Primary motor cortex reports efferent control of vibrissa motion on multiple time scales
Identifieur interne : 001A28 ( Pmc/Curation ); précédent : 001A27; suivant : 001A29Primary motor cortex reports efferent control of vibrissa motion on multiple time scales
Auteurs : Daniel N. Hill [États-Unis, Allemagne] ; John C. Curtis [États-Unis] ; Jeffrey D. Moore [États-Unis] ; David Kleinfeld [États-Unis]Source :
- Neuron [ 0896-6273 ] ; 2011.
Abstract
Exploratory whisking in rat is an example of self-generated movement on multiple time scales, from slow variations in the envelope of whisking to the rapid sequence of muscle contractions during a single whisk cycle. We find that, as a population, spike trains of single units in primary vibrissa motor cortex report the absolute angle of vibrissa position. This representation persists after sensory nerve transection, indicating an efferent source. About two-thirds of the units are modulated by slow variations in the envelope of whisking while relatively few units report rapid changes in position within the whisk cycle. The combined results from this study and past measurements, which show that primary sensory cortex codes the whisking envelope as a motor copy signal, imply that signals present in both sensory and motor cortices are necessary to compute coordinates based on vibrissa touch.
Url:
DOI: 10.1016/j.neuron.2011.09.020
PubMed: 22017992
PubMed Central: 3717360
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<front><div type="abstract" xml:lang="en"><p id="P1">Exploratory whisking in rat is an example of self-generated movement on multiple time scales, from slow variations in the envelope of whisking to the rapid sequence of muscle contractions during a single whisk cycle. We find that, as a population, spike trains of single units in primary vibrissa motor cortex report the absolute angle of vibrissa position. This representation persists after sensory nerve transection, indicating an efferent source. About two-thirds of the units are modulated by slow variations in the envelope of whisking while relatively few units report rapid changes in position within the whisk cycle. The combined results from this study and past measurements, which show that primary sensory cortex codes the whisking envelope as a motor copy signal, imply that signals present in both sensory and motor cortices are necessary to compute coordinates based on vibrissa touch.</p>
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Computational Neuroscience Graduate Program, University of California, San Diego, CA, USA</aff>
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Department of Physics, Division of Physical Sciences, University of California, San Diego, CA, USA</aff>
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Institute of Neuroscience, Technical University Munich, Germany</aff>
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The Salk Institute for Biological Studies, San Diego, CA, USA</aff>
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Section of Neurobiology, Division of Biological Sciences, University of California, San Diego, CA, USA</aff>
<author-notes><corresp id="cor1"><bold>Correspondence:</bold>
David Kleinfeld, Department of Physics 0374, University of California, 9500 Gilman Drive, La Jolla, CA 92093, Office: 858-822-0342, Fax: 858-534-7697, <email>dk@physics.ucsd.edu</email>
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<abstract><p id="P1">Exploratory whisking in rat is an example of self-generated movement on multiple time scales, from slow variations in the envelope of whisking to the rapid sequence of muscle contractions during a single whisk cycle. We find that, as a population, spike trains of single units in primary vibrissa motor cortex report the absolute angle of vibrissa position. This representation persists after sensory nerve transection, indicating an efferent source. About two-thirds of the units are modulated by slow variations in the envelope of whisking while relatively few units report rapid changes in position within the whisk cycle. The combined results from this study and past measurements, which show that primary sensory cortex codes the whisking envelope as a motor copy signal, imply that signals present in both sensory and motor cortices are necessary to compute coordinates based on vibrissa touch.</p>
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