Functionally specific oscillatory activity correlates between visual and auditory cortex in the blind.
Identifieur interne : 000C47 ( PubMed/Corpus ); précédent : 000C46; suivant : 000C48Functionally specific oscillatory activity correlates between visual and auditory cortex in the blind.
Auteurs : Inga M. Schepers ; Joerg F. Hipp ; Till R. Schneider ; Brigitte Röder ; Andreas K. EngelSource :
- Brain : a journal of neurology [ 1460-2156 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Algorithms, Auditory Cortex (physiopathology), Auditory Perception (physiology), Blindness (congenital), Blindness (physiopathology), Data Interpretation, Statistical, Electrophysiological Phenomena, Female, Functional Laterality (physiology), Humans, Magnetoencephalography, Male, Middle Aged, Neuronal Plasticity (physiology), Neurons (physiology), Psychomotor Performance (physiology), Semantics, Visual Cortex (physiopathology), Young Adult.
- MESH :
- congenital : Blindness.
- physiology : Auditory Perception, Functional Laterality, Neuronal Plasticity, Neurons, Psychomotor Performance.
- physiopathology : Auditory Cortex, Blindness, Visual Cortex.
- Adult, Algorithms, Data Interpretation, Statistical, Electrophysiological Phenomena, Female, Humans, Magnetoencephalography, Male, Middle Aged, Semantics, Young Adult.
Abstract
Many studies have shown that the visual cortex of blind humans is activated in non-visual tasks. However, the electrophysiological signals underlying this cross-modal plasticity are largely unknown. Here, we characterize the neuronal population activity in the visual and auditory cortex of congenitally blind humans and sighted controls in a complex cognitive task. We recorded magnetoencephalographic responses from participants performing semantic categorization of meaningful sounds that followed the presentation of a semantically related or unrelated haptic object. Source analysis of the spectrally resolved magnetoencephalography data revealed that: (i) neuronal responses to sounds were stronger and longer lasting in the auditory cortex of blind subjects; (ii) auditory stimulation elicited strong oscillatory responses in the visual cortex of blind subjects that closely resembled responses to visual stimulation in sighted humans; (iii) the signal in the gamma frequency range was modulated by semantic congruency between the sounds and the preceding haptic objects; and (iv) signal power in the gamma range was correlated on a trial-by-trial basis between auditory and visual cortex in blind subjects, and the strength of this correlation was modulated by semantic congruency. Our results suggest that specifically oscillatory activity in the gamma range reflects non-visual processing in the visual cortex of blind individuals. Moreover, our results provide evidence that the deprived visual cortex is functionally integrated into a larger network that serves non-visual functions.
DOI: 10.1093/brain/aws014
PubMed: 22366801
Links to Exploration step
pubmed:22366801Le document en format XML
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Schneider</name></author><author><name sortKey="Roder, Brigitte" sort="Roder, Brigitte" uniqKey="Roder B" first="Brigitte" last="Röder">Brigitte Röder</name></author><author><name sortKey="Engel, Andreas K" sort="Engel, Andreas K" uniqKey="Engel A" first="Andreas K" last="Engel">Andreas K. Engel</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1093/brain/aws014</idno><idno type="RBID">pubmed:22366801</idno><idno type="pmid">22366801</idno><idno type="wicri:Area/PubMed/Corpus">000C47</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Functionally specific oscillatory activity correlates between visual and auditory cortex in the blind.</title><author><name sortKey="Schepers, Inga M" sort="Schepers, Inga M" uniqKey="Schepers I" first="Inga M" last="Schepers">Inga M. Schepers</name><affiliation><nlm:affiliation>Department of Neurophysiology and Pathophysiology University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. i.schepers@uke.de</nlm:affiliation></affiliation></author><author><name sortKey="Hipp, Joerg F" sort="Hipp, Joerg F" uniqKey="Hipp J" first="Joerg F" last="Hipp">Joerg F. Hipp</name></author><author><name sortKey="Schneider, Till R" sort="Schneider, Till R" uniqKey="Schneider T" first="Till R" last="Schneider">Till R. Schneider</name></author><author><name sortKey="Roder, Brigitte" sort="Roder, Brigitte" uniqKey="Roder B" first="Brigitte" last="Röder">Brigitte Röder</name></author><author><name sortKey="Engel, Andreas K" sort="Engel, Andreas K" uniqKey="Engel A" first="Andreas K" last="Engel">Andreas K. Engel</name></author></analytic><series><title level="j">Brain : a journal of neurology</title><idno type="eISSN">1460-2156</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Auditory Cortex (physiopathology)</term><term>Auditory Perception (physiology)</term><term>Blindness (congenital)</term><term>Blindness (physiopathology)</term><term>Data Interpretation, Statistical</term><term>Electrophysiological Phenomena</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Neuronal Plasticity (physiology)</term><term>Neurons (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Semantics</term><term>Visual Cortex (physiopathology)</term><term>Young Adult</term></keywords><keywords scheme="MESH" qualifier="congenital" xml:lang="en"><term>Blindness</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Auditory Perception</term><term>Functional Laterality</term><term>Neuronal Plasticity</term><term>Neurons</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Auditory Cortex</term><term>Blindness</term><term>Visual Cortex</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Algorithms</term><term>Data Interpretation, Statistical</term><term>Electrophysiological Phenomena</term><term>Female</term><term>Humans</term><term>Magnetoencephalography</term><term>Male</term><term>Middle Aged</term><term>Semantics</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many studies have shown that the visual cortex of blind humans is activated in non-visual tasks. However, the electrophysiological signals underlying this cross-modal plasticity are largely unknown. Here, we characterize the neuronal population activity in the visual and auditory cortex of congenitally blind humans and sighted controls in a complex cognitive task. We recorded magnetoencephalographic responses from participants performing semantic categorization of meaningful sounds that followed the presentation of a semantically related or unrelated haptic object. Source analysis of the spectrally resolved magnetoencephalography data revealed that: (i) neuronal responses to sounds were stronger and longer lasting in the auditory cortex of blind subjects; (ii) auditory stimulation elicited strong oscillatory responses in the visual cortex of blind subjects that closely resembled responses to visual stimulation in sighted humans; (iii) the signal in the gamma frequency range was modulated by semantic congruency between the sounds and the preceding haptic objects; and (iv) signal power in the gamma range was correlated on a trial-by-trial basis between auditory and visual cortex in blind subjects, and the strength of this correlation was modulated by semantic congruency. Our results suggest that specifically oscillatory activity in the gamma range reflects non-visual processing in the visual cortex of blind individuals. Moreover, our results provide evidence that the deprived visual cortex is functionally integrated into a larger network that serves non-visual functions.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">22366801</PMID><DateCreated><Year>2012</Year><Month>02</Month><Day>27</Day></DateCreated><DateCompleted><Year>2012</Year><Month>04</Month><Day>09</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1460-2156</ISSN><JournalIssue CitedMedium="Internet"><Volume>135</Volume><Issue>Pt 3</Issue><PubDate><Year>2012</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Brain : a journal of neurology</Title><ISOAbbreviation>Brain</ISOAbbreviation></Journal><ArticleTitle>Functionally specific oscillatory activity correlates between visual and auditory cortex in the blind.</ArticleTitle><Pagination><MedlinePgn>922-34</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1093/brain/aws014</ELocationID><Abstract><AbstractText>Many studies have shown that the visual cortex of blind humans is activated in non-visual tasks. However, the electrophysiological signals underlying this cross-modal plasticity are largely unknown. Here, we characterize the neuronal population activity in the visual and auditory cortex of congenitally blind humans and sighted controls in a complex cognitive task. We recorded magnetoencephalographic responses from participants performing semantic categorization of meaningful sounds that followed the presentation of a semantically related or unrelated haptic object. Source analysis of the spectrally resolved magnetoencephalography data revealed that: (i) neuronal responses to sounds were stronger and longer lasting in the auditory cortex of blind subjects; (ii) auditory stimulation elicited strong oscillatory responses in the visual cortex of blind subjects that closely resembled responses to visual stimulation in sighted humans; (iii) the signal in the gamma frequency range was modulated by semantic congruency between the sounds and the preceding haptic objects; and (iv) signal power in the gamma range was correlated on a trial-by-trial basis between auditory and visual cortex in blind subjects, and the strength of this correlation was modulated by semantic congruency. Our results suggest that specifically oscillatory activity in the gamma range reflects non-visual processing in the visual cortex of blind individuals. Moreover, our results provide evidence that the deprived visual cortex is functionally integrated into a larger network that serves non-visual functions.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schepers</LastName><ForeName>Inga M</ForeName><Initials>IM</Initials><AffiliationInfo><Affiliation>Department of Neurophysiology and Pathophysiology University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany. i.schepers@uke.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hipp</LastName><ForeName>Joerg F</ForeName><Initials>JF</Initials></Author><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>Till R</ForeName><Initials>TR</Initials></Author><Author ValidYN="Y"><LastName>Röder</LastName><ForeName>Brigitte</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Engel</LastName><ForeName>Andreas K</ForeName><Initials>AK</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Brain</MedlineTA><NlmUniqueID>0372537</NlmUniqueID><ISSNLinking>0006-8950</ISSNLinking></MedlineJournalInfo><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000328">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000465">Algorithms</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001303">Auditory Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001307">Auditory Perception</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D001766">Blindness</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000151">congenital</QualifierName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003627">Data Interpretation, Statistical</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055724">Electrophysiological Phenomena</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D005260">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007839">Functional Laterality</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D015225">Magnetoencephalography</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008297">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D008875">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009473">Neuronal Plasticity</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D009474">Neurons</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011597">Psychomotor Performance</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000502">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D012660">Semantics</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D014793">Visual Cortex</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000503">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D055815">Young Adult</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>2</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>4</Month><Day>10</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">aws014</ArticleId><ArticleId IdType="doi">10.1093/brain/aws014</ArticleId><ArticleId IdType="pubmed">22366801</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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