Accommodation-Amplitudes following an Accommodative Lens Refilling Procedure — an in vivo Update
Identifieur interne : 001A04 ( Pmc/Curation ); précédent : 001A03; suivant : 001A05Accommodation-Amplitudes following an Accommodative Lens Refilling Procedure — an in vivo Update
Auteurs : Okihiro Nishi [Japon] ; Yutaro Nishi [Japon] ; S. Chang [États-Unis] ; Kayo Nishi [Japon]Source :
- Journal of cataract and refractive surgery [ 0886-3350 ] ; 2014.
Abstract
To investigate whether a newly developed lens refilling procedure can provide some accommodation in monkey eyes and to evaluate the difference in accommodation with different degrees of capsular bag refilling.
Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.
Experimental monkey study.
Following a central 3–4 mm continuous curvilinear capsulorhexis, phacoemulsification was performed in the usual manner. A novel accommodative membrane intraocular lens for sealing capsular opening was implanted into the capsular bag. Silicone polymers were injected beneath the intraocular lens into the capsular bag through the delivery hole. In three study groups, each with six monkey eyes, the lens capsule was refilled with 0.08 ml corresponding to 65% bag volume, 0.1 ml corresponding to 80% bag volume, and 0.125 ml of silicone polymers corresponding to 100% bag volume, respectively. To calculate the accommodation-amplitudes achieved, automated refractometry was performed before and 1 hour after the topical 4% pilocarpine application before and four weeks after surgery.
The refilling technique was successful in all monkeys without polymer leakage. Accommodation-amplitudes attained were 2.56 ± 0.74 dioptries (D), 2.42 ± 1.00D, and 2.71 ± 0.63D, respectively, 4 weeks after surgery in the three study groups.
Using the technique, some accommodation could be obtained in the young monkey eyes. Leakage of the injectable silicone polymer and anterior capsular opacification at least in the visual axis could be avoided. The results suggest that this lens refilling procedure warrants further studies for a possible clinical application.
Url:
DOI: 10.1016/j.jcrs.2013.06.028
PubMed: 24461501
PubMed Central: 3955758
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<author><name sortKey="Nishi, Okihiro" sort="Nishi, Okihiro" uniqKey="Nishi O" first="Okihiro" last="Nishi">Okihiro Nishi</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan</nlm:aff>
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<author><name sortKey="Nishi, Yutaro" sort="Nishi, Yutaro" uniqKey="Nishi Y" first="Yutaro" last="Nishi">Yutaro Nishi</name>
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<author><name sortKey="Chang, S" sort="Chang, S" uniqKey="Chang S" first="S." last="Chang">S. Chang</name>
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<author><name sortKey="Nishi, Kayo" sort="Nishi, Kayo" uniqKey="Nishi K" first="Kayo" last="Nishi">Kayo Nishi</name>
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<author><name sortKey="Chang, S" sort="Chang, S" uniqKey="Chang S" first="S." last="Chang">S. Chang</name>
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<author><name sortKey="Nishi, Kayo" sort="Nishi, Kayo" uniqKey="Nishi K" first="Kayo" last="Nishi">Kayo Nishi</name>
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<series><title level="j">Journal of cataract and refractive surgery</title>
<idno type="ISSN">0886-3350</idno>
<idno type="eISSN">1873-4502</idno>
<imprint><date when="2014">2014</date>
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<front><div type="abstract" xml:lang="en"><sec id="S1"><title>Purpose</title>
<p id="P2">To investigate whether a newly developed lens refilling procedure can provide some accommodation in monkey eyes and to evaluate the difference in accommodation with different degrees of capsular bag refilling.</p>
</sec>
<sec id="S2"><title>Setting</title>
<p id="P3">Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.</p>
</sec>
<sec id="S3"><title>Design</title>
<p id="P4">Experimental monkey study.</p>
</sec>
<sec id="S4"><title>Methods</title>
<p id="P5">Following a central 3–4 mm continuous curvilinear capsulorhexis, phacoemulsification was performed in the usual manner. A novel accommodative membrane intraocular lens for sealing capsular opening was implanted into the capsular bag. Silicone polymers were injected beneath the intraocular lens into the capsular bag through the delivery hole. In three study groups, each with six monkey eyes, the lens capsule was refilled with 0.08 ml corresponding to 65% bag volume, 0.1 ml corresponding to 80% bag volume, and 0.125 ml of silicone polymers corresponding to 100% bag volume, respectively. To calculate the accommodation-amplitudes achieved, automated refractometry was performed before and 1 hour after the topical 4% pilocarpine application before and four weeks after surgery.</p>
</sec>
<sec id="S5"><title>Results</title>
<p id="P6">The refilling technique was successful in all monkeys without polymer leakage. Accommodation-amplitudes attained were 2.56 ± 0.74 dioptries (D), 2.42 ± 1.00D, and 2.71 ± 0.63D, respectively, 4 weeks after surgery in the three study groups.</p>
</sec>
<sec id="S6"><title>Conclusions</title>
<p id="P7">Using the technique, some accommodation could be obtained in the young monkey eyes. Leakage of the injectable silicone polymer and anterior capsular opacification at least in the visual axis could be avoided. The results suggest that this lens refilling procedure warrants further studies for a possible clinical application.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8604171</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5175</journal-id>
<journal-id journal-id-type="nlm-ta">J Cataract Refract Surg</journal-id>
<journal-id journal-id-type="iso-abbrev">J Cataract Refract Surg</journal-id>
<journal-title-group><journal-title>Journal of cataract and refractive surgery</journal-title>
</journal-title-group>
<issn pub-type="ppub">0886-3350</issn>
<issn pub-type="epub">1873-4502</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">24461501</article-id>
<article-id pub-id-type="pmc">3955758</article-id>
<article-id pub-id-type="doi">10.1016/j.jcrs.2013.06.028</article-id>
<article-id pub-id-type="manuscript">NIHMS552741</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Accommodation-Amplitudes following an Accommodative Lens Refilling Procedure — an in vivo Update</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Nishi</surname>
<given-names>Okihiro</given-names>
</name>
<degrees>MD, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nishi</surname>
<given-names>Yutaro</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Chang</surname>
<given-names>S.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nishi</surname>
<given-names>Kayo</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan</aff>
<aff id="A2"><label>2</label>
Calhoun Vision Institute, Pasadena, CA, USA</aff>
<author-notes><corresp id="FN1">Corresponding Author: Okihiro Nishi, MD, PhD, Nishi Eye Hospital, 4-14-26 Nakamichi, Higashinari-ku, Osaka 537-0025, Japan. Phone: +81 6 6981 1132, Fax: +81 6 6981 5630, <email>okihiro@nishi-ganka.or.jp</email>
</corresp>
<fn id="FN2"><p><bold>Reprint Request:</bold>
Okihiro Nishi, MD, PhD, Nishi Eye Hospital, Osaka, Japan</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>2</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>01</day>
<month>2</month>
<year>2015</year>
</pub-date>
<volume>40</volume>
<issue>2</issue>
<fpage>295</fpage>
<lpage>305</lpage>
<pmc-comment>elocation-id from pubmed: 10.1016/j.jcrs.2013.06.028</pmc-comment>
<permissions><copyright-statement>© 2013 American Society of Cataract and Refractive Surgery and European Society of Cataract and Refractive Surgeons. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2013</copyright-year>
</permissions>
<abstract><sec id="S1"><title>Purpose</title>
<p id="P2">To investigate whether a newly developed lens refilling procedure can provide some accommodation in monkey eyes and to evaluate the difference in accommodation with different degrees of capsular bag refilling.</p>
</sec>
<sec id="S2"><title>Setting</title>
<p id="P3">Jinshikai Medical Foundation, Nishi Eye Hospital, Osaka, Japan.</p>
</sec>
<sec id="S3"><title>Design</title>
<p id="P4">Experimental monkey study.</p>
</sec>
<sec id="S4"><title>Methods</title>
<p id="P5">Following a central 3–4 mm continuous curvilinear capsulorhexis, phacoemulsification was performed in the usual manner. A novel accommodative membrane intraocular lens for sealing capsular opening was implanted into the capsular bag. Silicone polymers were injected beneath the intraocular lens into the capsular bag through the delivery hole. In three study groups, each with six monkey eyes, the lens capsule was refilled with 0.08 ml corresponding to 65% bag volume, 0.1 ml corresponding to 80% bag volume, and 0.125 ml of silicone polymers corresponding to 100% bag volume, respectively. To calculate the accommodation-amplitudes achieved, automated refractometry was performed before and 1 hour after the topical 4% pilocarpine application before and four weeks after surgery.</p>
</sec>
<sec id="S5"><title>Results</title>
<p id="P6">The refilling technique was successful in all monkeys without polymer leakage. Accommodation-amplitudes attained were 2.56 ± 0.74 dioptries (D), 2.42 ± 1.00D, and 2.71 ± 0.63D, respectively, 4 weeks after surgery in the three study groups.</p>
</sec>
<sec id="S6"><title>Conclusions</title>
<p id="P7">Using the technique, some accommodation could be obtained in the young monkey eyes. Leakage of the injectable silicone polymer and anterior capsular opacification at least in the visual axis could be avoided. The results suggest that this lens refilling procedure warrants further studies for a possible clinical application.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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