[In vitro and in vivo investigations of a modified textile keratoprosthesis. ACTO TexKPRO].
Identifieur interne : 000938 ( PubMed/Corpus ); précédent : 000937; suivant : 000939[In vitro and in vivo investigations of a modified textile keratoprosthesis. ACTO TexKPRO].
Auteurs : N. Schrage ; A K Cordes ; J. Storsberg ; S. Sel ; H. Röthgen ; N. Nass ; E. Berndt ; S. Jockenhövel ; A. Me Ner ; C. PanfilSource :
- Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft [ 1433-0423 ] ; 2014.
English descriptors
- KwdEn :
- MESH :
- instrumentation : Corneal Transplantation.
- surgery : Corneal Diseases.
- Animals, Equipment Failure Analysis, Humans, In Vitro Techniques, Prosthesis Design, Rabbits, Surgical Mesh, Textiles, Treatment Outcome.
Abstract
Clinical application of a keratoprosthesis (KPRO) is still a challenging task. Recent developments reflect the concepts of nut and bolt, intrastromal implantation or an osteoodontokeratoprosthesis (OOKP). A new concept of a textile KPRO has been evaluated in a limited human study with considerable difficulties which after termination of the study and considerable improvements was restarted using animal experiments.
DOI: 10.1007/s00347-013-2871-5
PubMed: 23765372
Links to Exploration step
pubmed:23765372Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[In vitro and in vivo investigations of a modified textile keratoprosthesis. ACTO TexKPRO].</title><author><name sortKey="Schrage, N" sort="Schrage, N" uniqKey="Schrage N" first="N" last="Schrage">N. Schrage</name><affiliation><nlm:affiliation>Aachener Centrum für Technologietransfer in der Ophthalmologie, Aachen, Deutschland, schrage@acto.de.</nlm:affiliation></affiliation></author><author><name sortKey="Cordes, A K" sort="Cordes, A K" uniqKey="Cordes A" first="A K" last="Cordes">A K Cordes</name></author><author><name sortKey="Storsberg, J" sort="Storsberg, J" uniqKey="Storsberg J" first="J" last="Storsberg">J. Storsberg</name></author><author><name sortKey="Sel, S" sort="Sel, S" uniqKey="Sel S" first="S" last="Sel">S. Sel</name></author><author><name sortKey="Rothgen, H" sort="Rothgen, H" uniqKey="Rothgen H" first="H" last="Röthgen">H. Röthgen</name></author><author><name sortKey="Nass, N" sort="Nass, N" uniqKey="Nass N" first="N" last="Nass">N. Nass</name></author><author><name sortKey="Berndt, E" sort="Berndt, E" uniqKey="Berndt E" first="E" last="Berndt">E. Berndt</name></author><author><name sortKey="Jockenhovel, S" sort="Jockenhovel, S" uniqKey="Jockenhovel S" first="S" last="Jockenhövel">S. Jockenhövel</name></author><author><name sortKey="Me Ner, A" sort="Me Ner, A" uniqKey="Me Ner A" first="A" last="Me Ner">A. Me Ner</name></author><author><name sortKey="Panfil, C" sort="Panfil, C" uniqKey="Panfil C" first="C" last="Panfil">C. Panfil</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="doi">10.1007/s00347-013-2871-5</idno><idno type="RBID">pubmed:23765372</idno><idno type="pmid">23765372</idno><idno type="wicri:Area/PubMed/Corpus">000938</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[In vitro and in vivo investigations of a modified textile keratoprosthesis. ACTO TexKPRO].</title><author><name sortKey="Schrage, N" sort="Schrage, N" uniqKey="Schrage N" first="N" last="Schrage">N. Schrage</name><affiliation><nlm:affiliation>Aachener Centrum für Technologietransfer in der Ophthalmologie, Aachen, Deutschland, schrage@acto.de.</nlm:affiliation></affiliation></author><author><name sortKey="Cordes, A K" sort="Cordes, A K" uniqKey="Cordes A" first="A K" last="Cordes">A K Cordes</name></author><author><name sortKey="Storsberg, J" sort="Storsberg, J" uniqKey="Storsberg J" first="J" last="Storsberg">J. Storsberg</name></author><author><name sortKey="Sel, S" sort="Sel, S" uniqKey="Sel S" first="S" last="Sel">S. Sel</name></author><author><name sortKey="Rothgen, H" sort="Rothgen, H" uniqKey="Rothgen H" first="H" last="Röthgen">H. Röthgen</name></author><author><name sortKey="Nass, N" sort="Nass, N" uniqKey="Nass N" first="N" last="Nass">N. Nass</name></author><author><name sortKey="Berndt, E" sort="Berndt, E" uniqKey="Berndt E" first="E" last="Berndt">E. Berndt</name></author><author><name sortKey="Jockenhovel, S" sort="Jockenhovel, S" uniqKey="Jockenhovel S" first="S" last="Jockenhövel">S. Jockenhövel</name></author><author><name sortKey="Me Ner, A" sort="Me Ner, A" uniqKey="Me Ner A" first="A" last="Me Ner">A. Me Ner</name></author><author><name sortKey="Panfil, C" sort="Panfil, C" uniqKey="Panfil C" first="C" last="Panfil">C. Panfil</name></author></analytic><series><title level="j">Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft</title><idno type="eISSN">1433-0423</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Corneal Diseases (surgery)</term><term>Corneal Transplantation (instrumentation)</term><term>Equipment Failure Analysis</term><term>Humans</term><term>In Vitro Techniques</term><term>Prosthesis Design</term><term>Rabbits</term><term>Surgical Mesh</term><term>Textiles</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Corneal Transplantation</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Corneal Diseases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Equipment Failure Analysis</term><term>Humans</term><term>In Vitro Techniques</term><term>Prosthesis Design</term><term>Rabbits</term><term>Surgical Mesh</term><term>Textiles</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Clinical application of a keratoprosthesis (KPRO) is still a challenging task. Recent developments reflect the concepts of nut and bolt, intrastromal implantation or an osteoodontokeratoprosthesis (OOKP). A new concept of a textile KPRO has been evaluated in a limited human study with considerable difficulties which after termination of the study and considerable improvements was restarted using animal experiments.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">23765372</PMID><DateCreated><Year>2014</Year><Month>03</Month><Day>17</Day></DateCreated><DateCompleted><Year>2015</Year><Month>04</Month><Day>13</Day></DateCompleted><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1433-0423</ISSN><JournalIssue CitedMedium="Internet"><Volume>111</Volume><Issue>3</Issue><PubDate><Year>2014</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft</Title><ISOAbbreviation>Ophthalmologe</ISOAbbreviation></Journal><ArticleTitle>[In vitro and in vivo investigations of a modified textile keratoprosthesis. ACTO TexKPRO].</ArticleTitle><Pagination><MedlinePgn>247-53</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00347-013-2871-5</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Clinical application of a keratoprosthesis (KPRO) is still a challenging task. Recent developments reflect the concepts of nut and bolt, intrastromal implantation or an osteoodontokeratoprosthesis (OOKP). A new concept of a textile KPRO has been evaluated in a limited human study with considerable difficulties which after termination of the study and considerable improvements was restarted using animal experiments.</AbstractText><AbstractText Label="MATERIALS" NlmCategory="METHODS">The ACTO TexKPRO is made from polyvinylidene difluoride (PVDF) fibers and transparent silicone. The first and second developmental stages differed in density and size of fibers and furthermore in surface modifications of the fibers and optics which were improved for the second prototype.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Implantation of the prosthesis was performed in four patients with corneal blindness and in two cases retinal disease which required surgery. In the later animal experiments surgery was performed on three rabbits. Surgery was performed by redressing the conjunctiva, opening of the eyeball with a central 6.5 mm trephination, removal of the lens and iris and implantation and suturing of the TexKPRO. If required a silicone oil endotamponade was placed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">All eyes were stable with the keratoprosthesis. The first prototype showed conjunctival recession on the textile haptics with highly susceptible endopthalmitis risk due to infection of the PVDF so that we decided to remove the prosthesis from all eyes after one case of severe endophthalmitis occurred. The longest time of placement was 40 months and the shortest time 6 months. All eyes were restored by keratoplasty. In animals with the new haptic we found better conjunctivalization and stable implantation of the KPRO.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">The textile KPRO provides a stable implantation procedure and safe connection of fibers to the scleral wound bed. The optical and mechanical implantation is safe and stable. Surface epithelialization is improved with the new surface modifications and different PVDF fiber density but beforel new implantations are planned further conceptual changes will be introduced.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schrage</LastName><ForeName>N</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Aachener Centrum für Technologietransfer in der Ophthalmologie, Aachen, Deutschland, schrage@acto.de.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cordes</LastName><ForeName>A K</ForeName><Initials>AK</Initials></Author><Author ValidYN="Y"><LastName>Storsberg</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Sel</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Röthgen</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Nass</LastName><ForeName>N</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Berndt</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Jockenhövel</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Meßner</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Panfil</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>In-vitro- und In-vivo-Untersuchung einer modifizierten textilen Keratoprothese. ACTO TexKPRO.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Ophthalmologe</MedlineTA><NlmUniqueID>9206148</NlmUniqueID><ISSNLinking>0941-293X</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N" UI="D000818">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D003316">Corneal Diseases</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000601">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016039">Corneal Transplantation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000295">instrumentation</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019544">Equipment Failure Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D066298">In Vitro Techniques</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011474">Prosthesis Design</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D011817">Rabbits</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D013526">Surgical Mesh</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y" UI="D013784">Textiles</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D016896">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>6</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>4</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1007/s00347-013-2871-5</ArticleId><ArticleId IdType="pubmed">23765372</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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