Visual performance in cataract patients with low levels of postoperative astigmatism: full correction versus spherical equivalent correction
Identifieur interne : 001C35 ( Pmc/Curation ); précédent : 001C34; suivant : 001C36Visual performance in cataract patients with low levels of postoperative astigmatism: full correction versus spherical equivalent correction
Auteurs : Robert P. Lehmann [États-Unis] ; Diane M. Houtman [États-Unis]Source :
- Clinical Ophthalmology (Auckland, N.Z.) [ 1177-5467 ] ; 2012.
Abstract
To evaluate whether visual performance could be improved in pseudophakic subjects by correcting low levels of postoperative astigmatism.
An exploratory, noninterventional study was conducted using subjects who had been implanted with an aspheric intraocular lens and had 0.5–0.75 diopter postoperative astigmatism. Monocular visual performance using full correction was compared with visual performance using spherical equivalent correction. Testing consisted of high- and low-contrast visual acuity, contrast sensitivity, and reading acuity and speed using the Radner Reading Charts.
Thirty-eight of 40 subjects completed testing. Visual acuities at three contrast levels (100%, 25%, and 9%) were significantly better using full correction than when using spherical equivalent correction (all
In this study of pseudophakic subjects with low levels of postoperative astigmatism, full correction yielded significantly better reading performance and high- and low-contrast visual acuity than spherical equivalent correction, suggesting that cataractous patients may benefit from surgical correction of low levels of preoperative corneal astigmatism.
Url:
DOI: 10.2147/OPTH.S28241
PubMed: 22399846
PubMed Central: 3295631
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Visual performance in cataract patients with low levels of postoperative astigmatism: full correction versus spherical equivalent correction</title><author><name sortKey="Lehmann, Robert P" sort="Lehmann, Robert P" uniqKey="Lehmann R" first="Robert P" last="Lehmann">Robert P. Lehmann</name><affiliation wicri:level="2"><nlm:aff id="af1-opth-6-333">Lehmann Eye Center, Nacogdoches, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Lehmann Eye Center, Nacogdoches</wicri:cityArea></affiliation></author><author><name sortKey="Houtman, Diane M" sort="Houtman, Diane M" uniqKey="Houtman D" first="Diane M" last="Houtman">Diane M. Houtman</name><affiliation wicri:level="1"><nlm:aff id="af2-opth-6-333">Alcon Research Ltd, Fort Worth, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alcon Research Ltd, Fort Worth, TX</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22399846</idno><idno type="pmc">3295631</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3295631</idno><idno type="RBID">PMC:3295631</idno><idno type="doi">10.2147/OPTH.S28241</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">001C35</idno><idno type="wicri:Area/Pmc/Curation">001C35</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Visual performance in cataract patients with low levels of postoperative astigmatism: full correction versus spherical equivalent correction</title><author><name sortKey="Lehmann, Robert P" sort="Lehmann, Robert P" uniqKey="Lehmann R" first="Robert P" last="Lehmann">Robert P. Lehmann</name><affiliation wicri:level="2"><nlm:aff id="af1-opth-6-333">Lehmann Eye Center, Nacogdoches, TX</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Texas</region></placeName><wicri:cityArea>Lehmann Eye Center, Nacogdoches</wicri:cityArea></affiliation></author><author><name sortKey="Houtman, Diane M" sort="Houtman, Diane M" uniqKey="Houtman D" first="Diane M" last="Houtman">Diane M. Houtman</name><affiliation wicri:level="1"><nlm:aff id="af2-opth-6-333">Alcon Research Ltd, Fort Worth, TX, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Alcon Research Ltd, Fort Worth, TX</wicri:regionArea></affiliation></author></analytic><series><title level="j">Clinical Ophthalmology (Auckland, N.Z.)</title><idno type="ISSN">1177-5467</idno><idno type="eISSN">1177-5483</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To evaluate whether visual performance could be improved in pseudophakic subjects by correcting low levels of postoperative astigmatism.</p></sec><sec><title>Methods</title><p>An exploratory, noninterventional study was conducted using subjects who had been implanted with an aspheric intraocular lens and had 0.5–0.75 diopter postoperative astigmatism. Monocular visual performance using full correction was compared with visual performance using spherical equivalent correction. Testing consisted of high- and low-contrast visual acuity, contrast sensitivity, and reading acuity and speed using the Radner Reading Charts.</p></sec><sec><title>Results</title><p>Thirty-eight of 40 subjects completed testing. Visual acuities at three contrast levels (100%, 25%, and 9%) were significantly better using full correction than when using spherical equivalent correction (all <italic>P</italic> < 0.001). For contrast sensitivity testing under photopic, mesopic, and mesopic with glare conditions, only one out of twelve outcomes demonstrated a significant improvement with full correction compared with spherical equivalent correction (at six cycles per degree under mesopic without glare conditions, <italic>P</italic> = 0.046). Mean reading speed was numerically faster with full correction across all print sizes, reaching statistical significance at logarithm of the reading acuity determination (logRAD) 0.2, 0.7, and 1.1 (<italic>P</italic> < 0.05). Statistically significant differences also favored full correction in logRAD score (<italic>P</italic> = 0.0376), corrected maximum reading speed (<italic>P</italic> < 0.001), and logarithm of the minimum angle of resolution/logRAD ratio (<italic>P</italic> < 0.001).</p></sec><sec><title>Conclusions</title><p>In this study of pseudophakic subjects with low levels of postoperative astigmatism, full correction yielded significantly better reading performance and high- and low-contrast visual acuity than spherical equivalent correction, suggesting that cataractous patients may benefit from surgical correction of low levels of preoperative corneal astigmatism.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ferrer Blasco, T" uniqKey="Ferrer Blasco T">T Ferrer-Blasco</name></author><author><name sortKey="Montes Mic, R" uniqKey="Montes Mic R">R Montés-Micó</name></author><author><name sortKey="Peixoto De Matos, Sc" 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Ophthalmol</journal-id><journal-id journal-id-type="iso-abbrev">Clin Ophthalmol</journal-id><journal-id journal-id-type="publisher-id">Clinical Ophthalmology</journal-id><journal-title-group><journal-title>Clinical Ophthalmology (Auckland, N.Z.)</journal-title></journal-title-group><issn pub-type="ppub">1177-5467</issn><issn pub-type="epub">1177-5483</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22399846</article-id><article-id pub-id-type="pmc">3295631</article-id><article-id pub-id-type="doi">10.2147/OPTH.S28241</article-id><article-id pub-id-type="publisher-id">opth-6-333</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Visual performance in cataract patients with low levels of postoperative astigmatism: full correction versus spherical equivalent correction</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lehmann</surname><given-names>Robert P</given-names></name><xref ref-type="aff" rid="af1-opth-6-333">1</xref></contrib><contrib contrib-type="author"><name><surname>Houtman</surname><given-names>Diane M</given-names></name><xref ref-type="aff" rid="af2-opth-6-333">2</xref><xref ref-type="corresp" rid="c1-opth-6-333"></xref></contrib></contrib-group><aff id="af1-opth-6-333"><label>1</label>Lehmann Eye Center, Nacogdoches, TX</aff><aff id="af2-opth-6-333"><label>2</label>Alcon Research Ltd, Fort Worth, TX, USA</aff><author-notes><corresp id="c1-opth-6-333">Correspondence: Diane Houtman, Alcon Research Ltd, 6201 South Freeway, Fort Worth, TX 76134, USA, Tel +1 817 293 0450, Fax +1 817 302 5047, Email <email>diane.houtman@alconlabs.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2012</year></pub-date><pmc-comment>Dove Press titles changed from ppub to collections in 2009.
Fake ppub written to satisfy Coll Date Type=ppub</pmc-comment>
<pub-date pub-type="ppub"><year>2012</year></pub-date><pub-date pub-type="epub"><day>02</day><month>3</month><year>2012</year></pub-date><volume>6</volume><fpage>333</fpage><lpage>338</lpage><permissions><copyright-statement>© 2012 Lehmann and Houtman, publisher and licensee Dove Medical Press Ltd.</copyright-statement><copyright-year>2012</copyright-year><license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>To evaluate whether visual performance could be improved in pseudophakic subjects by correcting low levels of postoperative astigmatism.</p></sec><sec><title>Methods</title><p>An exploratory, noninterventional study was conducted using subjects who had been implanted with an aspheric intraocular lens and had 0.5–0.75 diopter postoperative astigmatism. Monocular visual performance using full correction was compared with visual performance using spherical equivalent correction. Testing consisted of high- and low-contrast visual acuity, contrast sensitivity, and reading acuity and speed using the Radner Reading Charts.</p></sec><sec><title>Results</title><p>Thirty-eight of 40 subjects completed testing. Visual acuities at three contrast levels (100%, 25%, and 9%) were significantly better using full correction than when using spherical equivalent correction (all <italic>P</italic> < 0.001). For contrast sensitivity testing under photopic, mesopic, and mesopic with glare conditions, only one out of twelve outcomes demonstrated a significant improvement with full correction compared with spherical equivalent correction (at six cycles per degree under mesopic without glare conditions, <italic>P</italic> = 0.046). Mean reading speed was numerically faster with full correction across all print sizes, reaching statistical significance at logarithm of the reading acuity determination (logRAD) 0.2, 0.7, and 1.1 (<italic>P</italic> < 0.05). Statistically significant differences also favored full correction in logRAD score (<italic>P</italic> = 0.0376), corrected maximum reading speed (<italic>P</italic> < 0.001), and logarithm of the minimum angle of resolution/logRAD ratio (<italic>P</italic> < 0.001).</p></sec><sec><title>Conclusions</title><p>In this study of pseudophakic subjects with low levels of postoperative astigmatism, full correction yielded significantly better reading performance and high- and low-contrast visual acuity than spherical equivalent correction, suggesting that cataractous patients may benefit from surgical correction of low levels of preoperative corneal astigmatism.</p></sec></abstract><kwd-group><kwd>aspheric intraocular lens</kwd><kwd>astigmatism</kwd><kwd>cataract surgery</kwd><kwd>contrast sensitivity</kwd><kwd>reading acuity</kwd><kwd>visual acuity</kwd></kwd-group></article-meta></front><body><sec><title>Introduction</title><p>The majority of patients who undergo cataract surgery have some degree of pre-existing corneal astigmatism, with a recent study reporting that 58% of over 4500 eyes exhibited between 0.25 diopter (D) and 1.0 D of corneal astigmatism.<xref ref-type="bibr" rid="b1-opth-6-333">1</xref> Low levels of corneal astigmatism (eg, ≤1.0 D) are often left uncorrected. For example, many peripheral corneal relaxing incision (PCRI) nomograms do not even include specifications for eyes with less than 1 D of preoperative astigmatism,<xref ref-type="bibr" rid="b2-opth-6-333">2</xref> and studies of toric intraocular lenses (IOLs) often have inclusion criteria specifying preoperative corneal astigmatism of at least 1 D or more.<xref ref-type="bibr" rid="b3-opth-6-333">3</xref> Even if patients with lower levels of corneal astigmatism have not been explicitly excluded from toric IOL studies, their visual outcomes have not been analyzed and presented separately.<xref ref-type="bibr" rid="b4-opth-6-333">4</xref>,<xref ref-type="bibr" rid="b5-opth-6-333">5</xref> Thus, the clinical benefits of correcting low levels of corneal astigmatism are not well established.</p><p>Clinical studies have demonstrated that subjects with low levels of astigmatism who were being fitted for contact lenses experienced greater improvements in visual acuity with the use of toric contact lenses compared with either spherical<xref ref-type="bibr" rid="b6-opth-6-333">6</xref> or aspheric lenses,<xref ref-type="bibr" rid="b7-opth-6-333">7</xref> suggesting that correction of even low levels of astigmatism can positively influence visual outcomes. This study investigated whether improvements in visual performance could be demonstrated by correcting low levels of postoperative astigmatism using full correction, instead of spherical equivalent correction, in pseudophakic subjects.</p></sec><sec sec-type="materials|methods"><title>Materials and methods</title><p>This was an exploratory, single-site, noninterventional study of subjects who had been implanted with the aspheric SN60WF IOL (Alcon Laboratories, Inc, Fort Worth, TX) more than 3 months prior to enrollment. The visual performance of these subjects using full correction was compared with their visual performance using spherical equivalent correction. The protocol was approved by the Institutional Review Board, and the study was performed in compliance with the ethical principles of the Declaration of Helsinki and Good Clinical Practice. All participating subjects provided written informed consent.</p><sec sec-type="subjects"><title>Subjects</title><p>Eligible subjects were adults who had undergone surgery for uncomplicated, age-related cataracts (Nuclear Sclerosis Grade 1–4) more than 3 months prior to enrollment. They also had to have a best-corrected Snellen visual acuity of 20/20 or better, 0.5–0.75 D of astigmatism at the spectacle plane (as measured with manifest refraction), and proof of an eye examination in the last year. One operative eye per subject was included. If both eyes qualified for inclusion, the dominant eye was selected.</p><p>Subjects were excluded if they met any of the following criteria: history of intraoperative complications during cataract surgery, extremes of axial length (<22 mm or >25 mm), amblyopia, corneal dystrophy, previous corneal transplant or retinal detachment, previous ocular or refractive surgery/trauma (other than cataract surgery), recurrent severe anterior or posterior segment inflammation of unknown etiology, uncontrolled glaucoma, uveitis, optic nerve atrophy, pregnancy, or diagnosed degenerative visual disorders that were predicted to cause future visual acuity losses greater than 0.2 logarithm of the minimum angle of resolution (logMAR).</p></sec><sec sec-type="methods"><title>Testing methods</title><p>All subjects received monocular visual testing in the study eye using both full correction and spherical equivalent correction; this design allowed each subject to serve as his or her own control. Testing consisted of high-contrast and low-contrast visual acuity, contrast sensitivity, and reading acuity and speed.</p><p>High-contrast visual acuity was tested using a 100% contrast Early Treatment Diabetic Retinopathy Study (ETDRS) chart under photopic (160 cd/m<sup>2</sup>) conditions at a distance of 4 meters. Low-contrast visual acuity was tested using 25% and 9% contrast ETDRS charts under photopic conditions at a distance of 4 meters.</p><p>Contrast sensitivity was tested at three, six, twelve, and 18 cycles per degree (cpd) using the CSV-1000E contrast sensitivity chart (VectorVision Inc, Greenville, OH) at a distance of 8 feet. Contrast sensitivity testing was conducted under photopic (chart luminance of 85 cd/m<sup>2</sup>) and mesopic (chart luminance of 3 cd/m<sup>2</sup>) conditions without glare and mesopic conditions with glare source.</p><p>Reading acuity and speed were measured with the Radner Reading Charts, a series of sentence optotypes that vary in size by 0.1 log unit steps.<xref ref-type="bibr" rid="b8-opth-6-333">8</xref> The visual acuity correction used for these assessments was best near power for reading at 40 centimeters. Logarithm of the reading acuity determination (logRAD) score was recorded for the sentence with the smallest print size that was read completely. Corrected logRAD score was determined by accounting for reading errors (total number of incorrectly read syllables × 0.005 + uncorrected logRAD score). Reading speed in words/minute was calculated by measuring the time taken to read a sentence from the Radner Reading Chart, each of which has 14 words (14 words ÷ X seconds × 60 seconds/minute). Corrected reading speed was calculated by subtracting words missed from the words/minute calculation. Both maximum and mean reading speeds were calculated. Critical print size was measured as the print size at which maximum reading speed was achieved. Corrected critical print size was determined by accounting for reading errors (total number of incorrectly read syllables × 0.005 + uncorrected critical print size). The logMAR/logRAD ratio was defined as (1 − logRAD) × 100 ÷ (1 − logMAR).</p></sec><sec><title>Statistics</title><p>Paired <italic>t</italic>-tests were used to estimate the difference in outcomes for full correction versus spherical equivalent correction. Analysis of variance was used to examine the least-squares mean differences between full correction and spherical equivalent correction for reading speed at each print size. With a sample size of 40 eyes, a two-sided 95% confidence interval on the mean was estimated to within ±0.45 standard deviations of the measurement. Results are presented as mean ± standard error of the mean unless otherwise noted.</p></sec></sec><sec sec-type="results"><title>Results</title><p>Forty subjects were enrolled in this study. Twenty-four (60%) were female and 16 (40%) were male. The mean age of these subjects was 70 ± 5 years. The mean prescription had −0.58 ± 0.06 D of spherical correction and 0.59 ± 0.02 D of cylindrical correction. Thirty-eight subjects completed testing.</p><p>High-contrast visual acuity (100% contrast) using full correction was −0.01 ± 0.01 logMAR compared with 0.08 ± 0.02 logMAR using only spherical equivalent correction, which was a statistically significant difference favoring full correction (<italic>P</italic> < 0.001; <xref ref-type="fig" rid="f1-opth-6-333">Figure 1</xref>). Low-contrast visual acuity using 25% contrast was significantly better with full correction than with spherical equivalent correction (0.14 ± 0.01 logMAR vs 0.21 ± 0.02 logMAR, <italic>P</italic> < 0.001), as was low-contrast visual acuity using 9% contrast (0.28 ± 0.02 logMAR vs 0.37 ± 0.02 logMAR, <italic>P</italic> < 0.001).</p><p>No statistically significant differences between full correction and spherical equivalent correction were observed for contrast sensitivity performed under photopic conditions (<xref ref-type="table" rid="t1-opth-6-333">Table 1</xref>). Under mesopic conditions, the six cpd spatial frequency demonstrated a significant improvement with full correction (<italic>P</italic> = 0.046). When a glare source was added to the mesopic condition, none of the spatial frequencies exhibited a significant difference between correction conditions.</p><p>Across all print sizes on the Radner Reading Chart, the mean reading speed was numerically faster with full correction than with spherical equivalent correction, reaching a statistically significant difference at print sizes of logRAD 0.2, 0.7, and 1.1 (<italic>P</italic> < 0.05; <xref ref-type="fig" rid="f2-opth-6-333">Figure 2</xref>). Statistically significant differences also favored full correction over spherical equivalent correction in logRAD score (<italic>P</italic> = 0.0376), corrected maximum reading speed (<italic>P</italic> < 0.001), and logMAR/logRAD ratio (<italic>P</italic> < 0.001; <xref ref-type="table" rid="t2-opth-6-333">Table 2</xref>). No significant differences between correction conditions were noted for critical print size.</p></sec><sec sec-type="discussion"><title>Discussion</title><p>Moderate to high levels of corneal astigmatism in patients with cataract have conventionally been corrected with spectacles after surgery or with toric IOLs or PCRIs (also called limbal relaxing incisions) at the time of cataract surgery. For lower levels of corneal astigmatism (eg, <1 D), few studies have been published examining the visual outcomes of cataract patients who have had low levels of astigmatism surgically corrected. Of these studies, most reported only astigmatic reduction and postoperative uncorrected and/or best-corrected visual acuities;<xref ref-type="bibr" rid="b9-opth-6-333">9</xref>–<xref ref-type="bibr" rid="b11-opth-6-333">11</xref> another study reported on postoperative higher-order aberrations.<xref ref-type="bibr" rid="b12-opth-6-333">12</xref> The current study focused on visual performance parameters, including contrast visual acuity, contrast sensitivity, and reading performance. Specifically, it examined the postoperative visual performance of pseudophakic subjects having low levels of residual astigmatism after applying either full correction or spherical equivalent correction in order to isolate the impact of astigmatic correction on several performance parameters. Little difference in contrast sensitivity was observed between full correction and spherical equivalent correction, with a significant improvement observed with full correction for only one of twelve outcomes (perception of four spatial densities tested under three lighting conditions). This is consistent with the results from a previous study, which reported that contrast sensitivity was not affected by low levels of astigmatism (0.25–1.0 D).<xref ref-type="bibr" rid="b13-opth-6-333">13</xref> The current study did demonstrate that subjects achieved significant improvements in visual acuity under high- and low-contrast conditions and in reading performance when astigmatism was corrected compared with spherical equivalent correction alone. The fact that these subjects could benefit from postoperative correction of low-level astigmatism suggests that they may also have benefited from surgical correction of their pre-existing astigmatism at the time of cataract surgery.</p><p>Astigmatism can be corrected during cataract surgery in a number of ways, including placement of the phacoemulsification incision on the steepest meridian of the cornea (commonly referred to as the steep axis), use of opposite clear corneal incisions (OCCIs), use of PCRIs, and implantation of a toric IOL.<xref ref-type="bibr" rid="b14-opth-6-333">14</xref> Placement of the incision on the steep axis is attractive due to its simplicity; however, outcomes can be highly variable.<xref ref-type="bibr" rid="b15-opth-6-333">15</xref> Variability in surgically induced astigmatism has been correlated with age, preoperative astigmatism, and postoperative IOP.<xref ref-type="bibr" rid="b16-opth-6-333">16</xref> This type of on-axis incision is performed primarily in patients with low levels of astigmatism, because it can correct only approximately 0.5–0.6 D of astigmatism.<xref ref-type="bibr" rid="b14-opth-6-333">14</xref>,<xref ref-type="bibr" rid="b17-opth-6-333">17</xref> Paired on-axis OCCIs can provide additional astigmatic correction and thus are typically used when higher levels of astigmatism are present.<xref ref-type="bibr" rid="b17-opth-6-333">17</xref>,<xref ref-type="bibr" rid="b18-opth-6-333">18</xref> Although on-axis incisions are meant to reduce corneal astigmatism, in one recent study these incisions produced similar proportions of eyes having an increase in residual astigmatism compared with conventional temporal incisions.<xref ref-type="bibr" rid="b15-opth-6-333">15</xref> In another study they produced significantly more axis shifts greater than 30° than did temporal incisions (<italic>P</italic> < 0.05).<xref ref-type="bibr" rid="b19-opth-6-333">19</xref></p><p>Compared with on-axis incisions, PCRIs have been reported to be less variable and more stable over time.<xref ref-type="bibr" rid="b20-opth-6-333">20</xref> In a consecutive case series studying the predictability of PCRIs, 54% of eyes with low-level astigmatism (0.5 D or 1.0 D) exhibited a postoperative increase, rather than decrease, in cylinder magnitude with PCRIs.<xref ref-type="bibr" rid="b2-opth-6-333">2</xref> Most PCRI nomograms do not currently include specifications for eyes with less than 1 D of pre-existing astigmatism.<xref ref-type="bibr" rid="b2-opth-6-333">2</xref> In addition to the challenges of variability, lack of precision, and limited range, both on-axis incisions and PCRIs also have the potential to induce complications associated with an additional surgical step, including delayed wound healing, corneal epithelial defects, and exacerbation of dry-eye symptoms.<xref ref-type="bibr" rid="b21-opth-6-333">21</xref> These surgical approaches require additional surgical skill and operating time to achieve desired results.</p><p>Toric IOL implantation has the advantage of bypassing an additional surgical interventional step and has been shown to produce superior astigmatic correction compared with both OCCIs<xref ref-type="bibr" rid="b22-opth-6-333">22</xref> and PCRIs.<xref ref-type="bibr" rid="b23-opth-6-333">23</xref> Toric IOLs have also been shown to provide lower refractive cylinder/postoperative astigmatism<xref ref-type="bibr" rid="b24-opth-6-333">24</xref> and superior uncorrected visual acuity than spherical IOLs in patients with low levels of astigmatism.<xref ref-type="bibr" rid="b11-opth-6-333">11</xref>,<xref ref-type="bibr" rid="b25-opth-6-333">25</xref> The main disadvantage of toric IOLs is the potential for IOL misalignment to reduce the astigmatic correction or even, in some cases, to worsen preoperative astigmatism. However, rotational stability has improved over time as better haptics have been introduced. For instance, two recent studies of toric IOLs each reported a mean axis rotation of less than 4° and IOL rotation between 10° and 20° in a small proportion of eyes (1% [N = 100] and 6.7% [N = 243]).<xref ref-type="bibr" rid="b4-opth-6-333">4</xref>,<xref ref-type="bibr" rid="b5-opth-6-333">5</xref></p><p>The current study does have some limitations. First, the population consisted of pseudophakic subjects having low levels of postoperative astigmatism, whereas other studies of low astigmatism focused on pre-existing astigmatism. In the current study, preoperative astigmatic levels were not reported and were almost certainly different from postoperative levels. Furthermore, the astigmatism was corrected only with phoropter lenses, rather than surgically. Thus, although these results do not allow us to draw firm conclusions regarding the ability of surgical correction to improve visual performance in patients with preoperative low levels of corneal astigmatism, they do strongly suggest that surgical correction of astigmatism less than 1 D should be explored with comparative clinical studies.</p></sec><sec><title>Conclusion</title><p>In this study of pseudophakic subjects with low levels of postoperative astigmatism, full correction of astigmatism was significantly better than spherical equivalent correction for outcomes of reading performance, high-contrast visual acuity, and low-contrast visual acuity, though most contrast sensitivity outcomes indicated no difference between full correction and spherical equivalent correction. These results indicate that correcting low levels of preoperative astigmatism at the time of cataract surgery may be efficacious in providing optimal visual outcomes; however, the balance of safety with this expected efficacy should be investigated in a randomized, controlled manner.</p></sec></body><back><ack><title>Acknowledgments</title><p>This study was supported by Alcon Laboratories, Inc. Medical writing assistance was provided by Jennifer Klem PhD and was funded by Alcon Laboratories, Inc.</p></ack><fn-group><fn id="fn1-opth-6-333"><p><bold>Disclosures</bold></p><p>This study has not been previously presented. The authors have no proprietary interest in this study. Diane Houtman is an employee of Alcon Laboratories, Inc. 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clear corneal incisions to correct astigmatism in eyes having cataract surgery</article-title><source>J Cataract Refract Surg</source><year>2009</year><volume>35</volume><issue>3</issue><fpage>451</fpage><lpage>458</lpage><pub-id pub-id-type="pmid">19251137</pub-id></element-citation></ref><ref id="b23-opth-6-333"><label>23</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Poll</surname><given-names>JT</given-names></name><name><surname>Wang</surname><given-names>L</given-names></name><name><surname>Koch</surname><given-names>DD</given-names></name><name><surname>Weikert</surname><given-names>MP</given-names></name></person-group><article-title>Correction of astigmatism during cataract surgery: Toric intraocular lens compared to peripheral corneal relaxing incisions</article-title><source>J Refract Surg</source><year>2011</year><volume>27</volume><issue>3</issue><fpage>165</fpage><lpage>171</lpage><pub-id pub-id-type="pmid">20873707</pub-id></element-citation></ref><ref id="b24-opth-6-333"><label>24</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ernest</surname><given-names>P</given-names></name><name><surname>Potvin</surname><given-names>R</given-names></name></person-group><article-title>The effects of preoperative corneal astigmatism orientation on results with a low cylinder power toric IOL</article-title><source>J Cataract Refract Surg</source><year>2011</year><volume>37</volume><issue>4</issue><fpage>727</fpage><lpage>732</lpage><pub-id pub-id-type="pmid">21333485</pub-id></element-citation></ref><ref id="b25-opth-6-333"><label>25</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lane</surname><given-names>SS</given-names></name><name><surname>Ernest</surname><given-names>P</given-names></name><name><surname>Miller</surname><given-names>KM</given-names></name><name><surname>Hileman</surname><given-names>KS</given-names></name><name><surname>Harris</surname><given-names>B</given-names></name><name><surname>Waycaster</surname><given-names>CR</given-names></name></person-group><article-title>Comparison of clinical and patient-reported outcomes with bilateral AcrySof toric or spherical control intraocular lenses</article-title><source>J Refract Surg</source><year>2009</year><volume>25</volume><issue>10</issue><fpage>899</fpage><lpage>901</lpage><pub-id pub-id-type="pmid">19835331</pub-id></element-citation></ref></ref-list></back><floats-group><fig id="f1-opth-6-333" position="float"><label>Figure 1</label><caption><p>High-contrast (100%) and low-contrast (25% and 9%) visual acuity with full correction versus spherical equivalent correction (N = 37).</p><p><bold>Note:</bold> Error bars represent standard error of the mean.</p><p><bold>Abbreviation:</bold> logMAR, logarithm of the minimum angle of resolution.</p></caption><graphic xlink:href="opth-6-333f1"></graphic></fig><fig id="f2-opth-6-333" position="float"><label>Figure 2</label><caption><p>Mean differences in reading speed across print sizes between use of full correction and spherical equivalent correction (N = 37).</p><p><bold>Notes:</bold> Error bars represent standard error of the mean; *Hommel’s adjusted <italic>P</italic> value, <italic>P</italic> < 0.05.</p><p><bold>Abbreviation:</bold> logRAD, logarithm of the reading acuity determination; SE, spherical equivalent.</p></caption><graphic xlink:href="opth-6-333f2"></graphic></fig><table-wrap id="t1-opth-6-333" position="float"><label>Table 1</label><caption><p>Mean differences in contrast sensitivity between full correction and spherical equivalent correction (N = 38)</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Contrast sensitivity condition</th><th colspan="4" align="left" valign="top" rowspan="1">Mean difference<xref ref-type="table-fn" rid="tfn2-opth-6-333">a</xref> ± SEM (logMAR)</th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"></th><th colspan="4" align="left" valign="top" rowspan="1"><hr></hr></th></tr><tr><th align="left" valign="top" rowspan="1" colspan="1"></th><th align="left" valign="top" rowspan="1" colspan="1">3 cpd</th><th align="left" valign="top" rowspan="1" colspan="1">6 cpd</th><th align="left" valign="top" rowspan="1" colspan="1">12 cpd</th><th align="left" valign="top" rowspan="1" colspan="1">18 cpd</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Photopic without glare</td><td align="center" valign="top" rowspan="1" colspan="1">0.008 ± 0.04</td><td align="left" valign="top" rowspan="1" colspan="1">0.01 ± 0.04</td><td align="left" valign="top" rowspan="1" colspan="1">0.01 ± 0.06</td><td align="left" valign="top" rowspan="1" colspan="1">0.02 ± 0.05</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Mesopic without glare</td><td align="center" valign="top" rowspan="1" colspan="1">−0.05 ± 0.05</td><td align="left" valign="top" rowspan="1" colspan="1">0.12 ± 0.06<xref ref-type="table-fn" rid="tfn3-opth-6-333">b</xref></td><td align="left" valign="top" rowspan="1" colspan="1">0.03 ± 0.06</td><td align="left" valign="top" rowspan="1" colspan="1">0.02 ± 0.05</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Mesopic with glare</td><td align="center" valign="top" rowspan="1" colspan="1">0.02 ± 0.04</td><td align="left" valign="top" rowspan="1" colspan="1">0.03 ± 0.05</td><td align="left" valign="top" rowspan="1" colspan="1">0.03 ± 0.045</td><td align="left" valign="top" rowspan="1" colspan="1">0.07 ± 0.04</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-opth-6-333"><p><bold>Notes:</bold></p></fn><fn id="tfn2-opth-6-333"><label>a</label><p>Mean difference = score with full correction – score with spherical equivalent correction;</p></fn><fn id="tfn3-opth-6-333"><label>b</label><p><italic>P</italic> = 0.046.</p></fn><fn id="tfn4-opth-6-333"><p><bold>Abbreviations:</bold> cpd, cycles per degree; logMAR, logarithm of the minimum angle of resolution; SEM, standard error of the mean.</p></fn></table-wrap-foot></table-wrap><table-wrap id="t2-opth-6-333" position="float"><label>Table 2</label><caption><p>Mean differences in additional Radner reading test outcomes between full correction and spherical equivalent correction (N = 37)</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" valign="top" rowspan="1" colspan="1">Outcome</th><th align="left" valign="top" rowspan="1" colspan="1">Mean difference<xref ref-type="table-fn" rid="tfn6-opth-6-333">a</xref> 95% confidence limit (lower, upper)</th><th align="left" valign="top" rowspan="1" colspan="1"><italic>P</italic> value</th></tr></thead><tbody><tr><td align="left" valign="top" rowspan="1" colspan="1">Corrected critical print size, logRAD</td><td align="left" valign="top" rowspan="1" colspan="1">0.02 (−0.09, 0.14)</td><td align="left" valign="top" rowspan="1" colspan="1">0.6803</td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Reading acuity @ 40 cm, logRAD</td><td align="left" valign="top" rowspan="1" colspan="1">−0.02 (−0.04, −0.001)</td><td align="left" valign="top" rowspan="1" colspan="1">0.0376<xref ref-type="table-fn" rid="tfn7-opth-6-333">b</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">Corrected maximum reading speed, words/minute</td><td align="left" valign="top" rowspan="1" colspan="1">19.2 (10.4, 28.0)</td><td align="left" valign="top" rowspan="1" colspan="1"><0.001<xref ref-type="table-fn" rid="tfn7-opth-6-333">b</xref></td></tr><tr><td align="left" valign="top" rowspan="1" colspan="1">LogMAR/logRAD ratio</td><td align="left" valign="top" rowspan="1" colspan="1">−6.54 (−9.95, −3.12)</td><td align="left" valign="top" rowspan="1" colspan="1"><0.001<xref ref-type="table-fn" rid="tfn7-opth-6-333">b</xref></td></tr></tbody></table><table-wrap-foot><fn id="tfn5-opth-6-333"><p><bold>Notes:</bold></p></fn><fn id="tfn6-opth-6-333"><label>a</label><p>Mean difference = score with full correction – score with spherical equivalent correction;</p></fn><fn id="tfn7-opth-6-333"><label>b</label><p><italic>P</italic> values signify statistically significant differences, all of which favored outcomes using full correction.</p></fn><fn id="tfn8-opth-6-333"><p><bold>Abbreviations:</bold> logMAR, logarithm of the minimum angle of resolution; logRAD, logarithm of the reading acuity determination.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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