RGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification.
Identifieur interne : 000559 ( PubMed/Checkpoint ); précédent : 000558; suivant : 000560RGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification.
Auteurs : Yi-Shiang Huang [France] ; Virginie Bertrand [Belgique] ; Dimitriya Bozukova [Belgique] ; Christophe Pagnoulle [Belgique] ; Christine Labrugère [France] ; Edwin De Pauw [Belgique] ; Marie-Claire De Pauw-Gillet [Belgique] ; Marie-Christine Durrieu [France]Source :
- PloS one [ 1932-6203 ] ; 2014.
English descriptors
- KwdEn :
- Animals, Capsule Opacification (pathology), Capsule Opacification (surgery), Cataract (pathology), Cataract (therapy), Cataract Extraction (adverse effects), Cell Adhesion (drug effects), Cell Dedifferentiation (drug effects), Cell Line, Epithelial Cells (drug effects), Epithelial Cells (pathology), Epithelial-Mesenchymal Transition (drug effects), Humans, Lenses, Intraocular (adverse effects), Prostheses and Implants (adverse effects), Swine.
- MESH :
- adverse effects : Cataract Extraction, Lenses, Intraocular, Prostheses and Implants.
- drug effects : Cell Adhesion, Cell Dedifferentiation, Epithelial Cells, Epithelial-Mesenchymal Transition.
- pathology : Capsule Opacification, Cataract, Epithelial Cells.
- surgery : Capsule Opacification.
- therapy : Cataract.
- Animals, Cell Line, Humans, Swine.
Abstract
Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient's age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative biomaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting material. In addition, compared to the hydrophobic IOL material, our bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this biomaterial has the potential to reduce the risk factor of PCO development.
DOI: 10.1371/journal.pone.0114973
PubMed: 25501012
Affiliations:
- Belgique, France
- Aquitaine, Province de Liège, Région wallonne
- Bordeaux, Liège
- Université de Bordeaux, Université de Liège
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GIGA R, Université de Liège, Liège, Belgium; CBMN UMR5248, Institute of Chemistry & Biology of Membranes & Nanoobjects, Université de Bordeaux, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium; CBMN UMR5248, Institute of Chemistry & Biology of Membranes & Nanoobjects, Université de Bordeaux, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Bertrand, Virginie" sort="Bertrand, Virginie" uniqKey="Bertrand V" first="Virginie" last="Bertrand">Virginie Bertrand</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Bozukova, Dimitriya" sort="Bozukova, Dimitriya" uniqKey="Bozukova D" first="Dimitriya" last="Bozukova">Dimitriya Bozukova</name><affiliation wicri:level="1"><nlm:affiliation>Research and Development Department, PhysIOL SA, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Research and Development Department, PhysIOL SA, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Pagnoulle, Christophe" sort="Pagnoulle, Christophe" uniqKey="Pagnoulle C" first="Christophe" last="Pagnoulle">Christophe Pagnoulle</name><affiliation wicri:level="1"><nlm:affiliation>Research and Development Department, PhysIOL SA, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Research and Development Department, PhysIOL SA, Liège</wicri:regionArea><wicri:noRegion>Liège</wicri:noRegion></affiliation></author><author><name sortKey="Labrugere, Christine" sort="Labrugere, Christine" uniqKey="Labrugere C" first="Christine" last="Labrugère">Christine Labrugère</name><affiliation wicri:level="4"><nlm:affiliation>PLACAMAT, Plateforme Aquitaine de Caractérisation des Matériaux, UMS 3626, Université de Bordeaux, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>PLACAMAT, Plateforme Aquitaine de Caractérisation des Matériaux, UMS 3626, Université de Bordeaux, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName></affiliation></author><author><name sortKey="De Pauw, Edwin" sort="De Pauw, Edwin" uniqKey="De Pauw E" first="Edwin" last="De Pauw">Edwin De Pauw</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="De Pauw Gillet, Marie Claire" sort="De Pauw Gillet, Marie Claire" uniqKey="De Pauw Gillet M" first="Marie-Claire" last="De Pauw-Gillet">Marie-Claire De Pauw-Gillet</name><affiliation wicri:level="4"><nlm:affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium.</nlm:affiliation><country xml:lang="fr">Belgique</country><wicri:regionArea>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège</wicri:regionArea><orgName type="university">Université de Liège</orgName><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName></affiliation></author><author><name sortKey="Durrieu, Marie Christine" sort="Durrieu, Marie Christine" uniqKey="Durrieu M" first="Marie-Christine" last="Durrieu">Marie-Christine Durrieu</name><affiliation wicri:level="4"><nlm:affiliation>CBMN UMR5248, Institute of Chemistry & Biology of Membranes & Nanoobjects, Université de Bordeaux, Pessac, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>CBMN UMR5248, Institute of Chemistry & Biology of Membranes & Nanoobjects, Université de Bordeaux, Pessac</wicri:regionArea><wicri:noRegion>Pessac</wicri:noRegion><orgName type="university">Université de Bordeaux</orgName><placeName><settlement type="city">Bordeaux</settlement><region type="region" nuts="2">Aquitaine</region></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Capsule Opacification (pathology)</term><term>Capsule Opacification (surgery)</term><term>Cataract (pathology)</term><term>Cataract (therapy)</term><term>Cataract Extraction (adverse effects)</term><term>Cell Adhesion (drug effects)</term><term>Cell Dedifferentiation (drug effects)</term><term>Cell Line</term><term>Epithelial Cells (drug effects)</term><term>Epithelial Cells (pathology)</term><term>Epithelial-Mesenchymal Transition (drug effects)</term><term>Humans</term><term>Lenses, Intraocular (adverse effects)</term><term>Prostheses and Implants (adverse effects)</term><term>Swine</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Cataract Extraction</term><term>Lenses, Intraocular</term><term>Prostheses and Implants</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Adhesion</term><term>Cell Dedifferentiation</term><term>Epithelial Cells</term><term>Epithelial-Mesenchymal Transition</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Capsule Opacification</term><term>Cataract</term><term>Epithelial Cells</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Capsule Opacification</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Cataract</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cell Line</term><term>Humans</term><term>Swine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient's age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative biomaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting material. In addition, compared to the hydrophobic IOL material, our bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this biomaterial has the potential to reduce the risk factor of PCO development.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">25501012</PMID><DateCreated><Year>2014</Year><Month>12</Month><Day>16</Day></DateCreated><DateCompleted><Year>2015</Year><Month>12</Month><Day>21</Day></DateCompleted><DateRevised><Year>2014</Year><Month>12</Month><Day>20</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Electronic">1932-6203</ISSN><JournalIssue CitedMedium="Internet"><Volume>9</Volume><Issue>12</Issue><PubDate><Year>2014</Year></PubDate></JournalIssue><Title>PloS one</Title><ISOAbbreviation>PLoS ONE</ISOAbbreviation></Journal><ArticleTitle>RGD surface functionalization of the hydrophilic acrylic intraocular lens material to control posterior capsular opacification.</ArticleTitle><Pagination><MedlinePgn>e114973</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1371/journal.pone.0114973</ELocationID><Abstract><AbstractText>Posterior Capsular Opacification (PCO) is the capsule fibrosis developed on implanted IntraOcular Lens (IOL) by the de-differentiation of Lens Epithelial Cells (LECs) undergoing Epithelial Mesenchymal Transition (EMT). Literature has shown that the incidence of PCO is multifactorial including the patient's age or disease, surgical technique, and IOL design and material. Reports comparing hydrophilic and hydrophobic acrylic IOLs have shown that the former has more severe PCO. On the other hand, we have previously demonstrated that the adhesion of LECs is favored on hydrophobic compared to hydrophilic materials. By combining these two facts and contemporary knowledge in PCO development via the EMT pathway, we propose a biomimetically inspired strategy to promote LEC adhesion without de-differentiation to reduce the risk of PCO development. By surface grafting of a cell adhesion molecule (RGD peptide) onto the conventional hydrophilic acrylic IOL material, the surface-functionalized IOL can be used to reconstitute a capsule-LEC-IOL sandwich structure, which has been considered to prevent PCO formation in literature. Our results show that the innovative biomaterial improves LEC adhesion, while also exhibiting similar optical (light transmittance, optical bench) and mechanical (haptic compression force, IOL injection force) properties compared to the starting material. In addition, compared to the hydrophobic IOL material, our bioactive biomaterial exhibits similar abilities in LEC adhesion, morphology maintenance, and EMT biomarker expression, which is the crucial pathway to induce PCO. The in vitro assays suggest that this biomaterial has the potential to reduce the risk factor of PCO development.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Yi-Shiang</ForeName><Initials>YS</Initials><AffiliationInfo><Affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium; CBMN UMR5248, Institute of Chemistry & Biology of Membranes & Nanoobjects, Université de Bordeaux, Pessac, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bertrand</LastName><ForeName>Virginie</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozukova</LastName><ForeName>Dimitriya</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Research and Development Department, PhysIOL SA, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pagnoulle</LastName><ForeName>Christophe</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Research and Development Department, PhysIOL SA, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Labrugère</LastName><ForeName>Christine</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>PLACAMAT, Plateforme Aquitaine de Caractérisation des Matériaux, UMS 3626, Université de Bordeaux, Pessac, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Pauw</LastName><ForeName>Edwin</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>De Pauw-Gillet</LastName><ForeName>Marie-Claire</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Departments of Chemistry & Bio-Medical and Preclinical Sciences, Mass Spectrometry Laboratory & Mammalian Cell Culture Laboratory - GIGA R, Université de Liège, Liège, Belgium.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Durrieu</LastName><ForeName>Marie-Christine</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>CBMN UMR5248, Institute of Chemistry & Biology of Membranes & Nanoobjects, Université de Bordeaux, Pessac, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate 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UI="Q000628">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002387">Cataract Extraction</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002448">Cell Adhesion</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D054337">Cell Dedifferentiation</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D002460">Cell Line</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D004847">Epithelial Cells</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000187">drug effects</QualifierName><QualifierName MajorTopicYN="N" UI="Q000473">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D058750">Epithelial-Mesenchymal Transition</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000187">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D006801">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D007910">Lenses, Intraocular</DescriptorName><QualifierName MajorTopicYN="Y" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D019736">Prostheses and Implants</DescriptorName><QualifierName MajorTopicYN="N" UI="Q000009">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N" UI="D013552">Swine</DescriptorName></MeshHeading></MeshHeadingList><OtherID Source="NLM">PMC4263720</OtherID></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="ecollection"><Year>2014</Year><Month></Month><Day></Day></PubMedPubDate><PubMedPubDate PubStatus="received"><Year>2014</Year><Month>7</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2014</Year><Month>11</Month><Day>17</Day></PubMedPubDate><PubMedPubDate PubStatus="epublish"><Year>2014</Year><Month>12</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>12</Month><Day>16</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2015</Year><Month>12</Month><Day>22</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="doi">10.1371/journal.pone.0114973</ArticleId><ArticleId IdType="pii">PONE-D-14-33490</ArticleId><ArticleId IdType="pubmed">25501012</ArticleId><ArticleId IdType="pmc">PMC4263720</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Belgique</li><li>France</li></country><region><li>Aquitaine</li><li>Province de Liège</li><li>Région wallonne</li></region><settlement><li>Bordeaux</li><li>Liège</li></settlement><orgName><li>Université de Bordeaux</li><li>Université de Liège</li></orgName></list><tree><country name="France"><region name="Région wallonne"><name sortKey="Huang, Yi Shiang" sort="Huang, Yi Shiang" uniqKey="Huang Y" first="Yi-Shiang" last="Huang">Yi-Shiang Huang</name></region><name sortKey="Durrieu, Marie Christine" sort="Durrieu, Marie Christine" uniqKey="Durrieu M" first="Marie-Christine" last="Durrieu">Marie-Christine Durrieu</name><name sortKey="Labrugere, Christine" sort="Labrugere, Christine" uniqKey="Labrugere C" first="Christine" last="Labrugère">Christine Labrugère</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Bertrand, Virginie" sort="Bertrand, Virginie" uniqKey="Bertrand V" first="Virginie" last="Bertrand">Virginie Bertrand</name></region><name sortKey="Bozukova, Dimitriya" sort="Bozukova, Dimitriya" uniqKey="Bozukova D" first="Dimitriya" last="Bozukova">Dimitriya Bozukova</name><name sortKey="De Pauw Gillet, Marie Claire" sort="De Pauw Gillet, Marie Claire" uniqKey="De Pauw Gillet M" first="Marie-Claire" last="De Pauw-Gillet">Marie-Claire De Pauw-Gillet</name><name sortKey="De Pauw, Edwin" sort="De Pauw, Edwin" uniqKey="De Pauw E" first="Edwin" last="De Pauw">Edwin De Pauw</name><name sortKey="Pagnoulle, Christophe" sort="Pagnoulle, Christophe" uniqKey="Pagnoulle C" first="Christophe" last="Pagnoulle">Christophe Pagnoulle</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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