subjects correctly perceived a curved contour at the 75% level). Compared to the control group, thresholds were elevated by 55% in the PD patient group. During the ON medication state, the mean detection threshold of the patient group was reduced by 15% (ON: 4.71 m(-1); OFF: 5.42 m(-1)). Increases in curvature sensitivity were highly correlated with improved clinical scores of motor function (r = 0.74) with more affected patients showing higher gains in sensitivity as the result of DRT (r = 0.80). This report documents that DRT can ameliorate haptic and kinaesthetic function in patients with mild to moderate PD, suggesting that DRT can have beneficial effects on perceptual function.
DOI: 10.1007/s00415-010-5646-9
PubMed: 20628883
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pubmed:20628883Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The effect of dopamine replacement therapy on haptic sensitivity in Parkinson's disease.</title><author><name sortKey="Li, Kuan Yi" sort="Li, Kuan Yi" uniqKey="Li K" first="Kuan-Yi" last="Li">Kuan-Yi Li</name><affiliation><nlm:affiliation>Department of Occupational Therapy, Chang Gung University, 259 Wen-hwa 1st Rd, Kwei-shan Township, Tao-yuan, 333, Taiwan. kyli@mail.cgu.edu.tw</nlm:affiliation></affiliation></author><author><name sortKey="Pickett, Kristen" sort="Pickett, Kristen" uniqKey="Pickett K" first="Kristen" last="Pickett">Kristen Pickett</name></author><author><name sortKey="Nestrasil, Igor" sort="Nestrasil, Igor" uniqKey="Nestrasil I" first="Igor" last="Nestrasil">Igor Nestrasil</name></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name></author><author><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2010">2010</date><idno type="doi">10.1007/s00415-010-5646-9</idno><idno type="RBID">pubmed:20628883</idno><idno type="pmid">20628883</idno><idno type="wicri:Area/PubMed/Corpus">001064</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">The effect of dopamine replacement therapy on haptic sensitivity in Parkinson's disease.</title><author><name sortKey="Li, Kuan Yi" sort="Li, Kuan Yi" uniqKey="Li K" first="Kuan-Yi" last="Li">Kuan-Yi Li</name><affiliation><nlm:affiliation>Department of Occupational Therapy, Chang Gung University, 259 Wen-hwa 1st Rd, Kwei-shan Township, Tao-yuan, 333, Taiwan. kyli@mail.cgu.edu.tw</nlm:affiliation></affiliation></author><author><name sortKey="Pickett, Kristen" sort="Pickett, Kristen" uniqKey="Pickett K" first="Kristen" last="Pickett">Kristen Pickett</name></author><author><name sortKey="Nestrasil, Igor" sort="Nestrasil, Igor" uniqKey="Nestrasil I" first="Igor" last="Nestrasil">Igor Nestrasil</name></author><author><name sortKey="Tuite, Paul" sort="Tuite, Paul" uniqKey="Tuite P" first="Paul" last="Tuite">Paul Tuite</name></author><author><name sortKey="Konczak, Jurgen" sort="Konczak, Jurgen" uniqKey="Konczak J" first="Jürgen" last="Konczak">Jürgen Konczak</name></author></analytic><series><title level="j">Journal of neurology</title><idno type="eISSN">1432-1459</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Dopamine Agonists (pharmacology)</term><term>Dopamine Agonists (therapeutic use)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Perceptual Disorders (drug therapy)</term><term>Perceptual Disorders (etiology)</term><term>Perceptual Disorders (physiopathology)</term><term>Somatosensory Disorders (drug therapy)</term><term>Somatosensory Disorders (etiology)</term><term>Somatosensory Disorders (physiopathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agonists</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term><term>Perceptual Disorders</term><term>Somatosensory Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Perceptual Disorders</term><term>Somatosensory Disorders</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term><term>Perceptual Disorders</term><term>Somatosensory Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Increasing evidence indicates that processing of proprioceptive information is altered in Parkinson's disease (PD), leading to reduced kinaesthetic and haptic sensitivity. However, there is inconclusive evidence whether dopamine replacement therapy (DRT) ameliorates or worsens kinaesthetic and haptic function in PD. For assessing perceptual function, we employed a task that did not require active motion or stressed working memory function, which may become impaired in PD. A group of mild to moderate stage PD patients (n = 9) and a group of age-matched healthy controls participated in this study. Without vision, a subject's hand was moved by a robotic manipulandum along the contours of a small "virtual box" (5 × 15 cm). At the end of each trial, they indicated whether the contour was "curved" or "straight". PD patients were tested ON and OFF antiparkinsonian medication. Psychophysical detection thresholds were determined (curvature at which subjects correctly perceived a curved contour at the 75% level). Compared to the control group, thresholds were elevated by 55% in the PD patient group. During the ON medication state, the mean detection threshold of the patient group was reduced by 15% (ON: 4.71 m(-1); OFF: 5.42 m(-1)). Increases in curvature sensitivity were highly correlated with improved clinical scores of motor function (r = 0.74) with more affected patients showing higher gains in sensitivity as the result of DRT (r = 0.80). This report documents that DRT can ameliorate haptic and kinaesthetic function in patients with mild to moderate PD, suggesting that DRT can have beneficial effects on perceptual function.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">20628883</PMID><DateCreated><Year>2010</Year><Month>11</Month><Day>30</Day></DateCreated><DateCompleted><Year>2011</Year><Month>11</Month><Day>10</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1432-1459</ISSN><JournalIssue CitedMedium="Internet"><Volume>257</Volume><Issue>12</Issue><PubDate><Year>2010</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Journal of neurology</Title><ISOAbbreviation>J. Neurol.</ISOAbbreviation></Journal><ArticleTitle>The effect of dopamine replacement therapy on haptic sensitivity in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>1992-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00415-010-5646-9</ELocationID><Abstract><AbstractText>Increasing evidence indicates that processing of proprioceptive information is altered in Parkinson's disease (PD), leading to reduced kinaesthetic and haptic sensitivity. However, there is inconclusive evidence whether dopamine replacement therapy (DRT) ameliorates or worsens kinaesthetic and haptic function in PD. For assessing perceptual function, we employed a task that did not require active motion or stressed working memory function, which may become impaired in PD. A group of mild to moderate stage PD patients (n = 9) and a group of age-matched healthy controls participated in this study. Without vision, a subject's hand was moved by a robotic manipulandum along the contours of a small "virtual box" (5 × 15 cm). At the end of each trial, they indicated whether the contour was "curved" or "straight". PD patients were tested ON and OFF antiparkinsonian medication. Psychophysical detection thresholds were determined (curvature at which subjects correctly perceived a curved contour at the 75% level). Compared to the control group, thresholds were elevated by 55% in the PD patient group. During the ON medication state, the mean detection threshold of the patient group was reduced by 15% (ON: 4.71 m(-1); OFF: 5.42 m(-1)). Increases in curvature sensitivity were highly correlated with improved clinical scores of motor function (r = 0.74) with more affected patients showing higher gains in sensitivity as the result of DRT (r = 0.80). This report documents that DRT can ameliorate haptic and kinaesthetic function in patients with mild to moderate PD, suggesting that DRT can have beneficial effects on perceptual function.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Kuan-yi</ForeName><Initials>KY</Initials><AffiliationInfo><Affiliation>Department of Occupational Therapy, Chang Gung University, 259 Wen-hwa 1st Rd, Kwei-shan Township, Tao-yuan, 333, Taiwan. kyli@mail.cgu.edu.tw</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pickett</LastName><ForeName>Kristen</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Nestrasil</LastName><ForeName>Igor</ForeName><Initials>I</Initials></Author><Author ValidYN="Y"><LastName>Tuite</LastName><ForeName>Paul</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Konczak</LastName><ForeName>Jürgen</ForeName><Initials>J</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2010</Year><Month>07</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>J Neurol</MedlineTA><NlmUniqueID>0423161</NlmUniqueID><ISSNLinking>0340-5354</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018491">Dopamine Agonists</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000368">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D018491">Dopamine Agonists</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000494">pharmacology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000627">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010300">Parkinson Disease</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000150">complications</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D010468">Perceptual Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D020886">Somatosensory Disorders</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000188">drug therapy</QualifierName><QualifierName MajorTopicYN="N" UI="Q000209">etiology</QualifierName><QualifierName MajorTopicYN="N" UI="Q000503">physiopathology</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2010</Year><Month>3</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2010</Year><Month>6</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2010</Year><Month>6</Month><Day>10</Day></PubMedPubDate><PubMedPubDate PubStatus="aheadofprint"><Year>2010</Year><Month>7</Month><Day>14</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2010</Year><Month>7</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2010</Year><Month>7</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2011</Year><Month>11</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s00415-010-5646-9</ArticleId><ArticleId IdType="pubmed">20628883</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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