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Perceptual decision making in less than 30 milliseconds

Identifieur interne : 002553 ( Pmc/Curation ); précédent : 002552; suivant : 002554

Perceptual decision making in less than 30 milliseconds

Auteurs : Terrence R. Stanford ; Swetha Shankar ; Dino P. Massoglia ; M. Gabriela Costello ; Emilio Salinas

Source :

RBID : PMC:2834559

Abstract

In perceptual discrimination tasks, a subject’s response time is determined both by sensory and motor processes. Measuring the time consumed by the perceptual evaluation step alone is thus complicated by factors such as motor preparation, task difficulty and speed-accuracy tradeoffs. Here we present a task design that minimizes these confounds and allows us to track a subject’s perceptual performance with unprecedented temporal resolution. We find that monkeys can make accurate color discriminations in less than 30 ms. Furthermore, our simple task design provides a novel tool for elucidating how neuronal activity relates to sensory versus motor processing, as demonstrated with neural data from cortical oculomotor neurons. In these cells, perceptual information acts by accelerating and decelerating the ongoing motor plans associated with correct and incorrect choices, as predicted by a race-to-threshold model, and the time course of these neural events parallels the time course of the subject's choice accuracy.


Url:
DOI: 10.1038/nn.2485
PubMed: 20098418
PubMed Central: 2834559

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PMC:2834559

Le document en format XML

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<surname>Costello</surname>
<given-names>M. Gabriela</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Salinas</surname>
<given-names>Emilio</given-names>
</name>
<xref ref-type="corresp" rid="cor1">*</xref>
</contrib>
<aff id="A1">Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA</aff>
</contrib-group>
<author-notes>
<corresp id="cor1">
<label>*</label>
To whom correspondence should be addressed,
<email>esalinas@wfubmc.edu</email>
, Tel: (336) 713-5176, Fax: (336) 716-4534</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted">
<day>7</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub">
<day>24</day>
<month>1</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="ppub">
<month>3</month>
<year>2010</year>
</pub-date>
<pub-date pub-type="pmc-release">
<day>01</day>
<month>9</month>
<year>2010</year>
</pub-date>
<volume>13</volume>
<issue>3</issue>
<fpage>379</fpage>
<lpage>385</lpage>
<pmc-comment>elocation-id from pubmed: 10.1038/nn.2485</pmc-comment>
<permissions>
<license>
<license-p>Users may view, print, copy, download and text and data- mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:
<uri xlink:type="simple" xlink:href="http://www.w3.org/1999/xlink"></uri>
<uri xlink:type="simple" xlink:href="http://www.nature.com/authors/editorial_policies/license.html#terms">http://www.nature.com/authors/editorial_policies/license.html#terms</uri>
</license-p>
</license>
</permissions>
<abstract>
<p id="P1">In perceptual discrimination tasks, a subject’s response time is determined both by sensory and motor processes. Measuring the time consumed by the perceptual evaluation step alone is thus complicated by factors such as motor preparation, task difficulty and speed-accuracy tradeoffs. Here we present a task design that minimizes these confounds and allows us to track a subject’s perceptual performance with unprecedented temporal resolution. We find that monkeys can make accurate color discriminations in less than 30 ms. Furthermore, our simple task design provides a novel tool for elucidating how neuronal activity relates to sensory versus motor processing, as demonstrated with neural data from cortical oculomotor neurons. In these cells, perceptual information acts by accelerating and decelerating the ongoing motor plans associated with correct and incorrect choices, as predicted by a race-to-threshold model, and the time course of these neural events parallels the time course of the subject's choice accuracy.</p>
</abstract>
<kwd-group>
<kwd>Choice</kwd>
<kwd>discrimination</kwd>
<kwd>mental chronometry</kwd>
<kwd>race to threshold</kwd>
<kwd>reaction time</kwd>
<kwd>reward</kwd>
<kwd>psychophysics</kwd>
<kwd>saccade</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<p id="P2">Perceptual decision-making capacity has been intensely studied in psychophysical and neurophysiological experiments as a function of signal quality, strength, and subjective value
<xref rid="R1" ref-type="bibr">1</xref>
–
<xref rid="R10" ref-type="bibr">10</xref>
. However, there is a fundamental question that has been more difficult to address: how long does it take to make a perceptual judgement? This issue is relevant to many real-life situations in which a choice must be made very quickly. Here is a common example. A driver sees a traffic light and must rapidly decide whether to step on the brake or the accelerator. The ensuing action on the pedal will take at least a few hundred milliseconds to be initiated
<xref rid="R11" ref-type="bibr">11</xref>
,
<xref rid="R12" ref-type="bibr">12</xref>
. How much of this reaction time (RT) is dedicated to the perceptual analysis of the visual scene, i.e. to determining whether the light is red or green?</p>
<p id="P3">The basic measurement seems deceptively simple. In well-trained macaque monkeys, which are the subjects of our study, a fixational eye movement (saccade) to a highly salient, unambiguous target takes about 150–200 ms to execute
<xref rid="R13" ref-type="bibr">13</xref>
. This must be the time that the motor apparatus needs to produce an unambiguous response, so the difference between this number and the RT in a two-alternative forced-choice task should be equal to the time that is necessary for making an additional sensory discrimination. Although this subtractive approach is a classic one
<xref rid="R11" ref-type="bibr">11</xref>
,
<xref rid="R12" ref-type="bibr">12</xref>
,
<xref rid="R14" ref-type="bibr">14</xref>
–
<xref rid="R17" ref-type="bibr">17</xref>
, it has three shortcomings. (1) Forced-choice paradigms typically require cognitive resources other than just sensory analysis, such as working memory and a rule that links sensory stimuli to appropriate motor responses, so the two situations may not be directly comparable. (2) In tasks involving a sensory discrimination, what the experimenter measures is typically the point in time at which the motor action is initiated, but this is not necessarily the same as the point in time at which the sensory processing ends, which is what is needed. (3) When a change in a task parameter causes a change in RT, it is usually accompanied by a concurrent change in performance, and vice versa. Hence, a given change in RT may be caused either by an actual change in sensory processing speed or by an internal tradeoff between speed and accuracy to which the experimenter has no access.</p>
<p id="P4">Another approach is to manipulate the duration of stimulus presentation. Studies based on this idea
<xref rid="R1" ref-type="bibr">1</xref>
,
<xref rid="R18" ref-type="bibr">18</xref>
–
<xref rid="R20" ref-type="bibr">20</xref>
have shown that sensory information gradually accumulates over time in order to influence a behavioral choice, and that visual discrimination improves with stimulus duration. However, the accuracy with which sensory processing speed can be inferred with this method is limited, particularly for highly discriminable stimuli, which may be processed very rapidly. The main problem, besides the often necessary use of a mask
<xref rid="R18" ref-type="bibr">18</xref>
,
<xref rid="R19" ref-type="bibr">19</xref>
that introduces further complexities and unknown sources of variance
<xref rid="R21" ref-type="bibr">21</xref>
,
<xref rid="R22" ref-type="bibr">22</xref>
, is again that changes in stimulus duration produce both variations in performance and large, correlated variations in RT (i.e., point 3 above).</p>
<p id="P5">The compelled-response paradigm described below largely avoids these problems and can be easily adapted to a variety of experimental conditions. Its crucial element is that the sensory cues to be discriminated (two colored spots in this experiment) are revealed
<italic>after</italic>
the go signal that instructs the subject to respond. Thus, the percentage of correct choices varies with the time gap between the go and the cues, whereas motor execution and mean RT remain approximately constant. This approach results in an accurate time course for perceptual performance, which can be temporally correlated with neuronal activity and from which sensory processing speed can be directly measured.</p>
<sec sec-type="results" id="S1">
<title>RESULTS</title>
<sec id="S2">
<title>Task design</title>
<p id="P6">The compelled-saccade (CS) task is schematized in
<xref ref-type="fig" rid="F1">Figure 1</xref>
. A monkey subject first fixates on a central spot, and the color of this spot, red or green, indicates the color of the target. Then two yellow spots — potential targets — appear in the periphery. Next, the disappearance of the fixation spot is the go signal that tells the animal to initiate a saccade, although at this point the identities of the target and distracter are still unknown; these are revealed later, after a time gap that varies between 50 and 250 ms in duration, at the point marked “Cue”. At the cue, one yellow spot turns red and the other green. Finally, a saccade is executed, and if the response is correct, a drop of liquid is given as a reward. The RT is the time between the onset of the go signal and the onset of the saccade, and the key parameter is the time gap, which varies pseudo-randomly across trials.</p>
<p id="P7">The idea behind the compelled-response paradigm is to separate the perceptual decision-making and motor-planning stages of the task by always instructing the subject when to respond. Because the motor response is triggered first, at the go signal, mean RTs should stay approximately constant, and the perceptual information should influence a saccadic choice process that is already ongoing. The expected task performance is best understood at two extremes. At long or infinite gaps the sensory information never becomes available; the subject must guess which spot is the target because both of them are yellow. In contrast, at zero or short gaps the sensory information is revealed early; the subject is able to identify target and distracter and look at the appropriate spot (red or green). Thus, performance is expected to change systematically as a function of gap, but motor execution is not.</p>
</sec>
<sec id="S3">
<title>Motor and perceptual dependencies on the gap</title>
<p id="P8">We examined the behavior of two macaque monkeys trained to perform the CS task. First we analyzed their eye movements (
<xref ref-type="fig" rid="F2">Fig. 2</xref>
) and found that, for a given pair of targets, the velocity profiles generated in short- and long-gap trials were statistically identical. That is, for each monkey, the mean peak velocity was the same across gaps (Wilcoxon,
<italic>p</italic>
> 0.25 for both monkeys; see
<xref ref-type="fig" rid="F2">Fig. 2</xref>
), and so was the mean width at half height (Wilcoxon,
<italic>p</italic>
> 0.29 for both monkeys; see
<xref ref-type="fig" rid="F2">Fig. 2</xref>
). Thus, the gap had no discernible effect on saccadic execution.</p>
<p id="P9">In contrast, perceptual performance was indeed strongly dependent on the gap, as revealed by the psychometric curves (
<xref ref-type="fig" rid="F3">Fig. 3a</xref>
). The percentage of correct choices was much higher at short gaps, when the cue was revealed early and subjects could discriminate the red and green spots, than at long gaps, when the cue was revealed late and subjects had to guess the target’s location. Importantly, however, mean RTs changed little over this range of gaps (
<xref ref-type="fig" rid="F3">Fig. 3b</xref>
), indicating that the monkeys did not try to wait for the cue (see
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
). So, as anticipated, variations in performance in the CS task were largely dissociated from variations in motor execution.</p>
</sec>
<sec id="S4">
<title>The tachometric curve</title>
<p id="P10">Crucially, the behavioral data just discussed (
<xref ref-type="fig" rid="F3">Fig. 3a,b</xref>
) can be sorted differently to directly reveal the perceptual processing speed of each subject — but before discussing that result, it is useful to consider a simple heuristic model that reproduces much of the observed behavior (
<xref ref-type="fig" rid="F4">Fig. 4</xref>
). As in previous models
<xref rid="R11" ref-type="bibr">11</xref>
,
<xref rid="R19" ref-type="bibr">19</xref>
,
<xref rid="R23" ref-type="bibr">23</xref>
–
<xref rid="R31" ref-type="bibr">31</xref>
, a saccadic choice is conceived as a race toward a threshold. In our case there are two variables,
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
, which represent the activities of two neuronal populations that trigger saccades to different locations. A movement to the left spot is produced if
<italic>x
<sub>L</sub>
</italic>
reaches threshold first, and vice versa, the movement is to the right when
<italic>x
<sub>R</sub>
</italic>
wins the race. Our model, however, uniquely combines random and deterministic choices.</p>
<p id="P11">In each trial, the go signal starts the race (after an afferent delay); this means that a positive build-up rate is drawn for one of the variables and a lower or negative rate is drawn for the other. These initial rates are assigned randomly because at this point the two spots are still yellow. Thus, if
<italic>x
<sub>L</sub>
</italic>
or
<italic>x
<sub>R</sub>
</italic>
reaches threshold during this pre-cue stage, the outcome of the race is a coin toss (
<xref ref-type="fig" rid="F4">Fig. 4d,e</xref>
). However, once the cue information becomes available (after a total delay equal to gap + afferent delay), the build-up rates change depending on the target and distracter locations. For instance,
<xref ref-type="fig" rid="F4">Figure 4a</xref>
shows a trial in which initially
<italic>x
<sub>L</sub>
</italic>
approached threshold faster than
<italic>x
<sub>R</sub>
</italic>
, but then, because the target was on the right,
<italic>x
<sub>L</sub>
</italic>
decelerated and
<italic>x
<sub>R</sub>
</italic>
accelerated, eventually winning the race. One of the parameters in the model (τ in
<xref ref-type="disp-formula" rid="FD3">Eqn. 3</xref>
, Methods) is proportional to the speed with which the perceptual process occurs and thus determines how fast
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
are accelerated, i.e., how fast the cue information can alter the ongoing motor plans once the cue is revealed. In each trial, the model produces a RT and a motor outcome, left or right (for details, see Methods).</p>
<p id="P12">Importantly, in this model the time during which the color information is available for guiding the choice in each trial, which we call the effective processing time (ePT), is clearly defined. It is
<disp-formula id="FD1">
<label>(1)</label>
<mml:math id="M1" display="block" overflow="scroll">
<mml:mrow>
<mml:mtext>ePT</mml:mtext>
<mml:mo>=</mml:mo>
<mml:mtext>RT</mml:mtext>
<mml:mo>−</mml:mo>
<mml:mtext>gap</mml:mtext>
<mml:mo>−</mml:mo>
<mml:msub>
<mml:mi>T</mml:mi>
<mml:mrow>
<mml:mtext mathvariant="italic">ND</mml:mtext>
</mml:mrow>
</mml:msub>
</mml:mrow>
</mml:math>
</disp-formula>
where the constant
<italic>T
<sub>ND</sub>
</italic>
is the total non-decision time (afferent + efferent delay). Note that this expression requires gap and RT values specific for each trial, not mean values. In the five examples of
<xref ref-type="fig" rid="F4">Figure 4</xref>
, each ePT period is indicated by a horizontal bar. Races that end after the cue information becomes available have positive ePTs and an accuracy that increases with increasing ePT (
<xref ref-type="fig" rid="F4">Fig. 4a–c</xref>
); in contrast, races that end before the cue information becomes available have negative ePTs and random outcomes (
<xref ref-type="fig" rid="F4">Fig. 4d,e</xref>
), thus leading to 50% accuracy.</p>
<p id="P13">For each monkey, we fitted the model parameters to the experimental data (
<xref ref-type="fig" rid="F3">Fig. 3a–d</xref>
; see Methods). We computed an ePT for each trial performed by the monkeys by applying
<xref ref-type="disp-formula" rid="FD1">Equation 1</xref>
using the
<italic>T
<sub>ND</sub>
</italic>
value from the model. The resulting ePT distributions are shown in
<xref ref-type="fig" rid="F3">Figure 3c</xref>
. Note that, for ePT ≤ 0, the ePT distributions for correct and incorrect trials are practically identical, indicating that, as in the model, performance is at chance level in this range. In contrast, as ePT increases above 0 ms, a larger proportion of the trials tends to be correct.</p>
<p id="P14">The ePT is the amount of time during which the cue is effectively visible in each trial; it is the fundamental variable that determines perceptual performance in the CS task. This is seen most clearly by plotting the percentage of correct responses as a function of ePT. The resulting curve (
<xref ref-type="fig" rid="F3">Fig. 3d</xref>
) may be referred to as a `tachometric curve’, because it reveals the speed of the perceptual process embedded in the task. For instance, for monkeys S and G, an accuracy of 75% correct was achieved with ePTs of 26 ± 2 ms (± s.e., from bootstrap) and 42 ± 2 ms, respectively. Importantly, the parameter
<italic>T
<sub>ND</sub>
</italic>
is not crucial to this analysis; it simply sets the origin of the x-axis in
<xref ref-type="fig" rid="F3">Figure 3c,d</xref>
without affecting the shapes of the curves (see
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
). The key quantity is the difference between the RT and the gap in each trial, which we call the raw processing time (rPT).</p>
</sec>
<sec id="S5">
<title>Predicted versus measured RT distributions</title>
<p id="P15">For each monkey, we found model parameter values that best fitted the data in
<xref ref-type="fig" rid="F3">Figure 3a–d</xref>
(Methods). Importantly, only the proportions of errors and the overall variability of the RTs at each gap were used to fit the model. We then generated model RT distributions for correct and incorrect responses at each gap, with the idea that any salient features in the shapes of the simulated distributions would thus constitute specific predictions that we could analyze in order to validate the model.</p>
<p id="P16">RT distributions obtained from the experiments and from computer simulations at various gaps are shown side by side in
<xref ref-type="fig" rid="F3">Figure 3e</xref>
. The shapes of these distributions indeed change dramatically from short to long gaps, and the progression predicted by the model agrees extremely well with that observed in the monkey data. The key is that the model mixes random choices (of 50% accuracy) with deterministic choices (of nearly 100% accuracy) in the right proportions for each gap. These correspond to the monkeys’ guesses and informed discriminations, respectively. Further quantification of the match between model and experimental results is described in the
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
online.</p>
</sec>
<sec id="S6">
<title>A motor bias experiment</title>
<p id="P17">We interpret the slope of the tachometric curve (
<xref ref-type="fig" rid="F3">Fig. 3d</xref>
) as a direct indicator of the speed of the perceptual process that guides the subject's choices in the CS task. If this is correct, then manipulations that alter the motor responses but not the perceptual difficulty of the task should lead to little or no change in slope. To test this, we varied the task conditions so that the monkeys would develop a motor bias, a tendency to make more saccades to one side than to the other
<xref rid="R32" ref-type="bibr">32</xref>
. We gave the monkeys a large reward (0.3 ml) following correct saccades to one side and a small reward (0.1 ml) following correct saccades to the other (
<xref ref-type="fig" rid="F5">Fig. 5</xref>
; see Methods). As a consequence, on average the animals chose the high-reward side about 76% of the time (75% for monkey S, 78% for monkey G;
<xref ref-type="fig" rid="F5">Fig. 5a</xref>
). This result agrees well with the 3:1 ratio expected from Herrnstein’s matching law
<xref rid="R4" ref-type="bibr">4</xref>
,
<xref rid="R33" ref-type="bibr">33</xref>
,
<xref rid="R34" ref-type="bibr">34</xref>
, but does not capture the full complexity of the effects generated by the asymmetric reward, which depended strongly on the availability of the sensory information
<xref rid="R32" ref-type="bibr">32</xref>
.</p>
<p id="P18">We analyzed the choices that the monkeys made to the high- and low-reward sides and found three prominent effects: (1) the bias was stronger at long than at short gaps (
<xref ref-type="fig" rid="F5">Fig. 5a</xref>
), (2) responses in the high-reward direction were much more prone to errors than in the low-reward direction (
<xref ref-type="fig" rid="F5">Fig. 5b</xref>
), and (3) responses in the high-reward direction were also initiated sooner (
<xref ref-type="fig" rid="F5">Fig. 5c</xref>
). Results are shown for monkey S only (
<xref ref-type="fig" rid="F5">Fig. 5</xref>
) but were similar with monkey G (
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
). Crucially, in spite of these striking differences in motor execution, the slopes of the tachometric curves were not significantly different across reward conditions (monkey S,
<italic>p</italic>
= 0.18; monkey G,
<italic>p</italic>
= 0.53, permutation test). This, we believe, is because the perceptual discrimination itself did not change.</p>
<p id="P19">These results shed some light on how reward information and sensory evidence are combined when two motor responses are rewarded differently. They suggest that the low-reward side is chosen only if there is little uncertainty about the target’s position, i.e., when there is enough time to discriminate red from green accurately; otherwise, the high-reward side is the default. Two observations support this explanation. First, consider the ePT distributions obtained for correct and error trials. For high-reward choices the results are indicative of a large fraction of guesses (
<xref ref-type="fig" rid="F5">Fig. 5d</xref>
), whereas for low-reward choices the results are indicative of a majority of correct perceptual judgements (
<xref ref-type="fig" rid="F5">Fig. 5e</xref>
). Second, consider the fraction of choices made to the low-reward side as a function of ePT (
<xref ref-type="fig" rid="F5">Fig. 5g</xref>
). The curve shows that the monkey’s preference varied extremely sharply as a function of ePT (compare to the weak dependence as a function of gap shown in
<xref ref-type="fig" rid="F5">Fig. 5a</xref>
). Therefore, the amount of time during which a monkey is exposed to the sensory cue — that is, the ePT — is an excellent predictor of his choice. This effect was also seen in the model (
<xref ref-type="fig" rid="F5">Fig. 5g</xref>
), which, with minor modifications (see Methods), was able to reproduce quite accurately all the major differences between high- and low-reward choices (
<xref ref-type="fig" rid="F5">Fig. 5</xref>
, “Model”).</p>
</sec>
<sec id="S7">
<title>Neuronal sensitivity to processing time</title>
<p id="P20">In our race model,
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
are conceived as the firing rates of two populations of neurons that generate movements to the left and right targets but are also influenced by perceptual information
<xref rid="R8" ref-type="bibr">8</xref>
,
<xref rid="R19" ref-type="bibr">19</xref>
,
<xref rid="R28" ref-type="bibr">28</xref>
,
<xref rid="R35" ref-type="bibr">35</xref>
–
<xref rid="R39" ref-type="bibr">39</xref>
. If this representation is correct, oculomotor neurons in cortical areas that participate in the saccadic choice process should qualitatively behave like
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
; in particular, they should exhibit similar dependencies on processing time. To investigate this, we recorded neuronal activity from oculomotor neurons in the frontal eye field (FEF) while monkeys S and G performed the CS task. We report results from a population of 30 neurons, 18 from monkey S and 12 from monkey G, that had stereotypical motor properties
<xref rid="R24" ref-type="bibr">24</xref>
,
<xref rid="R40" ref-type="bibr">40</xref>
and little or no sensory-evoked activity (Methods;
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
). Such “movement” cells were selected because they correspond most closely to the model variables
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
.</p>
<p id="P21">In a first analysis, we subdivided all recorded trials into short- and long-rPT groups (
<xref ref-type="fig" rid="F6">Fig. 6a</xref>
) and compared the neuronal responses across groups. Recall that in short-rPT trials choices are not guided by sensory information, whereas in long-rPT trials they are. According to the model, the fundamental action of the cue information is to accelerate the developing motor plan for the target side and decelerate the plan for the distracter side, producing curved trajectories (
<xref ref-type="fig" rid="F4">Fig. 4a–c</xref>
). Here we mean acceleration in the literal, physical sense, because the cue information changes the second derivatives of the decision variables
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
(
<xref ref-type="disp-formula" rid="FD3">Eqn. 3</xref>
). By averaging over many simulated trials, this effect becomes manifest in two ways: (1) the oculomotor activity leading to saccades away from the cells’ movement field (MF) should be stronger with long rPTs than with short rPTs, but should also decline markedly before movement onset (
<xref ref-type="fig" rid="F6">Fig. 6b</xref>
, green traces), and (2) the activity leading to saccades into the MF should rise to threshold more steeply with long than with short rPTs (
<xref ref-type="fig" rid="F6">Fig. 6b</xref>
, red traces). Are these patterns found in the neural data?</p>
<p id="P22">The responses of a single neuron during the CS task are shown in
<xref ref-type="fig" rid="F6">Figure 6c,d</xref>
. Activity is aligned on saccade onset, with trials sorted according to saccade direction (
<xref ref-type="fig" rid="F6">Fig. 6c</xref>
, into the MF;
<xref ref-type="fig" rid="F6">Fig. 6d</xref>
, away from the MF) and processing time (left side, short rPTs; right side, long rPTs). This unit’s behavior was generally consistent with the model, but its responses were quite variable, as expected. However, the population average showed good agreement with the model’s predictions: before saccades away from the MF (
<xref ref-type="fig" rid="F6">Fig. 6e</xref>
, green traces), the firing rate reaches a higher level and then declines more sharply at long rPTs than at short rPTs (see ref.
<xref rid="R31" ref-type="bibr">31</xref>
); and before saccades into the MF (
<xref ref-type="fig" rid="F6">Fig. 6e</xref>
, red traces), the firing rate trajectory is steeper at long rPTs than at short ones. This difference in curvature is somewhat subtle, but was very highly significant (
<italic>p</italic>
= 0.0006, permutation test).</p>
</sec>
<sec id="S8">
<title>Temporal correlates of choice accuracy</title>
<p id="P23">In the CS task, performance changes sharply with the amount of exposure to the sensory cue. We thus hypothesized that, as a function of rPT, the neural activity associated with the oculomotor choice should change with a time course similar to that observed behaviorally. To test this, we measured the mean convexity of the firing rate trajectories as a function of rPT. We chose convexity because this quantity is closely related to acceleration, and its calculation is simple and robust to noise (
<xref ref-type="fig" rid="F7">Fig. 7a</xref>
). Trajectories that decelerate have negative convexity and curve downward, whereas trajectories that accelerate have positive convexity and curve upward.</p>
<p id="P24">We first analyzed the convexity associated with the model variables
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
, and found that the responses in and out of the MF behave in opposite ways as functions of rPT: the former have an approximately constant convexity at first, which then increases steadily (
<xref ref-type="fig" rid="F7">Fig. 7b</xref>
), whereas for the latter, the convexity also stays constant initially but then decreases toward strongly negative values (
<xref ref-type="fig" rid="F7">Fig. 7c</xref>
). This simply restates the result in
<xref ref-type="fig" rid="F6">Figure 6b</xref>
and quantifies it with a fine temporal grain. That is, the firing rate trajectories should curve upward before correct saccades into the MF, whereas they should turn downward before correct saccades away from the MF. Crucially, however, both effects must start at about the same time as the subject’s rise in performance (
<xref ref-type="fig" rid="F7">Fig. 7d</xref>
), and their magnitude must depend on the amount of exposure to the cue.</p>
<p id="P25">This prediction was verified. We plotted the mean convexity of the neuronal responses as a function of rPT for trials into (
<xref ref-type="fig" rid="F7">Fig. 7e</xref>
) and away from the MF (
<xref ref-type="fig" rid="F7">Fig. 7f</xref>
). The results from the 30 FEF neurons were somewhat noisy, but the time courses clearly matched those expected from the model. In particular, the two transition points at which convexity starts changing steadily (arrows in
<xref ref-type="fig" rid="F7">Figs. 7e,f</xref>
) occurred very close to each other and to the transition point of the tachometric curve, as predicted (transition points were determined by fitting the data with analytical functions that contain such transitions; see Methods). Furthermore, after the transitions, the slopes of the convexity plots had a very high significance (
<italic>p</italic>
= 0.002 and
<italic>p</italic>
= 0.0004 for trials into and away from the MF, respectively, permutation test). Therefore, during the task the cue information accelerates the motor plan for the target and decelerates the plan for the distracter — the main premise of the race model — and the onset of these dynamical changes coincides with the onset of the subject’s rise in performance above chance.</p>
</sec>
</sec>
<sec sec-type="discussion" id="S9">
<title>DISCUSSION</title>
<p id="P26">The compelled-response paradigm presented here is able, to a large extent, to decouple the perceptual-evaluation and motor-execution steps of a behavioral choice. Part of its success depends on simultaneously controlling the timing of the sensory information (cue) and of the response trigger (go), as suggested by earlier studies in motor control
<xref rid="R41" ref-type="bibr">41</xref>
,
<xref rid="R42" ref-type="bibr">42</xref>
, but its minimalistic design goes much further: it achieves fine temporal resolution in a perceptual discrimination process without additional stimuli or masks, and monkeys readily learn the task. The resulting tachometric curve is an excellent diagnostic of perceptual ability because performance varies much more rapidly with ePT (
<xref ref-type="fig" rid="F3">Fig. 3d</xref>
) than with RT or with gap (
<xref ref-type="fig" rid="F3">Fig. 3a</xref>
). This means that, by computing the tachometric curve, a major source of variability unrelated to sensory processing is filtered out. Importantly, however, this is achieved with a very simple calculation (
<xref ref-type="disp-formula" rid="FD1">Eqn. 1</xref>
).</p>
<p id="P27">Our results indicate that, given highly discriminable stimuli, color information needs to be processed for just 25–50 ms to have a sizeable impact on behavioral outcome. But note that our model does not attribute this processing time to a specific color-sensitive area, such as the retina, or area V4, and that it also remains agnostic regarding the biophysical origin of this time scale, i.e., whether it results from slow sensory transduction or from internal noise in more central circuits
<xref rid="R25" ref-type="bibr">25</xref>
,
<xref rid="R26" ref-type="bibr">26</xref>
,
<xref rid="R36" ref-type="bibr">36</xref>
,
<xref rid="R38" ref-type="bibr">38</xref>
, for instance. What the model does show, however, is that such a time scale for sensory processing is consistent with all the behavioral data in the task — e.g., RT distributions, choice preferences under bias, etc. — and with the oculomotor activity observed in FEF.</p>
<p id="P28">Our results provide converging evidence that, within a choice process that takes a few hundred milliseconds, the sensory evaluation step may consume much less than 100 ms, as suggested by previous experiments
<xref rid="R43" ref-type="bibr">43</xref>
–
<xref rid="R46" ref-type="bibr">46</xref>
. In particular, our findings are close to a measurement of ~25 ms made in humans
<xref rid="R46" ref-type="bibr">46</xref>
, and which likely reflects the minimum time necessary for color identification only, without the computational overhead needed to compare two stimuli and communicate the result of the discrimination (red or green) to the correct motor output (left or right) on the fly. Our results are also in agreement with an earlier study of FEF visuo-movement cells
<xref rid="R43" ref-type="bibr">43</xref>
, which showed that an ideal observer can reliably differentiate the activity evoked by a target from that evoked by a distracter within ~25 ms of the onset of neural discrimination, on average. Importantly, however, the advantage of the present approach is that it does not require any assumptions about the relationship between neuronal and behavioral performance (e.g., identities and numbers of participating neurons, ideal-observer criterion, etc.), but rather is based on a direct behavioral manifestation of the subject’s perceptual discrimination process — the tachometric curve — which explicitly depicts how the perceptual decision unfolds in time.</p>
<p id="P29">More generally, the techniques described here may be used to understand how reward contingencies and perceptual knowledge are combined, as shown with the motor bias experiment, and to reveal how perceptual and motor processes interact, as illustrated with the FEF data. Furthermore, the present task design is not limited to color discrimination; it can be extended to investigate processing speed under many other experimental conditions. For instance, the task can be easily adapted to the auditory modality and to visual features other than color, such as object shape or motion direction. These applications will be explored in future studies.</p>
</sec>
<sec sec-type="methods" id="S10">
<title>METHODS</title>
<sec id="S11">
<title>Behavior and Electrophysiology</title>
<p id="P30">All protocols complied with NIH guidelines, USDA regulations, and policies set forth by Wake Forest University School of Medicine. Before training, under general anesthesia, an MRI-compatible titanium post was attached to each monkey’s skull. The post served to stabilize their heads during subsequent experimental sessions. In monkey S, eye movements were monitored with an eye coil that provided an analog eye-position signal at a rate of 500 Hz. For monkey G, we used an EyeLink1000 infrared tracking system (SR Research) with a sampling rate of 1000 Hz. Color stimuli were delivered through an array of light-emitting diodes placed at a viewing distance of 145 cm from the monkey’s chair. Pairs of saccade targets were separated by 10–20° of visual angle. RT was measured as the amount of time from the go signal until the velocity of the saccade reached a cutoff value of 50°/s. To discourage the monkeys from waiting for the cue, they were allowed to initiate a response up to 600 ms after the go signal, and a trial was aborted if the response took longer. In the motor bias sessions, large and small rewards were 0.3 and 0.1 ml in volume, respectively. The high-reward side was kept constant for a block of 150–250 trials and was then switched. In all conditions, standard and biased, red and green targets were presented with equal probability at all target locations.</p>
<p id="P31">In both monkeys, stereotactic coordinates and MRI images were used to place a recording cylinder (20 mm dia.) over the arcuate sulcus of frontal cortex. Putative FEF neurons were recorded using tungsten microelectrodes (FHC). The majority of neurons reported on here (23/30) were constrained to recording sites in which we verified that saccade-like eye movements could be evoked with microstimulation at low current threshold (< 50 µA). Once a single unit was isolated, a single-target delayed-saccade task was used to render an online estimate of preferred response direction and eccentricity prior to testing with the CS task. To explore the predictions of the present model, we explicitly chose for analysis a subset of neurons having strong saccade-related bursts but little or no transient activation linked to stimulus onset (see
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
).</p>
</sec>
<sec id="S12">
<title>Modeling</title>
<p id="P32">The race-to-threshold model has ten free parameters that varied for each monkey. The free parameters were optimized to minimize the root-mean-square error between the simulated and the experimental data for each animal. In the standard CS task, the error function had six terms, one for each of the curves in
<xref ref-type="fig" rid="F3">Figure 3a–d</xref>
plus one for the standard deviations included in
<xref ref-type="fig" rid="F3">Figure 3b</xref>
. All simulations were run in Matlab (The Mathworks). A Supplementary Movie showing ten simulated trials is available online, and a Matlab script that replicates the model results in
<xref ref-type="fig" rid="F3">Figure 3</xref>
is available from the authors upon request.</p>
<p id="P33">In the race model, the competing variables
<italic>x
<sub>R</sub>
</italic>
and
<italic>x
<sub>L</sub>
</italic>
represent developing motor plans. They start at 0 and the race is over when one of them reaches a threshold of 1000 (arbitrary units). When
<italic>x
<sub>L</sub>
</italic>
(
<italic>x
<sub>R</sub>
</italic>
) wins, the oculomotor response is considered to be to the left (right). In each simulated trial there are two integration stages, a random and a deterministic one. In the first stage of each race, before the cue information is available, the two build-up rates,
<italic>r
<sub>R</sub>
</italic>
and
<italic>r
<sub>L</sub>
</italic>
, are drawn from a bivariate Gaussian distribution with mean
<italic>r
<sub>G</sub>
</italic>
(same for both variables), standard deviation σ
<italic>
<sub>G</sub>
</italic>
(same for both variables), and correlation coefficient ρ. Thus,
<italic>x
<sub>R</sub>
</italic>
and
<italic>x
<sub>L</sub>
</italic>
change according to
<disp-formula id="FD2">
<label>(2)</label>
<mml:math id="M2" display="block" overflow="scroll">
<mml:mrow>
<mml:mtable columnalign="left">
<mml:mtr columnalign="left">
<mml:mtd columnalign="left">
<mml:mrow>
<mml:mi mathvariant="normal">d</mml:mi>
<mml:msub>
<mml:mi>x</mml:mi>
<mml:mi>R</mml:mi>
</mml:msub>
<mml:mo>/</mml:mo>
<mml:mtext>dt</mml:mtext>
<mml:mo>=</mml:mo>
<mml:msub>
<mml:mi>r</mml:mi>
<mml:mi>R</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mtd>
</mml:mtr>
<mml:mtr columnalign="left">
<mml:mtd columnalign="left">
<mml:mrow>
<mml:mi mathvariant="normal">d</mml:mi>
<mml:msub>
<mml:mi>x</mml:mi>
<mml:mi>L</mml:mi>
</mml:msub>
<mml:mo>/</mml:mo>
<mml:mtext>dt</mml:mtext>
<mml:mo>=</mml:mo>
<mml:msub>
<mml:mi>r</mml:mi>
<mml:mi>L</mml:mi>
</mml:msub>
</mml:mrow>
</mml:mtd>
</mml:mtr>
</mml:mtable>
</mml:mrow>
</mml:math>
</disp-formula>
where the rates are constant. Because ρ is negative, one variable tends to approach threshold faster than the other, but this assignment is random in each trial. This integration process lasts a time equal to the gap plus Δ
<italic>T</italic>
, where Δ
<italic>T</italic>
is drawn from a Gaussian distribution with zero mean and s.d. of 10 ms. The term Δ
<italic>T</italic>
represents variability in the afferent delay (or whatever processes occur before the integration starts). The second stage of the race begins gap + Δ
<italic>T</italic>
ms after the start of the first stage, at which point the target and distracter locations become known to the circuit. At this transition, two things happen. First, the integration is halted for a time
<italic>T
<sub>I</sub>
</italic>
, which is drawn from a Gaussian distribution with mean μ
<italic>
<sub>I</sub>
</italic>
and s.d. σ
<italic>
<sub>I</sub>
</italic>
, but such that any negative
<italic>T
<sub>I</sub>
</italic>
values are discarded. This interruption time is not essential to the model but accounts for a small dip near zero that is often seen in the ePT distributions (most obvious in
<xref ref-type="fig" rid="F3">Fig. 3c</xref>
, Monkey G). During
<italic>T
<sub>I</sub>
</italic>
, none of the variables change. Second, integration is resumed after the interruption, but the build-up rates start changing towards asymptotic values
<italic>r
<sub>T</sub>
</italic>
for target (large, positive value) and
<italic>r
<sub>D</sub>
</italic>
for distracter (negative value). For instance, if the target is on the right, the rate for
<italic>x
<sub>R</sub>
</italic>
begins to change toward
<italic>r
<sub>T</sub>
</italic>
and the rate for
<italic>x
<sub>L</sub>
</italic>
begins to change toward
<italic>r
<sub>D</sub>
</italic>
. That is, during this second stage,
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
still follow the equations above, but also
<disp-formula id="FD3">
<label>(3)</label>
<mml:math id="M3" display="block" overflow="scroll">
<mml:mrow>
<mml:mtable columnalign="left">
<mml:mtr columnalign="left">
<mml:mtd columnalign="left">
<mml:mrow>
<mml:mi mathvariant="normal">d</mml:mi>
<mml:msub>
<mml:mi>r</mml:mi>
<mml:mi>R</mml:mi>
</mml:msub>
<mml:mo>/</mml:mo>
<mml:mtext>dt</mml:mtext>
<mml:mo>=</mml:mo>
<mml:mo stretchy="false">(</mml:mo>
<mml:msub>
<mml:mi>r</mml:mi>
<mml:mi>T</mml:mi>
</mml:msub>
<mml:mo>−</mml:mo>
<mml:msub>
<mml:msup>
<mml:mi>r</mml:mi>
<mml:mn>0</mml:mn>
</mml:msup>
<mml:mi>R</mml:mi>
</mml:msub>
<mml:mo stretchy="false">)</mml:mo>
<mml:mo>/</mml:mo>
<mml:mi>τ</mml:mi>
</mml:mrow>
</mml:mtd>
</mml:mtr>
<mml:mtr columnalign="left">
<mml:mtd columnalign="left">
<mml:mrow>
<mml:mi mathvariant="normal">d</mml:mi>
<mml:msub>
<mml:mi>r</mml:mi>
<mml:mi>L</mml:mi>
</mml:msub>
<mml:mo>/</mml:mo>
<mml:mtext>dt</mml:mtext>
<mml:mo>=</mml:mo>
<mml:mo stretchy="false">(</mml:mo>
<mml:msub>
<mml:mi>r</mml:mi>
<mml:mi>D</mml:mi>
</mml:msub>
<mml:mo>−</mml:mo>
<mml:msub>
<mml:msup>
<mml:mi>r</mml:mi>
<mml:mn>0</mml:mn>
</mml:msup>
<mml:mi>L</mml:mi>
</mml:msub>
<mml:mo stretchy="false">)</mml:mo>
<mml:mo>/</mml:mo>
<mml:mi>τ</mml:mi>
</mml:mrow>
</mml:mtd>
</mml:mtr>
</mml:mtable>
</mml:mrow>
</mml:math>
</disp-formula>
where
<italic>r</italic>
<sup>0</sup>
<italic>
<sub>R</sub>
</italic>
and
<italic>r</italic>
<sup>0</sup>
<italic>
<sub>L</sub>
</italic>
are the rate values drawn originally, during the first stage, and τ is the time required to reach the final values
<italic>r
<sub>T</sub>
</italic>
and
<italic>r
<sub>D</sub>
</italic>
. We stress that these equations (
<xref ref-type="disp-formula" rid="FD3">Eqns. 3</xref>
) apply only after the cue has been revealed. Once
<italic>r
<sub>R</sub>
</italic>
and
<italic>r
<sub>L</sub>
</italic>
are equal to
<italic>r
<sub>T</sub>
</italic>
and
<italic>r
<sub>D</sub>
</italic>
, respectively, they do not change any more. Of course, if the target is on the left, then
<italic>r
<sub>L</sub>
</italic>
tends to
<italic>r
<sub>T</sub>
</italic>
and
<italic>r
<sub>R</sub>
</italic>
tends to
<italic>r
<sub>D</sub>
</italic>
instead. The integration process (
<xref ref-type="disp-formula" rid="FD2">Eqns. 2</xref>
) continues until
<italic>x
<sub>L</sub>
</italic>
or
<italic>x
<sub>R</sub>
</italic>
reaches threshold. In most trials, the build-up rates
<italic>r
<sub>R</sub>
</italic>
and
<italic>r
<sub>L</sub>
</italic>
are correctly assigned according to the target and distracter locations, as described. However, there is a small probability
<italic>p
<sub>e</sub>
</italic>
that this assignment is incorrect (i.e., reversed). This accounts for trials in which, even though the ePT is long, the response is wrong (e.g., the curve for monkey G in
<xref ref-type="fig" rid="F3">Fig. 3d</xref>
does not reach 100%). The duration of the second stage is equal to the ePT. The reaction time in each trial is computed as RT = gap + ePT +
<italic>T
<sub>ND</sub>
</italic>
, where
<italic>T
<sub>ND</sub>
</italic>
is the total non-decision time. Note that although it is easier to think of separate afferent and efferent delays, as schematized in
<xref ref-type="fig" rid="F4">Figure 4</xref>
, the model is sensitive only to the total non-decision time
<italic>T
<sub>ND</sub>
</italic>
(see
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
). Parameter values are listed in
<xref ref-type="table" rid="T1">Table 1</xref>
.</p>
<p id="P34">In simulations of the motor-bias experiment, the race model is the same but the parameters that determine
<italic>x
<sub>R</sub>
</italic>
and
<italic>x
<sub>L</sub>
</italic>
are no longer identical (the only exception is τ). For instance, in the first stage of each race, the two build-up rates,
<italic>r
<sub>R</sub>
</italic>
and
<italic>r
<sub>L</sub>
</italic>
, are now drawn from a bivariate Gaussian distribution with means
<italic>r
<sub>G</sub>
</italic>
+ Δ
<italic>r
<sub>G</sub>
</italic>
(for
<italic>r
<sub>R</sub>
</italic>
) and
<italic>r
<sub>G</sub>
</italic>
− Δ
<italic>r
<sub>G</sub>
</italic>
(for
<italic>r
<sub>L</sub>
</italic>
), standard deviations σ
<italic>
<sub>G</sub>
</italic>
+ Δσ
<italic>
<sub>G</sub>
</italic>
(for
<italic>r
<sub>R</sub>
</italic>
) and σ
<italic>
<sub>G</sub>
</italic>
− Δσ
<italic>
<sub>G</sub>
</italic>
(for
<italic>r
<sub>L</sub>
</italic>
), and correlation coefficient ρ. The bias terms Δ
<italic>r
<sub>G</sub>
</italic>
and Δσ
<italic>
<sub>G</sub>
</italic>
thus make the left and right sides asymmetric. With such manipulation, the model still generates random choices before the cue information is revealed, but it tilts the odds in favor of one side (
<xref ref-type="table" rid="T1">Table 1</xref>
).</p>
</sec>
<sec id="S13">
<title>Statistical Analysis</title>
<p id="P35">We obtained several curves with a particular characteristic in common: they remain approximately flat for a certain range of x-axis values and then start increasing or decreasing steadily (
<xref ref-type="fig" rid="F7">Fig. 7b–f</xref>
). We refer to the point at which the slope becomes non-zero in those curves as the transition point
<italic>x</italic>
<sub>trans</sub>
. This is an important quantity in our analysis, because according to the model (
<xref ref-type="fig" rid="F7">Fig. 7b,c</xref>
), it should be nearly the same for the tachometric curve (
<xref ref-type="fig" rid="F7">Fig. 7d</xref>
) and for the two convexity curves derived from the neuronal data (
<xref ref-type="fig" rid="F7">Fig. 7e,f</xref>
). We estimated
<italic>x</italic>
<sub>trans</sub>
as follows. For a given curve, we fitted the data to an analytic function composed of two line segments, a flat segment and a non-flat segment, that intersect at
<italic>x</italic>
<sub>trans</sub>
. We refer to this as a threshold-linear function. Each threshold-linear function is characterized by three parameters: the height of the flat segment along the y-axis, the slope of the non-flat segment, and the transition point
<italic>x</italic>
<sub>trans</sub>
. Optimal parameter values were found with standard algebraic methods used to fit a single straight line to a data set (i.e., least-squares minimization). The
<xref ref-type="supplementary-material" rid="SD1">Supplementary Information</xref>
online illustrates the resulting fits.</p>
<p id="P36">The error in
<italic>x</italic>
<sub>trans</sub>
was estimated using the jackknife method, which is based on the idea of recalculating a statistic multiple times, each time deleting a different contributing sample
<xref rid="R47" ref-type="bibr">47</xref>
,
<xref rid="R48" ref-type="bibr">48</xref>
. In our case, we recalculated
<italic>x</italic>
<sub>trans</sub>
30 times, on each pass omitting the data contributed by one of the recorded neurons and repeating the fit.</p>
<p id="P37">Finally, each linear-threshold fit produced a slope for the increasing or decreasing part of a curve. To calculate its significance we used a permutation test
<xref rid="R49" ref-type="bibr">49</xref>
. For each curve, we shuffled the values on the y axis and computed the slope of the line that best fitted the shuffled data between
<italic>x</italic>
<sub>trans</sub>
and the maximum rPT value used in the original fit. This randomization was repeated 5000 times. Then we computed the fraction of times that the slopes of the randomized data equaled or exceeded the slope of the original, non-shuffled data. This fraction was taken as the probability of having observed the original slope value just by chance, when there was actually no correlation between the quantities on the x and y axes.</p>
</sec>
</sec>
<sec sec-type="supplementary-material" id="SM">
<title>Supplementary Material</title>
<supplementary-material content-type="local-data" id="SD1">
<label>1</label>
<media xlink:href="NIHMS166710-supplement-1.pdf" mimetype="application" mime-subtype="pdf" xlink:type="simple" id="d37e1307" position="anchor"></media>
</supplementary-material>
</sec>
</body>
<back>
<ack id="S14">
<title>Acknowledgements</title>
<p id="P38">Research was supported by the National Institutes of Health/National Eye Institute grant R01 EY12389 to TRS.</p>
</ack>
<fn-group>
<fn id="FN1" fn-type="con">
<p id="P39">
<bold>Author Contributions</bold>
: TRS conceived the task, supervised all experiments and data analyses, and co-wrote the manuscript; SS contributed to the collection, analysis and modeling of the behavioral data; DPM contributed to the design of the experiments and to the collection of behavioral data; MGC contributed to the collection of behavioral data and to the collection and analysis of neural data; ES developed the race model, contributed to the experimental design and data analysis, and co-wrote the manuscript.</p>
</fn>
</fn-group>
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<floats-group>
<fig id="F1" position="float">
<label>Figure 1</label>
<caption>
<p id="P40">Sequence of events in the CS task. A trial is correct if the subject makes an eye movement to the peripheral location that matches the color of the fixation spot (red in this example). The subject must initiate a response (left or right) when the fixation spot disappears (Go), although target and distracter are revealed gap ms later (Cue).</p>
</caption>
<graphic xlink:href="nihms166710f1"></graphic>
</fig>
<fig id="F2" position="float">
<label>Figure 2</label>
<caption>
<p id="P41">Oculomotor execution during the CS task.
<bold>a</bold>
,
<bold>b</bold>
, Eye velocity (
<bold>a</bold>
) and eye position (
<bold>b</bold>
) as functions of time for 30 saccades performed by monkey S in short-gap (50–100 ms) trials. Only horizontal components are shown. Black lines are single-trial traces; gray lines are averages. Numbers shown are mean peak velocity and mean width at half-height ± s.e.m.
<bold>c</bold>
,
<bold>d</bold>
, Eye velocity (
<bold>c</bold>
) and eye position (
<bold>d</bold>
) as functions of time for 30 saccades performed by monkey S in long-gap (200–250 ms) trials.
<bold>e</bold>
–
<bold>h</bold>
, As in
<bold>a</bold>
–
<bold>d</bold>
, but for 30 short-gap (
<bold>e</bold>
,
<bold>f</bold>
) and 30 long-gap (
<bold>g</bold>
,
<bold>h</bold>
) trials performed by monkey G.</p>
</caption>
<graphic xlink:href="nihms166710f2"></graphic>
</fig>
<fig id="F3" position="float">
<label>Figure 3</label>
<caption>
<p id="P42">Behavioral and model performance in the CS task.
<bold>a</bold>
, Percentage of correct responses as a function of time gap (psychometric curve). Numbers of trials per point are 568 ≤
<italic>n</italic>
≤ 598 for monkey S and 702 ≤
<italic>n</italic>
≤ 777 for monkey G.
<bold>b</bold>
, Mean RT ± 1 s.d. as a function of gap (chronometric curve). Each point includes both correct and incorrect trials.
<bold>c</bold>
, Distributions of ePT values for correct (black and blue bars) and incorrect (magenta lines) trials.
<bold>d</bold>
, Percentage of correct responses as a function of ePT (tachometric curve).
<bold>e</bold>
, Distributions of RT values at five gaps. Gap values are indicated on upper left corners. RTs for correct (black and blue bars) and incorrect trials (magenta lines) are shown. In
<bold>c</bold>
and
<bold>d</bold>
, bin width is 20 ms; in
<bold>e</bold>
it is 40 ms. All results labeled “Model” are from simulated trials generated with identical parameter values for each monkey.</p>
</caption>
<graphic xlink:href="nihms166710f3"></graphic>
</fig>
<fig id="F4" position="float">
<label>Figure 4</label>
<caption>
<p id="P43">Five trials of the race-to-threshold model. Each plot shows the decision variables
<italic>x
<sub>L</sub>
</italic>
(green) and
<italic>x
<sub>R</sub>
</italic>
(red) as functions of time. Black triangles and vertical lines mark when the go signal is given (Go) and when the saccade is initiated (Sac); the interval between them is the RT. In these examples
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
start racing 60 ms (afferent delay) after the go signal and a saccade is produced 30 ms (efferent delay) after the threshold (dotted line) is crossed. Initially, build-up rates are drawn randomly and remain constant during the gap period (gray shade), but once the cue information becomes available (end of gray shade), the build-up rate for the target side (
<italic>x
<sub>R</sub>
</italic>
in these examples) starts increasing and that for the distracter side starts decreasing.
<bold>a</bold>
–
<bold>c</bold>
, Three trials with a 100 ms gap.
<bold>d</bold>
,
<bold>e</bold>
, Two trials with a 250 ms gap. In all examples the target was red and was located on the right, so
<bold>a</bold>
,
<bold>b</bold>
,
<bold>d</bold>
are correct and
<bold>c</bold>
,
<bold>e</bold>
are incorrect trials. Horizontal bars at the bottom indicate the ePT period in each trial; ePT values are positive (black) for races that are influenced by the sensory information (
<bold>a</bold>
–
<bold>c</bold>
) and negative (dark gray) for races that end before the cue information becomes available (
<bold>d</bold>
,
<bold>e</bold>
).</p>
</caption>
<graphic xlink:href="nihms166710f4"></graphic>
</fig>
<fig id="F5" position="float">
<label>Figure 5</label>
<caption>
<p id="P44">Behavioral and model performance in the motor-bias experiment. Trials are sorted according to choices, either toward the high-reward side (black) or the low-reward side (orange).
<bold>a</bold>
, Fractions of saccades made to the high- and low-reward sides as functions of gap (330 ≤
<italic>n</italic>
≤ 361 trials per gap).
<bold>b</bold>
, Percentages of correct choices as functions of gap.
<bold>c</bold>
, Mean RTs ± 1 s.d. as functions of gap.
<bold>d</bold>
, Distributions of ePT values for correct (black bars) and incorrect responses (gray lines) toward the high-reward side.
<bold>e</bold>
, Distributions of ePT values for correct (orange bars) and incorrect responses (gray lines) toward the low-reward side.
<bold>f</bold>
, Percentages of correct responses as functions of ePT for high- (black lines) and low-reward (orange lines) trials.
<bold>g</bold>
, For each ePT, the curves show the fraction of all saccades (orange lines) or of all correct saccades (gray lines) made to the low-reward side. ePT bin size is 20 ms.</p>
</caption>
<graphic xlink:href="nihms166710f5"></graphic>
</fig>
<fig id="F6" position="float">
<label>Figure 6</label>
<caption>
<p id="P45">Oculomotor activity during the CS task.
<bold>a</bold>
, Tachometric curve obtained from all recording sessions;
<italic>n</italic>
= 7,282 trials. Note the x axis is rPT (= RT − gap). Shaded areas indicate short- and long-rPT groups.
<bold>b</bold>
, Mean time courses of the decision variables
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
synchronized on threshold crossing (dashed line), with saccades assumed to occur 30 ms later (triangles and vertical lines). Correct model responses into (red) and away (green) from the MF are shown for short (left side) and long (right side) rPTs.
<bold>c</bold>
, Responses of a single FEF neuron during correct trials into the MF, for short (left side) and long (right side) rPTs. Each panel shows spike trains from 30 trials synchronized on saccade onset (triangles and vertical lines). Firing rates as functions of time (red traces) were obtained by convolving the spikes with a Gaussian of σ = 6 ms. The key on the right indicates MF (gray patch), target (filled circle), and distracter (open circle) positions.
<bold>d</bold>
, Responses from the same cell as in
<bold>c</bold>
, but for correct saccades away from the MF.
<bold>e</bold>
, Average firing rates as functions of time obtained from 30 FEF neurons. For each cell, activity was normalized by the firing rate at saccade onset in short-rPT trials into the MF. Light colors indicate ± 1 s.e.m. Note differences between short- (left side) and long-rPT (right side) responses.</p>
</caption>
<graphic xlink:href="nihms166710f6"></graphic>
</fig>
<fig id="F7" position="float">
<label>Figure 7</label>
<caption>
<p id="P46">Sensory information accelerates oculomotor activity.
<bold>a</bold>
, The mean convexity
<italic>c</italic>
between two points on a curve is computed as the average difference between the line that joins those points (dotted line) and the curve values (continuous traces).
<bold>b</bold>
,
<bold>c</bold>
, Mean convexity of the trajectories of the model variables
<italic>x
<sub>L</sub>
</italic>
and
<italic>x
<sub>R</sub>
</italic>
as a function of rPT. Red and green lines indicate correct trials into and away from the MF, respectively. Insets above
<bold>b</bold>
show mean trajectories obtained in two rPT bins (keyed by a circle and a diamond). Shaded areas indicate the interval used to calculate convexity.
<bold>d</bold>
, Tachometric curve from all recording sessions. Arrow indicates the transition point at which the curve starts increasing. Horizontal line across arrow indicates error s.d. (from jackknife; see Methods).
<bold>e</bold>
,
<bold>f</bold>
, Mean convexity of the FEF population activity as a function of rPT, for correct trials into (red) and away (green) from the MF. Light colors indicate ± 1 s.e.m. Arrows indicate transition points and horizontal lines are error s.d. (from jackknife). Before averaging across cells, rates were normalized as in
<xref ref-type="fig" rid="F6">Figure 6e</xref>
. Other conventions as in
<bold>b</bold>
,
<bold>c</bold>
. rPT bin size is 40 ms.</p>
</caption>
<graphic xlink:href="nihms166710f7"></graphic>
</fig>
<table-wrap id="T1" position="float" orientation="landscape">
<label>Table 1</label>
<caption>
<p id="P47">Model parameter values in the standard CS task and the motor-bias experiment. Times are in ms.</p>
</caption>
<table frame="box" rules="all">
<thead>
<tr>
<th align="center" rowspan="1" colspan="1">Monkey/Condition</th>
<th align="center" rowspan="1" colspan="1">
<italic>r
<sub>G</sub>
</italic>
</th>
<th align="center" rowspan="1" colspan="1">σ
<sub>
<italic>G</italic>
</sub>
</th>
<th align="center" rowspan="1" colspan="1">ρ</th>
<th align="center" rowspan="1" colspan="1">μ
<sub>
<italic>I</italic>
</sub>
</th>
<th align="center" rowspan="1" colspan="1">σ
<sub>
<italic>I</italic>
</sub>
</th>
<th align="center" rowspan="1" colspan="1">
<italic>r
<sub>T</sub>
</italic>
</th>
<th align="center" rowspan="1" colspan="1">
<italic>r
<sub>D</sub>
</italic>
</th>
<th align="center" rowspan="1" colspan="1">τ</th>
<th align="center" rowspan="1" colspan="1">
<italic>T
<sub>ND</sub>
</italic>
</th>
<th align="center" rowspan="1" colspan="1">
<italic>p
<sub>e</sub>
</italic>
</th>
</tr>
</thead>
<tbody>
<tr>
<td align="center" rowspan="1" colspan="1">S/Standard CS</td>
<td align="center" rowspan="1" colspan="1">3.8</td>
<td align="center" rowspan="1" colspan="1">3.9</td>
<td align="center" rowspan="1" colspan="1">−0.6</td>
<td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">2</td>
<td align="center" rowspan="1" colspan="1">36</td>
<td align="center" rowspan="1" colspan="1">−20</td>
<td align="center" rowspan="1" colspan="1">180</td>
<td align="center" rowspan="1" colspan="1">108</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr>
<td align="center" rowspan="1" colspan="1">G/Standard CS</td>
<td align="center" rowspan="1" colspan="1">3.8</td>
<td align="center" rowspan="1" colspan="1">3</td>
<td align="center" rowspan="1" colspan="1">−0.8</td>
<td align="center" rowspan="1" colspan="1">20</td>
<td align="center" rowspan="1" colspan="1">10</td>
<td align="center" rowspan="1" colspan="1">340</td>
<td align="center" rowspan="1" colspan="1">−200</td>
<td align="center" rowspan="1" colspan="1">2200</td>
<td align="center" rowspan="1" colspan="1">112</td>
<td align="center" rowspan="1" colspan="1">0.02</td>
</tr>
<tr>
<td align="center" rowspan="1" colspan="1">S/Motor Bias,
<break></break>
preferred side</td>
<td align="center" rowspan="1" colspan="1">7.5</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">−0.8</td>
<td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">31</td>
<td align="center" rowspan="1" colspan="1">−12</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">109</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
<tr>
<td align="center" rowspan="1" colspan="1">S/Motor Bias,
<break></break>
non-preferred side</td>
<td align="center" rowspan="1" colspan="1">2.9</td>
<td align="center" rowspan="1" colspan="1">3.3</td>
<td align="center" rowspan="1" colspan="1">−0.8</td>
<td align="center" rowspan="1" colspan="1">7</td>
<td align="center" rowspan="1" colspan="1">4</td>
<td align="center" rowspan="1" colspan="1">17</td>
<td align="center" rowspan="1" colspan="1">−30</td>
<td align="center" rowspan="1" colspan="1">90</td>
<td align="center" rowspan="1" colspan="1">95</td>
<td align="center" rowspan="1" colspan="1">0</td>
</tr>
</tbody>
</table>
</table-wrap>
</floats-group>
</pmc>
</record>

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   |wiki=    Ticri/CIDE
   |area=    HapticV1
   |flux=    Pmc
   |étape=   Curation
   |type=    RBID
   |clé=     PMC:2834559
   |texte=   Perceptual decision making in less than 30 milliseconds
}}

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HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i   -Sk "pubmed:20098418" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd   \
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Data generation: Mon Jun 13 01:09:46 2016. Site generation: Wed Mar 6 09:54:07 2024