Experimental and numerical study on the mechanical behavior of rat brain tissue.
Identifieur interne : 000750 ( PubMed/Corpus ); précédent : 000749; suivant : 000751Experimental and numerical study on the mechanical behavior of rat brain tissue.
Auteurs : A. Karimi ; M. Navidbakhsh ; H. Yousefi ; A Motevalli Haghi ; Sja SadatiSource :
- Perfusion [ 1477-111X ] ; 2014.
Abstract
Brain tissue is a very soft tissue in which the mechanical properties depend on the loading direction. While few studies have characterized these biomechanical properties, it is worth knowing that accurate characterization of the mechanical properties of brain tissue at different loading directions is a key asset for neuronavigation and surgery simulation through haptic devices. In this study, the hyperelastic mechanical properties of rat brain tissue were measured experimentally and computationally. Prepared cylindrical samples were excised from the parietal lobes of rats' brains and experimentally tested by a tensile testing machine. The effects of loading direction on the mechanical properties of brain tissue were measured by applying load on both longitudinal and circumferential directions. The general prediction ability of the proposed hyperelastic model was verified using finite element (FE) simulations of brain tissue tension experiments. The uniaxial experimental results compared well with those predicted by the FE models. The results revealed the influence of loading direction on the mechanical properties of brain tissue. The Ogden hyperelastic material model was suitably represented by the non-linear behavior of the brain tissue, which can be used in future biomechanical simulations. The hyperelastic properties of brain tissue provided here have interest to the medical research community as there are several applications where accurate characterization of these properties are crucial for an accurate outcome, such as neurosurgery, robotic surgery, haptic device design or car manufacturing to evaluate possible trauma due to an impact.
DOI: 10.1177/0267659114522088
PubMed: 24519528
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Navidbakhsh</name><affiliation><nlm:affiliation>School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran Tissue Engineering and Biological Systems Research Lab, School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran mnavid@iust.ac.ir.</nlm:affiliation></affiliation></author><author><name sortKey="Yousefi, H" sort="Yousefi, H" uniqKey="Yousefi H" first="H" last="Yousefi">H. Yousefi</name><affiliation><nlm:affiliation>Faculty of New Science and Technology, Tehran University, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Haghi, A Motevalli" sort="Haghi, A Motevalli" uniqKey="Haghi A" first="A Motevalli" last="Haghi">A Motevalli Haghi</name><affiliation><nlm:affiliation>Medical Parasitology and Mycology Department, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Sadati, Sja" sort="Sadati, Sja" uniqKey="Sadati S" first="Sja" last="Sadati">Sja Sadati</name><affiliation><nlm:affiliation>Medical Parasitology and Mycology Department, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:24519528</idno><idno type="pmid">24519528</idno><idno type="doi">10.1177/0267659114522088</idno><idno type="wicri:Area/PubMed/Corpus">000750</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Experimental and numerical study on the mechanical behavior of rat brain tissue.</title><author><name sortKey="Karimi, A" sort="Karimi, A" uniqKey="Karimi A" first="A" last="Karimi">A. Karimi</name><affiliation><nlm:affiliation>School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran Tissue Engineering and Biological Systems Research Lab, School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Navidbakhsh, M" sort="Navidbakhsh, M" uniqKey="Navidbakhsh M" first="M" last="Navidbakhsh">M. Navidbakhsh</name><affiliation><nlm:affiliation>School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran Tissue Engineering and Biological Systems Research Lab, School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran mnavid@iust.ac.ir.</nlm:affiliation></affiliation></author><author><name sortKey="Yousefi, H" sort="Yousefi, H" uniqKey="Yousefi H" first="H" last="Yousefi">H. Yousefi</name><affiliation><nlm:affiliation>Faculty of New Science and Technology, Tehran University, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Haghi, A Motevalli" sort="Haghi, A Motevalli" uniqKey="Haghi A" first="A Motevalli" last="Haghi">A Motevalli Haghi</name><affiliation><nlm:affiliation>Medical Parasitology and Mycology Department, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author><author><name sortKey="Sadati, Sja" sort="Sadati, Sja" uniqKey="Sadati S" first="Sja" last="Sadati">Sja Sadati</name><affiliation><nlm:affiliation>Medical Parasitology and Mycology Department, Tehran University of Medical Sciences, Tehran, Iran.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Perfusion</title><idno type="eISSN">1477-111X</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Brain tissue is a very soft tissue in which the mechanical properties depend on the loading direction. While few studies have characterized these biomechanical properties, it is worth knowing that accurate characterization of the mechanical properties of brain tissue at different loading directions is a key asset for neuronavigation and surgery simulation through haptic devices. In this study, the hyperelastic mechanical properties of rat brain tissue were measured experimentally and computationally. Prepared cylindrical samples were excised from the parietal lobes of rats' brains and experimentally tested by a tensile testing machine. The effects of loading direction on the mechanical properties of brain tissue were measured by applying load on both longitudinal and circumferential directions. The general prediction ability of the proposed hyperelastic model was verified using finite element (FE) simulations of brain tissue tension experiments. The uniaxial experimental results compared well with those predicted by the FE models. The results revealed the influence of loading direction on the mechanical properties of brain tissue. The Ogden hyperelastic material model was suitably represented by the non-linear behavior of the brain tissue, which can be used in future biomechanical simulations. The hyperelastic properties of brain tissue provided here have interest to the medical research community as there are several applications where accurate characterization of these properties are crucial for an accurate outcome, such as neurosurgery, robotic surgery, haptic device design or car manufacturing to evaluate possible trauma due to an impact.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="PubMed-not-MEDLINE"><PMID Version="1">24519528</PMID><DateCreated><Year>2015</Year><Month>12</Month><Day>22</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>22</Day></DateCompleted><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1477-111X</ISSN><JournalIssue CitedMedium="Internet"><Volume>29</Volume><Issue>4</Issue><PubDate><Year>2014</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Perfusion</Title><ISOAbbreviation>Perfusion</ISOAbbreviation></Journal><ArticleTitle>Experimental and numerical study on the mechanical behavior of rat brain tissue.</ArticleTitle><Pagination><MedlinePgn></MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1177/0267659114522088</ELocationID><Abstract><AbstractText>Brain tissue is a very soft tissue in which the mechanical properties depend on the loading direction. While few studies have characterized these biomechanical properties, it is worth knowing that accurate characterization of the mechanical properties of brain tissue at different loading directions is a key asset for neuronavigation and surgery simulation through haptic devices. In this study, the hyperelastic mechanical properties of rat brain tissue were measured experimentally and computationally. Prepared cylindrical samples were excised from the parietal lobes of rats' brains and experimentally tested by a tensile testing machine. The effects of loading direction on the mechanical properties of brain tissue were measured by applying load on both longitudinal and circumferential directions. The general prediction ability of the proposed hyperelastic model was verified using finite element (FE) simulations of brain tissue tension experiments. The uniaxial experimental results compared well with those predicted by the FE models. The results revealed the influence of loading direction on the mechanical properties of brain tissue. The Ogden hyperelastic material model was suitably represented by the non-linear behavior of the brain tissue, which can be used in future biomechanical simulations. The hyperelastic properties of brain tissue provided here have interest to the medical research community as there are several applications where accurate characterization of these properties are crucial for an accurate outcome, such as neurosurgery, robotic surgery, haptic device design or car manufacturing to evaluate possible trauma due to an impact.</AbstractText><CopyrightInformation>© The Author(s) 2014.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Karimi</LastName><ForeName>A</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran Tissue Engineering and Biological Systems Research Lab, School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Navidbakhsh</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran Tissue Engineering and Biological Systems Research Lab, School of Mechanical Engineering, Iran University of Science and Technology, Tehran, Iran mnavid@iust.ac.ir.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Yousefi</LastName><ForeName>H</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Faculty of New Science and Technology, Tehran University, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Haghi</LastName><ForeName>A Motevalli</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Medical Parasitology and Mycology Department, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sadati</LastName><ForeName>Sja</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Medical Parasitology and Mycology Department, Tehran University of Medical Sciences, Tehran, Iran.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016441">Retracted Publication</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2014</Year><Month>02</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Perfusion</MedlineTA><NlmUniqueID>8700166</NlmUniqueID><ISSNLinking>0267-6591</ISSNLinking></MedlineJournalInfo><CommentsCorrectionsList><CommentsCorrections RefType="RetractionIn"><RefSource>Perfusion. 2015 Oct;30(7):604-5</RefSource><PMID Version="1">26291479</PMID></CommentsCorrections></CommentsCorrectionsList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Ogden model</Keyword><Keyword MajorTopicYN="N">brain tissue</Keyword><Keyword MajorTopicYN="N">finite element modeling</Keyword><Keyword MajorTopicYN="N">mechanical properties</Keyword><Keyword MajorTopicYN="N">tension experiment</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="aheadofprint"><Year>2014</Year><Month>2</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>2</Month><Day>13</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24519528</ArticleId><ArticleId IdType="pii">0267659114522088</ArticleId><ArticleId IdType="doi">10.1177/0267659114522088</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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