Peripheral Somatosensation: A Touch of Genetics
Identifieur interne : 001046 ( Pmc/Curation ); précédent : 001045; suivant : 001047Peripheral Somatosensation: A Touch of Genetics
Auteurs : Erin G. Reed-Geaghan [États-Unis] ; Stephen M. Maricich [États-Unis]Source :
- Current opinion in genetics & development [ 0959-437X ] ; 2011.
Abstract
The somatosensory system processes information that organisms “feel”: joint position, muscle stretch, pain, pressure, temperature, and touch. The system is composed of a diverse array of peripheral nerve endings specialized to detect these sensory modalities. Several recent discoveries have shed light on the genetic pathways that control specification and differentiation of these neurons, how they accurately innervate their central and peripheral targets, and the molecules that enable them to detect mechanical stimuli. Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch.
Url:
DOI: 10.1016/j.gde.2010.12.009
PubMed: 21277195
PubMed Central: 3097266
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Maricich</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Otolaryngology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Otolaryngology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21277195</idno><idno type="pmc">3097266</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3097266</idno><idno type="RBID">PMC:3097266</idno><idno type="doi">10.1016/j.gde.2010.12.009</idno><date when="2011">2011</date><idno type="wicri:Area/Pmc/Corpus">001046</idno><idno type="wicri:Area/Pmc/Curation">001046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Peripheral Somatosensation: A Touch of Genetics</title><author><name sortKey="Reed Geaghan, Erin G" sort="Reed Geaghan, Erin G" uniqKey="Reed Geaghan E" first="Erin G." last="Reed-Geaghan">Erin G. Reed-Geaghan</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation></author><author><name sortKey="Maricich, Stephen M" sort="Maricich, Stephen M" uniqKey="Maricich S" first="Stephen M." last="Maricich">Stephen M. Maricich</name><affiliation wicri:level="2"><nlm:aff id="A1"> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A2"> Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation><affiliation wicri:level="2"><nlm:aff id="A3"> Department of Otolaryngology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</nlm:aff><country xml:lang="fr">États-Unis</country><placeName><region type="state">Ohio</region></placeName><wicri:cityArea> Department of Otolaryngology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland</wicri:cityArea></affiliation></author></analytic><series><title level="j">Current opinion in genetics & development</title><idno type="ISSN">0959-437X</idno><idno type="eISSN">1879-0380</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Summary</title><p id="P2">The somatosensory system processes information that organisms “feel”: joint position, muscle stretch, pain, pressure, temperature, and touch. The system is composed of a diverse array of peripheral nerve endings specialized to detect these sensory modalities. Several recent discoveries have shed light on the genetic pathways that control specification and differentiation of these neurons, how they accurately innervate their central and peripheral targets, and the molecules that enable them to detect mechanical stimuli. Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch.</p></div></front></TEI><pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9111375</journal-id><journal-id journal-id-type="pubmed-jr-id">2199</journal-id><journal-id journal-id-type="nlm-ta">Curr Opin Genet Dev</journal-id><journal-title>Current opinion in genetics & development</journal-title><issn pub-type="ppub">0959-437X</issn><issn pub-type="epub">1879-0380</issn></journal-meta><article-meta><article-id pub-id-type="pmid">21277195</article-id><article-id pub-id-type="pmc">3097266</article-id><article-id pub-id-type="doi">10.1016/j.gde.2010.12.009</article-id><article-id pub-id-type="manuscript">NIHMS270799</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Peripheral Somatosensation: A Touch of Genetics</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Reed-Geaghan</surname><given-names>Erin G.</given-names></name><xref rid="A1" ref-type="aff">1</xref><email>egr3@case.edu</email></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Maricich</surname><given-names>Stephen M.</given-names></name><xref rid="A1" ref-type="aff">1</xref><xref rid="A2" ref-type="aff">2</xref><xref rid="A3" ref-type="aff">3</xref><email>smm18@case.edu</email></contrib></contrib-group><aff id="A1"><label>1</label> Department of Pediatrics, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</aff><aff id="A2"><label>2</label> Department of Neurosciences, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</aff><aff id="A3"><label>3</label> Department of Otolaryngology, Case Western Reserve University, School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106</aff><pub-date pub-type="nihms-submitted"><day>8</day><month>2</month><year>2011</year></pub-date><pub-date pub-type="epub"><day>27</day><month>1</month><year>2011</year></pub-date><pub-date pub-type="ppub"><month>6</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>1</day><month>6</month><year>2012</year></pub-date><volume>21</volume><issue>3</issue><fpage>240</fpage><lpage>248</lpage><abstract><title>Summary</title><p id="P2">The somatosensory system processes information that organisms “feel”: joint position, muscle stretch, pain, pressure, temperature, and touch. The system is composed of a diverse array of peripheral nerve endings specialized to detect these sensory modalities. Several recent discoveries have shed light on the genetic pathways that control specification and differentiation of these neurons, how they accurately innervate their central and peripheral targets, and the molecules that enable them to detect mechanical stimuli. Here, we review the cadre of genes that control these processes, focusing on mechanosensitive neurons and support cells of the skin that mediate different aspects of the sense of touch.</p></abstract><contract-num rid="AR1">R01 AR059114-01A1
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