Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients
Identifieur interne : 001974 ( Pmc/Curation ); précédent : 001973; suivant : 001975Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients
Auteurs : Timothy L. Hanson [États-Unis] ; Andrew M. Fuller [États-Unis] ; Mikhail A. Lebedev [États-Unis] ; Dennis A. Turner [États-Unis] ; Miguel A. L. Nicolelis [États-Unis, Brésil]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 0270-6474 ] ; 2012.
Abstract
Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson’s disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.
Url:
DOI: 10.1523/JNEUROSCI.0750-12.2012
PubMed: 22723703
PubMed Central: 3502028
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :001974
Links to Exploration step
PMC:3502028Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients</title>
<author><name sortKey="Hanson, Timothy L" sort="Hanson, Timothy L" uniqKey="Hanson T" first="Timothy L." last="Hanson">Timothy L. Hanson</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fuller, Andrew M" sort="Fuller, Andrew M" uniqKey="Fuller A" first="Andrew M." last="Fuller">Andrew M. Fuller</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lebedev, Mikhail A" sort="Lebedev, Mikhail A" uniqKey="Lebedev M" first="Mikhail A." last="Lebedev">Mikhail A. Lebedev</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turner, Dennis A" sort="Turner, Dennis A" uniqKey="Turner D" first="Dennis A." last="Turner">Dennis A. Turner</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosurgery, Duke University Medical Center, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nicolelis, Miguel A L" sort="Nicolelis, Miguel A L" uniqKey="Nicolelis M" first="Miguel A. L." last="Nicolelis">Miguel A. L. Nicolelis</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Psychology and Neuroscience, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology and Neuroscience, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">22723703</idno>
<idno type="pmc">3502028</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3502028</idno>
<idno type="RBID">PMC:3502028</idno>
<idno type="doi">10.1523/JNEUROSCI.0750-12.2012</idno>
<date when="2012">2012</date>
<idno type="wicri:Area/Pmc/Corpus">001974</idno>
<idno type="wicri:Area/Pmc/Curation">001974</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients</title>
<author><name sortKey="Hanson, Timothy L" sort="Hanson, Timothy L" uniqKey="Hanson T" first="Timothy L." last="Hanson">Timothy L. Hanson</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Fuller, Andrew M" sort="Fuller, Andrew M" uniqKey="Fuller A" first="Andrew M." last="Fuller">Andrew M. Fuller</name>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lebedev, Mikhail A" sort="Lebedev, Mikhail A" uniqKey="Lebedev M" first="Mikhail A." last="Lebedev">Mikhail A. Lebedev</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Turner, Dennis A" sort="Turner, Dennis A" uniqKey="Turner D" first="Dennis A." last="Turner">Dennis A. Turner</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A4">Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurosurgery, Duke University Medical Center, Durham, NC</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nicolelis, Miguel A L" sort="Nicolelis, Miguel A L" uniqKey="Nicolelis M" first="Miguel A. L." last="Nicolelis">Miguel A. L. Nicolelis</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Department of Neurobiology, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurobiology, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A2">Center for Neuroengineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Center for Neuroengineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A3">Department of Biomedical Engineering, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A5">Department of Psychology and Neuroscience, Duke University, Durham, NC, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology and Neuroscience, Duke University, Durham, NC</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A6">Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal, Brazil</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title>
<idno type="ISSN">0270-6474</idno>
<idno type="eISSN">1529-2401</idno>
<imprint><date when="2012">2012</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson’s disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8102140</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5035</journal-id>
<journal-id journal-id-type="nlm-ta">J Neurosci</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Neurosci.</journal-id>
<journal-title-group><journal-title>The Journal of neuroscience : the official journal of the Society for Neuroscience</journal-title>
</journal-title-group>
<issn pub-type="ppub">0270-6474</issn>
<issn pub-type="epub">1529-2401</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22723703</article-id>
<article-id pub-id-type="pmc">3502028</article-id>
<article-id pub-id-type="doi">10.1523/JNEUROSCI.0750-12.2012</article-id>
<article-id pub-id-type="manuscript">NIHMS372638</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Hanson</surname>
<given-names>Timothy L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Fuller</surname>
<given-names>Andrew M.</given-names>
</name>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="author-notes" rid="FN1">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Lebedev</surname>
<given-names>Mikhail A.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Turner</surname>
<given-names>Dennis A.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Nicolelis</surname>
<given-names>Miguel A. L.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
<xref ref-type="aff" rid="A5">5</xref>
<xref ref-type="aff" rid="A6">6</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Department of Neurobiology, Duke University, Durham, NC, USA</aff>
<aff id="A2"><label>2</label>
Center for Neuroengineering, Duke University, Durham, NC, USA</aff>
<aff id="A3"><label>3</label>
Department of Biomedical Engineering, Duke University, Durham, NC, USA</aff>
<aff id="A4"><label>4</label>
Department of Neurosurgery, Duke University Medical Center, Durham, NC, USA</aff>
<aff id="A5"><label>5</label>
Department of Psychology and Neuroscience, Duke University, Durham, NC, USA</aff>
<aff id="A6"><label>6</label>
Edmond and Lily Safra International Institute of Neuroscience of Natal, Natal, Brazil</aff>
<author-notes><corresp id="cor1"><bold>Corresponding Author:</bold>
Miguel A. L. Nicolelis, 311 Research Drive, Bryan Research Bldg., Room 327, Duke University, Durham, NC 27710, (919) 684-4580, <email>nicoleli@neuro.duke.edu</email>
</corresp>
<fn id="FN1" fn-type="equal"><label>*</label>
<p id="P1">These authors contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>26</day>
<month>10</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="ppub"><day>20</day>
<month>6</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>20</day>
<month>6</month>
<year>2013</year>
</pub-date>
<volume>32</volume>
<issue>25</issue>
<fpage>8620</fpage>
<lpage>8632</lpage>
<abstract><p id="P2">Deep brain stimulation (DBS) has expanded as an effective treatment for motor disorders, providing a valuable opportunity for intraoperative recording of the spiking activity of subcortical neurons. The properties of these neurons and their potential utility in neuroprosthetic applications are not completely understood. During DBS surgeries in 25 human patients with either essential tremor or Parkinson’s disease, we acutely recorded the single-unit activity of 274 ventral intermediate/ventral oralis posterior motor thalamus (Vim/Vop) neurons and 123 subthalamic nucleus (STN) neurons. These subcortical neuronal ensembles (up to 23 neurons sampled simultaneously) were recorded while the patients performed a target-tracking motor task using a cursor controlled by a haptic glove. We observed that modulations in firing rate of a substantial number of neurons in both Vim/Vop and STN represented target onset, movement onset/direction, and hand tremor. Neurons in both areas exhibited rhythmic oscillations and pairwise synchrony. Notably, all tremor-associated neurons exhibited synchrony within the ensemble. The data further indicate that oscillatory (likely pathological) neurons and behaviorally tuned neurons are not distinct but rather form overlapping sets. Whereas previous studies have reported a linear relationship between power spectra of neuronal oscillations and hand tremor, we report a nonlinear relationship suggestive of complex encoding schemes. Even in the presence of this pathological activity, linear models were able to extract motor parameters from ensemble discharges. Based on these findings, we propose that chronic multielectrode recordings from Vim/Vop and STN could prove useful for further studying, monitoring, and even treating motor disorders.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Institute of Neurological Disorders and Stroke : NINDS</funding-source>
<award-id>R01 NS073125 || NS</award-id>
</award-group>
<award-group><funding-source country="United States">Office of the Director : NIH</funding-source>
<award-id>DP1 OD006798 || OD</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Mental Health : NIMH</funding-source>
<award-id>DP1 MH099903 || MH</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Ticri/CIDE/explor/HapticV1/Data/Pmc/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001974 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd -nk 001974 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Ticri/CIDE |area= HapticV1 |flux= Pmc |étape= Curation |type= RBID |clé= PMC:3502028 |texte= Subcortical Neuronal Ensembles: An Analysis of Motor Task Association, Tremor, Oscillations, and Synchrony in Human Patients }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Curation/RBID.i -Sk "pubmed:22723703" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Curation/biblio.hfd \ | NlmPubMed2Wicri -a HapticV1
![]() | This area was generated with Dilib version V0.6.23. | ![]() |