Healthy and dystonic children compensate for changes in motor variability
Identifieur interne : 001426 ( Pmc/Curation ); précédent : 001425; suivant : 001427Healthy and dystonic children compensate for changes in motor variability
Auteurs : Virginia Way Tong Chu [États-Unis] ; Dagmar Sternad [États-Unis] ; Terence David Sanger [États-Unis]Source :
- Journal of Neurophysiology [ 0022-3077 ] ; 2013.
Abstract
Successful reaching requires that we plan movements to compensate for variability in motor output. Previous studies have shown that healthy adults optimally incorporate estimates of motor variability when planning a pointing task. Children with dystonia have increased variability compared with healthy children. It is not known whether they are able to compensate appropriately for the increased variability and whether this compensation leads to changes in reaching behavior. We examined healthy children and those with increased motor variability due to secondary dystonia. Using a simple virtual display, children performed a motor task where the variability of their movements was manipulated. Results showed that both subject groups changed their movement strategies in response to changes in the level of perceived motor variability. Both groups changed their strategy in a way that improved performance relative to the perceived motor variability. Importantly, dystonic children faced with decreased motor variability adapted their movement strategy to perform better and more similarly to healthy children. These findings show that both healthy and dystonic children are able to respond to changes in motor variability and alter their movement strategies.
Url:
DOI: 10.1152/jn.00908.2012
PubMed: 23343896
PubMed Central: 3628036
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<front><div type="abstract" xml:lang="en"><p>Successful reaching requires that we plan movements to compensate for variability in motor output. Previous studies have shown that healthy adults optimally incorporate estimates of motor variability when planning a pointing task. Children with dystonia have increased variability compared with healthy children. It is not known whether they are able to compensate appropriately for the increased variability and whether this compensation leads to changes in reaching behavior. We examined healthy children and those with increased motor variability due to secondary dystonia. Using a simple virtual display, children performed a motor task where the variability of their movements was manipulated. Results showed that both subject groups changed their movement strategies in response to changes in the level of perceived motor variability. Both groups changed their strategy in a way that improved performance relative to the perceived motor variability. Importantly, dystonic children faced with decreased motor variability adapted their movement strategy to perform better and more similarly to healthy children. These findings show that both healthy and dystonic children are able to respond to changes in motor variability and alter their movement strategies.</p>
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<journal-id journal-id-type="iso-abbrev">J. Neurophysiol</journal-id>
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<title-group><article-title>Healthy and dystonic children compensate for changes in motor variability</article-title>
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<contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Chu</surname>
<given-names>Virginia Way Tong</given-names>
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<xref ref-type="aff" rid="aff1"><sup>1</sup>
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<xref ref-type="aff" rid="aff4"><sup>4</sup>
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<contrib contrib-type="author"><name><surname>Sternad</surname>
<given-names>Dagmar</given-names>
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<xref ref-type="aff" rid="aff2"><sup>2</sup>
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<contrib contrib-type="author"><name><surname>Sanger</surname>
<given-names>Terence David</given-names>
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<xref ref-type="aff" rid="aff3"><sup>3</sup>
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<xref ref-type="aff" rid="aff4"><sup>4</sup>
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<aff id="aff1"><sup>1</sup>
Rehabilitation Institute of Chicago, Chicago, Illinois;</aff>
<aff id="aff2"><sup>2</sup>
Northeastern University, Boston, Massachusetts;</aff>
<aff id="aff3"><sup>3</sup>
University of Southern California, Los Angeles, California; and</aff>
<aff id="aff4"><sup>4</sup>
Department of Bioengineering, Stanford University, Stanford, California</aff>
</contrib-group>
<author-notes><corresp>Address for reprint requests and other correspondence: V. W. T. Chu, <addr-line>Rehabilitation Institute of Chicago, 345 E Superior St., Rm. 1406, Chicago, IL 60611</addr-line>
(e-mail: <email>vchu@ric.org</email>
).</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>15</day>
<month>4</month>
<year>2013</year>
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<pub-date pub-type="epub"><day>23</day>
<month>1</month>
<year>2013</year>
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<pub-date pub-type="pmc-release"><day>15</day>
<month>4</month>
<year>2014</year>
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<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>109</volume>
<issue>8</issue>
<fpage>2169</fpage>
<lpage>2178</lpage>
<history><date date-type="received"><day>15</day>
<month>10</month>
<year>2012</year>
</date>
<date date-type="accepted"><day>19</day>
<month>1</month>
<year>2013</year>
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<permissions><copyright-statement>Copyright © 2013 the American Physiological Society</copyright-statement>
<copyright-year>2013</copyright-year>
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<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="z9k00813002169.pdf"></self-uri>
<abstract><p>Successful reaching requires that we plan movements to compensate for variability in motor output. Previous studies have shown that healthy adults optimally incorporate estimates of motor variability when planning a pointing task. Children with dystonia have increased variability compared with healthy children. It is not known whether they are able to compensate appropriately for the increased variability and whether this compensation leads to changes in reaching behavior. We examined healthy children and those with increased motor variability due to secondary dystonia. Using a simple virtual display, children performed a motor task where the variability of their movements was manipulated. Results showed that both subject groups changed their movement strategies in response to changes in the level of perceived motor variability. Both groups changed their strategy in a way that improved performance relative to the perceived motor variability. Importantly, dystonic children faced with decreased motor variability adapted their movement strategy to perform better and more similarly to healthy children. These findings show that both healthy and dystonic children are able to respond to changes in motor variability and alter their movement strategies.</p>
</abstract>
<kwd-group><kwd>motor control</kwd>
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