Altered Connectivity and Action Model Formation in Autism Is Autism
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Auteurs : Stewart H. Mostofsky [États-Unis] ; Joshua B. Ewen [États-Unis]Source :
- The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry [ 1073-8584 ] ; 2011.
Abstract
Internal action models refer to sensory-motor programs that form the brain basis for a wide range of skilled behavior and for understanding others’ actions. Development of these action models, particularly those reliant on visual cues from the external world, depends on connectivity between distant brain regions. Studies of children with autism reveal anomalous patterns of motor learning and impaired execution of skilled motor gestures. These findings robustly correlate with measures of social and communicative function, suggesting that anomalous action model formation may contribute to impaired development of social and communicative (as well as motor) capacity in autism. Examination of the pattern of behavioral findings, as well as convergent data from neuroimaging techniques, further suggests that autism-associated action model formation may be related to abnormalities in neural connectivity, particularly decreased function of long-range connections. This line of study can lead to important advances in understanding the neural basis of autism and, more critically, can be used to guide effective therapies targeted at improving social, communicative, and motor function.
Url:
DOI: 10.1177/1073858410392381
PubMed: 21467306
PubMed Central: 3974163
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Ewen</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21467306</idno><idno type="pmc">3974163</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3974163</idno><idno type="RBID">PMC:3974163</idno><idno type="doi">10.1177/1073858410392381</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001B21</idno><idno type="wicri:Area/Pmc/Curation">001B21</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Altered Connectivity and Action Model Formation in Autism Is Autism</title><author><name sortKey="Mostofsky, Stewart H" sort="Mostofsky, Stewart H" uniqKey="Mostofsky S" first="Stewart H." last="Mostofsky">Stewart H. Mostofsky</name><affiliation wicri:level="1"><nlm:aff id="A1">Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, and Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, and Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author><author><name sortKey="Ewen, Joshua B" sort="Ewen, Joshua B" uniqKey="Ewen J" first="Joshua B." last="Ewen">Joshua B. Ewen</name><affiliation wicri:level="1"><nlm:aff id="A2">Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD</wicri:regionArea></affiliation></author></analytic><series><title level="j">The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry</title><idno type="ISSN">1073-8584</idno><idno type="eISSN">1089-4098</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="P1">Internal action models refer to sensory-motor programs that form the brain basis for a wide range of skilled behavior and for understanding others’ actions. Development of these action models, particularly those reliant on visual cues from the external world, depends on connectivity between distant brain regions. Studies of children with autism reveal anomalous patterns of motor learning and impaired execution of skilled motor gestures. These findings robustly correlate with measures of social and communicative function, suggesting that anomalous action model formation may contribute to impaired development of social and communicative (as well as motor) capacity in autism. Examination of the pattern of behavioral findings, as well as convergent data from neuroimaging techniques, further suggests that autism-associated action model formation may be related to abnormalities in neural connectivity, particularly decreased function of long-range connections. This line of study can lead to important advances in understanding the neural basis of autism and, more critically, can be used to guide effective therapies targeted at improving social, communicative, and motor function.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9504819</journal-id><journal-id journal-id-type="pubmed-jr-id">22458</journal-id><journal-id journal-id-type="nlm-ta">Neuroscientist</journal-id><journal-id journal-id-type="iso-abbrev">Neuroscientist</journal-id><journal-title-group><journal-title>The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry</journal-title></journal-title-group><issn pub-type="ppub">1073-8584</issn><issn pub-type="epub">1089-4098</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21467306</article-id><article-id pub-id-type="pmc">3974163</article-id><article-id pub-id-type="doi">10.1177/1073858410392381</article-id><article-id pub-id-type="manuscript">NIHMS450478</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Altered Connectivity and Action Model Formation in Autism Is Autism</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Mostofsky</surname><given-names>Stewart H.</given-names></name><xref ref-type="aff" rid="A1">1</xref></contrib><contrib contrib-type="author"><name><surname>Ewen</surname><given-names>Joshua B.</given-names></name><xref ref-type="aff" rid="A2">2</xref></contrib></contrib-group><aff id="A1"><label>1</label>Laboratory for Neurocognitive and Imaging Research, Kennedy Krieger Institute, and Departments of Neurology and Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff><aff id="A2"><label>2</label>Department of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA</aff><author-notes><corresp id="CR1"><bold>Corresponding Author:</bold> Joshua Ewen, MD, Kennedy Krieger Institute, 707 N Broadway, Baltimore, MD 21230, USA <email>ewen@kennedykrieger.org</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>27</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>05</day><month>4</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>8</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>03</day><month>4</month><year>2014</year></pub-date><volume>17</volume><issue>4</issue><fpage>437</fpage><lpage>448</lpage><pmc-comment>elocation-id from pubmed: 10.1177/1073858410392381</pmc-comment>
<permissions><copyright-statement>© The Author(s) 2011</copyright-statement><copyright-year>2011</copyright-year></permissions><abstract><p id="P1">Internal action models refer to sensory-motor programs that form the brain basis for a wide range of skilled behavior and for understanding others’ actions. Development of these action models, particularly those reliant on visual cues from the external world, depends on connectivity between distant brain regions. Studies of children with autism reveal anomalous patterns of motor learning and impaired execution of skilled motor gestures. These findings robustly correlate with measures of social and communicative function, suggesting that anomalous action model formation may contribute to impaired development of social and communicative (as well as motor) capacity in autism. Examination of the pattern of behavioral findings, as well as convergent data from neuroimaging techniques, further suggests that autism-associated action model formation may be related to abnormalities in neural connectivity, particularly decreased function of long-range connections. This line of study can lead to important advances in understanding the neural basis of autism and, more critically, can be used to guide effective therapies targeted at improving social, communicative, and motor function.</p></abstract><kwd-group><kwd>action models</kwd><kwd>autism</kwd><kwd>cerebral connectivity</kwd><kwd>EEG</kwd><kwd>motor function</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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