Is impaired set-shifting an endophenotype of anorexia nervosa?
Identifieur interne : 001704 ( PubMed/Checkpoint ); précédent : 001703; suivant : 001705Is impaired set-shifting an endophenotype of anorexia nervosa?
Auteurs : Joanna Holliday [Royaume-Uni] ; Kate Tchanturia ; Sabine Landau ; David Collier ; Janet TreasureSource :
- The American journal of psychiatry [ 0002-953X ] ; 2005.
English descriptors
- KwdEn :
- Adult, Age Factors, Age of Onset, Analysis of Variance, Anorexia Nervosa (diagnosis), Anorexia Nervosa (epidemiology), Anorexia Nervosa (genetics), Body Mass Index, Cognition Disorders (diagnosis), Cognition Disorders (epidemiology), Cognition Disorders (genetics), Comorbidity, Female, Genetic Markers, Humans, Intelligence Tests, Neuropsychological Tests (statistics & numerical data), Personality Inventory, Phenotype, Prefrontal Cortex (physiology), Psychomotor Performance (physiology), Siblings (psychology), Trail Making Test (statistics & numerical data).
- MESH :
- chemical : Genetic Markers.
- diagnosis : Anorexia Nervosa, Cognition Disorders.
- epidemiology : Anorexia Nervosa, Cognition Disorders.
- genetics : Anorexia Nervosa, Cognition Disorders.
- physiology : Prefrontal Cortex, Psychomotor Performance.
- psychology : Siblings.
- statistics & numerical data : Neuropsychological Tests, Trail Making Test.
- Adult, Age Factors, Age of Onset, Analysis of Variance, Body Mass Index, Comorbidity, Female, Humans, Intelligence Tests, Personality Inventory, Phenotype.
Abstract
Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance.
DOI: 10.1176/appi.ajp.162.12.2269
PubMed: 16330590
Affiliations:
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sortKey="Collier, David" sort="Collier, David" uniqKey="Collier D" first="David" last="Collier">David Collier</name></author><author><name sortKey="Treasure, Janet" sort="Treasure, Janet" uniqKey="Treasure J" first="Janet" last="Treasure">Janet Treasure</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2005">2005</date><idno type="doi">10.1176/appi.ajp.162.12.2269</idno><idno type="RBID">pubmed:16330590</idno><idno type="pmid">16330590</idno><idno type="wicri:Area/PubMed/Corpus">001879</idno><idno type="wicri:Area/PubMed/Curation">001879</idno><idno type="wicri:Area/PubMed/Checkpoint">001704</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Is impaired set-shifting an endophenotype of anorexia nervosa?</title><author><name sortKey="Holliday, Joanna" sort="Holliday, Joanna" uniqKey="Holliday J" first="Joanna" last="Holliday">Joanna Holliday</name><affiliation wicri:level="1"><nlm:affiliation>Division of Psychological Medicine, Institute of Psychiatry, King's College London, UK. joanna.holliday@hmc.ox.ac.uk</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Division of Psychological Medicine, Institute of Psychiatry, King's College London</wicri:regionArea><wicri:noRegion>King's College London</wicri:noRegion></affiliation></author><author><name sortKey="Tchanturia, Kate" sort="Tchanturia, Kate" uniqKey="Tchanturia K" first="Kate" last="Tchanturia">Kate Tchanturia</name></author><author><name sortKey="Landau, Sabine" sort="Landau, Sabine" uniqKey="Landau S" first="Sabine" last="Landau">Sabine Landau</name></author><author><name sortKey="Collier, David" sort="Collier, David" uniqKey="Collier D" first="David" last="Collier">David Collier</name></author><author><name sortKey="Treasure, Janet" sort="Treasure, Janet" uniqKey="Treasure J" first="Janet" last="Treasure">Janet Treasure</name></author></analytic><series><title level="j">The American journal of psychiatry</title><idno type="ISSN">0002-953X</idno><imprint><date when="2005" type="published">2005</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Analysis of Variance</term><term>Anorexia Nervosa (diagnosis)</term><term>Anorexia Nervosa (epidemiology)</term><term>Anorexia Nervosa (genetics)</term><term>Body Mass Index</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (epidemiology)</term><term>Cognition Disorders (genetics)</term><term>Comorbidity</term><term>Female</term><term>Genetic Markers</term><term>Humans</term><term>Intelligence Tests</term><term>Neuropsychological Tests (statistics & numerical data)</term><term>Personality Inventory</term><term>Phenotype</term><term>Prefrontal Cortex (physiology)</term><term>Psychomotor Performance (physiology)</term><term>Siblings (psychology)</term><term>Trail Making Test (statistics & numerical data)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Genetic Markers</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Anorexia Nervosa</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Anorexia Nervosa</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Anorexia Nervosa</term><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Prefrontal Cortex</term><term>Psychomotor Performance</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Siblings</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Neuropsychological Tests</term><term>Trail Making Test</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Age Factors</term><term>Age of Onset</term><term>Analysis of Variance</term><term>Body Mass Index</term><term>Comorbidity</term><term>Female</term><term>Humans</term><term>Intelligence Tests</term><term>Personality Inventory</term><term>Phenotype</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">16330590</PMID><DateCreated><Year>2005</Year><Month>12</Month><Day>06</Day></DateCreated><DateCompleted><Year>2006</Year><Month>02</Month><Day>06</Day></DateCompleted><DateRevised><Year>2007</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0002-953X</ISSN><JournalIssue CitedMedium="Print"><Volume>162</Volume><Issue>12</Issue><PubDate><Year>2005</Year><Month>Dec</Month></PubDate></JournalIssue><Title>The American journal of psychiatry</Title><ISOAbbreviation>Am J Psychiatry</ISOAbbreviation></Journal><ArticleTitle>Is impaired set-shifting an endophenotype of anorexia nervosa?</ArticleTitle><Pagination><MedlinePgn>2269-75</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">Set-shifting difficulties have been reported in subjects with anorexia nervosa and appear to persist after recovery; therefore, they may be endophenotypic traits. The goals of this study were to investigate whether set-shifting difficulties are familial by examining discordant sister-pairs in comparison with healthy unrelated women and to replicate, with a broader battery, the lack of influence of an acute illness state on neuropsychological performance.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Forty-seven pairs of sisters discordant for anorexia nervosa and 47 healthy unrelated women who were comparable in age and IQ completed neuropsychological tasks selected to assess set-shifting ability. Analyses of variance with standard errors that are robust against correlations within family clusters were used to compare the groups. Results were adjusted for obsessive-compulsive, anxiety, and depression symptoms. Subjects with acute (N=24) and fully remitted (N=23) anorexia nervosa were compared to assess state versus trait effects.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Sisters with and without anorexia nervosa took significantly longer than unrelated healthy women to shift their cognitive set (CatBat task) and demonstrated greater perceptual rigidity (Haptic Illusion task) but did not differ significantly from each other. Women with anorexia nervosa were slower than other groups on Trail Making tasks. Women who had fully recovered from anorexia nervosa made significantly fewer errors than those with acute anorexia nervosa on the Trail Making alphabet task, but these subgroups did not differ on other measures.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Both affected and unaffected sisters had more set-shifting difficulties than unrelated healthy women. This finding, together with the replicated finding that set-shifting difficulties persist after recovery, suggests that set-shifting difficulties are trait characteristics and may inform the search for the endophenotype in anorexia nervosa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Holliday</LastName><ForeName>Joanna</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Division of Psychological Medicine, Institute of Psychiatry, King's College London, UK. joanna.holliday@hmc.ox.ac.uk</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tchanturia</LastName><ForeName>Kate</ForeName><Initials>K</Initials></Author><Author ValidYN="Y"><LastName>Landau</LastName><ForeName>Sabine</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Collier</LastName><ForeName>David</ForeName><Initials>D</Initials></Author><Author 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sort="Treasure, Janet" uniqKey="Treasure J" first="Janet" last="Treasure">Janet Treasure</name></noCountry><country name="Royaume-Uni"><noRegion><name sortKey="Holliday, Joanna" sort="Holliday, Joanna" uniqKey="Holliday J" first="Joanna" last="Holliday">Joanna Holliday</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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