Neurophysiology of Prehension. I. Posterior Parietal Cortex and Object-Oriented Hand Behaviors
Identifieur interne : 000E67 ( Pmc/Curation ); précédent : 000E66; suivant : 000E68Neurophysiology of Prehension. I. Posterior Parietal Cortex and Object-Oriented Hand Behaviors
Auteurs : Esther P. Gardner ; K. Srinivasa Babu ; Shari D. Reitzen ; Soumya Ghosh ; Alice S. Brown ; Jessie Chen ; Anastasia L. Hall ; Michael D. Herzlinger ; Jane B. Kohlenstein ; Jin Y. RoSource :
- Journal of neurophysiology [ 0022-3077 ] ; 2006.
Abstract
Hand manipulation neurons in areas 5 and 7b/anterior intraparietal area (AIP) of posterior parietal cortex were analyzed in three macaque monkeys during a trained prehension task. Digital video recordings of hand kinematics synchronized to neuronal spike trains were used to correlate firing rates of 128 neurons with hand actions as the animals grasped and lifted rectangular and round objects. We distinguished seven task stages: approach, contact, grasp, lift, hold, lower, and relax. Posterior parietal cortex (PPC) firing rates were highest during object acquisition; 88% of task-related area 5 neurons and 77% in AIP/7b fired maximally during stages 1, 2, or 3. Firing rates rose 200–500 ms before contact, peaked at contact, and declined after grasp was secured. 83% of area 5 neurons and 72% in AIP/7b showed significant increases in mean rates during approach as the fingers were preshaped for grasp. Somatosensory signals at contact provided feedback concerning the accuracy of reach and helped guide the hand to grasp sites. In error trials, tactile information was used to abort grasp, or to initiate corrective actions to achieve task goals. Firing rates declined as lift began. 41% of area 5 neurons and 38% in AIP/7b were inhibited during holding, and returned to baseline when grasp was relaxed. Anatomical connections suggest that area 5 provides somesthetic information to circuits linking AIP/7b to frontal motor areas involved in grasping. Area 5 may also participate in sensorimotor transformations coordinating reach and grasp behaviors and provide on-line feedback needed for goal-directed hand movements.
Url:
DOI: 10.1152/jn.00558.2006
PubMed: 16971679
PubMed Central: 2868366
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<series><title level="j">Journal of neurophysiology</title>
<idno type="ISSN">0022-3077</idno>
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<front><div type="abstract" xml:lang="en"><p id="P1">Hand manipulation neurons in areas 5 and 7b/anterior intraparietal area (AIP) of posterior parietal cortex were analyzed in three macaque monkeys during a trained prehension task. Digital video recordings of hand kinematics synchronized to neuronal spike trains were used to correlate firing rates of 128 neurons with hand actions as the animals grasped and lifted rectangular and round objects. We distinguished seven task stages: approach, contact, grasp, lift, hold, lower, and relax. Posterior parietal cortex (PPC) firing rates were highest during object acquisition; 88% of task-related area 5 neurons and 77% in AIP/7b fired maximally during stages 1, 2, or 3. Firing rates rose 200–500 ms before contact, peaked at contact, and declined after grasp was secured. 83% of area 5 neurons and 72% in AIP/7b showed significant increases in mean rates during approach as the fingers were preshaped for grasp. Somatosensory signals at contact provided feedback concerning the accuracy of reach and helped guide the hand to grasp sites. In error trials, tactile information was used to abort grasp, or to initiate corrective actions to achieve task goals. Firing rates declined as lift began. 41% of area 5 neurons and 38% in AIP/7b were inhibited during holding, and returned to baseline when grasp was relaxed. Anatomical connections suggest that area 5 provides somesthetic information to circuits linking AIP/7b to frontal motor areas involved in grasping. Area 5 may also participate in sensorimotor transformations coordinating reach and grasp behaviors and provide on-line feedback needed for goal-directed hand movements.</p>
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<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">0375404</journal-id>
<journal-id journal-id-type="pubmed-jr-id">5013</journal-id>
<journal-id journal-id-type="nlm-ta">J Neurophysiol</journal-id>
<journal-title>Journal of neurophysiology</journal-title>
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<article-id pub-id-type="manuscript">NIHMS198287</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>Neurophysiology of Prehension. I. Posterior Parietal Cortex and Object-Oriented Hand Behaviors</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Gardner</surname>
<given-names>Esther P.</given-names>
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<contrib contrib-type="author"><name><surname>Babu</surname>
<given-names>K. Srinivasa</given-names>
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<contrib contrib-type="author"><name><surname>Reitzen</surname>
<given-names>Shari D.</given-names>
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<contrib contrib-type="author"><name><surname>Ghosh</surname>
<given-names>Soumya</given-names>
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<contrib contrib-type="author"><name><surname>Brown</surname>
<given-names>Alice S.</given-names>
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<contrib contrib-type="author"><name><surname>Chen</surname>
<given-names>Jessie</given-names>
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<contrib contrib-type="author"><name><surname>Hall</surname>
<given-names>Anastasia L.</given-names>
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<contrib contrib-type="author"><name><surname>Herzlinger</surname>
<given-names>Michael D.</given-names>
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<contrib contrib-type="author"><name><surname>Kohlenstein</surname>
<given-names>Jane B.</given-names>
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<contrib contrib-type="author"><name><surname>Ro</surname>
<given-names>Jin Y.</given-names>
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<aff id="A1">Department of Physiology and Neuroscience, New York University School of Medicine, New York, New York</aff>
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<author-notes><corresp id="FN1">Address for reprint requests and other correspondence: E. P. Gardner, Dept. of Physiology and Neuroscience. New York University School of Medicine. 550 First Ave., MSB 442, New York, NY 10016 (<email>gardne01@endeavor.med.nyu.edu</email>
)</corresp>
<fn id="FN2" fn-type="present-address"><p>Present addresses: Dr. K. Srinivasa Babu, Dept. of Neurological Sciences, Christian Medical College, Vellore – 632 004, India; S. Ghosh, Centre for Neuromuscular and Neurological Disorders, University of Western Australia, Queen Elizabeth II Medical Centre. Nedlands, Perth, Western Australia 6009; S. D. Reitzen, Dept. of Otolaryngology, New York University Medical Center, 550 First Ave., New York, NY 10016; J. Y. Ro, Dept. of Biomedical Sciences, Program in Neuroscience, University of Maryland Dental School, 666 W. Baltimore St., Room 5C-06, Baltimore, MD 21201.</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>27</day>
<month>4</month>
<year>2010</year>
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<pub-date pub-type="epub"><day>13</day>
<month>9</month>
<year>2006</year>
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<pub-date pub-type="ppub"><month>1</month>
<year>2007</year>
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<pub-date pub-type="pmc-release"><day>12</day>
<month>5</month>
<year>2010</year>
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<volume>97</volume>
<issue>1</issue>
<fpage>387</fpage>
<lpage>406</lpage>
<abstract><p id="P1">Hand manipulation neurons in areas 5 and 7b/anterior intraparietal area (AIP) of posterior parietal cortex were analyzed in three macaque monkeys during a trained prehension task. Digital video recordings of hand kinematics synchronized to neuronal spike trains were used to correlate firing rates of 128 neurons with hand actions as the animals grasped and lifted rectangular and round objects. We distinguished seven task stages: approach, contact, grasp, lift, hold, lower, and relax. Posterior parietal cortex (PPC) firing rates were highest during object acquisition; 88% of task-related area 5 neurons and 77% in AIP/7b fired maximally during stages 1, 2, or 3. Firing rates rose 200–500 ms before contact, peaked at contact, and declined after grasp was secured. 83% of area 5 neurons and 72% in AIP/7b showed significant increases in mean rates during approach as the fingers were preshaped for grasp. Somatosensory signals at contact provided feedback concerning the accuracy of reach and helped guide the hand to grasp sites. In error trials, tactile information was used to abort grasp, or to initiate corrective actions to achieve task goals. Firing rates declined as lift began. 41% of area 5 neurons and 38% in AIP/7b were inhibited during holding, and returned to baseline when grasp was relaxed. Anatomical connections suggest that area 5 provides somesthetic information to circuits linking AIP/7b to frontal motor areas involved in grasping. Area 5 may also participate in sensorimotor transformations coordinating reach and grasp behaviors and provide on-line feedback needed for goal-directed hand movements.</p>
</abstract>
<contract-num rid="NS1">R01 NS044820-04
||NS</contract-num>
<contract-num rid="NS1">R01 NS011862-26
||NS</contract-num>
<contract-sponsor id="NS1">National Institute of Neurological Disorders and Stroke : NINDS</contract-sponsor>
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