Quantitative aspects in the assessment of liver injury.
Identifieur interne : 000B31 ( Pmc/Curation ); précédent : 000B30; suivant : 000B32Quantitative aspects in the assessment of liver injury.
Auteurs : G L PlaaSource :
- Environmental Health Perspectives [ 0091-6765 ] ; 1976.
Abstract
Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed.
Url:
PubMed: 1001295
PubMed Central: 1475155
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Environ Health Perspect</journal-id><journal-title>Environmental Health Perspectives</journal-title><issn pub-type="ppub">0091-6765</issn></journal-meta><article-meta><article-id pub-id-type="pmid">1001295</article-id><article-id pub-id-type="pmc">1475155</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Quantitative aspects in the assessment of liver injury.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Plaa</surname><given-names>G L</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>6</month><year>1976</year></pub-date><volume>15</volume><fpage>39</fpage><lpage>46</lpage><abstract><p>Liver function data are usually difficult to use in their original form when one wishes to compare the hepatotoxic properties of several chemical substances. However, procedures are available for the conversion of liver function data into quantal responses. These permit the elaboration of dose-response lines for the substances in question, the calculation of median effective doses and the statistical analysis of differences in liver-damaging potency. These same procedures can be utilized for estimating the relative hazard involved if one compares the liver-damaging potency to the median effective dose for some other pharmacologie parameter. Alterations in hepatic triglycerides, lipid peroxidation, and the activities of various hepatic enzymes can also be quantitiated in a dose-related manner. This permits the selection of equitoxic doses required for certain comparative studies and the selection of doses in chemical interaction studies. The quantitative problems involved in low-frequency adverse reactions and the difficulty these present in the detection of liver injury in laboratory animals are discussed.</p></abstract></article-meta></front><body><supplementary-material content-type="scanned-pages"><graphic xlink:href="envhper00490-0042.tif" xlink:title="scanned-page" xlink:role="39" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0043.tif" xlink:title="scanned-page" xlink:role="40" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0044.tif" xlink:title="scanned-page" xlink:role="41" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0045.tif" xlink:title="scanned-page" xlink:role="42" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0046.tif" xlink:title="scanned-page" xlink:role="43" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0047.tif" xlink:title="scanned-page" xlink:role="44" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0048.tif" xlink:title="scanned-page" xlink:role="45" mimetype="image" mime-subtype="tiff"></graphic><graphic xlink:href="envhper00490-0049.tif" xlink:title="scanned-page" xlink:role="46" mimetype="image" mime-subtype="tiff"></graphic></supplementary-material></body></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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