The Science of Neural Interface Systems
Identifieur interne : 000F79 ( Pmc/Curation ); précédent : 000F78; suivant : 000F80The Science of Neural Interface Systems
Auteurs : Nicholas G. Hatsopoulos ; John P. DonoghueSource :
- Annual review of neuroscience [ 0147-006X ] ; 2009.
Abstract
The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of neural function. Although electrical stimulation systems have already reached widespread clinical application, neural interfaces that record neural signals to decipher movement intentions are only now beginning to develop into clinically viable systems to help paralyzed people. We begin by reviewing state-of-the-art research and early-stage clinical recording systems and focus on systems that record single-unit action potentials. We then address the potential for neural interface research to enhance basic scientific understanding of brain function by offering unique insights in neural coding and representation, plasticity, brain-behavior relations, and the neurobiology of disease. Finally, we discuss technical and scientific challenges faced by these systems before they are widely adopted by severely motor-disabled patients.
Url:
DOI: 10.1146/annurev.neuro.051508.135241
PubMed: 19400719
PubMed Central: 2921719
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PMC:2921719Le document en format XML
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<affiliation><nlm:aff id="A1">Department of Organismal Biology and Anatomy, and Committees on Computational Neuroscience and Neurobiology, University of Chicago, Chicago, Illinois 60637;<email>nicho@uchicago.edu</email>
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<author><name sortKey="Donoghue, John P" sort="Donoghue, John P" uniqKey="Donoghue J" first="John P." last="Donoghue">John P. Donoghue</name>
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<front><div type="abstract" xml:lang="en"><p id="P1">The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of neural function. Although electrical stimulation systems have already reached widespread clinical application, neural interfaces that record neural signals to decipher movement intentions are only now beginning to develop into clinically viable systems to help paralyzed people. We begin by reviewing state-of-the-art research and early-stage clinical recording systems and focus on systems that record single-unit action potentials. We then address the potential for neural interface research to enhance basic scientific understanding of brain function by offering unique insights in neural coding and representation, plasticity, brain-behavior relations, and the neurobiology of disease. Finally, we discuss technical and scientific challenges faced by these systems before they are widely adopted by severely motor-disabled patients.</p>
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<title-group><article-title>The Science of Neural Interface Systems</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Hatsopoulos</surname>
<given-names>Nicholas G.</given-names>
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<contrib contrib-type="author"><name><surname>Donoghue</surname>
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<aff id="A1"><label>1</label>
Department of Organismal Biology and Anatomy, and Committees on Computational Neuroscience and Neurobiology, University of Chicago, Chicago, Illinois 60637;<email>nicho@uchicago.edu</email>
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Department of Neuroscience, Brown University, Providence, Rhode Island 02912;<email>john_donoghue@brown.edu</email>
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<pub-date pub-type="nihms-submitted"><day>19</day>
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<month>8</month>
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<volume>32</volume>
<fpage>249</fpage>
<lpage>266</lpage>
<permissions><copyright-statement>Copyright © 2009 by Annual Reviews. All rights reserved</copyright-statement>
<copyright-year>2009</copyright-year>
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<abstract><p id="P1">The ultimate goal of neural interface research is to create links between the nervous system and the outside world either by stimulating or by recording from neural tissue to treat or assist people with sensory, motor, or other disabilities of neural function. Although electrical stimulation systems have already reached widespread clinical application, neural interfaces that record neural signals to decipher movement intentions are only now beginning to develop into clinically viable systems to help paralyzed people. We begin by reviewing state-of-the-art research and early-stage clinical recording systems and focus on systems that record single-unit action potentials. We then address the potential for neural interface research to enhance basic scientific understanding of brain function by offering unique insights in neural coding and representation, plasticity, brain-behavior relations, and the neurobiology of disease. Finally, we discuss technical and scientific challenges faced by these systems before they are widely adopted by severely motor-disabled patients.</p>
</abstract>
<kwd-group><kwd>brain-machine interface</kwd>
<kwd>neural prosthesis</kwd>
<kwd>multielectrode array</kwd>
<kwd>decoding</kwd>
<kwd>motor cortex</kwd>
</kwd-group>
<contract-num rid="NS1">R01 NS025074-22
||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
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